JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2025
·
IF 5.4
Pengtao Yuan,Xi Jiang,Xintong Ni,Xusheng Shao,Xuhong Qian,Qing Yang
Chitinase h (Chi-h) has been identified as a promising pesticide target due to its exclusive distribution in lepidopteran insects and its essential role in the moulting processes. In this study, we leverage OfChi-h from destructive agricultural pest Ostrinia furnacalis (Asian corn borer) as a model target to identify novel chitinase inhibitors. A conformational restriction approach was employed to design a series of novel OfChi-h inhibitors. Among these, compound 6a showed the highest inhibitory activity against OfChi-h, with a Ki value of 58 nM. Molecular docking analysis suggested that 6a tightly bound to three subsites (-3 to −1) of OfChi-h. The binding mode is further confirmed by the co-crystallization data of 6a with the SmChiA, a bacterial homologue of OfChi-h, at a resolution of 1.8 Å. This research presents a novel approach for the development of highly potent insect chitinase inhibitors, offering potential tools for effective pest control.
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PubMed
高影响因子
RARE METALS
·
2025
·
IF 11
Wu Yi-Ming,Hou Guo-Yuan,Fan Xin,Zhu Qian-Ye,Cui Ming-Jun,Ren Si-Ming
Polymer materials commonly employed in low Earth orbit (LEO) environments are highly susceptible to atomic oxygen (AO) attack, leading to severe degradation and deterioration of their properties. To address this challenge, 3-glycidyloxypropyltrimethoxysilane-modified hexagonal boron nitride (h-BN@KH560) nanohybrids were synthesized and incorporated into epoxy (EP) composites to enhance their AO erosion resistance. The resulting hexagonal boron nitride-based epoxy nanocomposites (FBN/EP) were systematically evaluated for their tribological performance and AO erosion resistance using a series of characterization techniques. The results demonstrated that the incorporation of h-BN@KH560 nanohybrids significantly improved the wear resistance and AO erosion resistance of the EP matrix. Specifically, the FBN 1.0 /EP nanocomposite exhibited an 86.1% reduction in wear rate compared to pure EP, while FBN 5.0 /EP nanocomposite achieved optimal AO erosion resistance, with a minimal erosion rate of 3.58 × 10 –24 cm 3 atoms −1 at an AO dose of 1.2 × 10 21 atoms cm −2 . These findings indicate that the incorporating content-induced distribution of h-BN@KH560 within the EP matrix strongly influences the wear resistance of FBN/EP nanocomposites, but there is a relatively minor effect on their AO erosion resistance. The enhanced AO erosion resistance is attributed to the synergistic barrier protection provided by h-BN@KH560 and the formed B 2 O 3 and SiO 2 layers under AO irradiation. This study offers a promising strategy for extending the service life of epoxy nanocomposites in harsh LEO environments. Graphical abstract
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Xihui Cheng,Pengcheng Wang,Jiwei Li,Na Wang
In the field of human thermal comfort management, the development of functional textiles plays a critical role in enhancing human health and energy efficiency. Although significant progress has been made in human thermal management textiles, the construction of radiative cooling textiles with superior wearing comfort remains a considerable challenge. In this work, we present a trilayer-structured fabric composed of an electrospun polyvinylidene fluoride-hexafluoropropylene/hexagonal boron nitride (PVDF-HFP/h-BN) nanofibrous membrane (NFM) as the underlying layer, a magnetron sputtered aluminum (Al) film as the intermediate layer, and a sprayed JF-6011 coating as the upper layer. The obtained composite JF-Al 20 @P/h-BN 7.5 NFM features a well-regulated micro-nano porous structure and distinctive optical properties, achieving a solar reflectance of 94.33 % and an atmospheric window emissivity of 92.63 %. Under a solar irradiance of approximately 950 W/m 2 , the skin simulator covered with the JF-Al 20 @P/h-BN 7.5 NFM showed temperature reductions of 13.5, 13.3, and 8 °C compared to those covered with commercial cotton, nylon, and polyester fabrics, respectively. Additionally, the composite NFM possesses unidirectional moisture transport capabilities while maintaining excellent air permeability (331.75 mm/s) and moisture vapor transmission rate (7.98 kg/m 2 /D). This study provides valuable insights into the design of thermally comfortable textiles for high-temperature environments.
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高影响因子
CATALYSIS LETTERS
·
2025
·Vol. 155
·期 12
·1-12
·
IF 2.4
Ge Pengyu,Liu Xiyu,Li Xincheng,Fan Mingming,Zhang Pingbo
In this study, highly crystalline ZSM-22 zeolite with a TON topology was synthesized via a seed–template co-assisted hydrothermal method and subsequently modified with low-concentration NH₄Cl to introduce Brønsted acid sites. The characterization of the catalyst revealed its well-defined rod-like crystals (2–5 μm), one-dimensional straight channels (0.46 × 0.57 nm), microporous surface area of 210 m 2 ·g −1 , Brønsted-to-Lewis (B/L) acid ratio of 0.45, and excellent thermal stability. Under optimized reaction conditions (270 °C, 3 h, 6 wt% catalyst), the catalyst achieved a 95.01% conversion of oleic acid and a 77.72% yield of isostearic acid. The confinement effect of the 1D channels effectively suppressed undesired side reactions, offering significantly enhanced selectivity compared to commercial zeolites such as ZSM-5. Thermogravimetric analysis demonstrated that calcination at 550 °C successfully removed coke deposits and restored catalyst activity. After five regeneration cycles, the conversion and yield remained at 89.50% and 72.80%, respectively, with less than 6% loss. These findings provide theoretical and technical guidance for the high-value catalytic transformation of biomass-derived fatty acids. Graphical H-ZSM-22 catalyst with good reusability
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Fuli Wang,Xintong Wei,Shumin Cheng,Denghao Ouyang,Guodong Li,Mirabbos Hojamberdiev,Bin Dong,Han Hu,Yongming Chai
Nickel sulfide (NiSx) catalysts typically suffer from sluggish kinetics and poor stability under ampere-level current densities in the alkaline hydrogen evolution reaction (HER). To address this, we construct Cr2O3-embedded Ni7S6 nanowires on nickel foam (Ni7S6−Cr2O3/NF) with tailored work function differences. Operando analyses and theoretical calculations reveal that interfacial charge redistribution creates a hydrogen-rich microenvironment by accelerating water dissociation at electron-deficient Cr sites and optimizing H* adsorption at electron-rich Ni sites. The catalyst achieves an industrially relevant current density of −1000 mA cm−2 at an overpotential of 369 mV and maintains stability for 1000 h due to the protective Cr2O3 layer. Furthermore, the assembled anion exchange membrane electrolyzer operates at only 1.86 V to deliver 1000 mA cm−2 and remains stable for 500 h. This work highlights interface engineering of local microenvironments as an effective strategy for developing industrial grade electrocatalysts for alkaline HER.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Heshun Jing,Qingtai Xie,Huijuan Su,Yuqi Zhai,Xun Sun,Baorong Duan,Lijun Zhao,Miao Zhang,Caixia Qi,Libo Sun
The research and progress of noble metal catalysts possessing good stability and extended service life holds significant importance in enhancing catalytic efficiency, reducing enterprise costs, and fostering sustainable social development. Here, a hollow magnetic h-Au/PDA@PDA@Fe 3 O 4 catalyst with a double-layer PDA structure was prepared to optimize the stability of gold nanoparticles (NPs) using for the 4-nitrophenol (4-NP) reduction. The research indicates that, despite the initial activity of h-Au/PDA@PDA@Fe 3 O 4 , with a mass-normalized rate ( k’ ) of 176.10 s −1 ·g Au -1 and a Turn Over Frequency (TOF) of 1757 h −1 , being smaller than h-Au/PDA@Fe 3 O 4 with a single-layer structure ( k’ = 461.76 s −1 ·g Au -1 , TOF = 6387 h −1 ), h-Au/PDA@PDA@Fe 3 O 4 exhibits significantly superior stability compared to h-Au/PDA@Fe 3 O 4 . After undergoing 12 cycles of use, the conversion rate of h-Au/PDA@PDA@Fe 3 O 4 decreased by only 4.3 %. After cyclic reaction, the conversion rate of h-Au/PDA@Fe 3 O 4 decreased by as much as 64.8 %. The distinctive hollow double-layer structure of h-Au/PDA@PDA@Fe 3 O 4 , along with the interaction between Au and PDA, contributes significantly to its exceptional activity and stability. The research presented in this paper offers valuable insights and guidance for the suitable construction and industrial application of gold-based nano catalyst with good activity and cyclic stability.
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高影响因子
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
·
2025
·
IF 4.7
Qianying Shen,Yue-Yue Zhou,Yan-Lin Wang,Yao Qi,Dong-Bo Lian,Zhe-Hong Li,Meng-Fei Chen,Xiao-Li Zhang,Yue Zhang,Jin Song,Li-Fei Zheng,Jin-Xia Zhu
Long-term infection with Helicobacter pylori (H. pylori) leads to elevated serum gastrin levels, which are closely related to gastric cancer. Eradication of H. pylori to treat the high gastrin levels is increasingly challenged by antibiotic resistance. Dopamine (DA) receptor 1 (D1R) is expressed on G cells in the gastric antrum. Parietal cells produce DA, which inhibits somatostatin (SOM) release through D2R on D cells in the gastric mucosa. Whether targeted intervention in DRs can improve high gastrin levels after H. pylori infection remains to be explored. In this study, human gastric tissue, H. pylori-infected mice, D1R and D2R knockout mice, RT‒qPCR, ELISA, IHC, Western Blot, HE staining and ex vivo incubation of gastric mucosae were used. We found that H. pylori infection destroyed the mitochondria of parietal cells and reduced DA content in the gastric mucosa at 10 weeks after infection. Moreover, gastrin-positive cell numbers and serum gastrin levels were increased. D1R, but not D2R, was observed in G cells. DA promoted gastric gastrin secretion. Interestingly, both D1- and D2-like agonists mimicked the effect of DA on the gastrin secretion, which was antagonized by their antagonists. Blocking D2R with domperidone or knocking out D2R resulted in decreased gastrin-positive cell numbers and gastrin levels but increased SOM levels at 10 weeks after H. pylori infection. Our findings highlight the key regulatory effect of D2R on gastrin secretion and elucidate the role of domperidone in reducing the elevated gastrin level associated with H. pylori infection.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Guiyin Li,Min Chen,Bo Wang,Chaoxian Wang,Guanxiong Wu,Jintao Liang,Zhide Zhou
Golgi protein 73 (GP73) is a new type of marker that can specifically detect hepatocellular carcinoma (HCC). Herein, a dual-signal sandwich-type electrochemical aptasensor for GP73 determination was constructed on the basis of hemin-reduced graphene oxide-manganese oxide (H-rGO-Mn 3 O 4 ) nanozymes. [email protected] ( o -phenylenediamine) ( [email protected] ) nanohybrids with a large specific surface area and conductance were co-electro-deposited onto a screen-printed electrode (SPE) surface to immobilize GP73 capture aptamer 2 (Apt2). H-rGO-Mn 3 O 4 nanozymes were used not only to immobilize amino functionalised GP73 aptamer 1 (Apt1) as the detection probe, but also to serve as an in-situ redox signal indicator because of the redox reaction of Hemin (Fe(Ш)/Hemin(Fe(II)). In addition, given their excellent peroxidase-like activity, H-rGO-Mn 3 O 4 nanozymes can catalyse the decomposition of H 2 O 2 and oxidation of substrate (3,3′,5,5′-tetramethylbenzidine, TMB) to oxTMB, which is used as another redox signal. In the presence of the target GP73, the two aptamers specifically bind to the target, thereby affecting two electrochemical signals. Under optimal conditions, the dual-signal sandwich-type electrochemical aptasensor had a salient analytical performance. The two electrochemical redox signals linearly increase with the logarithm of the GP73 concentration in the range of 0.01–100.0 ng/mL with the limit of detection (LOD) of 0.0071 ng/mL and sensitivity of 2.441 μA/μM/cm 2 . Moreover, the recovery of human serum samples ranged from 98.66% to 121.11%. Furthermore, the two redox signals can simultaneously corroborate each other, thereby preventing missed diagnosis and misdiagnosis. All the results can provide new insights into the clinically effective determination of HCC.
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高影响因子
ANALYST
·
2019
·Vol. 144
·期 13
·4086-4092
·
IF 4.019
Lili Chen,Xiangguang Li,Tongda Zou,Tiantian Wang,Xiping Cui,Yingshan Chen,Chunguo Zhang,Suqing Zhao
Given that Helicobacter pylori (H. pylori) generally infects people in early childhood and that such persons when not treated with antibiotics remain infected for the rest of their lives, it is quite important to detect H. pylori in children, and convenient to do so using non-invasive methods. Stool antigen tests constitute such an effective non-invasive method. In the current work, a novel fecal test was developed to detect H. pylori based on immunomagnetic beads (IMBs) with monoclonal antibodies sensitively recognizing and capturing the H. pylori, coupled with a polyclonal antibody-conjugating quantum dot probe, and ultrasensitive detection was achieved by using a fluorescence spectrometer. The detection method took 120 min to perform, and showed a limit of detection of 102 CFU mL−1 and a linear range of 10 to 106 CFU mL−1 (R2 = 0.9962). Most importantly, this method can be effectively applied to real samples. This study provided a novel method for the non-invasive detection of the fecal antigen H. pylori.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Jianfeng Fan,Jiarong Huang,Liming Cao,Shiheng Yin,Yukun Chen
Recyclable polyvinylidene fluoride/silicone rubber (PVDF/SR) thermoplastic vulcanizates (TPVs) containing a high mass ratio of SR (50%) with excellent mechanical performances and shape memory behavior were fabricated. The inert PVDF was first dehydrofluorinated via β-H elimination reaction to introduce reactive double bonds. Then, the functional groups were initiated by dicumyl peroxide (DCP) during dynamic vulcanization to realize interfacial grafting (SR-g-PVDF) simultaneously. In situ grafted PVDF chains tightly bridge the immiscible phases, leading to the excellent interfacial adhesion. Consequently, the tensile strength, elongation at break, and tensile toughness were significantly increased to 14.5 MPa, 174.6%, and 12.3 kJ/m3, respectively, which were almost 2.0, 13.6, and 10.3 times than that without interfacial grafting reaction (7.2 MPa, 12.8%, and 1.2 kJ/m3). Also, their excellent mechanical properties were almost perfectly maintained after multiple repetitive processing. Furthermore, the chemical anchoring structure of SR-g-PVDF across the interface could effectively and quickly transfer the force, contributing to the shape memory performances. The obtained TPVs (m60 and m80) showed an impressive shape recovery ratio (>80%) even after two fixing-recovery cycles.
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高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Fan Zhang,Mao chen,Hailong Wang,Gang Shao,Yongshun Qi,Chengliang Ma,Bingbing Fan,Xiaoxuan Pian,Rui Zhang,Hongxia Li,Yongqiang Chen
The h-BN/ZrO 2 composites with different 3Y–ZrO 2 content were prepared by spark plasma sintering at 1800 °C. The sintering behavior , bulk density, apparent porosity , thermal conductivity , thermal expansion coefficient , bending strength , thermal shock resistance , microstructure and phase were analyzed. The optimum specimens were used to test the resistance to corrosion of molten steel for 10, 20, 40, 80 min respectively. The results indicated that ZrO 2 could facilitate the sintering process of h-BN matrix under the action of spark plasma. Especially, for the composites with 30 wt% 3Y–ZrO 2 , the porosity could decrease to 1.1% and the flexural strength could exceed 150 MPa. The microstructure showed the h-BN grains and 3Y–ZrO 2 grains are closely combined. The XRD patterns indicated that the t-ZrO 2 diffraction peak gradually enhanced with the increase of density. With the increase of erosion time, the erosion rate increased significantly. After the surface of the specimen is eroded, the erosion resistance of the matrix would decrease significantly. This h-BN/ZrO 2 could be as side-dam used in the thin strip continuous casting process .
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高影响因子
CATALYSIS LETTERS
·
2013
·Vol. 143
·期 5
·463-468
·
IF 2.244
Zhu Anlian,Li Qianqian,Li Lingjun,Wang Jianji
Abstract A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO 4 ] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid. Graphical Abstract The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO 4 ] > [Choline] [HSO 4 ] > [DMEA][H 2 PO 4 ] > [Choline] [H 2 PO 4 ] .
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高影响因子
危险品化学品经营许可证（带存储）