Pharmacogenomics & Personalized Medicine
·
2021
·
IF 3.912
Xikun Wu,Weichong Dong,Haoran Li,Xiuling Yang,Yiran Jin,Zhiqing Zhang,Ye Jiang
Purpose To perform therapeutic drug monitoring (TDM) of total and free plasma valproic acid (VPA) concentrations in pediatric patients with epilepsy and to analyze related factors.Patients and Methods Pediatric epileptic patients treated in 2015–2019 in our hospital were assessed. Total and free plasma VPA concentrations were obtained by UPLC and LC-MS/MS, respectively. Regression analysis was performed to examine the associations of free plasma VPA with total plasma VPA and plasma protein binding rate. The impacts of individual situation, CYP2C9 genotype, and drug combination on VPA concentration were examined.Results Of the 251 patients, 81 had lower total concentrations than effective therapeutic levels; 86 and 31 patients had infections and central nervous system dysplasia, respectively. VPA’s daily doses and free drug concentrations were significantly lower in the CYP2C9 *3/*3 genotype group versus the CYP2C9 *1/*3 and CYP2C9 *1/*1 groups (P<0.05). Free and total VPA concentrations were linked by Y = 0.0004 X2 + 0.042 X + 0.3035 (r=0.6981); VPA plasma protein binding rate and free VPA concentration were related by Y = 0.0003 X2 - 0.0127 X + 0.9777 (r=0.8136). Both total and free VPA concentrations were significantly decreased in patients simultaneously administered phenobarbital, meropenem and biapenem (P<0.05), with therapeutic failure after meropenem/biapenem co-administration.Conclusion Free VPA amounts have nonlinear relationships with total VPA amounts and plasma protein binding rate in epileptic children. Additionally, CYP2C9 *3/*3 expression affects VPA metabolism. Since phenobarbital affects VPA metabolism, TDM is recommended. Meanwhile, carbapenem-co-administration with VPA should be prohibited.
研究领域:
医学
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药理学
·
遗传学
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DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Haomin Zhou,Zhangming Pei,Ning Wang,Zhifeng Fang,Wenbing Hu,Hongchao Wang,Wenwei Lu,Hao Zhang,Wei Chen
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disorder of global significance. Long-term use of conventional treatments like topical corticosteroids is associated with adverse effects and a substantial economic burden. Building on prior work demonstrating that specific probiotic strains and a tailored dietary fiber combination ameliorate AD in mice by modulating gut microbiota-derived tryptophan metabolites via the gut-skin axis, but the precise bioactive indoles and their underlying mechanisms remain elusive. Here, we induced AD in mice using 2,4-dinitrofluorobenzene and administered five representative indole derivatives via intragastric gavage. Disease amelioration was assessed through ear swelling quantification, histopathological analysis, enumeration of infiltrated mast cells, and measurement of serum IgE and cytokines by ELISA. Only indole-3-acetaldehyde (IAId) and indole-3-lactic acid (ILA) markedly attenuated AD pathology, reducing ear swelling by over 30% alongside decreased skin thickness and mast cell infiltration. Immunomodulatory profiling revealed these metabolites downregulated IL-4, IL-13, and TSLP expression by 25%–40% and upregulated IFN-γ production by 50%, thereby restoring the Th1/Th2 immune balance. To dissect the mechanism, we employed an aryl hydrocarbon receptor (AhR) inhibitor in parallel experiments, which completely abrogated the protective effects of IAId and ILA, confirming strict dependency on AhR pathway activation. Collectively, our study identifies IAId and ILA as microbiota-derived tryptophan metabolites that regulate immune homeostasis via the gut-skin axis in a murine AD model. These findings provide experimental support for the potential of targeting these specific microbial metabolites, warranting further investigation into their therapeutic or nutritional applications for AD.
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 47
·期 3
·1256-1267
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IF 3.925
Lei Yin,Hui Yang Li,Tingting Ge,Yuchao Li,Cuncun Zuo,Ming Wang,GuangJun Cui,Haofei Huang,Lin Guo
A series of acid–base-loaded γ-Al2O3 catalysts was applied as the catalysts for the isomerization of 3/4-methyl-tetrahydro phthalic anhydride. With a basic metal (K or Na) as the basic source and phosphorus (P) as the acid source, γ-Al2O3 was modified by equal volume immersion. NH3/CO2-TPD, XRD, TEM/EDS, BET, and TGA were used to analyze the catalysts, and 15%-K/Al2O3 and 10%-P/Al2O3 were determined as the most appropriate catalysts. The isomers were qualitatively and quantitatively analyzed using nuclear magnetic resonance (1H-NMR) and infrared spectroscopy (IR), and the reaction mechanism for the isomer formation was proposed. With 3-MTHPA as the substrate, the acid/base reaction temperature was 165/150 °C, the reaction time was 3 h and the amount of the catalyst added was 3%. A new type of continuous isomeric fixed-bed reactor was designed. The stability of the catalyst was tested, and the activity loss was 4.6–6.6% after 10 hours of operation.
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产品关联
DOI
高影响因子
Journal of Advanced Ceramics
·
2020
·Vol. 9
·期 3
·292-302
·
IF 2.889
Wang Hongxian,Zhao Peiyao,Chen Lingling,Li Longtu,Wang Xiaohui
Multilayer ceramic capacitors (MLCCs) for energy storage applications require a large discharge energy density and high discharge/charge efficiency under high electric fields. Here, 0.87BaTiO 3 -0.13Bi(Zn 2/3 (Nb 0.85 Ta 0.15 ) 1/3 )O 3 (BTBZNT) MLCCs with double active dielectric layers were fabricated, and the effects of inner electrode and sintering method on the energy storage properties of BTBZNT MLCCs were investigated. By using the pure Pt as inner electrode instead of Ag 0.6 Pd 0.4 alloys, an alternating current (AC) breakdown strength ( BDS ) enhancement from 1047 to 1500 kV/cm was achieved. By investigating the leakage current behavior of BTBZNT MLCCs, the Pt inner electrode and two-step sintering method (TSS) were confirmed to enhance the Schottky barrier and minimize the leakage current density. With relatively high permittivity, dielectric sublinearity, and ultra-high BDS , the Pt TSS BTBZNT MLCCs exhibited a surprisingly discharge energy density ( U dis ) of 14.08 J/cm 3 . Moreover, under an operating electric field of 400 kV/cm, the MLCCs also exhibited thermal stability with U dis variation < ±8% over a wide temperature ( t ) range from -50 to 175 °C and cycling reliability with U dis reduction < 0.3% after 3000 charge-discharge cycles. These remarkable performances make Pt TSS BTBZNT MLCCs promising for energy storage applications.
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产品关联
DOI
高影响因子
BIOORGANIC & MEDICINAL CHEMISTRY
·
2016
·
IF 2.923
Honglei Xie,Yiqun Li,Changlin Bai,Ruifeng Wang,Chunchi Liu,Chenzhou Hao,Bin Lin,Maosheng Cheng,Dongmei Zhao
Epidemiological studies have identified that the risk of cardiovascular events increases due to the decreased levels of high density lipoprotein-cholesterol and the elevated levels of low density lipoprotein-cholesterol. Herein, we report a novel series of N , N -3-phenyl-3-benzylaminopropionanilide derivatives, which were identified as potent cholesteryl ester transfer protein (CETP) inhibitor. The initial lead compound L10 (IC 50 8.06 μM) was found by pharmacophore-based virtual screening (Dong-Mei Zhao et al., Chin. Chem. Lett. 2014 , 25 , 299). After systematic structure variation and biological testing against CETP, two different series were identified as scaffolds for potent CETP inhibitors. One is N , N -3-phenyl-3-benzylaminopropanamide derivatives, which were investigated in our previous paper ( Bioorg. Med. Chem. 2015 , doi: http://dx.doi.org/10.1016/j.bmc.2015.12.010 ). The most potent compound HL16 in that series has the IC 50 of 0.69 μM. The other series is N , N -3-phenyl-3-benzylaminopropionanilide derivatives, which was investigated in current study. Further optimization of the structure–activity relationship (SAR) resulted in H16 (IC 50 0.15 μM), which was discovered as a potent CETP inhibitor in vitro by BODIPY-CE fluorescence assay . In addition, the results of pharmacodynamics studies showed that H16 exhibited both favorable HDL-C enhancement and LDL-C reduction in vivo by hamster. It also has an excellent stability in rat liver microsomal.
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DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2019
·Vol. 41
·期 1
·381-390
·
IF 2.268
Dongna Li,Jirui Fu,Xiaojun Ma
A biocomposite of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH)/nano-SiO 2 modified with silane coupling agent KH570 (KH570-SiO 2 /PHBH) were prepared by solution-casting method. SiO 2 modified with KH570 exhibited improved uniform dispersion than that of pure nano-SiO 2 , and maximum thermal decomposition temperature range and crystallinity ( X c ) of KH570-SiO 2 /PHBH are 8.6°C and 119.7% higher than that of neat PHBH. Compared to the neat PHBH, a 75.4% and 70.8% improvement in Young's modulus and tensile strength were obtained. The water-vapor transmission and oxygen permeance of KH570-SiO 2 /PHBH decreased by 46.2% and 618.6%, respectively. The oxygen barrier property is equivalent to that of polyvinylidene chloride. Simultaneous enhancements on the thermal stability, mechanical, crystallizing, and barrier properties were mainly caused by uniform dispersion of modified nano-SiO 2 and solid interfacial bonding between filler and matrix.
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产品关联
DOI
高影响因子
JOM
·
2024
·Vol. 76
·期 5
·2478-2490
·
IF 2.1
Wang Chengwang,Zhang Ruihan,Li Xingshi,Huang Yaoguo,Chen Linlin
The article presents the synthesis and application of a novel collector, 5-methyl butylxanthate-1,2,4-triazole-3-thione (MBuXTT), for chalcopyrite flotation separation from pyrite. Various interfaces and surface characterization analysis methods were employed to study the flotation separation mechanism. The micro-flotation and contact angle experiments demonstrated a significant enhancement in the surface hydrophobicity of chalcopyrite following treatment with MBuXTT. Within the pH range investigated, MBuXTT effectively enriched chalcopyrite while separating it from pyrite. Compared to the traditional collector sodium butyl xanthate, MBuXTT exhibited superior selectivity and collecting ability towards chalcopyrite. Adsorption of MBuXTT on the chalcopyrite surface was found to be an endothermic-spontaneous chemisorption process. ζ -Potential analyses and UV spectra confirmed specific adsorption of MBuXTT on chalcopyrite rather than pyrite surfaces. Additionally, FTIR, XPS, and DFT calculations were conducted to explore the adsorption mechanism on the chalcopyrite surface, and the results indicated that MBuXTT-Cu complexes can be covered on the chalcopyrite surface with formation of Cu(I)-S and Cu(I)-N bonds along with release of H + and oxidation product formation involving S–S bonds.
研究领域:
矿物加工
·
浮选化学
·
表面化学
·
吸附机理
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螯合化学
·
计算化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 38
·15115-15119
·
IF 3.069
Jifeng Chen,Yi Yu,Shujuan Zhang,Yuchuan Li,Siping Pang
3,3′-Difluoroazetidinium (DFAZ) possesses a high-tensile four-membered ring and fluorine atoms, which contributes to the specific impulse, detonation pressure and detonation velocity. High-density energetic salts that contain oxygen-rich anions and cations were synthesized. All of the salts were fully characterized by IR spectroscopy, single-crystal X-ray diffraction, elemental analysis, differential scanning calorimetry (DSC) as well as impact and friction sensitivity. Their detonation properties were calculated according to the densities and heats of formation. The results showed that compared to ADN, they all had a relatively high density and low impact sensitivity. The specific impulse of almost all of the salts were higher than that of the propellant component, ammonium dinitramide (ADN, Isp = 202 J). Moreover, the 3,3′-difluoroazetidinium nitroformate salt had the highest specific impulse and was relatively more stable. It is possible to obtain energetic cations with good properties by combining four-membered high-tension rings with fluorine atoms.
研究领域:
化学
·
材料科学
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DOI
高影响因子
TETRAHEDRON
·
2016
·
IF 2.645
Dong-Qing Zheng,Yu Jing,Bing-Ying Zheng,Yun-Fei Ye,Sheng Xu,Wei-Sheng Tian,Hai-Yan Ma,Kai Ding
The conventional etherification uses toxic or hardly degradable alkylating agents . An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1 . Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 5
·1772-1776
·
IF 3.288
Xin Shu,Yongren Chen,Chunling Yuan,Yilin Wang
A novel and sensitive method for ascorbic acid (AA) determination utilizing Ag+–3,3′,5,5′-tetramethylbenzidine (TMB) as a colorimetric probe was proposed. In a weak acidic medium, Ag+ could oxidize TMB to oxidized TMB (ox-TMB) and cause a blue color solution with an absorption peak centered at 652 nm. However, the addition of AA could induce the reduction of ox-TMB, leading to shallower blueness and lower absorbance. Under the selected experimental conditions, there was a good linear relationship between the decrease of absorbance (ΔA) and AA concentration in the range of 0.5–60 μM, and the detection limit was as low as 0.23 μM. The feasibility of this method was verified in commercial beverages with recoveries of 95.8–104.1%. The method has the advantages of simplicity and practicability. More importantly, no nanomaterials need to be prepared.
研究领域:
分析化学
·
食品科学
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DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 20
·15500-15506
·
IF 3.84
Na Wang,Xiaojing Liang,Qian Li,Yuan Liao,Shijun Shao
A novel solid-phase extraction (SPE) sorbent was synthesized by chemical immobilization of nitro-substituted 3,3′-bis(indolyl)methane onto pure silica. The nitro-substituted 3,3′-bis(indolyl)methane-modified silica was evaluated by elemental analysis (EA) and Fourier transform infrared spectroscopy (FT-IR). Coupled to high performance liquid chromatography (HPLC), the extraction performance of the sorbent was evaluated by using five flavonoids as model analytes. The results showed that the new sorbent could offer multiple intermolecular interactions, such as π–π, hydrophobic, and hydrogen bonding interactions. Several factors including the extraction material, sample solution pH, sample loading rate, eluent type, volume of eluent, elution rate, and volume of sample loading were optimized. Under the optimal conditions, the proposed method was applied for the analysis of five flavonoids in grape juice. Satisfactory linear ranges for flavonoids were obtained in the range of 10–200 ng mL−1 for myricetin, 5–200 ng mL−1 for quercetin and apigenin, and 1–200 ng mL−1 for luteolin and kaempferol, with correlation coefficients (R) ranging from 0.9908 to 0.9996. Limits of detection (LODs) were in the range of 0.5–10 ng mL−1. The recovery values of spiked grape juice ranged from 91.5% to 120.7% with relative standard deviations (RSDs) less than 9.12% (n = 5). As a novel solid-phase extraction sorbent, the nitro-substituted 3,3′-modified silica exhibited a higher extraction efficiency towards the tested compounds than diol-modified silica.
研究领域:
分析化学
·
食品科学
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DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Letao Guo,Mei Yang,Lixia Yang,Mei Han,Wenna Tang,Guangwen Chen
3-(3-Pyridyl)acrylic acid is a key cap motif in chidamide and related analogues. Conventional strategies, including Knoevenagel condensation, Horner-Wadsworth-Emmons reactions, and Heck couplings, suffer from limitations such as direct pyridine utilization, phosphorus-containing waste, or reliance on expensive palladium catalysts. Here, we presented a scalable, streamlined three-step platform for the synthesis of 3-(3-pyridyl)acrylic acid from ethyl acetate and 3-pyridine aldehyde. The process integrates sequential continuous-flow aldol condensation and hydrolysis with batch dehydration, coupled with online intermediate separation units. Each module was engineered to meet the kinetic and operational requirements of the subsequent step, thereby minimizing overall residence time. The aldol condensation, which typically requires cryogenic conditions and exhibits pronounced scale-up effects in batch reactors, was intensified in microreactors through precise residence time control, enabled room-temperature condensation to afford the β-hydroxy ester intermediate in 99% yield with a productivity of 116 g/h within 1.1 s. In the hydrolysis module, where the rate was constrained by mass transfer in the heterogeneous system, ethanol was introduced as a co-solvent to enhance phase interaction, enabling continuous-flow hydrolysis to deliver the β-hydroxy sodium salt intermediate in > 99% yield with a productivity of 88 g/h within 1 min at 60 °C. Subsequent batch dehydration, conducted at high concentration to maximize the reaction rate and optimized according to the upstream hydrolysis conditions, afforded 3-(3-pyridyl)acrylic acid in 96% yield (84% overall), producing 76 g/batch at 120 °C within 1 h. The product was isolated with ∼ 100% high performance liquid chromatography purity by simple pH-triggered precipitation, eliminating the need for recrystallization.
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高影响因子
危险品化学品经营许可证（带存储）