SENSORS AND ACTUATORS B-CHEMICAL
·
2013
·
IF 3.535
Yu Zhang,Yurong Tang,Xing Liu,Lichun Zhang,Yi Lv
At present, glutathione (GSH) is a very important biomarker in vivo. However, the sensitive and selective assay for the detection of GSH in biological matrix still keeps challenging due to the high complexity of samples. Lanthanide-doped upconverting phosphors (UCPs) which exhibit unique near-infrared (NIR) excitation nature are able to overcome interferences from complex samples. In this study, a novel probe based on the linkage of UCPs and dopamine-quinone through hydrogen bonding and electrostatic interaction has been designed for rapid, economic, sensitive and selective detection of GSH in aqueous solution and human blood serum . Here, dopamine-quinone served as an efficient quencher for upconverting fluorescence, while GSH as a strong reducing agent chemically reduced the dopamine-quinone turning on the fluorescence. The fluorescence recovery was found to be proportional to GSH concentration within the range from 1 to 75 μM. The detection limit of this sensor was 0.29 μM, which was quite competitive for GSH detection. The simple, sensitive and selective fluorescence method took full advantages of UCPs properties of low interferences and broadened the application scope of UCPs in complex biological detection.
研究领域:
分析化学
·
生物分析化学
·
生物传感器
·
纳米技术
·
荧光光谱学
✓ 已验证
DOI
高影响因子
Materialia
·
2025
·
IF 2.9
Jie Gao,Haiming Lu,Hui Yin,Guoming Zou,Xin Chen,Tao Jiang,Tao Wang,Yingbo Wang
Implant-related infections caused by drug-resistant bacteria pose a significant clinical concern for orthopedic surgeons. Therefore, developing an effective antibacterial coating to modify implant surfaces is crucial for preventing implant-related infections. In this study, we utilized a simple self-assembly method to prepare an antibacterial composite coating (Cu-NPs/PDA/PNIPAM) on larger pore-sized titanium dioxide nanotubes (TNTs) by combining copper nanoparticles (Cu-NPs) coated with polydopamine (PDA) and poly (N-isopropylacrylamide) (PNIPAM). Copper nanoparticles functioned as a photothermal transduction agent, converting light energy into heat under near-infrared (NIR) light irradiation, and acted as a source for releasing copper ions. The findings of the photothermal properties indicated that the composite coating may produce a substantial quantity of reactive oxygen species (ROS) when exposed to 808 nm NIR laser irradiation, exhibiting a photothermal conversion efficiency of 30.9 %. Moreover, the inhibitory efficacy of Cu-NPs/PDA/PNIPAM composite coating against Escherichia coli and S. aureus attained 100 % following NIR irradiation, in contrast to the non-irradiation group. This approach addressed the constraints of single-model photothermal therapy (PTT) and solely Cu-based antibacterial strategies, resulting in a synergistic antibacterial effect. Additionally, this antibacterial composite covering demonstrated superior cytocompatibility and biocompatibility, enhancing the osteogenic differentiation of osteoblasts and promoting bone apposition. This platform provided an effective and pragmatic approach to attain superior antibacterial activity and presented a viable alternative for combating harmful microorganisms.
研究领域:
生物医学工程
·
纳米技术
·
骨科
·
材料科学
·
抗菌治疗
·
光热疗法
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Jingjiao Xie,Huiyuan Gong,Zhihan Du,Chen Hong,Wen Luo
Hydrogen sulfide (H 2 S) plays an important role in various pathophysiological processes, and its concentration is associated with various diseases. As such, the development of new H 2 S probes for the early detection of these diseases is of great significance. To date, a variety of probes have been developed for H 2 S detection, however, most probes exhibit response to other sulfur-containing compounds, resulting in a lack of specificity and weaker anti-interference performance. In this paper, a new flavone-based near-infrared (NIR) fluorophore was synthesized by introducing a 5-[4-(dimethylamino) phenyl] thiophene group at the 2-position of the chromone structure. Moreover, using nitrobenzoate as recognition group, two novel probes (TF-3NO 2 and TF-4NO 2 ) were synthesized to detection of H 2 S in biological systems. Among them, TF-3NO 2 exhibited a more specific fluorescent response to H 2 S compared to TF-4NO 2 . Upon treatment with H 2 S, the fluorescence intensity showed a significant increase, showcasing the high specificity, strong anti-interference capability, near-infrared emission (690 nm), and large Stokes shift (∆λ = 223 nm) of the probe. Moreover, the probe was successfully applied for imaging both exogenous and endogenous H 2 S in cells and mice, and enabled to distinguish changes in the H 2 S concentration in the brains of APP/PS1 transgenic and wild-type mice. The above results indicate that TF-3NO 2 can penetrate the mouse blood brain barrier, and is expected to be a powerful molecular tool for detecting H 2 S in living systems within basic and biomedical research fields.
研究领域:
生物化学
·
分子生物学
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生物医学工程
·
神经科学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2024
·
IF 6.6
Zhenlei Wang,Zengci Run,Huamin Wang,Xiaojun He,Jian Li
Purpose The search for effective and low-risk treatment methods for colorectal cancer (CRC) is a pressing concern, given the inherent risks and adverse reactions associated with traditional therapies. Photothermal therapy (PTT) has emerged as a promising approach for cancer treatment, offering advantages such as non-radiation, non-invasiveness, and targeted treatment. Consequently, the development of nanoparticles with high stability, biocompatibility, and photothermal effects has become a significant research focus within the field of PTT.Methods In this study, TiO2-Ti3C2 nanocomposites were synthesized and characterized, and their photothermal conversion efficiency in the near-infrared region II (NIR-II) was determined. Then studied the in vivo and in vitro photothermal activity and anti-tumor effect of TiO2-Ti3C2 in human colorectal cancer cell lines and nude mice subcutaneous tumor model.Results The results showed that TiO2-Ti3C2 nanocomposites have strong absorption ability in the NIR-II, and have high photothermal conversion efficiency under 1064 nm (0.5 W/cm2, 6 min) laser stimulation. In addition, in vitro experiments showed that TiO2-Ti3C2 nanocomposites significantly inhibited the invasion, migration, and proliferation of colorectal cancer cells, and induced cell apoptosis; in vivo, experiments showed that TiO2-Ti3C2 nanocomposites-mediated PTT had good biocompatibility and efficient targeted inhibition of tumor growth.Conclusion In conclusion, TiO2-Ti3C2 nanocomposites can be used as NIR-II absorption materials in PTT to suppress the invasion, migration, and proliferation of colorectal cancer cells, induce colorectal cancer cell apoptosis, and thus inhibit the development of CRC. Therefore, TiO2-Ti3C2 nanocomposites can be used as potential anti-tumor drugs for photothermal ablation of colorectal cancer cells.
研究领域:
纳米技术
·
癌症研究
·
生物医学工程
·
材料科学
·
光热疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Chao Li,Ying Li,Yi Xu,Jiyou Zhong
Near-infrared (NIR) phosphors as crucial components of NIR light sources have multifunctional and smart spectroscopy applications, prompting an increasing research interest in developing efficient and stable NIR materials. Focusing on this issue, the present study explored the luminescent properties of Cr 3+ -doped Ca 3 ZnMGe 3 O 12 (M = Zr, Hf, Sn and Ti) garnet family. These materials exhibit an emission peak falls within the range of 785–805 nm with a full width at half maximum (FWHM) varying from 114 to 123 nm. Among them, the Ca 3 ZnZrGe 3 O 12 :Cr 3+ phosphor shows the highest photoluminescence quantum yield (PLQY = 60.3 %) and an excellent thermal stability ( I 423K / I 298K = 77.51 %). Moreover, the performance of a prototype Ca 3 ZnZrGe 3 O 12 :Cr 3+ -containing NIR pc-LED device was estimated, which achieves an NIR output of 23.46 mW and a photonic efficiency of 14.09 % under 100 mA driving current. Non-destructive examination can be realized using this light source, demonstrating the good potential of the material in NIR spectroscopy applications.
研究领域:
材料科学
·
光电技术
·
光子学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 51
·1803815
·
IF 13.325
Lingyu Zhang,Shengnan Li,Xiangjun Chen,Tingting Wang,Lu Li,Zhongmin Su,Chungang Wang
The development of novel Janus nanostructure with desired compositions and functionalities is essential for various applications, especially as drug delivery system to deliver multiple payloads with total different solubility. Here, a unidentified flying object (UFO)-like cyclodextrin–palladium nanosheet/zeolitic imidazolate framework-8 Janus nanoparticle (CD–PdNS/ZIF-8 JNP) prepared via a selective coating of polyacrylic acid (PAA) on one of the flat surfaces of 2D PdNS followed by further formation of ZIF-8 on a PAA template, and alternative modification of CDs on exposed PdNS surface is reported. The CD-PdNS and PAA-ZIF-8 parts are designed to load hydrophobic10-hydroxycamptothecin (HCPT) and hydrophilic doxorubicin (Dox) independently for synergistic chemotherapy (combination index = 0.65). Because of the broad near-infrared (NIR) absorption band of PdNSs, the photothermal effect of UFO-like CD-PdNS/ZIF-8 JNPs in NIR-II biowindow is studied. The in vitro and in vivo results show that the dual-drug loaded JNPs under a laser-irradiation group present highest cancer therapeutic efficiency. The good performance is due to the synergistic chemotherapy and photothermal therapy in NIR-II biowindow. This work significantly broadens the application prospects of metal–metal organic framework JNPs by rationally designing their compositions and discovering related physiochemical properties.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
药物递送系统
✓ 已验证
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Mengmeng Hou,Ruihao Yang,Lei Zhang,Leiyang Zhang,Gang Liu,Zhigang Xu,Yuejun Kang,Peng Xue
The injection of theranostic drug-laden hydrogels into subcutaneous tumors has proven to be a promising strategy to achieve precise local tumor eradication. Humic acid, a natural product of biochemical decomposition of animal and plant residues, abundantly exists in soils, peats, oceans, etc. In this study, a robust injectable thermoresponsive agarose hydrogel incorporating sodium humate (SH) and doxorubicin (DOX) was constructed as a unique agent for tumor management based on the combined chemo-photothermal therapeutic effect. SH, which strongly absorbs near-infrared (NIR) light, can efficiently convert light energy into thermal energy, induce local hyperthermia and subsequently trigger sustained drug release from the complex of the SH/DOX@hydrogel through a typical gel–sol transition, resulting in enhanced cellular uptake of therapeutic drugs. Moreover, intratumoral injection of the SH/DOX@hydrogel resulted in a simultaneous chemo-photothermal therapeutic effect against solid tumors under NIR laser irradiation, which may collectively prevent tumor recurrence. In addition, the SH/DOX@hydrogel exhibited ultralow systemic toxicity as demonstrated using an animal model. This work provides a promising attempt to develop a low-cost, light-responsive hydrogel for precise tumor therapy, which may also incorporate extra theranostic modules as an advanced platform for the treatment of cancer or other critical diseases.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Jia Yang,Lifang Yuan,Di Qian,Haoyi Wu,Yahong Jin
Broadband near-infrared phosphor-converted LED (NIR pc-LED) light sources have attracted considerable attentions due to their widespread applications in active security defense, nondestructive detection, and online chemometric analysis. The broadband NIR phosphor, determining the overall performance of NIR pc-LED, is still to be explored. In this study, a series of CdGa 2-x O 4 :xCr 3+ phosphors are prepared by a solid state reaction. Owning to the electron population in 2 E and 4 T 2 energy levels of Cr 3+ ions with an intermediate crystal field, CdGa 2 O 4 :Cr 3+ exhibits a sharp line and broad band overlapped NIR emission spectrum, covering 600–1300 nm with a peak wavelength ( λ max ) of 740 nm and a full width at half maximum (FWHM) of 160 nm. A robust luminescence thermal stability that the NIR emission intensity remains 95 % of the initial level at 423 K is achieved, caused by a weak electron-phonon coupling (EPC) effect. Finally, a prototype NIR pc-LED is fabricated by using the as-obtained broadband NIR phosphor to demonstrate the application for night vision.
研究领域:
材料科学
·
光电技术
·
光子学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
Yu Chen,Yumin Wang,Xiang Hua Wu,Bo Liu,Jun Feng Zhang
Biothiols such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) play important roles in various physiological and pathological processes. However, it is still a great challenge to selectively detect Cys/Hcy and GSH in biological samples due to the similarity of structures and re-activities of these biothiols. In this paper, a new dual-channel near infrared-7-nitro-1,2,3-benzoxadiazole ( NIR-NBD ) fluorescent probe has been developed for the discriminative detection of Cys/Hcy and GSH. The probe is composed of two functional parts: a near-infrared dye of dicyanoisophorone, as fluorophore precursor, and NBD as both fluorophore precursor and sensing group. It was observed that NIR-NBD probe displayed two different fluorescent signals in response to biothiols, green-red for Cys/Hcy and red for GSH. It also showed a near infrared emission (756 nm), low detection limit, fast response, high stability, selectivity and sensitivity. Furthermore, NIR-NBD was effectively applied for the discriminative detection of Cys/Hcy and GSH in HeLa cells .
研究领域:
化学
·
生物化学
·
细胞生物学
·
分析化学
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Yibing Shi,Xiaoyi Zhu,Qingyuan Xu,Yanling Wu,Yishuo Sun,Xin Zhao,Yulong Liu,Wei Feng,Youhua Xie,Tianlei Ying,Zhenlin Yang
The oral administration of immunofluorophores has been limited by gastrointestinal degradation. To address this, a novel immunofluorophore (ICGM-B9-FCS), based on a single-domain antibody-dye targeting the CEACAM5 antigen, is coated with trifluoromethyl chitosan (5 mg kg −1 ) for NIR-II bioimaging of colorectal cancer and its distant metastases. ICGM-B9-FCS demonstrates unique advantages over existing intraoperative tumor-guidance bioagents, including resistance to liver metabolism, well-retained bioaffinity (EC 50 = 58.09 nmol L −1 ), enhanced relative quantum yield (up to 12 equivalents), significant redshifts in absorption (from 783 to 957 nm), effective oral delivery to colonic metastases, and in situ exploration of the capillary-lymphatic network transportation. These findings establish a regulatory pathway for modifying immunofluorophores as orally administered bioagents, offering innovative methods for preoperative diagnosis and intraoperative guidance in colorectal cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Haohao Zhang,Mingyuan Pang,Min Yang,Zhen Kong,Jiajia Ye,Wensi Li,Yen Leng Pak,Juan An,Koulong Wu,Jibin Song
Chemotherapy, as a primary cancer treatment modality, faces limitations in efficacy and patient tolerance due to non-specific cytotoxicity, drug resistance, and adverse effects. This study develops a multifunctional nanoplatform (DOX-FA-CS-BiO 1 . 5 ) for NIR-Ⅱ photoacoustic imaging-guided visualized synergistic photothermal-chemotherapy, aiming to achieve enhanced therapeutic outcomes. The BiO 1 . 5 component ensures superior photothermal conversion efficiency and photoacoustic imaging performance, while the synergistic platform's high drug loading capacity and pH-responsive controlled release profile significantly improve tumor cell eradication rates. The chitosan-folic acid dual coating enhances biocompatibility and tumor-targeting specificity. Through synergistic effects, this nanoplatform demonstrates superior antitumor efficacy, offering a novel paradigm for constructing integrated platforms for imaging-guided visualized cancer theranostics.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2025
·
IF 4.7
Jiye Jia,Xiaoxin Shi,Feng Yang,Huanxin Luo,Pei Feng,Cijun Shuai
Fenton reaction can kill bacteria by producing strong oxidizing •OH by the chain reaction between Fe 2+ and H 2 O 2 , exhibiting great potential in the treatment of bacterial infection caused by bone graft. However, the properties of bone implants endowed by the Fenton reaction are generally insufficient due to the limitation of the concentration of Fe ions and reaction conditions. Herein, photothermal therapy was applied to enhance the Fenton reaction of scaffold to obtain excellent antibacterial properties, and the scaffold composited of polycaprolactone/polyglycolic acid blends (PCLGA) and oxygen vacancy Fe 3 O 4 /TiO 2 (OV-FeTiO 2 ) nanoparticles was fabricated by selective laser sintering. The results showed that OV-FeTiO 2 nanoparticles possessed excellent photothermal conversion capability, and the temperature of scaffold rose from 20 to 45 °C after 5 min of irradiation by near-infrared (NIR) light at 0.3 W/cm 2 . Consequently, the Fe ions release rate increased due to the accelerated degradation of PCLGA, and the release of Fe ions reached about 5.1 ‰ at 54 °C, which was 1.41 times than that at 25 °C. Benefiting the increase of reaction temperature and release rate of Fe ions, the Fenton reaction activity was enhanced to generate more •OH. The antibacterial experiments showed that the PCLGA/OV-FeTiO 2 scaffold possessed the best antibacterial properties, and the bactericidal rates against E. coli and S. aureus were 97.2 % and 93.5 %, respectively. Besides, in vitro cell experiments demonstrated that the scaffold possessed good biocompatibility and the treatment of NIR irradiation was harmless for cell growth, proliferation and differentiation.
研究领域:
生物材料
·
生物医学工程
·
抗菌治疗
·
组织工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）