EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2025
·
IF 4.7
Min Feng,Wei Gong,Xin Zhu,Juan Zhu,Junjie Hu,Weihua Xu,Zhichao Ma,Shengmiao Fu,Xinping Chen
As the world's only commercially available paclitaxel liposome, Lipusu (Lip) has been clinically used in chemotherapy for >20 years, but the design concept of Lip remains largely unchanged since its initial development. Based on the study of Acetyl-CoA-carboxylase 1 (ACC1) in nasopharyngeal carcinoma (NPC), we proposed the concept of next-generation liposomes (NGL) utilizing lipid demand balance. In this study, we evaluated the feasibility of ACC1 and integrin α V β 3 as NPC targets, and designed 10 conjugates of 5-tetradecyloxy-2-furoic acid (TOFA) and c(RGDfK) that can bind to Lip. Considering the results of chemical parameter prediction, molecular docking, molecular dynamics simulation (MD) and other aspects, we finally selected and synthesized the compound F, and successfully constructed F-Lip by simple incubation method. Compared with Lip, F-Lip showed stronger toxicity in both HONE-1 cells and corresponding tumor-bearing mice. In conclusion, by regulating the balance of lipid demand, the toxicity of Lip can be improved so as to achieve the goal of inhibiting the proliferation of NPC. This study provides a new model for the future design and development of Lip.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Ruiyu Liang,Yuling Hu,Gongke Li
The monodisperse pillar[5]arene-based polymeric sub-microsphere was prepared by polycondensation of hydroxylated pillar[5]arene and cyanuric chloride through a one-pot reaction in mild condition. The preparation was realized by a simple two-step temperature-programmed process without heating operation. The obtained polymeric sub-microsphere exhibited monodisperse and regular spherical structure with uniform particle size distribution of 220–320 nm accounting for 94%. The prominent adsorption capacity of the polymeric sub-microsphere for antioxidants was demonstrated and attributed to the synergistic effect of the cladding interaction with the π-electron rich cavity and hydrophilic interaction with terminal hydroxyl on pillar[5]arene. Then the pillar[5]arene sub-microsphere was packed into a micro-column to realize effective on-line enrichment of antioxidants coupling with high-performance liquid chromatography (HPLC). The flow rate of extraction and desorption solvent, clean-up and desorption volume were assessed to optimize the method. The method showed wide linear ranges with R 2 greater than 0.9926, low limits of detection (0.030–0.20 μg/L) and limits of quantification (0.10–0.67 μg/L). The developed method was successfully applied to determine trace antioxidants in the migration of food contact materials with simulated solution, which demonstrated the promising potential of this method for practical analysis. Furthermore, the migration behavior of antioxidants from food packaging materials into different food matrix was also investigated.
研究领域:
分析化学
·
食品科学
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DOI
PubMed
高影响因子
Carbon Letters
·
2026
·
IF 6.2
Liang Yuwei,Huang Yufan,Hu Chunling,Cai Jinyu,Cao Yifan,Meng Guihua,Wu Jianning,Li Qi,Liu Zhiyong
Designing catalysts with suitable valence conduction band positions to generate reactive oxygen species (ROS) with moderate redox capacity is to achieve efficient photocatalytic biomass-selective value-added oxidation. This protocol addresses the issue by tuning material structural defects, altering the surface electronic structure, and ultimately enhancing the raw material’s performance. Here, an appropriate amount of one - dimensional nanorods α -MnO 2 adjusted material structural defects, increased the adsorbed oxygen (O ads )/lattice oxygen (O latt ) and Mn 3+ ratios, and served as an electron transport conduit, facilitating O₂ activation to generate ROS. The Cd 1.7 In 2 S 4.7 solid solution enables the optimal valence band position by adjusting the Cd 2+ : In 3+ ratio, thus selectively oxidizing 5-hydroxymethylfurfural (HMF) to 2,5-dicarbonylfuran (DFF). In situ XPS revealed that photogenerated electrons in Cd 1.7 In 2 S 4.7 quickly transferred to the conduction band of α -MnO 2 , and photogenerated holes from α -MnO 2 moved to the valence band of Cd 1.7 In 2 S 4.7 . This significantly enhanced the separation and transfer efficiency of photogenerated carriers at the interface. The optimal sample achieved 56% conversion of HMF and 72% selectivity of DFF under simulated sunlight. This protocol provides a new approach for the establishment of electron transport channel structures based on α -MnO 2 constructs and value-added biomass photocatalytic conversion under simulated sunlight.
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产品关联
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2024
·
IF 2.5
Zhang Yanting
Both seed solution and Cetyltrimethylammonium bromide(CTAB) serve as common template agents in the synthesis of hierarchical ZSM-5 zeolites. However, their specific roles in the synthesis process have not been clearly understood. In this study, hierarchical ZSM-5 zeolites were successfully synthesized using a 1.5% mass fraction (relative to the silicon source) seed solution in combination with varying amounts of CTAB. The physical and chemical properties of the hierarchical ZSM-5 zeolites were characterized using X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), low-temperature N 2 adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TG), ammonia temperature-programmed desorption (NH 3 -TPD), pyridine-IR, and 2,4,6-collidine-IR. The investigation revealed that the CTAB content significantly influenced the synthesis of hierarchical ZSM-5 zeolites, with CTAB contributing to framework filling, charge balancing, and acting as a mesoporous template during the synthesis process, while the seed solution primarily served as a structure-directing agent. Moreover, utilizing the conversion of C8 aromatic hydrocarbons as a probe reaction, it was demonstrated that ZSM-5 zeolites synthesized with the co-assistance of seeds and CTAB exhibited enhanced conversion for ethylbenzene and m-xylene compared to samples synthesized exclusively with a seed solution.
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DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2021
·Vol. 23
·期 35
·19729-19739
·
IF 3.676
Shijie Wang,Yihang Chen,Yu Jia,Guizhuan Xu,Chun Chang,Qianhui Guo,Hongge Tao,Caihong Zou,Kai Li
The fundamental understanding of glucose conversion to 5-ethoxymethylfurfural (EMF) and ethyl levulinate (EL) (value-added chemicals from biomass) in ethanol solution catalyzed by a Brønsted acid is limited at present. Consequently, here, the reaction pathways and mechanism of glucose conversion to EMF and EL catalyzed by a Brønsted acid were studied, using an experimental method and quantum chemical calculations at the B3LYP/6-31G(D) and B2PLYPD3/Def2TZVP level under a polarized continuum model (PCM-SMD). By further verification through GC/MS tests, the mechanism and reaction pathways of glucose conversion in ethanol solution catalyzed by a Brønsted acid were revealed, showing that glucose is catalyzed by proton and ethanol, and ethanol plays a bridging role in the process of proton transfer. There are three main reaction pathways: through glucose and ethyl glucoside (G/EG), through fructose, 5-hydroxymethylfurfural (HMF), levulinic acid (LA), and EL (G/F/H/L/EL), and through fructose, HMF, EMF, and EL (G/F/H/E/EL). The G/F/H/E/EL pathway with an energy barrier of 20.8 kcal mol−1 is considered as the thermodynamic and kinetics primary way, in which the reaction rate of this is highly related to the proton transfer in the isomerization of glucose to fructose. The intermediate HMF was formed from O5 via a ring-opening reaction and by the dehydration of fructose, and was further converted to the main product of EMF by etherification or by LA through hydrolysis. EMF and LA are both unstable, and can partially be transformed to EL. This study is beneficial for the insights aiding the understanding of the process and products controlling biomass conversion in ethanol solution.
研究领域:
生物化学
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催化化学
·
理论化学
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DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 62
·39221-39227
·
IF 3.108
Songyan Jia,Xinjun He,Zhanwei Xu
Converting saccharides into 5-hydroxymethylfurfural (5-HMF) has attracted more and more research interest under the background of global energy shortage. A lot of effort has been devoted to the conversion of fructose and glucose. However, other underused sugars receive very limited attention, although some of them have considerable reserves in nature as well. In this work, mannose, a major component from hemicellulose, was effectively converted into 5-HMF under mild conditions. AlCl3·6H2O exhibited superior activity among the tested catalysts, achieving a maximum 5-HMF yield of 60% in a dimethyl sulfoxide (DMSO)/water mixed solvent at 130 °C within 45 min. Adding an appropriate amount of water in DMSO could suppress some side reactions while preserving the reactivity of mannose dehydration. Mannose showed a comparable reactivity to fructose in the employed catalytic system. The studied system was also effective in the conversion of di/trisaccharides such as cellobiose and melezitose into 5-HMF. A number of control experiments with different catalysts and additives were conducted to elucidate the preliminary mechanism.
研究领域:
生物化学
·
能源化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Bei Zhang,Zhong-Kai Zou,Jian-Fan Cai,Wen-Ming Tan,Jun-Wei Chen,Wei-En Li,Jing-Nan Liang,Wei-Pei Wu,Gang Wang,Xiao-Hong Ruan,Pei-Liang Zhao
Phosphodiesterase 5 (PDE5) is a cGMP-specific hydrolytic enzyme and widely distributed in versatile tissues. PDE5 has been identified as a valid therapeutic target for treating erectile dysfunction and pulmonary arterial hypertension (PAH). Herein, a hit-to-lead structural optimizations were performed on the PDE1 inhibitor 10c, leading to compound 14b possessing great potency against PDE5A (IC50 = 3 nM) with high selectivity over PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11 by more than 1125-fold, and remarkable safety properties. Furthermore, oral administration of 14b (5.0 mg/kg) exerted much better pharmacodynamics effects on both mPAP (mean pulmonary artery pressure) and RVHI (index of right ventricle hypertrophy) than sildenafil citrate (10.0 mg/kg) in a monocrotaline-induced PAH rat model. Overall, these results proposed a novel highly selective PDE5 inhibitor 14b which could serve as a potential candidate for treatment of PAH.
研究领域:
药理学
·
心血管疾病研究
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Guohao Xu,Jiaqi Liu,Xin Gao,Xuedong Zhu
Hollow b-oriented ZSM-5 with a thickness of approximately 80 nm was synthesized for methane co-aromatization with propane (MCP) through the desilication–recrystallization of b-oriented ZSM-5 using tetrapropylammonium hydroxide (TPAOH) as a template. A hollow structure was introduced into b-oriented ZSM-5 via desilication with OH− and a thin intact shell was formed during recrystallization of leached Si species under TPA+ template application. By regulating the recrystallization time, shell thicknesses could be controlled from 120 nm to 60 nm. Under a recrystallization time of 24 h, the hollow b-oriented ZSM-5 possessed suitable acidity as well as the largest SBET and daver. When the hollow b-oriented ZSM-5 zeolite was used as the support for a zinc-based catalyst, aromatic selectivity and the conversion of methane and propane were improved. A maximum aromatic selectivity of 87.5% was achieved, with methane and propane conversion of 10.7% and 77.9%, respectively.
研究领域:
催化化学
·
材料科学
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产品关联
DOI
高影响因子
Coatings
·
2025
·Vol. 15
·期 9
·1012
·
IF 2.8
Shijian Sun,Mengquan Liu,Zheng Li,Junqiang Cheng,Dechuan Li
Hollow dendritic Na4La2(CO3)5crystals doped with Sm3+ions were synthesized with sodium carbonate using a hydrothermal method. The unique lifetime of Sm3+enables the optical measurement of luminescent ion content. The X-ray diffraction spectrum indicates that the nanocrystals maintain structural stability with a hexagonal arrangement, even when the concentration of Sm3+reaches 50 at.%. As the concentration of Sm3+increases, the emission intensity of Na4(La1−xSmx)2(CO3)5first rises and then falls. The maximum emission intensity of the fluorescent powder occurs at a Sm3+concentration of 0.04. Beyond this concentration, concentration quenching takes place, primarily due to electric dipole–dipole interactions. Using an excitation wavelength of 404 nm and monitoring at 596 nm, the fluorescence lifetime of Na4(La1−xSmx)2(CO3)5shows a strong dependence on Sm3+concentration, which can be described by a precise equation. Over the range of Sm3+concentrations from 0.005 to 1, the lifetime decreases from 3.126 ms to 0.023 ms. Therefore, optical monitoring of fluorescent powders is crucial for confirming the composition of coatings used in applications such as solid-state lighting and anti-counterfeiting, by utilizing the relationship between lifetime and doping concentration.
研究领域:
材料科学
·
光学材料
·
发光光谱学
·
固态化学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2013
·Vol. 38
·期 2
·845-851
·
IF 2.966
Li-Li Tan,Yumo Zhang,Bao Li,Kai Wang,Sean Xiao-An Zhang,Yanchun Tao,Ying-Wei Yang
Highly selective binding of “solvent” molecules by 1,4-dimethoxypillar[5]arene (DMP[5]A) and their host–guest complexation in solution and the solid state have been investigated by multiple methods. Enthalpy changes and the size-fit effect play an important role in the high selectivity.
研究领域:
超分子化学
·
有机化学
·
物理化学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Chendong Yang,Entao Li,Xiaoping Guo,Wenyu Xie,Yuanzhan Wang,Xuefei Huang,Sandra Chiu,Xuanjun Wu
Over the past 3 years, SARS-CoV-2 Omicron has been circulating globally with the emergence of multiple subvariants, including BA.5, BA.5.2, XBB, XBB.1, EG.5.1, HK.3, BA.2.86, JN.1, and KP.2. To combat these Omicron subvariants, several vaccines based on receptor-binding domain (RBD) dimers have been developed; however, RBD dimer vaccines require frequent updates to cope with the emergence of new variants. In contrast, the development of a safe, effective, and broad-spectrum vaccine against multiple Omicron subvariants, including the latest JN.1 and KP.2, would be a one-size-fits-all solution. Here, we designed BA.4/5 RBD-PC7A conjugate micelles by displaying the BA.4/5 RBD in PC7A micelles. Remarkably, the micelles elicited potent neutralizing antibodies (NAbs) in rabbits, effectively neutralizing BA.5.2, XBB.1.18, and HK.3 infections. Moreover, the micelles alone were able to induce NAbs in mice against the BA.5 variant. When a cytosine-phosphate-guanine (CpG) adjuvant was added and electrostatically adsorbed to the micelles, there was a significant increase in the antibody titers of IgG1, IgG2b, and IgG2c. This enhancement facilitated the broad neutralization of various strains, including BA.5.2, XBB.1.18, HK.3, JN.1, and KP.2. Furthermore, the micelles adsorbed with CpG protected golden hamsters from infection with the BA.5.2 strain. This study presents a potent and broadly neutralizing nanovaccine that includes the BA.4/5 RBD antigen and a CpG adjuvant. It demonstrates efficacy against multiple Omicron subvariants, including BA.5, BA.5.2, XBB.1.18, HK.3, JN.1, and KP.2, highlighting its potential for clinical translation.
研究领域:
免疫学
·
病毒学
·
疫苗学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Bowen Zhao,Jianyi Lu,Qing Xu,Fei Zheng,Zhiyong Zhou
Owing to its strong chemical inertness, sulfur hexafluoride (SF 6 ) is intrinsically resistant to degradation. Accordingly, a composite material was developed by coupling sulfidated nanoscale zero-valent iron (S-nZVI) with fly ash-derived zeolite ZSM-5, forming a multi-level heterostructure for efficient SF 6 degradation. Experimental results confirmed that the composite exhibited exceptional low-temperature degradation performance, achieving complete removal of 2 vol% SF 6 at 600 °C with a specific degradation amount of 206.1 mL/g. Remarkably, effective degradation was still maintained at 300 °C, surpassing the previously reported minimum temperature limit (∼450 °C) for SF 6 degradation. Kinetic analysis revealed a near-zero-order reaction behavior with an apparent activation energy of only 27.61 kJ/mol, indicating that the initial stage was dominated by adsorption, diffusion, or interfacial electron transfer rather than S F bond cleavage. Comprehensive characterization showed that the composite possessed Fe 0 /FeS and FeS/ZSM-5 dual heterointerfaces, serving simultaneously as adsorption carriers, electron donors and acceptors. Specifically, the microporous framework of ZSM-5 physically confines nonpolar SF 6 molecules through van der Waals and confinement effects, enriching their local concentration and forming a favorable adsorption-activation interface. Electrons released by Fe 0 migrate directionally to these enrichment sites under the drive of the multi-level heterostructure, enabling concurrent adsorption and electron-induced activation of SF 6 , and thereby facilitating S F bond cleavage. The resulting fluoride ions initially react with Fe 0 to generate FeF 3 , which subsequently interacts with the silicate framework to produce SiF 4 , establishing a mediated fluorine migration pathway from SF 6 to SiF 4 and enabling deep degradation with sustained reactivity.
研究领域:
环境化学
·
材料科学
·
催化化学
·
大气污染控制
·
无机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）