JOURNAL OF CHEMICAL RESEARCH
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2023
·
IF 1.4
Mei Wang,Shenghu Yan,Yue Zhang,Shunlin Gu
A new continuous flow synthetic method for preparing indole and its derivatives are successfully developed to overcome the disadvantages of traditional batch methods, such as low conversion rates, long reaction times, and amplification effects. The method represents a sustainable and efficient preparation of indole and its derivatives without the need for additional catalysts. By investigating the effects of the reaction temperature, the solvent, the equivalence ratio, and the residence time, high conversion rates and excellent yields were simultaneously achieved within 20 min under optimized conditions. For the template reaction, DMSO/H2O/AcOH = 2:1:1 is used as the solvent, the reaction temperature is 110 °C, and the ratio of phenylhydrazine hydrochloride to cyclopentanone is 1:1.05. Indole and a wide array of its derivatives are synthesized to verify the universality of the method, and most of the reactions exhibit satisfactory conversion rates and high yields are obtained. This new continuous flow method is more suitable for industrial scale-up relative to traditional batch methods.
研究领域:
有机化学
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化学工程
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2018
·Vol. 29
·期 21
·18868-18877
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IF 2.324
Zheng Haisong,Li Chenghui,Wei Aixiang,Liu Jun,Zhao Yu,Xiao Zhiming
In this paper, a two-step method is used to prepare a high-quality CH 3 NH 3 PbI 3 layer for carbon-based hole conductor-free perovskite solar cells (PSCs). In the first step, the solvent for the PbI 2 /DMF solution is changed to a mixed solvent of N,N -dimethylformamide (DMF) with dimethyl sulfoxide (DMSO) from pure DMF solvent. This process requires 3.5 h for PbI 2 films deposited from the PbI 2 /DMF solution to completely convert to perovskite in a methyl amine iodide (MAI)/iso-propyl alcohol (IPA) solution, and perovskite films have a rough surface with a few large crystals. This mixed solvent accelerates the conversion of PbI 2 to CH 3 NH 3 PbI 3 , resulting in smooth CH 3 NH 3 PbI 3 films without residual PbI 2 . Only 15 min are required for PbI 2 films to completely convert to perovskite when the volume ratio of DMSO to DMF is 1:4. As a result, the photovoltaic performance, especially on the fill factor (FF) of PSCs fabricated from DMF/DMSO solvent, improved mainly due to the better contact of perovskite/carbon interface and faster charge transport of the perovskite layer.
研究领域:
材料科学
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能源技术
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DOI
高影响因子
ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2024
·
IF 3.1
Shichun Weng,Juan Zhou,Yingtao Tian,Xigui Jiang,Rong Chen,Jinyao Hu,Zichao Guo,Liping Chen,Wanghua Chen
In this article, a mixture of sulfuric acid and 50% hydrogen peroxide solution was used to produce Caro’s acid, which serves as an oxidant frequently encountered in the fine chemical industry. The chemical compatibility between 50% H2O2/H2SO4 and organic solvents is an important safety issue. The compatibility of 50% H2O2/H2SO4 and several organic solvents, including ethanol, acetonitrile, ethyl acetate, DMF, dichloroethane, DMSO, ether, and toluene, was studied by reaction calorimetry and thermal analysis techniques. It was found that the first five solvents presented good compatibility with 50% H2O2/H2SO4. DSC tests indicated that these five solvents almost did not react with 50% H2O2/H2SO4 before the onset decomposition temperature of 50% H2O2/H2SO4 (∼93.3 °C). RADEX tests showed that the reactions of 50% H2O2/H2SO4 with these solvents released heats from 800 to 1100 J g–1, and the pressure effect was obvious for these mixtures. In contrast, the last three solvents, namely, DMSO, ether, and toluene, were incompatible with 50% H2O2/H2SO4, exhibiting a significant exothermic signal at lower temperatures. Most interestingly, the mixture of DMSO and 50% H2O2/H2SO4 presented a thermal runaway phenomenon below 40 °C. The causes of this thermal runaway incident were confirmed to be the oxidation of DMSO by Caro’s acid. Reaction calorimetry tests also indicated that the oxidation rate of DMSO was fast even at 40 °C, and the adiabatic temperature rise for the oxidation of DMSO was higher than 400 K.
研究领域:
化学工程
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安全科学
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2024
·
IF 3.3
Hui Xu,Zhi-Jiang Jiang,Yun Jia,Yuhang Su,Jian-Fei Bai,Zhanghua Gao,Jia Chen,Kun Gao
Aromatic sulfones are the prevailing scaffolds in pharmaceutical and material sciences. However, compared to their widespread application, the selective deuterium labeling of these structures is restricted due to their electron-deficient properties. This study presents two comprehensive strategies for the deuteration of aromatic sulfones. The base-promoted deuteration uses DMSO-d6 as the deuterium source, resulting in a rapid H/D exchange within 2 h. Meanwhile, a silver-catalyzed protocol offers a much milder option by using economical D2O to furnish the labeled sulfones.
研究领域:
药物化学
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材料科学
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有机合成
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DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2024
·
IF 5.6
Wenbin Zhang,Xiangsheng Han,Zhiqiang Qi,Hao Tan,Keyan Yang,Hongzhen Cai
Lignin-containing cellulose nanofibers (LCNFs) with promising sustainability and multiple functionalities are highly in demand while still limited by the high energy consumption and potential environment disruption in preparation. In this work, the super-base system (dimethyl sulfoxide/potassium hydroxide, DMSO/KOH) was firstly employed as pseudosolvent to swell melon vine powder by partially remove some non-cellulose components (such as extraction, lignin and ash) in plant cell wall, and facilitate the following production of LCNFs. Due to the strong nucleophilicity of DMSO/KOH, universal swollen effects toward corn husk , poplar, bagasse , rice husk, and cotton stalk were achieved, and the LCNFs from them were also successfully obtained (with yields of ∼78.75%, 55.60%, 51.33%, 46.13%, and 53.90%, respectively). Besides, this method resulted in high lignin content among LCNFs (∼19.54%), which endowed the resultant membranes with superior mechanical strength, thermal stability, and dye rejection performance (a rejection rate of ∼92.7%, and a flux of 15.16 L•m -2 •h -1 •bar -1 toward methyl violet at 250 ppm). Thus, this research paves a simple, efficient, and universal way to prepare LCNFs from various biomass.
研究领域:
材料科学
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环境科学
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生物质工程
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高影响因子
CARBON
·
2017
·
IF 6.337
Xiaoyan Pei,Dazhen Xiong,Jing Fan,Zhiyong Li,Huiyong Wang,Jianji Wang
In recent years, carbon nanodots (CDs) have attracted increasing attention in many applications because of their superior optical and chemical properties. To manipulate CDs properties for their smart applications, CDs with CO 2 switchable luminescence property have been designed and prepared in the present work. It is found that fluorescence of the polyamine-functionalized CDs can be switched “off” and “on” in DMSO-water mixture by alternatively bubbling and removal of CO 2 . 13 C NMR spectra suggest that the mechanism behind the fluorescence “on-off” results involves the reversible acid-base reaction of the functionalized CDs with CO 2 and the formation of hydrophilic polyammonium bicarbonates. Due to the poor solubility of polyammonium bicarbonates in DMSO-water mixture, the formation of the polyammonium bicarbonates precipitation, by CO 2 bubbling, decreases the concentration of the functionalized CDs in aqueous DMSO, leading to the switch off of the fluorescence. When CO 2 is removed by N 2 bubbling, the precipitation is returned to the DMSO-water mixture, and thereby the fluorescence is switched on again. Based on this novel CO 2 -switchable photoluminescence property, the functionalized CDs have been used for the quantitative detection of CO 2 and SO 2 in aqueous solution and in the air.
研究领域:
材料科学
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化学
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环境科学
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DOI
高影响因子
Arabian Journal of Chemistry
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2020
·
IF 4.762
Muhammad Sajid,Yuchen Bai,Dehua Liu,Xuebing Zhao
Fructose was converted to 5-hydroxymethylfurfural (HMF), an important biomass-derived platform chemical, under mild conditions (100–130 °C) with several organic acids including p -toluene sulfonic ( p TSA), oxalic, maleic, malonic and succinic acids as the catalysts. The process kinetics was compared considering fructose dehydration to HMF as the objective reaction and condensation of fructose and HMF to humin and rehydration of HMF as the main side reactions. DMSO was found to be the most effective solvent reaction medium to obtain high fructose conversion and HMF yield. Observed kinetic modeling illustrated that the rehydration and condensation of HMF in DMSO actually could be neglected, especially for the oxalic acid catalyzed system. The determined observed activation energy for fructose conversion to HMF and humin in DMSO medium was 33.75 and 24.94 kJ/mol for p TSA catalyzed system, and 96.51 and 78.39 kJ/mol for oxalic acid-catalyzed system, respectively. HMF yields of 90.2% and 84.1% were obtained for p TSA and oxalic acid catalyzed systems, respectively.
研究领域:
化学工程
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生物化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Qinrui Du,Xusheng Guo,Haoxiang Zhu,Youwei Cheng,Lijun Wang,Xi Li
As a crucial bio-based platform chemical, the production of 5-hydroxymethylfurfural (HMF) from the abundant substrate cellulose has garnered significant attention. However, tedious reaction steps are inevitable because of the complex tandem conversions of dissolution, hydrolysis, and dehydration. Furthermore, due to the ultralow solubility of cellulose, harsh reaction conditions are inevitable, which can exacerbate HMF degradation. To this end, we investigated the structural changes in microcrystalline cellulose (MCC) after its dissolution and regeneration in various dimethyl sulfoxide (DMSO)/deep eutectic solvents (DESs) to clarify the mechanisms underlying its dissolution. The results revealed that the highly crystalline cellulose I in MCC was converted into amorphous cellulose II after treatment with DMSO/tetraethylammonium chloride (TEAC), which led to the complete dissolution of MCC. Accordingly, a dissolution-catalysis coupling reaction strategy was proposed for converting MCC to HMF via a one-pot method in DMSO/TEAC, simultaneously reducing the number of steps necessary for the reaction and achieving mild reaction conditions. In addition, the pathway for the one-pot reaction was clarified by analyzing the intermediate yields. The combination of AlCl 3 as a catalyst and DMSO/TEAC resulted in a notable MCC conversion of 93.3 wt% and a high HMF yield of 53.1%. Remarkably, the reaction conditions employed in this study (130 °C, 1 h) were milder in terms of shorter reaction times and lower temperatures than those reported in most current literature. This was attributed to the complete dissolution of MCC resulting from decrystallization. Therefore, the proposed reaction strategy enabled the efficient production of HMF from cellulose.
研究领域:
化学工程
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绿色化学
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生物化工
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高影响因子
ChemCatChem
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2017
·Vol. 9
·期 13
·2565-2573
·
IF 4.803
Wei Su,Hussein A. Younus,Somboon Chaemchuen,Cheng Chen,Francis Verpoort
Graphical Tune up the backbone : The effects on water oxidation of tuning the donating ability of carbon donors by ligand substitutions in the backbones of N-heterocyclic carbenes (NHCs) in Ru–NC NHC O type complexes were investigated. In this work, the effects of substitutions in the backbone of imidazolylidene and axial ligands on the reactivity and stability of water-oxidation catalysts were investigated. Three pincer-type asymmetric imidazolium salts NC NHC O , NC NHC-4Br O , and NC NHC-B O (NHC: N-heterocyclic carbene), of which the donating ability of the corresponding imidazolylidene decreases in the same sequence, were prepared. Their application in metalation afforded the corresponding Ru complexes 1 a , 1 b , 2 , and 3 . It was found that the complexes incorporating the stronger donor displayed lower potential for each redox couple and longer lifetimes, but relatively low reaction rates. Under acidic conditions, water oxidation driven by cerium ammonium nitrate resulted in turnover numbers (TONs) of 2322, 1728, 1928, and 2208 for 1 a , 1 b , 2 , and 3 , respectively. Complex 2 exhibited a good match of reactivity and stability with a TON of 136 in a typical three-component photocatalysis. Importantly, NHCs could be another powerful tool for tuning the reactivity and stability of water-oxidation catalysts, in addition to substituted pyridines. Rational orchestration of modified NHCs and pyridines could eventually result in water-oxidation catalysts exhibiting appreciable effectiveness and considerable robustness.
研究领域:
化学
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催化化学
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配位化学
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DOI
高影响因子
eFood
·
2025
·Vol. 6
·期 6
·e70091
·
IF 5.7
Quanyong Wu,Caohuizi Xiao,Boya Ouyang,Jesus Simal-Gandara,Yaping Qi,Zi Chen
Tea polyphenols (TPs), potent antioxidants found in tea, offer cellular protection and health benefits. Dimethyl sulfoxide (DMSO), a widely used organic solvent in medicine, remains controversial due to its potential embryonic toxicity. This study explored the effects of TPs from oolong and black tea, DMSO exposure, and their combined treatment on embryonic development using a fruit fly model. TPs from oolong tea (rich in catechin and EGCG) and black tea (mainly catechin) promoted embryonic development, enhanced larval vitality, and improved oxidative stress resistance in adults. Catechin intervention mirrored the effects of TPs from oolong and black tea, while the effect of EGCG was sex-dependent. DMSO showed dose-dependent toxicity, with 1% concentrations disrupting organ development and preventing emergence. Notably, EGCG and oolong tea TPs supported normal organ formation. Furthermore, catechin and tea TPs alleviated 0.5% DMSO-induced damage, boosting larval vitality, adult locomotion, and body weight in males, while reducing oxidative stress.
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高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2014
·Vol. 52
·期 1
·284-295
·
IF 0.873
F. Zhang,H. Chang,W. Wei
A facile and efficient KOH-oriented regioselective ring-opening reaction for the acetolysis of N -tosylaziridines in DMSO was developed under mild conditions. This operationally simple protocol could tolerate a variety of functionalized carboxylic acids as well as several N -tosylaziridines. Moreover, this strategy provided the corresponding ring-opening products with good results.
研究领域:
有机化学
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合成化学
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2022
·
IF 6.633
Shen Zhang,Caidi Jin,Kuichuan Sheng,Ximing Zhang
5-hydroxymethylfurfural (HMF) primary can be synthesized from monosaccharides including glucose and fructose, cost is one of barriers to realize HMF large-scale production. In this study, a high HMF yield of 69.6 mol% was obtained at 180℃ for 5 min using biomass derived cellulose formate as reactant, which was prepared by formylation of cellulose using recyclable formic acid, and sequentially catalyzed by hydrochloric acid (HCl) and aluminum chloride (AlCl 3 ) in dimethyl sulfoxide (DMSO) and H 2 O system. To investigate the effect of cosolvents and formyl groups on the cellulose formate conversion, kinetics analysis and molecular dynamics simulations were conducted. Reaction kinetics study shows that the rate constant of hydrolysis of cellulose formate to glucose increased by almost three times in DMSO-H 2 O and the reaction rates’ constants of glucose, fructose and HMF to humins decreased with the presence of DMSO. Molecular dynamics simulations show that formyl group and DMSO increased its hydrophilicity around the reactive hydroxyl group on the carbon ring and steric hindrance of formyl group affect the distribution of water molecular and DMSO molecular around formylated glucose, resulting in facilitating the formation of a precursor to fructose and inhibiting the formation of humins during formylated glucose conversion.
研究领域:
化学工程
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生物化学
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产品关联
DOI
高影响因子
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