FLUID PHASE EQUILIBRIA
·
2020
·
IF 2.838
Jinbei Yang,Shucui Han,Qiuju Xu,Meiqiong Yu
The density and viscosity of pure liquid 2, 4-dichlorofluorobenzene and 2, 6-dichlorofluorobenzene were measured in the temperature range of (318.15–348.15) K at the local atmospheric pressure of 99.8 kPa. The saturated vapor pressures of pure 2, 4-dichlorofluorobenzene and 2, 6-dichlorofluorobenzene and the isobaric vapor-liquid equilibria (VLE) data for the 2, 4-dichlorofluorobenzene + 2, 6-dichlorofluorobenzene binary system at atmospheric pressure were determined experimentally by a modified Rose still. The density values were accurately described by DIPPR equation. The viscosity data were well correlated using the Litovitz, Ghatee and VFT, and Andrade equations, and the VFT equation shows the best accuracy. Both Antoine and Riedel equations can well describe the relationship between saturated vapor pressure and temperature, which meet the requirements of engineering design. The Riedel equation is more accurate due to the lower average relative deviation. The VLE data were successfully correlated with NRTL and Wilson activity coefficient models, and the interaction parameters were obtained. The result indicates that there is no azeotrope in the binary mixture. The above thermodynamic properties of pure component and the VLE data presented are crucial for the design and operation of distillation for the isomeric mixture separation of 2, 4-dichlorofluorobenzene + 2, 6-dichlorofluorobenzene.
研究领域:
化学工程
·
热力学
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产品关联
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2024
·
IF 6.9
Linquan Dai,Bo Feng,Mengyan Tang,Yuangan Chen
It is challenging to separate between molybdenite and chalcopyrite due to their comparable hydrophobic characteristics. Inorganic depressants were previously used to separate two minerals, but the results were unsatisfactory and polluted the environment. In this study, the molybdenite and chalcopyrite were separated using a highly effective and ecologically safe depressant, 2,4-Diamino-6-hydroxypyrimidine (DAHP). According to the single mineral experiment, chalcopyrite is totally depressed while molybdenite has superior floatability. The efficacy of DAHP as the depressant was validated by further artificially mixed mineral flotation experiments, indicating the possibility of separating chalcopyrite and molybdenite. The adsorption capacity experiment results showed that the adsorption capacity of DAHP on the surface of chalcopyrite was greater than that on the surface of molybdenite. Zeta potential experiment results show that DAHP is adsorbed on the surface of chalcopyrite and molybdenite through static electrostatic interactions . X-ray photoelectron spectroscopy (XPS) experiment results show that DAHP is mainly adsorbed on chalcopyrite surface through –NH 3 + group, which hinders the adsorption of kerosene. The electrostatic contact between DAHP and molybdenite has the least effect on kerosene adsorption. This study shows that DAHP has the potential to separate chalcopyrite and molybdenite as an efficient and environmentally friendly depressant.
研究领域:
矿物加工工程
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环境科学
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Shuling Liu,Ruirui Teng,Xiangyang Wei,Yupei Li,Zixiang Zhou,Xiaoqiang Shi,Jiebing Li,Jianbo Tong
Manganese dioxide nanorods (Na0.4MnO2) with a typical 2 × 4 tunnel structure are successfully synthesized by the simple hydrothermal method in the presence of 5 M NaCl. The nanorods are about 30 nm in diameter. ZIBs (zinc-ion batteries) with Na0.4MnO2 display a specific capacity of 274.6 mA h g−1 at 0.2 A g−1 and have a high reversible capacity of 182.6 mA h g−1 after 1400 charge–discharge cycles at 1 A g−1 with a capacity retention of 96.5%. The unique morphology endows abundant electrochemical active sites and facile ion diffusion kinetics, which contributes to high specific capacity and stability. Both Zn2+ and H+ are inserted/extracted during the discharging/charging processes, and the crystalline structure and morphology of the nanorods do not change after repetitive cycling. The Na0.4MnO2 with the 2 × 4 tunnel structure is a promising candidate as the electrode material for ZIBs.
研究领域:
材料科学
·
能源存储与转换
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DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2026
·
IF 9.6
Yuejia Wu,Li Li,Lina Su,Ling Huang
The elemental doping strategy was widely adopted to improve the ion transport of lanthanum silicate apatites (La 9.33 Si 6 O 26 , LSO), a very promising electrolyte for solid oxide fuel cells (SOFCs). Specifically, La 9.33 Si 5.5 (Ga 1/2 V 1/2 ) 0.5 O 26 , i.e., LSGV 0.5 is obtained through (Ga 1/2 V 1/2 ) 4+ doping, which leads to not only a 4-fold oxygen ion conductivity (15.8 mS/cm at 800 °C) improvement, but also a 150 °C reduced sintering temperature compared with that of LSO. The as-such fabricated SOFC achieves a peak power density of 0.357 W/cm 2 at 800 °C using LSGV 0.5 as the electrolyte, demonstrating the effective complex ion doping towards enhanced performance for apatite-based electrolytes.
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产品关联
DOI
高影响因子
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
·
2025
·
IF 1.3
Ning Li,Xing-Long Dai,Gui-Xin Xiong,Wan-Li Meng,Jie Hao,Jie-Jie Hao
N-(4-Guanidinobutyl)-2-(4-hydroxyphenyl)-2-oxoacetamide (C1), a marine-derived leonurine analogue, was synthesized via a six-step route with 38% total yield. Biological evaluation demonstrated potent anticoagulant activity through significant prolongation of APTT (20 mM) and PT (5 mM). C1 dose-dependently (100–200 μM) suppressed LPS-induced NO production in RAW 264.7 macrophages without cytotoxicity and modulated phagocytosis. In LPS-induced acute lung injury rats, C1 reduced proinflammatory cytokines in BALF. These findings highlight C1’s dual anticoagulant and anti-inflammatory properties as a promising lead compound.
研究领域:
药物化学
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海洋药理学
·
炎症研究
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心血管药理学
·
药物发现
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2017
·
IF 2.726
Hui Ding,Wenjing Ke,Dan Zhao,Lulu Wang,Yujie Gao,Shejiang Liu
In this work, we measured the isobaric vapor-liquid equilibrium (VLE) data for the binary system of methyl caprate (1) + methyl laurate (2) at 2,4 and 6 kPa with a modified Othmer still. The point consistency test of Van Ness test method was applied to check the thermodynamic consistency of all the experimental values, which guaranteed the reliability of our measurements. Afterwards, the experimental data were regressed by two activity coefficient models (Wilson, NRTL). Furthermore, we made the data prediction with the group contribution method (UNIFAC) and the COSMO-SAC model. The results of all the regressions and predictions are satisfying and reasonable, while the results provided by the NRTL model are relatively better than the other three models, with the root mean square deviations of temperature and vapor-phase mole fraction less than 0.33 K and 0.0069, respectively.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Yating Jia,Fan Hu,Yuancai Lv,Yuancai Chen,Yongyou Hu
Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and challenges for water treatment due to their persistence and toxicity. In this study, the reduction of 2′2′4′4′-tetrabromodiphenyl ether (BDE-47) was investigated in a nano-bio-integrated system. Results showed that the introducing of P. putida could markedly accelerate the demineralization of BDE-47 in nZVI/Pd- P.p system; the continuous generation of acidic metaboliates by P. putida could decrease pH, which could alleviate the surface passivation to some extent, resulting in the releasing of Fe 2+ and high generation of H 2 O 2 , the shift in reactive oxygen species from Fe(IV) to •OH. The BDE-47 was firstly debrominated to the DE by the highly reductive [Pd·2H] generated by nZVI/Pd, then oxidized to bromophenol and phenol, catechol as well as hydroquinone via the P. putida strain and the Fenton-like system. The toxicity assays confirmed the combined system could avert generation of nocuous intermediates, and could be an alternative strategy for complete remediation of recalcitrant POPs.
研究领域:
环境科学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2023
·
IF 12.8
Wei-Ran Han,Wen-Long Wang,Tie-Jun Qiao,Wei Wang,Hang Su,Chen-Xin Xu,Qian-Yuan Wu
Micro-bubble aeration is an efficient way to promote ozonation performance, but the technology is challenged by extensive energy cost. Here, a ceramic ultrafiltration membrane was used to achieve ozone micro-bubble (0–80 µm) aeration in a simple way at gaseous pressures of 0.14–0.19 MPa. Compared with milli-bubble aeration, micro-bubble aeration increased the equilibrium aquatic O 3 concentrations by 1.53–3.25 times and apparent O 3 transfer rates by 3.12–3.35 times at pH 5.0–8.0. Consequently, the • OH yield was 2.67–3.54 times via faster O 3 transfer to the aquatic solution followed by decomposition rather than interfacial reaction. Ozone micro-bubble aeration outperformed milli-bubble aeration, with the degradation kinetics of 2,4-D being 3.08–4.36 times higher. Both O 3 -oxidation and • OH oxidation were important to the promotion with the contributions being 35.8%-45.9% and 54.1%-64.2%, respectively. The operational and water matric conditions influenced the oxidation performance via both O 3 oxidation and • OH oxidation, which is reported for the first time. In general, the ceramic membrane offered a low-energy approach of ozone micro-bubble aeration for efficient pollutant degradation. The O 3 oxidation and • OH oxidation were proportionally promoted by ozone micro-bubble due to O 3 transfer enhancement. Thus, the promotive mechanism can be interpreted as the synchronous enchantment on ozone exposure and • OH exposure for the first time.
研究领域:
环境科学
·
水处理技术
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 15
·4996
·
IF 4.927
Guang-Xi Yu,Ying Hu,Wei-Xin Zhang,Xin-Yi Tian,Sai-Yang Zhang,Yan Zhang,Shuo Yuan,Jian Song
[1,2,4]Triazolo[1,5-a]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization strategy. The antiproliferative activities of the target compoundsH1–H18against three human cancer cell lines, MGC-803, HCT-116 and MCF-7, were tested. Among them, compoundH12exhibited the most active antiproliferative activities against MGC-803, HCT-116 and MCF-7 cells, with IC50values of 9.47, 9.58 and 13.1 μM, respectively, which were more potent than that of the positive drug5-Fu. In addition, compoundH12could dose-dependently inhibit the growth and colony formation of MGC-803 cells. CompoundH12exhibited significant inhibitory effects on the ERK signaling pathway, resulting in the decreased phosphorylation levels of ERK1/2, c-Raf, MEK1/2 and AKT. Furthermore, compound12induced cell apoptosis and G2/M phase arrest, and regulated cell cycle-related and apoptosis-related proteins in MGC-803 cells. Taken together, we report here that [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives, used as anticancer agents via the suppression of ERK signaling pathway and the most active compound,H12, might be a valuable hit compound for the development of anticancer agents.Keywords:[1,2,4]triazolo[1,5-a]pyrimidine;indole;antiproliferative activities;ERK signaling pathway
研究领域:
药物化学
·
肿瘤学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
EXPERIMENTAL DERMATOLOGY
·
2020
·Vol. 30
·期 2
·237-248
·
IF 3.368
Liu Tang,Xiaoqin Cao,Xiaolei Li,Hong Ding
Atopic dermatitis (AD) is a multifactorial chronic inflammatory skin disease characterized by skin barrier dysfunction, eczematous lesions, pruritus, and abnormal immune responses. In this study, we assessed the therapeutic effect of topical applied conjugated linoleic acid (CLA) on a murine AD model that was developed by repetitive applications of 2, 4-dinitrofluorobenzene (DNFB). 2% or 5% CLA could markedly ameliorate AD-like skin lesions, scratching behaviour and skin inflammation as evidenced by the reduced inflammatory blood cells, IgE and Th2-related cytokine levels, and the infiltration of mast cells and inflammatory cells to the dermal tissues. Moreover, topical application with CLA modulated skin barrier repair including maintaining a balanced skin pH and increasing skin hydration, partially mediated by upregulating skin barrier-related protein, filaggrin (FLG). In addition, topical CLA significantly dose-dependently inhibited pro-inflammatory cytokines including interleukin (IL)-6, IL-1β, tumour necrosis factor (TNF)-α and pro-inflammatory enzyme expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in inflamed mice skin. Its anti-inflammatory effect was associated with the inhibition of DNFB-stimulated IκBα and NF-κB p65 phosphorylation in mouse skin. Taken together, our results suggest that locally applied CLA exerts potentially protective effects against AD lesional skin at least in part, due to regulation of skin barrier function and inflammatory response.
研究领域:
皮肤病学
·
免疫学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Jiawei Liu,Xiaole Yu,Kaibiao Xi,Xueting Wang,Kailong Huang,Zichen Liu,Jingbo Wang,Junyan Wang,Lei Dai
Bi 4 Ti 3 O 12 -based high-temperature piezoceramics are promising for applications in harsh environments such as aerospace and oil exploration. However, their low piezoelectric coefficient ( d 33 ) and high leakage current at elevated temperatures limit their use. Herein, a B-site isovalent ion-pair co-doping strategy is proposed. Ferroelectric active Zn 2+ and higher-valent W 6+ are co-introduced in a nominal (Zn 1/2 W 1/2 ) 4+ ion-pair substitution scheme to isovalently replace the B-site Ti 4+ in the Bi 3.96 Ce 0.04 Ti 3 O 12 matrix, thereby enhancing d 33 and resistivity ( ρ ) while maintaining a high Curie temperature ( T C ). The optimal ceramic Bi 3.96 Ce 0.04 Ti 2.95 (Zn 1/2 W 1/2 ) 0.05 O 12 achieves a balanced performance profile: a respectable d 33 of 28.9 pC/N, a high T C of 654 °C, and an excellent resistivity of 8.5 × 10 6 Ω·cm at 500 °C. This balanced combination of properties is attributed to the synergistic effect of Zn 2+ and W 6+ , which promotes grain growth, enhances polarization, and reduces the concentration of mobile oxygen vacancies. This work offers a promising material for high-temperature piezoelectric applications.
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Yao Zhang,Leyu Zhan,Xiangyang Zhuang,Yunfeng Zhu,Neng Wan,Xinli Guo,Jian Chen,Zengmei Wang,Liquan Li
LiBH 4 possesses high ionic conductivity (σ) at a temperature over 373 K and wide window voltage over 5 V, but low σ value below 373 K. Li 2 NH owns excellent ionic conductivity at low temperature but performs in a narrow window voltage (only 0.7 V). xLiBH 4 -Li 2 NH composites (x = 1, 2, 4) were therefore synthesized to eliminate their respective drawbacks. By alternating current impedance spectra, we observed that xLiBH 4 -Li 2 NH (x = 1, 2, 4) composites offer σ of 10 −2 Scm −1 at a temperature over 373 K, and lift σ value by 100 times from that of LiBH 4 at a temperature below 373 K. According to the cyclic voltammetry (CV for 10 cycles) results, the window voltage of 3 V can be achieved for LiBH 4 -Li 2 NH (1:1). X-ray diffraction (XRD) and Fourier Transform infrared spectroscopy (FTIR) measurements on xLiBH 4 -Li 2 NH (x = 1, 2, 4) samples inform that original phases were well preserved after ball milling and temperature ramping. Their chemical stabilities were also demonstrated by differential scanning calorimetry (DSC) measurements. The enhanced lithium mobility at low temperature in LiBH 4 -Li 2 NH should be ascribed to the favorable boundaries between both phases according to the investigations by both in-situ nuclear magnetic resonance (NMR) and high-resolution transmission electron microscope (HRTEM). However, at a temperature above 373 K, the enhanced ionic mobility of LiBH 4 -Li 2 NH should be mainly contributed by HT-LiBH 4 phase.
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DOI
高影响因子
危险品化学品经营许可证（带存储）