CELLULAR SIGNALLING
·
2026
·
IF 4.7
Qi-Hao Li,Tian-Ze Li,Yong-Cui Wang,Yao Yang,Ji-Jun Chen
Hepatocellular carcinoma (HCC) remains a highly malignant cancer with limited treatment options. HCC cells (HCCs) activate hepatic stellate cells (HSCs) and transform them into cancer-associated fibroblasts (CAFs), forming a vicious cycle for hepatocarcinogenesis. Therefore, inhibition of the communication between HCCs and HSCs is expected to emerge as a novel strategy for HCC treatment. Artematrolide F (AF), a sesquiterpenoid dimers (SDs) isolated from Artemisia atrovirens , exhibited significantly inhibitory activity on tumor cells in our previous report, but its mechanism remains unknown. This further study demonstrated that AF significantly inhibited the proliferation, colony formation and metastasis of HCCs. Notably, the inhibitory effect was enhanced when HCCs were cocultured with HSCs, suggesting that AF may suppress tumor progression through regulating the crosstalk of HCCs and HSCs. The vesicular transport protein YKT6 was identified as a target of AF through integrating bioinformatics analysis and machine learning model, which were verified by DARTS, CETSA, molecular docking, molecular dynamics simulation, and knockdown experiments. Further mechanistic research revealed that AF targeting YKT6 disrupted the crosstalk between HSCs and HCCs, suppressed HSC-driven tumor proliferation by inhibiting extracellular vesicles (EVs) secretion from HCCs, and blocked tumor autophagy by disrupting vesicular transport. These findings demonstrate that AF could serve as a novel therapeutic candidate for HCC treatment through regulating YKT6 to suppress HCCs–HSCs communication, block EV-dependent tumor progression, and inhibit tumor autophagy.
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PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Yang Hu,Dewei Ni,Bowen Chen,Feiyan Cai,Xiaoyu Wang,Yanmei Kan,Yusheng Ding,Shaoming Dong
Structure and stealth integrated materials that simultaneously deliver mechanical loading and broadband electromagnetic wave (EMW) absorption performance are critical for next generation stealth aircraft. Although conventional carbon fiber reinforced ceramic matrix composites (C f /CMCs) exhibit outstanding load-bearing capacity, their inherent EMW reflection characteristics often fail to meet stealth requirements. This work proposes a multiscale design strategy synergizing microscopic defect engineering with macroscopic gradient permittivity modulation. Accordingly, (SiO 2 –C) f /(CrZrHfNbTa)C–Si 3 N 4 –SiBCN composite featuring self-adaptive impedance matching and multi-mechanism EMW absorption were successfully constructed. The material demonstrates acceptable load-bearing capacity (101 ± 5 MPa) while achieving a remarkably high effective absorption bandwidth (EAB) per unit thickness (2.68 GHz mm −1 ). More importantly, radar cross section (RCS) simulations reveal that the sample achieves a remarkable RCS reduction of 35.52 dB m 2 . This surpasses most reported materials system, demonstrating high practical application potential. Density functional theory calculations reveals that defect engineering (lattice distortion and point defects) in the sample constructs new polarization centers at the microscopic level, which significantly enhances polarization relaxation loss for improved EMW absorption. On the other hand, macroscopic structural design (SiO 2f -C f -SiO 2f ) significantly optimizes the impedance matching, which effectively broadens EAB. The multiscale design strategy overcomes the inherent conflict between strong EMW reflection and attenuation in carbon fibers, which provides a novel material solution for stealth aircraft.
研究领域:
材料科学
·
电磁学
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高影响因子
GREEN CHEMISTRY
·
2025
·
IF 9.2
Kuan Wang,Xue Jiang,Xin-Peng Li,Zhe Cao,Zhen-Hong He,Weitao Wang,Huan Wang,Xiaojuan Lai,Zhao-Tie Liu
The electrocatalytic reduction of carbon dioxide (CO2) to methane (CH4) represents a promising strategy for carbon utilization, however, achieving high selectivity and efficiency remains a significant challenge. Herein, a copper foil-based catalyst with abundant interfaces was synthesized through electrodeposition to achieve Sb and F dual doping on the copper surface (CuSbF-ED), enabling efficient methane production through pulsed CO2 electrolysis. Under the pulsed electrolysis condition, the CuSbF-ED catalyst achieved a remarkably high CH4 Faradaic efficiency of approximately 92.6% and a partial current density of 60.3 mA•cm-2 at an overpotential of -1.2 V vs RHE, representing significant advancement over the static electrolysis performance of pristine copper foil. The in situ infrared spectroscopy results revealed an enhanced coverage of key intermediates *CHO on the CuSbF-ED surface during pulsed electrolysis. Theoretical calculations further confirmed that the CuSbF-ED structure with Sb and F dual doping stabilizes *CO intermediates and promotes the formation and adsorption of *CHO intermediates. Under the pulsed electrolysis conditions, the stabilized Cu species on CuSbF-ED surface facilitate the further conversion of adsorbed *CHO and *CH2O intermediates by deep hydrogenation processes toward high CH4 selectivity. The present research highlights Sb-F dual doping combined with pulsed potential electrolysis as a promising approach for the efficient and selective electroreduction of CO2 to CH4, contributing to sustainable carbon management
研究领域:
材料科学
·
电化学
·
环境科学
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DOI
高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Fang Huang,Aihao Xu,Xiangyu Chen,Huanhuan Sun,Siyu He,Dong Wei,Boran Wang,Anxiang Guan,Xucai Yin,Jing Xu,Huibing He
The direct electrocatalytic conversion of carbon dioxide to methane using water as a medium is a reliable way to store intermittent renewable energy and solve environmental problems. However, in such multielectron/proton transfer reactions, the role of water is often overlooked. Specifically, the sluggish kinetics of water dissociation limit the effective proton supply during methane formation. Here, we propose a copper-doped CeO2 catalyst with frustrated Lewis pairs (FLPs), which can effectively reduce carbon dioxide to methane. Combined experimental analysis and theoretical calculations reveal that the synergistic interaction between Cu and FLPs forms an f-p-d gradient orbital coupling system, which significantly promotes water dissociation to generate active protons and optimizes the adsorption behavior of the *H and *COOH intermediates. Even at the large current density of −273 mA cm–2, the Faraday efficiency of Cu/CeO2-FLPs for methane was as high as 78.0%, with a conversion frequency of 15784.1 h–1 in the flow cell. This work provides a strategy for the rational design of efficient multipoint catalytic systems.
研究领域:
催化化学
·
电化学
·
材料科学
·
可再生能源
·
环境科学
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高影响因子
DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Xiangjun Li,Yuxin Shi,Miaomiao Li,Shengwei Deng,Yinxia Dong,Libo Tong,Zhongze Du,Kuaishe Wang
The exceptional protection of epoxy resin (EP) is restricted in practical applications due to high electrical insulation and inherent microporous defects. In this study, acid-doped polypyrrole (f-PPy)/MXene hybrid nanomaterials incorporated into the EP matrix to construct three-dimensional (3D) conductive network that simultaneously enhances corrosion resistance and imparts antistatic capability. Electrochemical impedance measurements demonstrate a long-term stability, maintaining 9.73 × 10 10 Ω cm 2 even after 14 days of immersion, which is significantly higher than the EP coatings. Compared with pure EP, the composite SiO 2 @f-PPy/MXene/EP coating shows a 3 times reduction in surface resistivity (8.68 × 10 7 Ω m) and exceeds the industrial antistatic threshold by two orders of magnitude. The enhanced anticorrosion is attributed to the synergistic contribution of the triple properties of the SiO 2 @f-PPy/MXene: “labyrinth effect”, redox effect and corrosion inhibition. SiO 2 @f-PPy/MXene 3D conductive network enhances the antistatic ability of EP. This dual-functional strategy addresses the critical gap of combining anticorrosion and antistatic performance in EP coatings and offers a practical route for protective applications on Mg alloys.
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiaotong Huang,Qi Chen,Xianling Wei,Jingjing Wang,Zhi Lu,Qingping Wu,Chao Li,Xiaofang Zeng,Weidong Bai,Hao Dong
In this study, the effects of various sources polysaccharides, including chitosan, hawthorn polysaccharide and lentinan, on MeIQx (2-amino-3,8-dimethylimidazole[4,5- f ] quinoxaline) formation in roasted beef patties were investigated. Results showed that hawthorn polysaccharide had the strongest inhibitory effect, while only chitosan decreased free MeIQx in a dose-dependent manner. For bound MeIQx, the inhibitory effect of chitosan, hawthorn polysaccharide, and lentinan were 14 %, 22 %, and 39 % at 0.1 % addition. When increased to 0.5 %, the inhibition rate was 26 %, 40 %, and 36 %. None of the polysaccharides increased the inhibition rate of MeIQx at 1 % addition (25 %, 36 %, and 33 %, respectively). Overall, the MeIQx content may be related to the polysaccharides themselves have excellent water retention capability. Additionally, polysaccharides effectively eliminated the intermediates. The carbonyl content and TBARS were reduced due to the free radical scavenging activity of polysaccharides. This study provides a theoretical basis for the polysaccharides to reduce MeIQx in high-temperature meat processing.
研究领域:
食品化学
·
毒理学
·
食品加工安全
·
分子化学
·
营养科学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 4
·318
·
IF 3.2
Su Xiuyuan,Chen Yuan-Bin,Tang Ruxuan
Based on the Na 0.48 La 0.52 MoO 4 ceramic, this study replaced La 3+ ions with Nd 3+ ions through ion substitution, which significantly increased the Q × f of Na 0.48 La 0.52 MoO 4 and reduced the sintering temperature. The good sintering state of this series of ceramics was demonstrated by scanning electron microscopy (SEM) and density tests. X-ray diffraction (XRD) and Raman spectroscopy results revealed the formation of solid solutions without the presence of secondary phases or impurities. The P–V–L theory indicated that the Na/La/Nd–O bond-to-bond ionicity (fi) contribution was dominant, while the Mo–O bond also played a significant role in the lattice energy ( U ), bond energy ( E ), and thermal expansion coefficient ( α ). Among them, the Na 0.48 La 0.48 Nd 0.04 MoO 4 ceramic achieved the best dielectric performance at 900 °C, with ɛ r = 11.027 ± 0.018, Q × f = 113,805 ± 6,358 GHz, and τ f = − 23.36 ppm/℃. Through ion substitution, these materials all have low sintering temperatures and high Q × f values, making them ideal candidates for low-temperature co-fired ceramics (LTCC).
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ChemNanoMat
·
2022
·Vol. 8
·期 6
·e202200085
·
IF 3.82
Yang Gu,Chuqian Meng,Shuyue Dong,Hexin Zhu,Qian Liu,Yonglan Luo,Qingquan Kong,Tingshuai Li
High-performance earth-abundant electrocatalysts for oxygen evolution reaction (OER) are highly desirable. In this report, we successfully synthesized amorphous Fe−P shell electrodeposited on Co(OH)F nanowire arrays supported on titanium mesh (Fe−P@Co(OH)F/TM) as an efficient catalyst for OER. Such catalyst exhibits excellent OER activity with a low overpotential of 267 mV to reach the geometrical current density of 10 mA cm −2 in 1.0 M KOH. In addition, it has good electrochemical durability to maintain its activity for at least 20 h.
研究领域:
材料科学
·
电化学
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高影响因子
International Journal of Electrochemical Science
·
2023
·Vol. 11
·期 7
·5395-5402
·
IF 1.5
Xin Zhao,Yun Deng,Jiang Cheng
High-quality SnO 2 :F films with an area of 15×15 cm 2 were prepared from stannic chloride (SnCl 4 ) solution via a house-made ultrasonic spray pyrolysis instrument. The focus of this investigation was on the volatilization of solution and doping process of fluorine, the main influencing factors on F doping content, and the effects of F doping content on the crystal structure, surface morphology, electrical, and optical properties. The results indicated that the crystallinity was enhanced with increasing doping concentration; the films exhibited (101) oriented growth and the resistivity decreased at first and then increased. During the preparation route, the droplet momentum and the temperature field above the hot plate demonstrate the most dominate influence on the film’s properties. The spray droplet gradually hydrolyzed during the moving process from sprinkler to substrate while the F doping content decreased with the increasing distance between the sprinkler and the substrate. By controlling the doping of F, high-quality and large area SnO 2 :F films with a resistivity of 1.2×10 -3 Ω⋅cm and a visible light transmittance of 82% were prepared, demonstrating a promising application for organic solar cells and low emissivity glass.
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高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Xue Bai,Wen Li,Aijia Wei,Xiaohui Li,Lihui Zhang,Zhenfa Liu
Spinel Li 4 Ti 5 O 12 co-doped with Mg 2+ and F − was synthesized by solid-state reaction of anatase TiO 2 , Li 2 CO 3 , NH 4 F, and Mg(NO 3 ) 2 . For comparison, Mg 2+ -doped and F − -doped Li 4 Ti 5 O 12 were prepared using the same method. The structure and electrochemical performance of the prepared materials were investigated by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, electrochemical impedance spectroscopy, and galvanostatic charge-discharge tests. Using an internal standard and Rietveld refinement, we calculated the lattice parameters of the samples. After co-doping with Mg 2+ and F − , the dopant ions enter the Li 4 Ti 5 O 12 lattice, resulting in the reduction of Ti 4+ to Ti 3+ , and increasing the conductivity of the material. Furthermore, the Mg 2+ and F − co-doping technique resulted in smaller primary particles with a narrow size distribution, factors that can accelerate transfer of Li + between the electrode and electrolyte. Consequently, the Mg 2+ and F − co-doped Li 4 Ti 5 O 12 material exhibits a superior rate performance and delivers discharge capacities of 159.4, 154.1, 146.5, 120.8, 102.7, and 76 mAh g −1 at 0.2C, 0.5C, 1C, 3C, 5C, and 10C, respectively, significantly higher than those of pure Li 4 Ti 5 O 12 (155.4, 138.6, 124.2, 94.1, 76.7, and 52.2 mAh g −1 at the same C-rates). Moreover, the Mg 2+ and F − co-doped Li 4 Ti 5 O 12 showed outstanding cycling stability, and the capacity retention was 99.62% after 150 cycles at 5C rate. Therefore, the Mg 2+ and F − co-doping technique has proven an effective approach to improve the electrochemical performance of Li 4 Ti 5 O 12 .
研究领域:
材料科学
·
电化学
·
储能技术
·
锂离子电池
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Weimin Kang,Nanping Deng,Xiaomin Ma,Jingge Ju,Lei Li,Xiaohong Liu,Bowen Cheng
In this study, the F-doped poly-m-phenyleneisophthalamide (PMIA) solution was synthesized by low temperature polymerization method and spun to be three-dimensional nanofibrous membranes by electrospinning. The Energy Dispersive X-Ray Spectroscopy and Fourier Transform Infrared Spectroscopy investigations verified that F was successfully doped in PMIA membrane. The X-ray diffraction patterns showed the crystallinity degree of PMIA membrane decreased with the addition of F. The morphology, pore size and aperture distribution tests manifested that the average diameter of F-PMIA fibers became finer and their distribution was more uniform than these of PMIA fibers. The electrolyte uptake, preserving liquid electrolyte, thermal stability and shrinkage resistance of the F-dopoed membrane were also significantly enhanced than that of pure PMIA membrane. The F-PMIA membrane could be acted as matrix to prepare gel polymer electrolyte. Finally, the F-doped PMIA membrane was used in the assembled coin cells to test the properties including the electronic conductivity , battery interfacial characteristics, electrochemical stability windows and cycle performances of battery. The lower electronic conductivity and interfacial resistance , higher electrochemical stability window (5.7 V) of F-doped PMIA membranes were obtained when comparing to the pure PMIA and commercial polyethylene membrane. The cell exhibited high first-cycle discharge capacity with 145 mAh g −1 and excellent cycling stability with good capacity retention of 93.1% and coulombic efficiency of 99.3% after 100 cycles.
研究领域:
材料科学
·
储能技术
·
高分子化学
·
电化学
·
纳米技术
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9
Diwen Xiao,Jiahao Cao,Hongjie Wang,Wenyi Dong,Fang Ma
Fluoride-containing wastewater pollution poses a serious threat to the global environment. Adsorption represents the most widely employed defluoridation process. Among various adsorbents, metal-organic frameworks (MOFs) demonstrate considerable potential. However, current zirconium-based MOFs for fluoride removal face challenges such as high cost, low adsorption capacity, insufficient mechanistic understanding, and difficulties in reuse due to the lack of stable immobilization methods. Herein, a zirconium‑cerium MOF (denoted as Zr/Ce-M) was prepared by doping MOF-801 with the low-cost metal cerium. At an initial F − concentration of 26 mg/L, its actual adsorption capacity reached 213 mg/g. This represents a 326% improvement compared to conventional MOF-801 and is 66% higher than the adsorbent with the highest known adsorption capacity.Further, zirconium/cerium MOF-based sponge (Zr/Ce-MS) was prepared via a simple method. Zr/Ce-MS exhibited exceptional loading stability under mechanical stress and solvent corrosion. Regeneration tests confirmed effective fluoride removal after eight cycles. Computational results revealed an upward shift in the d-band center of metals and enhanced electron-donating capability after Ce doping. Monodentate coordination (Zr F and Ce F) proved more stable than μ₂- or μ₃-bridging configurations. Strong hybridization occurred between Zr d/Ce d and F p orbitals, with Ce doping strengthening electron transfer from Zr to F − . The defluoridation mechanism of Zr/Ce-MS involves ion exchange, electrostatic interactions, hydrogen bonding, and Lewis acid–base complexation.This work provides new insights for developing fluoride adsorbents and mechanistic analysis.
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高影响因子
危险品化学品经营许可证（带存储）