CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Xiaoxiao Liang,Yanru Wu,Yuehua Deng,Xingye Zeng,Shufeng Shan,Yanbin Jiang,Huaiyu Yang
Multi-component crystal based on supramolecular self-assembly is an effective strategy to modify the physicochemical properties of poorly water-soluble drugs. In this study, eight novel multi-component crystals of Osimertinib (AZD) were firstly synthesized under the guidance of theoretical analysis. Five single crystals were successfully obtained, and the AZD-FMS cocrystal shows a distinctive structure wherein free FMS filled in the skeleton, which may be crucial for maintaining morphology. Analysis of crystal structures and Hirshfeld surfaces indicated the involvement of N−H···O and N···H−O hydrogen bonds in the multi-component crystals. Owing to robust intermolecular interactions, multi-component crystals exhibited improved solubility/dissolution rate compared to pure AZD. Multivariate analysis revealed coformers and strong solute–solvent interactions determined the solubility/dissolution rate. Multi-component crystals showed superior stability in solution and low humidity. Moreover, AZD-FSM increased 5.2-fold anti-tumor activity over AZD, which is anticipated to enhance efficacy, reduce drug toxicity, combat drug resistance, and transform from laboratory to clinical application.
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高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Nanjun Chen,Zichen Ning,Zhuoshan Gong,Limin Zhou,Li Xu,Feiqiang He,Zhi Gao,Jerry Y. Y. Heng,Shichao Du,Jinbo Ouyang
Modulating the luminescent characteristics of solid materials via the multicomponent crystallization process to form cocrystals and hydrates poses a formidable and significant challenge. In this study, we demonstrated the aggregation-induced emission characteristics of piroxicam and synthesized four distinct cocrystals using salicylic acid, m-chlorobenzoic acid, saccharin, and 1-hydroxy-2-naphthalenecarboxylic acid as coformers. We comprehensively characterized the crystal structures and luminescent properties of these cocrystals using powder X-ray diffractometer, fluorescence microscopy, and fluorescence spectrophotometry. Moreover, the relationship between the crystal structure and fluorescence properties was established through theoretical analyses, including the calculation of intermolecular interactions, the distribution of frontier orbitals obtained based on density functional theory, and the electron density distribution derived from molecular electrostatic potential calculations. Additionally, we synthesized a novel piroxicam hydrate that exhibits a reversible fluorescence switching effect in response to acidic, basic, and thermal stimuli upon absorbing, eliminating, or replacing water molecules within the lattice, which renders it suitable for application in thermal and pH sensors, as well as information encryption. Overall, this approach offers a promising framework for precisely tuning the fluorescent properties of AIE molecules through the hydration and dehydration processes of organic crystals.
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高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2024
·
IF 5.3
Jinxue Song,Yi He,Bo Liu,Ruxia Song,Zhifei Zhang,Hongjie Li,Huilian Zhou,Zhiyuan Li,Xinyu Cheng,Jiamin Zhong,Liping Yan
This study developed a novel Ni B/Ca-CNFs/MWCNTs/h-BN coating on N80 steel. The disadvantages of hexagonal boron nitride (h-BN) were improved by creatively combining multi-walled carbon nanotubes (MWCNTs), cellulose nanofibers (CNFs), and calcium ion cross-linking strategies. This led to the creation of Ca-CNFs/MWCNTs/h-BN hybrids, which were then doped into Ni B coatings by varying pulse current densities. The results demonstrated that the surface morphology , mechanical properties, and toughness of the composite coating are all influenced by the Ca-CNFs/MWCNTs/h-BN doped at various current densities. Meanwhile, the Ni B/Ca-CNFs/MWCNTs/h-BN (4 A/dm 2 ) coating has the greatest microhardness (902.42 Hv) and the smallest friction coefficient (0.487) under reciprocating dry sliding friction conditions of Si 3 N 4 friction balls. In addition, the results of nanoindentation and tensile tests show that the elastic modulus of Ni B/Ca-CNFs/MWCNTs/h-BN (4 A/dm 2 ) composite coating is 194.096 MPa and the tensile elongation is 12.2 %.
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高影响因子
ADVANCED ENGINEERING MATERIALS
·
2025
·
IF 3.3
You Li,Zhichao Gan,Yunshu Zhang,Yuxin Zhai,Lulu Zhan,Weiming Chen
Graphene oxide (GO) has become an important reinforcing phase in metal matrix composites due to its excellent mechanical and thermal properties. However, existing studies have predominantly focused on traditional alloys or high-entropy alloys, while significant gaps remain in the investigation of synergistic strengthening mechanisms of GO and microforming behavior in medium-entropy alloys. In this article, FeCoNi/GO nanocomposites are fabricated through composite pulsed electrodeposition. GO can be efficiently incorporated into the FeCoNi medium-entropy alloy matrix, which not only markedly refines the matrix grains, effectively suppressing the excessive growth of grains during high-temperature stretching and thereby enhancing the plasticity of the composites, but also impedes the dislocation movement during the deformation process, leading to the formation of dislocation plugging and the improvement of the mechanical properties of the composites. The experimental results indicate that a moderate addition of GO can augment the tensile strength of the material up to 1657 MPa at room temperature, the elongation up to 93% at high temperature, and the maximum depth-to-diameter ratio of the microformed parts up to 0.404. This work provides a new synergistic strengthening strategy of “medium-entropy alloys + nanoreinforcing phases” for material design of microdevices in fields such as aerospace and biomedical engineering.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Liandong Li,Ziqi Qiao,Bing Lin,Hailong Zhang,Yingying Wang,Zhe Sun,Yiping Hu,Denghao Ouyang,Shiyu Li,Hangzhou Wang,Junlei Tang,Caineng Zou
Electrolysis of neutral saline wastewater/seawater enables sustainable hydrogen production but faces sluggish hydrogen evolution reaction (HER) kinetics and poor durability in chloride-rich media. Herein, a novel Cu 2 S/Amorphous/Cu–Ni–Mo heterostructure electrocatalyst, prepared by electrodeposition and atomic layer deposition (ALD), was introduced to address these challenges. The electrode was synthesized by electrodepositing a Cu–Ni–Mo coating onto a stainless steel substrate, followed by in-situ sulfurization using ALD technology to form an amorphous layer, yielding a heterostructure with optimized interfacial properties. This heterostructure electrode exhibited an overpotential of 63.29 mV at −10 mA cm −2 and maintained stable operation at −100 mA cm −2 for over 180 h in 0.5 mol/L NaCl +1 mol/L phosphate buffered saline (PBS). A 10 cm × 10 cm electrode was successfully fabricated using this scalable method, which exhibited uniform morphology and stability exceeding 240 h. This work advances HER performance and scalability in neutral environments, facilitating industrial-scale electrocatalytic hydrogen production.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yawen Xu,Ye Li,Yizhi Du,Jinlong Zhang,Siyi Li,Chao Zhang,Xiaoli Ren,Zhiqiang Xu,Bing Xue,Fangfei Li
In this work, a W O bond-enriched NiFe layered double hydroxide composite (NiFe-LDH@NWT) was synthesized as a high-performance electrocatalyst for the oxygen evolution reaction (OER) in alkaline media. The incorporation of W O bonds effectively modulates the local electronic environment and surface charge distribution of the NiFe-LDH, thereby enhancing its intrinsic activity and interfacial reactivity. Electrochemical measurements reveal that NiFe-LDH@NWT delivers low overpotentials of 236 mV at current densities of 100 mA cm −2 , respectively, with a small Tafel slope of 33.53 mV dec −1 , indicating favorable reaction kinetics. In addition, the electrochemically active surface area (ECSA) reaches 7.82 mF cm −2 , confirming the increased density of accessible active sites upon W O bond integration. Notably, the catalyst maintains excellent operational stability for over 1000 h at a current density of 100 mA cm −2 . These findings highlight a promising strategy to tailor the physicochemical properties of LDH-based catalysts, providing valuable insights into the rational design of stable and efficient OER systems for water-splitting applications.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Zejie Zhang,Mingni Hong,Yihui Wu
Seawater electrolysis is a pivotal approach for hydrogen production. However, the sluggish oxygen evolution reaction (OER) occurring at the anode poses a significant obstacle to its practical application. Replacing the OER with the urea oxidation reaction (UOR), which has a lower theoretical voltage of −0.46 V, has the potential to decrease energy consumption. Nevertheless, the intricate six-electron process of UOR limits its efficiency. In this study, cobalt-sulfur (Co–S) electrocatalysts were synthesized on nickel foam via electrodeposition, using CoCl 2 ·6H 2 O and thiourea as the sources of Co and S, respectively. The optimized Co–S electrocatalyst exhibits low overpotentials: 412 mV in 1.0 M KOH freshwater and 469 mV in 1.0 M KOH seawater to reach 50 mA cm −2 . More importantly, the catalyst displays excellent catalytic activity (10 mA cm −2 at 1.400 V) as well as long-term stability for 50 h in 1.0 M KOH + 0.33 M urea seawater. The excellent performance of the catalyst is attributed to the synergistic effect between Co and S, which optimizes the electronic configuration and accelerates charge and electron transfer, thus significantly improves the kinetics of the reactions. Furthermore, the abundance of sulfur vacancies reduces the adsorption energy of urea and strengthens electron interactions, thereby enhancing the UOR. Additionally, the superhydrophilic/superaerophobic nature of the Co–S electrocatalyst facilitates the diffusion of gases and liquids, thus improving the OER/UOR performance.
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高影响因子
Metals
·
2025
·Vol. 15
·期 12
·1320
·
IF 2.5
Xinyi Yuan,Rongcheng Sheng,Yizhe Du,Dengfu Chen,Mujun Long,Huamei Duan
To address the demands of modern high-speed and high-quality continuous casting production, depositing high-performance coatings on the surface of mold copper plates is critically important for extending the service life of continuous casting molds. To this end, a Ni-Co-Cr/SiC nanocomposite coating was developed, and cryogenic treatment was applied to further improve its hardness and wear resistance. This work systematically investigates the microstructural evolution and performance enhancement of the Ni-Co-Cr/SiC nanocomposite coating under different cryogenic treatment parameters, with special emphasis on the effects of treatment temperature on the coating’s microstructure, hardness, wear resistance, and adhesion to the substrate. The results demonstrate that decreasing the cryogenic treatment temperature and extending the holding time effectively refine the grains of the coating while simultaneously promoting the accumulation of microstrain and dislocation density. These changes lead to significant improvements in hardness, wear resistance, and interfacial bonding performance. Specifically, after direct immersion at −196 °C for 16 h, the coating reached a hardness value of 946.5 HV, and the wear rate was reduced to 0.032 mm3·(N·m)−1, representing only 54.6% of that of the untreated coating. The dominant wear mechanism transitioned to a mixed mode of abrasive wear and oxidative wear. Moreover, the cryogenic treatment enhanced the stability of the coating-substrate adhesion.
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高影响因子
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
·
2025
·
IF 3.8
Xia Liu,Weiwei Ju,Erjiao Qiang,Dongning Li,Qing Liang,Meina Guo,Weijing Yun,Zhenzhen Chen
3.: Cardiac fibrosis is a prevalent characteristic of various cardiovascular diseases and poses a significant global health challenge. Recent research has established a robust correlation between gut microbiota and cardiovascular diseases. Hesperidin has been shown to possess cardioprotective properties to some extent. Furthermore, studies suggest that hesperidin may enhance overall health by regulating intestinal flora. However, there is a lack of reports regarding the effects of hesperidin on cardiac fibrosis. The present study aims to investigate the mechanisms by which hesperidin ameliorates cardiac fibrosis through the regulation of gut microbiota and associated metabolites. Cardiac fibrosis was induced in C57BL/6 mice via subcutaneous injection of isoproterenol (5 mg/kg/day) for a duration of 7 days. Echocardiography was employed to assess cardiac function, while Masson staining, Western blot analysis, and real-time PCR were utilized to evaluate fibrosis-related indicators. Changes in gut microbiota were analyzed through 16S rRNA gene sequencing. Our findings indicate that hesperidin significantly mitigates cardiac fibrosis in mice. These beneficial effects are associated with improvements in the dysbiosis of intestinal microbiota observed in fibrotic mouse models. The involvement of gut microbiota in cardiac fibrosis was further corroborated by administering hesperidin therapy to mice depleted of gut microbiota. This study provides the first evidence that the modulation of gut microbiota by hesperidin contributes to improved outcomes in cardiac fibrosis. The use of traditional Chinese medicine to modulate gut microbiota presents a promising strategy for the treatment of cardiac fibrosis.
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PubMed
高影响因子
TRIBOLOGY INTERNATIONAL
·
2025
·
IF 6.9
Renjie Ji,Xiaorui Li,Yonghong Liu,Hui Jin,Lixin Wang,Hao Sun,Shuo Liu,Xinlei Wu,Chao Zheng,Runsheng Li,Xiaopeng Li
A superamphiphobic microporous array surface was prepared for the first time by adding diamagnetic MoS₂ particles in the process of magnetic field-assisted jet electrodeposition in this paper. The diamagnetic MoS₂ particles were added to the electrodeposition solution. Then, the edges of MoS₂ provided preferential nucleation and deposition sites, and thus they were codeposited on the substrate surface with Ni²⁺ and Fe²⁺. With a magnetic field, the magnetization effect made the microstructures with the same magnetic pole repel each other and they were connected by the MoS₂ to form micropores. Finally, the superamphiphobic effect was achieved through low surface energy modification. Experiments showed that when the concentration of MoS₂ was 6 g/L and the magnetic field intensity was 50 mT, a Ni-Fe-MoS₂ surface with a longitudinal “olive-shaped” microporous structure could be prepared on the substrate. The contact angles of the deposition layer surface to water and oil were 160.87° and 153.92°. In addition, the surface of the deposition layer had good friction performance. The wear debris generated after friction and wear filled the gaps in the hole structure, which leveled the surface of the deposition layer. Moreover, the wear debris produced rolling friction during friction and wear, reducing the dry friction coefficient of the deposition layer surface to as low as 0.153, and the weight-loss rate after friction and wear was only 0.05 %. This paper provided a method for forming a superamphiphobic microstructure on the surface of the deposition layer under the coupling effect of diamagnetic MoS₂ and a magnetic field, which was of great significance for the efficient and rapid preparation of superamphiphobic surfaces with a low friction coefficient.
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高影响因子
LANGMUIR
·
2025
·
IF 3.9
Xianmin Gong,Shijun Xu,Yiling He,Kaijun Wei,Quangang Chen,Qing Yuan,Yi He,Yi Fan,Xingtao Cheng
Metal-based composite coatings have been widely studied for their excellent properties. In order to improve the properties of nickel tungsten boron (Ni–W–B) matrix, Ni–W–B/PC coatings were prepared by electrodeposition in the presence of polydopamine functionalized VC (P–VC) and cerium oxide (CeO2) nanoparticles. The effect of cerium oxide content in the nanomaterials on the properties of Ni–W–B coatings was investigated. The results showed that the prepared coatings were dense, uniform, and crack-free, and the best performance was achieved at a cerium oxide content of 2 g/L. The addition of CeO2 nanoparticles can fill the tiny defects in the coating and optimize the coating structure. The addition of these two materials refines the size of the coating grains. In terms of coating performance, the corrosion resistance of the composite coating was enhanced with the addition of CeO2 at a certain P–VC concentration, and the total impedance of the composite coating was 24,030 Ω·cm2, which was 4.8 times higher than that of the Ni–W–B coating and 1.7 times higher than that of the Ni–W–B/P–VC coating. In addition, the hardness of the Ni–W–B/PC-2 composite coating reached 1033.93 HV at a CeO2 content of 2 g/L. The wear resistance of this composite coating was also optimized. Compared with the Ni–W–B/P–VC composite coating, the average coefficient of friction was reduced by 8.8%, and the wear resistance of the composite coating was further improved, which was attributed to the synergistic effect of the two materials. Moreover, the Ni–W–B/PC film has excellent hardness and corrosion resistance, which is promising for the application in harsh environments.
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PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Detao Li,Wenqian Chen,Limin Zhou,Li Xu,Feiqiang He,Jerry Y Y Heng,Hamza Shehzad,Jinbo Ouyang
Understanding drug cocrystal formation and its competitive mechanism is important for improving the physicochemical properties of drugs. In this article, the cocrystal formation of polyhydroxy natural products and their competitive mechanisms are discussed through experimental screening and theoretical calculations. The formation conditions and types of cocrystals were determined based on efficient screening experiments of polyhydroxy natural product cocrystals. To investigate the difficulty and stability of cocrystal formation, competitive cocrystal experiments of polyhydroxy natural products were carried out simultaneously. By simulation of the electrostatic potential surface of molecules and the Hirshfeld surface of crystals, the mode of hydrogen bonding within the crystals was determined. The strength of hydrogen bonding was assessed based on the intermolecular interactions and energy framework within the crystal structure. A “substitution model” was constructed based on experimental results and theoretical calculations, which is of great significance for the prediction and design of natural product cocrystals and provides a feasible solution for improving the physicochemical properties of drugs.
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高影响因子
危险品化学品经营许可证（带存储）