JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2021
·
IF 4.464
Fuad Abduro Bushira,Shimeles Addisu Kitte,Haijuan Li,Lirong Zheng,Ping Wang,Yongdong Jin
Simultaneous highly sensitive and accurate detection of dopamine (DA) and uric acid (UA) is of great importance since they are important biomolecules that are commonly coexisted in the human body and play a crucial role in numerous physiological and pathological features. In this work, Fe-N 5 single atom catalyst (SAC) supported on graphene was firstly employed for simultaneous electrochemical detection DA and UA. Owing to its unique electronic structure and abundant active sites, under optimal conditions, the enzyme-like Fe-N 5 SAC constructed electrochemical (bio)sensor exhibits excellent linear characteristic responses in the range of 0.005–500 and 0.01–480 µM, as well as the low limit of detection of 0.007 and 0.027 nM for DA and UA, respectively. More critically, the developed electrochemical system shows promising merits of exceptional stability, good repeatability, and, consequently, it was successfully applied for simultaneous sensitive detection of DA and UA in human serum samples.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
DOI
高影响因子
ELECTROANALYSIS
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2020
·Vol. 32
·期 9
·2010-2017
·
IF 2.544
Shengbiao Zheng,Jiaqi Hu,Xue Cui,Tao Hu,Yuyang Zhang,Jiahao Guo,Jing Tang,Xuchun Wang
In the present study, we report a facile method for preparing a porous MWCNTs/ZIF-67 nanocomposite with the help of a morphology-maintained ZIF-67 in situ growth on multi-walled carbon nanotubes. Interesting, the MWCNTs/ZIF-67 nanocomposite demonstrated excellent electrochemical activity for hydroquinone (HQ) and catechol (CC) attribute to the effective interconnections ZIF-67 crystals and MWCNTs. The analytical curves for HQ and CC obtained by differential pulse voltammetry (DPV) were linear in the range from 0.5 to 100 μM. Benefitting from the excellent conductivity of MWCNTs as well as the high surface area and porosity of ZIF-67, the advanced nanocomposite displayed good reproducibility, high selectivity and excellent stability, and was successfully employed to assay the content of dihydroxybenzene isomers in the lake water samples.
研究领域:
材料科学
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环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
·
IF 4.539
Hao Guo,Tingting Zhang,Mingyue Wang,Lei Sun,Junye Zhang,Meng Yang,Fan Yang,Ning Wu,Wu Yang
In this work, a novel sensor based on gold nanoparticle-modified zirconium-metal-organic frameworks (MOF-801) and carboxyl-functionalized carbon nanotube (MWCNT-COOH) composite material was built successfully for electrochemical detection of guanine and adenine in DNA sample, which exhibits diverse advantages such as fast, convenience and high efficiency. Guanine and adenine were detected by the cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under the optimal conditions, MOF-801/MWCNT-COOH/ AuNPs/GCE delivered linear DPV responses to guanine in the range of 0.8 ~ 60, 60 ~ 180 μM and the adenine in the range of 0.8 ~ 60, 60 ~ 180 μM with the low detection limit of 0.09 μM for guanine and 0.08 μM for adenine, respectively. The advantages of this method include simplicity, rapidity, high sensitivity, good selectivity as well as low cost. The modified GCE was successfully applied to the analysis of guanine and adenine in DNA samples.
研究领域:
生物化学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2016
·
IF 4.758
Wan Wang,Hua Bai,Haiyu Li,Qing Lv,Qing Zhang,Ning Bao
Fabrication of disposable gold working electrodes in bulk is desirable for their extensive application in electrochemical detection . In this paper the gold film electrodes were prepared by sputtering the gold film with the thickness of ∼12 nm on the double sided conductive carbon tape. The gold film coated carbon tape could be used like stickers with small square pieces and attached on ITO glass for fabrication of disposable gold film electrodes. The electrochemical responses of the gold film modified electrodes on Cr(VI) in acidic solutions were similar to previous gold electrodes, suggesting the similar mechanism as before. Cr(VI) could be determined by the amperometric method with the detection limit of 0.7 μg L −1 (0.013 μM), which was significantly improved compared with previously reported disposable gold-based electrodes. The batch-by-batch (n = 20) reproducibility of the fabricated electrodes was 7.3% at 50 μg L −1 and 3.8% at 5.0 mg L −1 , respectively. The disposable electrodes could be applied to quantify Cr(VI) in real samples including plastics, tap water and lake water with results in agreement with those obtained with HPLC-ICP-MS. This study provides a simple and effective alternative for preparation of disposable gold film electrodes.
研究领域:
分析化学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 11
·1-8
·
IF 5.479
Hu Xiaopeng,Xi Jiajia,Xia Yuanyuan,Zhao Faqiong,Zeng Baizhao
A space-confined synthesis method is employed for the preparation of a single-layer MoS 2 –boron doped ordered mesoporous carbon nanocomposite. A phenol-formaldehyde resin is used as carbon source to create a confined space for the formation of single-layer MoS 2 . The addition of pluronic F127, as a soft template, suppresses the stacking of MoS 2 layers and makes the composite porous. The nanocomposite is characterized by scanning electron and transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy. The single-layer MoS 2 sheets have a lateral size of about 5 nm and are uniformly embedded in the composite. They possess numerous active edge sites and display a strong synergistic effect with other components. The composite is modified on a glassy carbon electrode, followed by the electrochemical imprinting of theophylline, and the resulting electrode exhibits good electrochemical response to theophylline. The linear response range is 0.01–250 μM by differential pulse voltammetry, and the lower detection limit is 5 nM. It has been successfully applied to the determination of theophylline in spiked tea drink samples.
Single-layer MoS 2 –boron doped ordered mesoporous carbon nanocomposite has large surface area and high catalysis, when coupling with molecularly imprinted polymer the resulting electrode shows highly sensitive and selective response to theophylline.
研究领域:
材料科学
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分析化学
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药物分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Zhenzhen Wang,Ye Ying,Li Li,Ting Xu,Yiping Wu,Xiaoyu Guo,Feng Wang,Haojie Shen,Ying Wen,Haifeng Yang
A net-bracket built out from the core@shell structure of chemically oxidized polypyrrole (PPy) coated electrospun polycaprolactone (PCL) nanofibers, and the following surface modification of a thin layer of positively charged poly(dimethyl diallyl ammonium chloride) (PDDA) has been applied for stretching the reduced graphene oxide (RGO) sheets to some extent with the electrochemical deposition method. The as-formed RGO/PDDA/PCL@PPy nanocomposites were investigated by using scanning electron microscopy, transmission electron microscope, X-ray diffraction and Raman spectroscopy. The graphene tented by the net-bracket showed remarkable electrocatalytic properties in detecting the neurotransmitter dopamine (DA). Low detection limit of 0.34 μM (S/N = 3) with the wide linear detection range from 4 μM to 690 μM was obtained. The successful determination of DA in real urine samples and DA injection were achieved. Such attractive fabrication strategy can be extended to make other graphene sheet-based sensors.
研究领域:
材料科学
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神经生物学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2024
·
IF 2.7
Xin Hua,Tongxiao Zhao,Xueqin Gui,Baokang Jin
In this paper, a label-free electrochemical immunosensor for sensitive detection of prostate antigen (PSA) was developed based on a NiFe PBA/AuNPs composite. The prostate antigen antibody was immobilized and the immunosensor was constructed by using a glassy carbon electrode modified with a nanocomposite consisting of nickel–iron Prussian blue analog (NiFe PBA) and gold nanoparticles (AuNPs). Due to the good biological affinity of AuNPs for biomolecules, as well as the porous nanostructure and regular shape of NiFe PBA, NiFe PBA/AuNPs nanocomposites significantly improve the electron transport rate, while achieving excellent performance for the sensor. Due to the interaction between the antibody and the antigen on the modified electrode, the current signal of the NiFe PBA itself is reduced due to the redox changes in Fe2+ and Fe3+, which can be determined by differential pulse voltammetry (DPV). Therefore, the monitoring of prostate antigen detection is realized. Under optimal experimental conditions, the immunosensor exhibited excellent detection performance with a dynamic response range from 0.5 pg mL−1 to 1000 pg mL−1 for the PSA concentration and a detection limit of 0.23 pg mL−1 (S/N = 3). In addition, the PSA aptasensor has good selectivity, high stability, and satisfactory reproducibility and has broad potential in clinical research and diagnostic applications.
研究领域:
生物医学工程
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分析化学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small Methods
·
2021
·Vol. 5
·期 12
·2101072
·
IF 14.188
Xiyue Xie,Zhenqiang Wang,Meizhen Zhou,Yuxin Xing,Yuhua Chen,Jixi Huang,Kaiyong Cai,Jixi Zhang
Electrochemical nanosensors by integrating functional nucleic acids and nanomaterials hold a great promise in the fast detection of biomarkers, yet the current systems possess limitations on the accessibility of target–probe and probe–electrode interactions and the repeatability of detection. Herein, a host–guest assembly strategy is developed to build redox nanosensors for an immobilization-free and ratiometric electrochemical detection system. Specifically, electroactive molecule ( E m ) guests are loaded in porous hosts of polydopamine nanoparticles (MPDA) to act as dual-signal redox reporters. Hybrid DNA probes of G-quadruplex and a single-stranded anchor DNA are installed as gatekeepers for sealing the mesopores. Thereby, miRNA triggered E m release by strand displacement reactions and the homogeneous transportation of the hosts/guests to the electrode facilitate the generation of reference signal/response signal at different potentials. Concomitantly applied NIR irradiation boosts the electron transfer from MPDA to the electrode and results in a tenfold increase in the reference signal. Finally, the sensing system through the differential pulse voltammetry method achieves a highly repeatable detection (relative standard deviation 3.8%) of miRNA with a lower detection limit (362 × 10 −15 m ). This attractive system paves the way for rational designs of advanced electrochemical biosensors and smart diagnosis.
研究领域:
生物医学工程
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分析化学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemosensors
·
2022
·Vol. 10
·期 11
·443
·
IF 4.229
Luyi Zhu,Qinan Zhou,Wenqing Shao,Zhenbo Wei,Jun Wang
A novel Co-based organic frameworks/carbon nanotubes/silicon dioxide (Co-MOF/CNTs/SiO2)-modified Au electrode was fabricated and taken as a platform for gallic acid (GA) detection. The composite combined the advantages of Co-MOF, CNTs and SiO2, and higher electrochemical response of Co-MOF/CNTs/SiO2-modified electrode indicated that the composite material exhibited satisfied the catalytic activity towards GA. Moreover, the electrochemical oxidation process of GA was deeply investigated on the surface of electrode based on computational investigations. Hirshfeld charges and condensed Fukui functions of each atom in GA were calculated. Besides, the catalysis of Co-MOF to GA was further investigated based on density functional theory. The quantitative determination of GA was carried out and showed a linear range between 0.05–200 μM, with low limit of detection. The sensitivity value of the self-assembled electrochemical sensor was calculated to be 593.33 μA cm−2mM−1, and the selectivity, reproducibility and stability of the gallic acid sensor were also confirmed in the study.Keywords:gallic acid;electrochemical;electro-oxidation;detection;density functional theory
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2022
·Vol. 14
·期 38
·3802-3813
·
IF 3.532
Yang Yuan,Hui Jia,Jie Wang
Among various detection and analysis platforms, a microfluidic chip-based electrochemical sensing detection platform is a new type of detection platform. In this study, a microfluidic electrochemical detection platform for cadmium ion detection is proposed, and the performance of the detection platform is optimized in terms of both the microchannel size and electrode modifications. The detection mixing processes of the detector with different microchannel sizes, including the concentration distribution in the channel, pressure decay variation and electrolyte current density variation in the detector, were investigated by finite element model calculations. The analysis shows that the size of the microchannel in the detector affects the fluid and thus further affects the chemical reaction. If the size of the electrode does not match the size of the microchannel, insufficient sample volume will lead to inaccurate measurements, reduced sensitivity and increased detection limits. It was found that the sensitivity of the electrochemical sensor was highest when the size of the microchannel in the chip was 400 μm. After optimization, the optimal detection limit for cadmium ions was 0.03 μg L−1 (S/N = 3). The proposed sensing platform is simple in design and stable in structure, and is suitable for field screening and rapid response to heavy metal contamination events.
研究领域:
环境科学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Xu Zhu,Shufang Wu,Chunlan Li,Maotian Xu,Baoxian Ye
DNA was employed in a novel way to contribute to the electroanalysis. Electrochemical oxidized DNA modified glassy carbon electrode (DNA/GCE) by potentiostatic method for Levotetrahydropalmatine (L-THP) determination was prepared. For the first time, L-THP was investigated by electrochemical sensor, and the results indicated that this voltammetric sensor exhibited a special recognition capacity towards L-THP determination. Under the optimize condition, the response peak currents had a linear relationship with the L-THP concentrations in range from 5.6×10 -5 mol L -1 to 2.8×10 -3 molL -1 with detection limit of 2.×10 -6 moi . L -1 .
研究领域:
分析化学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Asia-Pacific Journal of Chemical Engineering
·
2023
·Vol. 18
·期 5
·e2962
·
IF 1.8
Tianming Yang,Xin Xin,Jin-Chi Jiang,Zhenhao Yin,Long-Yue Meng
The sensitive detection of heavy metal ions with high toxicity and mobility is extremely important for environmental monitoring. In this study, nitrogen-doped biochar (N-BC) was synthesized using waste mushroom bran as a raw material, and nitrogen atoms were successfully doped onto the surface of the biochar via a facile process using an activation-carbonation strategy. The functional groups on the surface of the biochar were enriched via doping, and the roughness of the biochar surface was significantly improved. Experimental results showed that N-BC was an efficient sensing material for electroanalysis; therefore, it was used to construct a novel electrochemical sensing platform. The electrochemical response of the biochar-modified working electrodes was effectively improved for the detection of heavy metals. Under optimized deposition potential, enrichment time, and pH, the N-BC-based sensing platform could detect Pb 2+ and Cd 2+ separately as well as simultaneously, indicating its significant potential for electrochemical sensing.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）