BIOMATERIALS
·
2018
·
IF 8.806
Feng Ren,Lihua Ding,Hanghang Liu,Qian Huang,Hao Zhang,Lijuan Zhang,Jianfeng Zeng,Qiao Sun,Zhen Li,Mingyuan Gao
In-vivo intravital short wavelength infrared (SWIR, 1000–2300 nm) fluorescence imaging has attracted considerable attention in the imaging of tumor vasculature due to its low background, high sensitivity, and deep penetration. It can noninvasively provide dynamic feedback on the tumorigenesis, growth, necrosis and metastasis. Herein, monodisperse Nd 3+ -doped core-shell downconversion luminescent nanocrystals with strong emission in the second near-infrared (NIR II) window, strong temperature-dependent paramagnetism and fast attenuation to X-rays were prepared from ultra-small nanoclusters . The use of nanoclusters resulted in very uniform bright nanocrystals with a relative quantum yield comparable to the standard dye IR-26. These bright NIR nanocrystals were modified with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)-2000] to endow with excellent water-solubility, biocompatibility and a blood circulation half-life of 5.9 h. They were then successfully used to demonstrate the variation of tumor vasculature with tumor progression from tumorigenesis, growth, to necrosis in the subcutaneous breast tumor through the NIR II fluorescence imaging. They were also used as contrast agent of magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging of tumor to provide complementary anatomic structure. Their great potential in NIR II imaging of tumor was further demonstrated with an orthotopic breast tumor. Their in-vivo biosafety was also investigated by hemanalysis and histological analyses.
研究领域:
生物医学工程
·
纳米医学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Xinlong Shang,Yang Li,Liang Chen,Quan Zhang,Leidang Zhou,Naizhe Zhao,Fangbao Wang,Jinlu Ruan,Shiyi He,Yapeng Zhang,Xue Du,Silong Zhang,Zhongfu An,Xiaoping Ouyang
Fast-response scintillators play a crucial role in rapid radiation detection, wherein two-dimensional (2D) perovskites have exhibited substantial potential. Enhancing the carrier confinement within 2D perovskites has been demonstrated to be effective in accelerating their luminescence decay. Despite extensive research employing carrier confinement in the interlayer direction, confinement from the inorganic layers remains relatively unexplored. In this study, intralayer carrier confinement in 2D perovskites is achieved through neodymium (Nd) doping. Centimeter-scale phenethylammonium lead bromide (PEA 2 PbBr 4 , PPB) single crystals doped with Nd 3+ are fabricated via a solution-based method. Compared to the undoped counterparts, their photoluminescence (PL) decay is markedly accelerated. Notably, the reduction in decay time is more pronounced for α rays than for γ rays , enabling the doped PPB to exhibit distinct luminescent decay characteristics for α and γ rays . This property is verified through the waveforms of single α particles and γ photons, highlighting the potential for enhanced pulse shape discrimination (PSD) between different radiation types. First-principles calculations reveal that Nd 3+ doped PPB exhibits a higher effective mass and enhanced carrier localization, signifying stronger carrier confinement. This study elucidates the impact of Nd 3+ doping on reducing the luminescent lifetime of 2D perovskite single crystals, and offers an approach to differentially regulating their scintillating decay response for high-energy particle discrimination.
研究领域:
材料科学
·
光电子学
·
辐射探测
·
钙钛矿物理
·
固态化学
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 26
·14180-14187
·
IF 6.895
Luyan Wu,Jie Hu,Qilin Zou,Yaling Lin,Decai Huang,Dejian Chen,Hongyu Lu,Haomiao Zhu
Persistent luminescence nanophosphors (PLNPs) emitting in the second near-infrared window (1000–1700 nm, NIR-II) are emerging as one promising class of in vivo bio-imaging agents due to their unique advantages including non-autofluorescence and low optical scattering in tissues. Currently, it remains a great challenge to synthesize nanosized lanthanide-doped inorganic NIR-II phosphors with a good persistent luminescence performance. Herein, we present a salt microemulsion method for synthesizing Ce3+, Cr3+, Nd3+ codoped Y3(Al/Ga)5O12 nanocrystals, which generate multi-wavelength persistent luminescence in the visible (∼508 nm, 5d1 → 4f of Ce3+), the first near-infrared window (∼890 nm, 4F3/2 → 4I9/2 of Nd3+) and NIR-II (∼1063 nm, 4F3/2 → 4I11/2 of Nd3+) regions. Under illumination of a 410 nm diode (3 W) for 10 min, the observed duration time of NIR-II persistent luminescence is as long as 60 min at room temperature. Moreover, the persistent luminescence can be excited efficiently by multiple excitation sources including a blue diode, white LEDs and an X-ray generator, which is crucial for deep tissue imaging applications. By comparing the penetration depth between NIR-I and NIR-II persistent luminescence through chicken breast, we prove that NIR-II photons exhibit a deeper optical penetration length (3.9 mm) than that of the NIR-I ones (2.5 mm). In addition, the NIR signals can still be detected 3 min after ceasing the excitation source by a small animal imaging system (InGaAs detector) when the thickness of the covering chicken breast is 20 mm. These results show great promise for Y3(Al/Ga)5O12:Ce3+,Cr3+,Nd3+ nanocrystals as a PLNP for bio-imaging applications with deep penetration depth and a high signal-to-noise ratio.
研究领域:
材料科学
·
生物医学工程
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2016
·
IF 1.879
Rong Chen,Ying Tian,Bingpeng Li,Feifei Huang,Caizhi Wang,Xufeng Jing,Junjie Zhang,Shiqing Xu
Nd 3+ /Ho 3+ co-doped silicate-germanate glass has been synthesized by high temperature melt-quenching method. Near infrared emission centered at 2 µm has been successfully obtained by incorporating Nd 3+ and Ho 3+ in present glass. The Judd-Ofelt intensity parameters Ω t (t=2, 4, 6), and radiative properties of Ho 3+ were calculated and discussed by using the Judd-Ofelt theory. The energy transfer processes and luminescence properties of Nd 3+ /Ho 3+ co-doped glasses were analyzed pumped by a conventional 808 nm laser diode . Desirable spectroscopic characteristics indicates that Nd 3+ /Ho 3+ co-doped silicate-germanate glass might be a good alternative matrix for 2 µm band mid-infrared laser.
研究领域:
光学材料
·
无机非金属材料
·
光子学
·
激光技术
·
固体物理
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 102
·期 10
·5899-5909
·
IF 3.094
Puxian Xiong,Mingying Peng,Jiangkun Cao,Xueliang Li
Mechanoluminescence (ML) is a phenomenon upon external mechanical stimuli and it has found diverse applications such as stress sensing, structure health diagnosis, 3-D signature, energy harvesting etc because of its unique properties of in situ and real-time response to the stimuli. However, ML of most of the state-of-art phosphors primarily appears within the spectral range from ultraviolet to visible, which does not lie in the biological transparent windows, and, therefore, limits its applications in biological field. Here, we report a strong near infrared (NIR) ML from orthorhombic Cmcm perovskite Sr 3 Sn 2 O 7 : Nd 3+ , which is peaked at ~ 900 nm and located exactly within the first optical transparent window of tissues. The ML apparates after gradual discharge of the traps deeper than 0.73 eV triggered by the external mechanical stimuli and subsequently excitation of Nd 3+ to the state of 4 F 3/2 . The rechargable ML presents well repeatable linearity to loaded force at least up to 5000 N, and it can penetrate tissues easily that are thick up to 30 mm such as pigskin and the ceramic disk of hydroxy apatite which is the main constituent of bone. These results demonstrate the potential application for in situ biomechanical sensor. Meanwhile, by recording and processing these ML signals during signing on a pellet sample, for the first time, we provide a novel signature system based on NIR ML. This could raise the security level of existed signature anti-countering to a higher level.
研究领域:
材料科学
·
生物医学工程
·
光学
·
安全系统
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Xiangling Tian,Zhijun Ma,Jianrong Qiu,Rongfei Wei
Optical fibers have been formed by replacing precursor glass core with precursor ceramic core, in which drawing process, the precursor ceramic melted to fill the space of the core region while the clad glass was softened. Nd 3+ doped LaNbO 4 nanocrystals were precipitated in the core after heat treatment. X-ray diffraction, Raman spectra, high-resolution transmission electron microscopy, electron paramagnetic resonance, optical microscope, and photoluminescence were used to characterize the obtained fiber. No crystallization, cracking, bubble, or undissolved substance is observed in the core region of precursor fiber. Nd 3+ doped LaNbO 4 nanocrystals are precipitated in the core region after thermal treatment. Under the pumping source of 808 nm, three emission bands located at ∼887 nm, ∼1064 nm, and ∼1337 nm are observed, which makes this GC fiber a promising material for the NIR fiber amplifier.
研究领域:
材料科学
·
光学
·
光子学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Yuxiang Xin,Xiachu Xiao,Jianru Wang,Nadeem Abbas,Shuo Zhang,Yibo Han,Jiang Tang,Artiom Skripka,Zhuolei Zhang
The development of multifunctional luminescent materials with tunable upconversion (UC), downshifting (DS), and thermally responsive emissions in a single host is essential for next-generation photonic and optoelectronic technologies. Here, we report a Nd 3+ -based low-phonon-energy lead-free halide double perovskite, Cs 2 NaNdCl 6 , which overcomes key limitations of conventional halide double perovskites, including doping inflexibility, concentration quenching, and lack of integration of diverse optical functionalities. Leveraging the large unit cell and the dual role of Nd 3+ as both emitter and sensitizer, we achieve efficient high-concentration doping of Tm 3+ , Er 3+ , and Yb 3+ without compromising emission intensity. Tm 3+ doping induces energy back transfer to Nd 3+ , leading to an 8.2-fold enhancement in the orange emission of Nd 3+ ions. Co-doping with Er 3+ /Yb 3+ enables excitation-dependent, color-tunable UC (green, orange, red) under 980 nm excitation, stable green UC emission under 808 nm excitation, and red DS emission under 365 nm excitation, useful for advanced anti-counterfeiting applications. Furthermore, the synergistic incorporation of multiple lanthanides facilitates multi-level fluorescence intensity ratio (FIR) thermometry via thermally coupled levels (TCLs), non-thermally coupled levels (non-TCLs), and Stark-split transitions, achieving a record relative sensitivity (S r ) of 11.4% K −1 in the 80–340 K temperature range. These findings establish Cs 2 NaNdCl 6 as a versatile platform for multifunctional lattice-engineered photonics.
研究领域:
光子学
·
光电子材料
·
发光材料
·
光学传感
·
防伪技术
·
稀土掺杂
·
固态化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2025
·
IF 3.5
Y.T. Liu,Y. Ji,W.J. Zhu,Q. Qian,Q.Y. Zhang
0.9 μm fiber lasers enable efficient generation of blue laser via second-harmonic conversion, which are essential light sources for applications such as undersea communications, laser displays, and biophotonic imaging. Glass fibers doped with Nd 3+ ions serve as the gain medium for these lasers; however, the competition from the four-energy-level transition 4 F 3/2 → 4 I 11/2 remains a significant challenge. Fluorophosphate (FP) glass combines the high rare-earth solubility of phosphate glasses with the low phonon energy of fluoride, particularly benefiting from large crystal field strength that enhances the 4 F 3/2 → 4 I 9/2 transition. Nonetheless, crystallization and phase separation in FP glass pose substantial challenges for this multi-component glass system. Herein, a novel Nd 3+ -doped Sr(PO 3 ) 2 −Ba(PO 3 ) 2 −AlF 3 −MgF 2 glass is reported. A thermodynamic approach was employed to predict the glass-forming region of the Sr(PO 3 ) 2 −AlF 3 −MgF 2 system, providing a robust design framework for FP compositions with superior glass-forming ability. Further investigations into the gradual substitution of Ba(PO 3 ) 2 to Sr(PO 3 ) 2 elucidate the structure-property relationship between the local network environment and Nd 3+ emission at 0.9 µm. The optimized FP glass demonstrates remarkable stability against crystallization (Δ T >100 °C), a high branching ratio (47.2 %), a large emission cross-section (2.36 × 10 −20 cm 2 ), an extended lifetime (334 μs), a high spectral quality factor (7.88 × 10 −24 cm 2 ·s), and a broad gain bandwidth (10.71 × 10 −26 cm 3 ) at 0.9 μm, surpassing previously reported glass hosts and establishing it as a highly promising host material for 0.9 μm fiber laser applications.
研究领域:
光子学
·
材料科学
·
光学材料
·
激光技术
·
玻璃科学
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2023
·Vol. 34
·期 23
·235704
·
IF 3.5
Yanxing Wang,Wenjing Li,Yaqun Ma,Bo Hu,Xueli Chen,Ruichan Lv
In this research, a thermally activated upconversion luminescence (UCL) probe with ratiometric temperature sensing under 1064 nm and 808 nm excitation was designed. Especially, Nd3+, Tm3+ and Ce3+ were doped in rare earth nanoparticles (RENPs) as UCL modulators. By optimizing the elements and ratios, the excitation wavelength is successfully modulated to 1064 nm excitation with UCL intensity enhanced. Additionally, the prepared RENPs have a significant temperature response at 1064 nm excitation and can be used for thermochromic coatings. The intensity ratio of three-photon UCL (1064 nm excitation) to two-photon UCL (808 nm excitation) as an exponential function of temperature can be used as a ratiometric temperature detector. Therefore, this designed thermochromic coatings may enable new applications in optoelectronic device and industrial sensor.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xiuna Tian,Youfeng Wen,Hongjian Dou,Lingyuan Wu,Changjun Wang,Youzi Zhang
In the clinical diagnosis and treatment of diseases, there is an urgent need to find suitable materials for real-time temperature monitoring of biological tissues. The paper provides a detailed study of the effects of Nd 3+ doping concentration on the negative thermal expansion performance and NIR fluorescence properties of Sc 2 (MoO 4 ) 3 . The results obtained from Rietveld refinement of in-situ XRD data indicates that high concentration of Nd 3+ doping significantly influences the negative thermal expansion performance of the material, as well as alters the temperature-dependent changes in NIR fluorescence intensity and lifetime. In addition, a NIR fluorescence lifetime temperature probe doped with Nd 3+ /Yb 3+ /Er 3+ has been constructed. When the temperature increased from 303 K to 403 K, the fluorescence intensity of the probe at 1538 nm increased by a factor of 127.5. Furthermore, as the temperature rose from 323 K to 403 K, the fluorescence lifetime of the probe at 1538 nm extended from 41.93 μs to 204 μs. By utilizing the lifetime of Er 3+ for temperature sensing, a relative sensitivity of 6.03%K −1 was achieved at 323 K, indicating significant potential application value of this probe in the field of biological temperature measurement.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Hongyu Lu,Yang Lu,Difan Lin,Jiang Zhu,Yangyang Du,Hua Zou
Luminescent materials usually suffer from thermal quenching at high temperature due to the aggravation of nonradiation relaxations. Herein, a giant enhancement of up conversion (UC) luminescence is observed in negative thermal expansion (NTE) Y 2 W 3 O 12 :Nd phosphor upon increasing the temperature from 310 to 790 K. In addition, the temperature-dependent UC emission is reversible. To penetrate into the mechanisms, the temperature-dependent luminescence intensity and lifetime are investigated for Nd doped negative and positive thermal expansion (PTE) phosphors. Based these investigation, we infer that the underlying mechanism of the giant enhancement for Y 2 W 3 O 12 :Nd phosphor are due to combined effects of phonon assisted absorptions and contraction of NTE crystals. Moreover, the observation of temperature-dependent near-infrared spectra (NIR) can support the mechanism from the other side. The present findings pave the way to overcome thermal quenching of Nd 3+ ions and explore new thermal enhancement materials sensitized by Nd 3+ ions.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
·
2022
·Vol. 648
·期 16
·e202200090
·
IF 1.414
Cong Cao,Shiwen Li,Jinsong Wang,Yu Li,Guangshen Li
Nanothermometers that can reflect temperature in real-time are crucial for photothermal therapy. Near-infrared (NIR) fluorescent probes that conform to Boltzmann distribution will play an important role if they have the above characteristics. Here, the LiLuF 4 : Nd 3+ /Yb 3+ nanocrystals were designed and synthesized by control, exhibiting multiple bright near-infrared emission peaks at 925–1080 nm region at 280–360 K under the excitation of an 808 nm laser. The feasibility of being used as a nanothermometer was confirmed by testing the spectral variation with temperature and analysis.
研究领域:
材料科学
·
生物医学工程
·
光学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）