ANALYST
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2025
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IF 3.3
Yuting Luo,Yiwei Sun,Haoxiang Wang,yuyang He,Ruoyu Wang,Mengqi Lu,Yingong Wang,Xinlong Yan,Dongpo Xu
An efficient Ce-MOF@Aptamer electrochemical aptamer sensing technology was established for the sensitive detection of chloramphenicol (CAP) in milk samples.Cerium-based metal-organic framework (Ce-MOF) was synthesized by using terephthalic acid as organic ligand and cerium nitrate as metal center. Subsequently, it was functionalized by EDC-NHS and covalently attached to the electrode, and then the functionalized aptamer was loaded to form a sensing platform. The octahedral Ce-MOF has a large surface area and can provide more binding sites for aptamers. The minimum detection limit of the sensor is 0.7 nM. In addition, the sensor can effectively detect CAP in milk samples with excellent selectivity, repeatability and stability.
研究领域:
材料科学
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电化学
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食品安全
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分析化学
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纳米技术
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DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
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IF 6
Qianqian Wang,Baoshan He,Yao Liu,Ligen Wu,Wenhong Zhao,Dongdong Xie,Wenjie Ren,Yiwei Xu
Antibiotic residues in food and the environment pose significant risks to public health and safety, necessitating the development of rapid, portable, and efficient detection methods. Ofloxacin (OFL), a widely used antibiotic, is of particular concern due to its potential for contamination in milk and surface water. Current detection methods often require expensive instrumentation and complex procedures, limiting their applicability for on-site testing. This work addresses the critical need for a cost-effective, portable approach to reliably detect OFL residues. We developed a novel personal glucose meter (PGM)-based aptasensor utilizing a porous spherical cerium-based metal-organic framework (Ce-MOF) as a loading platform for glucose oxidase (GOx) and oligonucleotide sequences (Ce-MOF-GOx-cDNA). The hybrid probe, formed by conjugating Ce-MOF-GOx-cDNA with aptamer-modified magnetic beads, enabled specific recognition of OFL through nucleobase pairing. The sensor exhibited a detection range of 50 pg/mL to 500 ng/mL with a detection limit of 40 pg/mL under optimal conditions. The process showed excellent selectivity, stability, and reproducibility. Real-sample testing in spiked milk and surface water demonstrated recovery rates of 99.5% – 108%, with relative standard deviations of less than 4.7%. This study presents a portable and efficient strategy for detecting OFL residues using a PGM-based aptasensor. The method combines simplicity, rapid detection, and high sensitivity, offering significant potential for on-site applications in food and environmental safety monitoring.
研究领域:
食品安全
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环境监测
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生物传感技术
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DOI
PubMed
高影响因子
Small
·
2023
·Vol. 20
·期 13
·2308743
·
IF 13.3
Hui Yang,Lu Jia,Qitao Zhang,Saisai Yuan,Teruhisa Ohno,Bin Xu
Long-term exposure to low concentration indoor VOCs of acetaldehyde (CH 3 CHO) is harmful to human health. Thus, a novel isogenous heterojunction CeO 2 /Ce-MOF photocatalyst is synthesized via a one-step hydrothermal method for the effective elimination of CH 3 CHO in this work. This CeO 2 /Ce-MOF photocatalyst performs well in CH 3 CHO removal and achieves an apparent quantum efficiency of 7.15% at 420 nm, which presents ≈6.7 and 3.4 times superior to those generated by CeO 2 and Ce-MOF, respectively. The enhanced efficiency is due to two main aspects including i) an effective photocarrier separation ability and the prolonged reaction lifetime of excitons play crucial roles and ii) the formation of an internal electric field (IEF) is sufficient to overcome the considerable exciton binding energy, and increases the exciton dissociation efficiency by up to 50.4%. Moreover, the reasonable pathways and mechanisms of CH 3 CHO degradation are determined by in situ DRIFTS analysis and simulated DFT calculations. Those results demonstrated that S-scheme heterojunction successfully increases the efficiency of harmful volatile organic compounds elimination, and it offers essential guidance for designing rare earth-based MOF photocatalysts.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2025
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IF 3
Feng Tianxu,Shan Wei,Zhang Yongzhou,Huang Haibo,Tang Hua
Solar photocatalytic degradation and adsorption using metalorganic frameworks (MOFs) offer safe and energy-efficient remediation for water contaminated with small organic pollutants, leveraging their semiconductor-like tunable band structures and inherent porosity. This study reports the de novo synthesis of a visible-light-responsive Ti@Ce MOF heterojunction composite for synergistic photocatalytic degradation and adsorption of recalcitrant organic contaminants. An in-situ growth strategy deposited NO.-functionalized UiO-66(Ce) onto NH 2 -modified MIL-125, forming an S-scheme heterojunction engineered for efficient visible-light-driven hydrogen peroxide (H 2 O 2 ) generation. This in-situ photogenerated H 2 O 2 acts as a potent oxidant, effectively degrading tetracycline. A significantly enhanced photocatalytic degradation rate constant ( k ) for tetracycline was observed, indicating boosted catalytic activity. Mechanistic analysis underscores the critical role of the S-scheme heterojunction in promoting charge carrier separation and enhancing H 2 O 2 production, thereby efficiently driving organic pollutant oxidative degradation. This work provides a novel strategic framework for designing multifunctional MOF composites, advancing high-performance, sustainable water purification technologies.
研究领域:
环境科学
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材料化学
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光催化
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水净化
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纳米材料
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DOI
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Fengtao Hu,Shunyan Ning,Zengzhiqiang Li,Hao Zhu,Toyohisa Fujita,Xiangbiao Yin,Lifeng Chen,Deqian Zeng,Mohammed F. Hamza,Yuezhou Wei,Xinpeng Wang
A MOF-on-MOF composite derivative material named ZIF-67@Ce-MOF-600 was designed and synthesized. The preparation of ZIF-67@Ce-MOF-600 was optimized from the aspects of the ratio of metal and ligand, heat-treatment temperature. It was demonstrated by XRD , FT-IR, SEM-EDS and TEM . The optimum conditions for the activation of PMS by ZIF-67@Ce-MOF-600 for the degradation of tetracycline (TC) were investigated by adjusting the catalyst dosage, TC, pH, peoxymonosulfate (PMS) concentration, and different kinds of water, co-existing anions and pollution. Under optimal conditions (20 mg catalysts and 50 mg PMS added) in 100 mL of tetracyclines (TC) solvent (20 mg TC/L), the removal rate could reach up to 99.2% and after five cycles was 70.5%. The EPR results indicated the presence of free radicals and non-free radical, among which free radicals intended to play a major role in the degradation process. Its possible degradation pathways and attack sites were analyzed by liquid-phase mass spectrometry and DFT analysis.
研究领域:
环境科学
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材料科学
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化学
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DOI
PubMed
高影响因子
RARE METALS
·
2026
·Vol. 45
·期 5
·e70256
·
IF 12.1
Qiang Miao,Sijun Huang,Zhexing Wang,Jiachen Lv,Huan Li,Ying Wang,Yi Guo,Li Xu
en This link goes to a English section zh This link goes to a Chinese section Selective molecular recognition is central to chemical sensing yet discriminating structurally similar molecules at complex interfaces remains challenging. Traditional strategies based on tuning size, charge, or binding-site chemistry often suffer from limited flexibility. Here, we employ dimensionality engineering of cerium-based metal-organic frameworks (Ce-MOFs), comparing 2D and 3D Ce-MOFs to modulate molecular interactions via spatial conformation matching. Phytic acid (PA), with its distinct 3D inositol hexaphosphate structure, exhibits dimension-dependent interfacial assembly behavior. In 2D Ce-MOF, PA acts as a “molecular bridge” inducing interlayer stacking (∼fivefold thickness increase) and leading to strong noncompetitive inhibition (IC 50 = 0.053 mM) of its hydrolase (phosphatase)-mimetic activity. Conversely, confinement within the large pores (14.42 Å) of 3D Ce-MOF allows partial pore penetration (PA cross section: 10.46 Å) resulting in weak competitive inhibition (IC 50 = 1.7 mM). Spectroscopy ( 31 P NMR, FTIR) and zeta potential testing confirmed analogous PA-Ce coordination modes in Ce-MOFs ruling out chemical disparity as the cause. Density functional theory (DFT) calculations further verified the interlayer bridging in 2D MOF and intrapore confinement in 3D MOF as distinct adsorption modes. This fundamental difference—interlayer stacking versus confined penetration driven by dimensionality engineering creates a unique “dimensional fingerprint” for PA. Leveraging this orthogonal response (noncompetitive vs. competitive inhibition), we demonstrate a sensing strategy for selective PA identification. This work establishes dimensionality engineering as a powerful paradigm for rational interface design and selective recognition based on analyte spatial architecture. 摘要 en This link goes to a English section zh This link goes to a Chinese section 选择性分子识别是化学传感的核心,但在复杂界面上实现对结构相似分子的精准区分仍具有挑战性。传统通过调整尺寸、电荷或结合位点化学性质的策略往往灵活性不足。本研究提出一种基于铈基金属有机框架(Ce-MOFs)的维度设计方法,通过构建二维与三维Ce-MOFs,并利用空间构型匹配调控其与植酸(PA)的相互作用。PA具有独特的三维肌醇六磷酸酯结构,因而呈现出显著的维度依赖界面组装行为: 在二维Ce-MOF中,PA作为“分子桥”诱导层间堆叠(厚度增加约5倍),从而对其水解酶活性产生强烈的非竞争性抑制; 而在具有大孔道(14.42 Å)的三维Ce-MOF中,PA(横截面约10.46 Å)可部分进入孔道,仅引起较弱的竞争性抑制。 31 P 核磁共振(NMR)、傅里叶变换红外光谱(FTIR)以及Zeta电位结果表明,两种Ce-MOFs中的PA-Ce配位方式相近,排除了配位化学差异导致响应分化的可能。密度泛函理论(DFT)计算进一步验证了两种截然不同的吸附模式: 二维MOF中的层间桥连与三维MOF中的孔内限域。这种由维度设计驱动的根本差异——层间堆叠与限域渗透,赋予PA独特的“维度指纹”。基于这种正交抑制响应(非竞争性 versus 竞争性),我们构建了用于PA选择性识别的传感策略。该研究确立了维度设计作为一种通用范式,可用于基于分析物空间结构的理性界面设计和选择性识别。
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
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IF 5.4
Jiaqi Dang,Min Zhen,Jinning Gu,Yuting Niu,Yunfei Zheng
The detection of biomolecules using MOF-based nanozymes is a widely adopted strategy due to their abundant active sites and inherent enzymatic properties. In this study, we have synthesized three types of cerium metal-organic frameworks (Ce-MOFs) with oxidase (OXD)-like activity using a facile one-pot solvothermal method, simply by adjusting the concentrations of the raw ingredients, for the monitoring of biomolecules. The synthesized Ce-MOFs exhibit strong stability, a higher specific surface area, and more active sites, attributed to their MOF structure. These Ce-MOFs, with their excellent OXD-like activity, demonstrate satisfactory analytical performance in the quantitative determination of glutathione (GSH), showing a linear relationship within the range of 4.7 to 32.5 μM and detection limits as low as 42.76 nM. Furthermore, this colorimetric biosensor was successfully applied to monitor the content of GSH in the gingival crevicular fluid of patients with periodontitis. This paper extends the application of Ce-MOFs in bioassays and provides new insights into the application of OXD-like nanozymes in bioassays.
研究领域:
纳米酶
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金属有机框架
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生物传感器
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酶活性
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生物分析
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牙周疾病
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分析化学
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DOI
高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2026
·
IF 2.6
Zhang Yanqiu,Zhao Hongwei,Tian Zhaowen,Ma Ruiyu,Tang Zheyan,Li Lixiang,Li Qingdong,Zhang Xueyuan,An Baigang
Both boron nitride (BN) and metal-organic framework (MOF) are ideal nanofillers to enlarge corrosion resistance of coating due to their two-dimensional layered or porous structure with special physical-chemical property. However, the agglomeration and weak interaction with epoxy resin (EP) blocks their effects on enhancing anticorrosion performance of EP coatings. In this work, BN was hydroxylated and subsequently coated with polydopamine (PDA), then onto which cerium metal-organic frameworks (Ce-MOFs) was in-situ grown to get BNOH@PDA-Ce-MOFs. This technology not only ensures good dispersibility of BN and Ce-MOF, but strengthens their interaction with EP through PDA modified layer. BN uniformly dispersed in EP can elongate the diffusion path of corrosive media to enhance the barrier properties of the coating. Meanwhile, Ce-MOF can form a dense passivation layer composed of hydroxide and oxides of cerium to further protect the metal from corrosion. Therefore, the electrochemical impedance spectroscopy (EIS) measured |Z| 0.01 Hz value of BNOH@PDA-Ce-MOFs/EP coating only relatively decreased after 56 days, remaining three orders of magnitude higher than that of pure EP coatings. Moreover, the accelerated salt spray test of 28 days, there are no obvious corrosion pits, confirming the excellent corrosion resistance of BNOH@PDA-Ce-MOFs/EP coating.
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Lulu Cui,Weijie Shi,Houshen Li,Xiuxian Zhao,Shiyun Ai,Xiangju Meng,Shuhong Sun,Zeyi Guo
For bimetallic nanozymes, the closeness between the two elements is closely related to their properties, but achieving tight contact between the two components still faces challenges. Herein, copper was introduced by the coordination effect between the organic ligand in Ce-MOF and Cu 2+ , then a series of Cu-CeO 2 nanozymes were obtained by thermal treatment. The content of copper can be easily controlled and the spindle-shaped structure assembled by multilayer flakes can be obtained. The total antioxidant capacity (TAC) detection program based on the excellent peroxidase (POD)-like activity of the as-prepared Cu-CeO 2 nanozyme showed a wide linear detection range and ideal detection limits for ascorbic acid (AA), glutathione (GSH), Trolox and cysteine (Cys). More importantly, this method can be applied in TAC detection of commercial samples. This work provided a method for the design of high performance bimetallic nanozymes and developed a sensor that can be applied to detect TAC in vitamin C tablets and beverages.
研究领域:
材料科学
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生物医学工程
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分析化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Wei-jia Li,Zhi-bo Zhang,Wan-jin Yan,Zhi Chen,Cong-ming Tang,Li Chang
Adsorption technology is essential for water remediation and resource recovery to reduce environmental pollution. Although Metal-organic frameworks (MOFs) exhibit outstanding adsorption capabilities, their high preparation cost hinders their wide application. Alternatively, chitosan (CS) hydrogels offer wastewater treatment at an affordable cost. Herein, polyethyleneimine-modified CS hydrogel coated with MOF (Ce-BTC/CS-PEI) was prepared as a high-capacity sorbent for methyl orange (MO) sequestration. A comprehensive characterization of the Ce-BTC/CS-PEI composite was carried out, involving morphological and elemental analysis (SEM-EDS), crystal phase identification (XRD), surface area and porosity measurements (BET), surface charge evaluation (zeta potential), molecular structure determination (FTIR), and surface chemical state analysis (XPS). The increased interfacial contact area and the positively charged zeta potential of Ce-BTC/CS-PEI enabled efficient adsorption of MO in MO/methylene blue mixtures. The experimental data demonstrated strong agreement with the Langmuir equilibrium isotherm and second-order rate equations. Ce-BTC/CS-PEI demonstrated exceptional uptake performance, reaching 819.67 mg·g −1 after 18 h. Thermodynamic analysis showed that adsorption was a natural exothermic procedure. After four cycles, the material retained 70% of its adsorption efficiency. Therefore, Ce-BTC/CS-PEI exhibits excellent capability as an excellent, ecologically friendly, and inexpensive adsorbent for selective MO removal.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Yan Ge,Caiyi Fan,Qiyue Zhang,Hui Yang,Saisai Yuan,Bin Xu
In situ synthesis of S-scheme COF/Ce-MOF heterojunctions significantly enhances photocatalytic H 2 O 2 production under ambient conditions. The directional charge separation, precise band alignment, and synergistic dual active sites of the heterojunction enable efficient, stable, and selective H 2 O 2 generation. The CRM (Ce-MOF/COF) heterojunction delivers an H 2 O 2 yield that is 11.2-fold higher than pristine Ce-MOF and 3.1-fold higher than pure COF. Moreover, the CRM heterojunction maintains excellent productivity over a 6-h reaction period. In situ X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) analyses revealed not only the elemental composition and chemical states at the heterojunction interface but also the interfacial electronic redistribution and band alignment responsible for the enhanced photocatalytic performance. Specifically, the combined experimental and theoretical results confirmed the presence of strong interfacial coupling, the formation of an internal electric field, and the establishment of an S-scheme charge transfer pathway, all of which contribute to efficient charge separation and the preservation of high redox potentials, thereby enabling superior H 2 O 2 generation activity. Overall, this work not only deepens the understanding of MOF-based photocatalysts but also provides valuable design principles for constructing next-generation heterojunction materials with superior efficiency in photocatalytic H 2 O 2 production for environmental remediation.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xiang Zou,Yicheng Liu,Pingli Dong,Haoyu Qiu,Rui Wen,Lanling Dai,Linzhu Yu,Fang Lan,Yao Wu
A multifunctional nanocomposite, composed of Ga-loaded Ce-MOF core and NO-responsive microgel shell, is designed to integrate effective drug loading, controlled drug release and multi-target synergy to therapy RA. • The Ga-loaded Ce-MOF core functions dually as a high-capacity drug carrier of natural compound and a nanozyme with superoxide dismutase/catalase-like activities for reactive oxygen species (ROS) elimination, effectively alleviating oxidative stress damage in RA and establishing initial synergistic effects with Ga intrinsic anti-inflammatory activity. • The NO-responsive microgel shell acted as pathological cue-triggered “gatekeeper”, enabling on-demand drug release specifically at inflammatory sites while concurrently scavenging excessive NO to synergetic treat RA. • The nanocomposite significantly inhibits pro-inflammatory cytokines, alleviates cartilage degradation and bone erosion by eliminating excessive RONS, promoting the repolarization of macrophages from M1 to M2 phenotypes, and regulating the MAPK and cGMP/PKG signaling pathways. • This “one-stone-three-birds” strategy that integrating natural drug therapy, stimuli-responsive drug release with synergistic RONS scavenging and immune homeostasis modulation, offers an innovative and efficient approach for treatment of RA and other inflammatory diseases. Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammatory injury and progressive destruction of joints. The elimination of excessive reactive oxygen and nitrogen species (RONS) and the restoration of immune homeostasis have emerged as promising therapeutic strategies for RA. Gastrodin (Ga), a bioactive natural constituent derived from Gastrodia elata, possesses inherent antioxidant and anti-inflammatory capacities, whereas its clinical translation and in vivo utility are substantially hampered by inferior environmental stability and uncontrollable drug release behavior. Herein, we fabricated a nitric oxide (NO)-responsive nanocomposite (NCMG) consisted of a Ce-based metal-organic framework (Ce-MOF) nanozyme loaded with Ga and encapsulated by a NO-responsive microgel shell for synergistic RA treatment. The Ce-MOF serves dual functions as a high-efficiency drug carrier and reactive oxygen species (ROS) scavenger, while the outer microgel shell enables precise on-demand Ga release and efficient NO depletion. In vitro experiments and in vivo validation based on adjuvant-induced arthritis (AIA) rat models demonstrated that NCMG markedly inhibits the secretion of pro-inflammatory cytokines, induces macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, and effectively alleviates joint inflammation and bone erosion. Transcriptomic profiling further showed that Ga treatment was associated with downregulation of Il1b and Tnf and alterations in MAPK related gene expression, suggesting the involvement of this pathway in its anti-arthritic activity. This work develops an integrated nanotherapeutic platform combining natural active compounds with multi-component synergistic effects, offering a feasible strategy for RA intervention.
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高影响因子
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