Acta Biomaterialia
·
2021
·
IF 8.947
Chuanchuan He,Xiaojuan Zhang,Chen Chen,Xiaoguang Liu,Yan Chen,Ruicong Yan,Ting Fan,Yongkang Gai,Robert J. Lee,Xiang Ma,Jun Luo,Yao Lu,Tan Yang,Guangya Xiang
The unfavorable factors in tumor microenvironment such as hypoxia and limited H 2 O 2 levels greatly impede the anticancer efficacy of chemotherapy and chemodynamic therapy (CDT). To address these issues and achieve O 2 /H 2 O 2 -sufficient chemo/chemodynamic combination therapy, we synthesized a solid lipid monostearin coated calcium peroxide (CaO 2 ) nanocarrier for the co-delivery of a chemotherapeutic drug doxorubicin (DOX) and a biocompatible Fenton catalyst iron-oleate complex. Specifically, the solid lipid shells of nanoparticles could disintegrate in lipase-overexpressed cancer cells to release iron-oleate and expose CaO 2 cores. Afterwards, the uncovered CaO 2 responded to the acidic aqueous environment within cancer cells, leading to the release of DOX molecules and generation of H 2 O 2 . Based on Fenton reactions, Fe 3+ liberated from iron-oleate reacted with H 2 O 2 to produce O 2 for hypoxia-relieved chemotherapy, and Fe 2+ for the catalytic generation of hydroxyl radical to initiate CDT. Both treatments synergistically contribute to the enhanced antitumor outcomes.
研究领域:
纳米技术
·
癌症治疗
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2022
·
IF 19.069
Liping Ren,Fanpeng Kong,Xufeng Wang,Yajie Song,Xudong Li,Fang Zhang,Nan Sun,Hanwen An,Zaixing Jiang,Jiajun Wang
The limited stability and the excessive dependence on external heating sources restrict the development of polymer-based solid-state Li-O 2 batteries . Herein, we propose a multifunctional composed cathode with the photo-electro-thermal synergy to achieve a PEO-based solid-state Li-O 2 (PSS Li-O 2 ) battery operating at room temperature. The multifunctional composed cathode consists of the traditional black TiO 2 photocatalyst and carbon cloth (b-TiO 2 /CC). The b-TiO 2 /CC harvests a full spectrum of sunlight, besides the photo-generated electrons and holes enhancing reaction kinetics during discharging and charging processes, though converting solar energy into heat to achieve self-heated replace on external. The photo-electro-thermal synergy-triggered PSS Li-O 2 battery establishes a low overpotential of 0.26 V and long durability of up to 90 cycles, which is a breakthrough for PEO-based Li-O 2 batteries operating at room temperature. A flexible PSS Li-O 2 battery is constructed and exhibits superior flexibility and mechanical stability . The mechanism of the photo-electro-thermal synergy provides a new strategy for PSS Li-O 2 batteries and advances the high-efficiency utilization of solar energy in portable devices.
研究领域:
材料科学
·
电化学
·
能量存储
·
太阳能利用
✓ 已验证
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Yujia Liang,Zhengmin Cai,Yamei Tang,Chenglin Su,Liye Xie,Yan Li,Xinqiang Liang
Introduction: Reactive oxygen species (ROS)-mediated therapies have typically been considered as noninvasive tumor treatments owing to their high selectivity and efficiency. However, the harsh tumor microenvironment severely impairs their efficiency. Methods: Herein, the biodegradable Cu-doped zeolitic imidazolate framework-8 (ZIF-8) was synthesized for loading photosensitizer Chlorin e6 (Ce6) and CaO 2 nanoparticles, followed by surface decoration by hyaluronic acid (HA), obtaining HA/CaO 2 -Ce6@Cu-ZIF nano platform. Results and Discussion: Once HA/CaO 2 -Ce6@Cu-ZIF targets tumor sites, the degradation of Ce6 and CaO 2 release from the HA/CaO 2 -Ce6@Cu-ZIF in response to the acid environment, while the Cu 2+ active sites on Cu-ZIF are exposed. The released CaO 2 decompose to generate hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 ), which alleviate the insufficiency of intracellular H 2 O 2 and hypoxia in tumor microenvironment (TME), effectively enhancing the production of hydroxyl radical (•OH) and singlet oxygen ( 1 O 2 ) in Cu 2+ -mediated chemodynamic therapy (CDT) and Ce6-induced photodynamic therapy (PDT), respectively. Importantly, Ca 2+ originating from CaO 2 could further enhance oxidative stress and result in mitochondrial dysfunction induced by Ca 2+ overloading. Conclusion: Thus, the H 2 O 2 /O 2 self-supplying and Ca 2+ overloading ZIF-based nanoplatform for cascade-amplified CDT/PDT synergistic strategy is promising for highly efficient anticancer therapy.
研究领域:
纳米技术
·
癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Chengwu Zhang,Anqi Yang,Bing Qin,Wei Zhao,Chuipeng Kong,Chuanyu Qin
It has been reported that tripolyphosphate (TPP) can effectively enhance the activation of O 2 by Fe(II) to remove organic pollutants in the environment. However, the influence of solution pH on the generation and conversion of reactive oxygen species (ROS) and their degradation of pollutants in the Fe(II)/O 2 /TPP system needs further investigation. In this study, we demonstrated that O 2 •– and •OH were the main ROS responsible for degradation in the system at different pH conditions, and their formation rates were calculated using a steady-state model. Experiments combined with density functional theory (DFT) calculations showed that the p -nitrophenol (PNP) degradation pathway in the Fe(II)/O 2 /TPP system is regulated by solution pH. Specifically, at pH = 3, the existence of Fe(II) in the solution is dominated by [Fe(II)(HTPP) 2 ] 2− , which leads to a rapid conversion from O 2 and HO 2 • to generate •OH, and PNP is primarily oxidatively degraded. However, at pH = 5/7, [Fe(II)(TPP) 2 ] 4− is taking the lead with which O 2 •– is accumulated in the solution due to the slow conversion to •OH in this condition, and the PNP is mainly reductively degraded. This study proposes a new strategy to achieve the targeted oxidative/reductive removal of different types of pollutants by simply varying the solution pH in the Fe(II)/O 2 /TPP system.
研究领域:
环境科学
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化学
·
污染控制
·
活性氧物种
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Zhanshuai Li,Jinsheng Li,Huanyu Zhao,Mengwen Zhang,Pengfei Li,Liang Dong,Lei Wu,Haipeng Ji,Xiwei Qi
A new high-entropy oxide, (Ge 0.2 Mn 0.2 Ti 0.2 Sn 0.2 Mo 0.2 )O 2 with rutile structure, was successfully synthesized using solid-state reaction method. The phase structure of the ceramic samples prepared forming a range of binary to quinary phase with increasing entropy were investigated, and the effects of atmosphere-induction and high-entropy synergistic behavior on the dielectric performance were studied. As the type of the cations increases, the temperature required to form a single rutile structure gradually decreases, while the dielectric properties of the ceramics gradually improved. The dielectric constant of the (Ge 0.2 Mn 0.2 Ti 0.2 Sn 0.2 Mo 0.2 )O 2 high-entropy oxide ceramics sintered in the nitrogen atmosphere at 1350°C is nearly 20 times higher of the ceramics sintered in the air. This significant enhancement can be attributed to the occurrence of two rutile structures and the generation of excessive oxygen vacancies as a result of high-entropy synergistic behavior under the nitrogen sintering atmosphere.
研究领域:
材料科学
·
陶瓷材料
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介电材料
·
高熵合金
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Yi Sun,Xin Peng,Yudong Guan,Tong Su,Zezun Xie,Ziying Wu,Yongxuan Long,Huihui Zhu,Jie Shao,Xiaoli Mai,Xuzhi Shi,Tingting Wu,Zhaogang Teng,Bing Zhang,Kun Chen,Xiaoyan Xin
Photodynamic Therapy (PDT) offers a promising minimally invasive treatment for breast cancer, but its efficacy is limited by the hostile tumor microenvironment (TME), including hypoxia and high glutathione (GSH) levels. Although various strategies to improve oxygen concentration or reduce reactive oxygen species (ROS) resistance for enhanced PDT have been explored, they typically require intricate design and complex synthesis of multifunctional nanocarriers. Thus, this study introduces a facile K 2 FeO 4 -induced strategy to enhance PDT efficiency in breast cancer through the tumor in situ synthesis of Fe 2 O 3 and O 2 . Inspired by the successful application of K 2 FeO 4 in ecological remediation and hemostasis, K 2 FeO 4 reacts with GSH, biological system, H 2 O 2 , and water, to generate Fe 2 O 3 and O 2 . Intratumoral injection of K 2 FeO 4 improves the TME, followed by Ce6 administration to enhance PDT through synergistic ferroptosis. This approach boosts PDT efficacy significantly by increasing ROS generation, lipid peroxidation, and inhibiting GSH and GPX4. Proteomic analysis revealed alterations in key pathways, including endocytosis and energy metabolism. This K 2 FeO 4 -PDT strategy creates a positive feedback loop by enhancing oxidative stress, providing an interesting and promising approach to PDT.
研究领域:
癌症研究
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Kudakwashe Meki,Zhuowen Wang,Baojian Jing,Shan Qiu,Fengxia Deng
In the face of challenges presented by rapid urbanization and industrialization, the surge in dye wastewater has emerged as a prominent concern. This study introduces a pioneering novel approach aimed at augmenting the electrocatalytic efficiency of O 2 reduction to H 2 O 2 through the modification of a hybrid catalyst with dimethyl sulfoxide (DMSO) to construct gas diffusion electrodes (GDEs). The hybrid catalyst, consisting of carbon black and DMSO, was meticulously fabricated, and its electrocatalytic activity was thoroughly investigated using various characterization techniques. Within 180 min, the 3 %DM cathode showcased efficient H 2 O 2 generation, reaching 850 μM, and remarkable oxygen utilization, achieving 60.49 %. Intriguingly, the fabricated 3 %DM hybrid catalyst maintained a three-phase interfacial (TPI) due to its super-hydrophilic property. This study elucidates the pivotal role of DMSO in enhancing the performance of hybrid catalysts for O 2 reduction to H 2 O 2 . The insights provide valuable perspectives into the development of efficient and resilient electrochemical systems for sustainable energy conversion and environmental applications.
研究领域:
环境科学
·
电化学
·
催化
·
废水处理
✓ 已验证
产品关联
DOI
高影响因子
Energy Storage Materials
·
2021
·
IF 17.789
Dongxiao Wang,Shuyin Xu,Jianlin Wang,Xiaohui Rong,Feiyu Zhou,Lifen Wang,Xuedong Bai,Bingan Lu,Chengjun Zhu,Yuesheng Wang,Yong-sheng Hu
Room-temperature Na-ion batteries have attracted great interest for over a decade owing to their natural abundance and similar intercalation chemistry with Li-ion. However, due to the uncontrolled decomposition of electrolyte and formation of solid electrolyte interphase, the large majority of sodium anode materials exhibit extremely low initial Coulombic efficiency and unsatisfactory cycling stability. Here we introduce a novel layered material, P2-Na 0.547 [M g 0.25 M n 0.75 ]O 2 , as an SEI-free negative electrode. This material, delivers a reversible capacity of 126 mAh g −1 with a high initial Coulombic efficiency of 108%, and capacity retention of ∼80% after 1000 cycles at 4C rate. Pairing with Na 3 V 2 (PO 4 ) 3 cathode, excellent rate performance of ∼60% capability at 15C, and extra-high initial Coulombic efficiency of 97% are achieved, all attributed to the SEI-free feature of Na 0.547 [M g 0.25 M n 0.75 ]O 2 . These results demonstrate the practical potential of our SEI-free anode material for high-power and long-life Na-ion batteries.
研究领域:
储能
·
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Fan Liu,Jing Ding,Qingliang Zhao,Guanshu Zhao,Kun Wang,Lili Li,Shuyan Guan
Advance oxidation process (AOP) is a promising way for micropollutants treatment, but the consumption of chemicals and energies limits its large-scale application. To address this issue, a novel boron-doped biochar (BBC) system was developed for the efficient removal of micropollutants, requiring no external energy or oxidant. Herein we demonstrated that the synthesized BBC could efficiently activate the dissolved oxygen (O 2 ) in the water or oxidize micropollutant directly. The complete sulfamethoxazole (SMX) could be removed within 30 min by the BBC synthesized at 600 °C (BBC-600). The experiments on material characterization and removal performance with quenchers revealed that the introduction of boron into biochar increased the active sites for O 2 activation, including persistent free radicals (PFRs) and boron moieties (BC 3 , BCO 2 , and BC 2 O) on the biochar. The generated reactive oxidation species (ROS), mainly O 2 − , were responsible for the SMX degradation in this BBC system. Different performance of aged experiments in air and N 2 conditions indicated that PFRs could also directly oxidize SMX. Density functional theory (DFT) was used to further illustrate the inner mechanism of enhanced electron transfer via boron moieties for O 2 activation and SMX degradation. Electrons of the adsorbed micropollutant could be transferred to boron moieties, and then trapped by O 2 in water to produce O 2 − and 1 O 2 for SMX degradation. This study provided a new insight into the structure–activity relationship of B-doped biochar for the direct and indirect degradation of micropollutant, and opened a new avenue for micropollutant degradation without external energy and oxidant.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nature Catalysis
·
2022
·Vol. 5
·期 3
·193-201
·
IF 40.706
Cao Deqing,Shen Xiaoxiao,Wang Aiping,Yu Fengjiao,Wu Yuping,Shi Siqi,Freunberger Stefan A.,Chen Yuhui
Redox mediators could catalyse otherwise slow and energy-inefficient cycling of Li–S and Li–O 2 batteries by shuttling electrons or holes between the electrode and the solid insulating storage materials. For mediators to work efficiently they need to oxidize the solid with fast kinetics but with the lowest possible overpotential. However, the dependence of kinetics and overpotential is unclear, which hinders informed improvement. Here, we find that when the redox potentials of mediators are tuned via, for example, Li + concentration in the electrolyte, they exhibit distinct threshold potentials, where the kinetics accelerate several-fold within a range as small as 10 mV. This phenomenon is independent of types of mediator and electrolyte. The acceleration originates from the overpotentials required to activate fast Li + /e − extraction and the following chemical step at specific abundant surface facets. Efficient redox catalysis at insulating solids therefore requires careful consideration of the surface conditions of the storage materials and electrolyte-dependent redox potentials, which may be tuned by salt concentrations or solvents.
研究领域:
电化学
·
电池技术
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Tao Sun,Qinjun Chen,Zheng Zhou,Chao Li,Teng Yu,Chen Jiang
Precisely reporting the inflammatory microenvironment, which can provide important basis for disease diagnosis and progression determination, is always challenging. In this work, we develop a targeting peptide-conjugated chemiluminescent reporter (OFF), which can be recognized by in-situ circulated neutrophils once injected, and then transported to the inflamed tissues characterized with overexpressed superoxide anion (O 2 − ), assisted by the chemotaxis natural of neutrophils. Subsequently, the chemiluminescent probe can particularly respond to O 2 − to release the caged photons (ON) for visualizing inflammatory diseases such as subcutaneous tumor, colorectal cancer peritoneal metastasis (CCPM), ear swelling and kidney failure. The chemiluminescent probe provides a reliable tool to early detect inflammation and precisely excise micrometastatic lesions under optical guidance. This study provides a potential approach for improving the performance of luminophore in advanced bioimaging applications.
研究领域:
生物医学工程
·
成像科学
·
炎症生物学
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Shuo Liu,Huiqi Yang,Liguo Zhang,Alberto Bianco,Baojin Ma,Shaohua Ge
The injured bone microenvironment is typically characterized by high-level reactive oxygen species (ROS, mainly H 2 O 2 ) and low content of oxygen. The former can cause cell apoptosis, induce immune imbalance and inflammation, inhibit osteogenic differentiation, and delay bone repair . In this work, barrier membranes made of a combination of hydroxyapatite nanowires (HAp NWs) and polylactic acid (PLA) loaded with manganese dioxide nanosheets (NSs) ( [email protected] ) were prepared to guide bone regeneration (GBR). Due to the catalytic function of MnO 2 , [email protected] membranes are able to effectively decompose H 2 O 2 to generate O 2 . In vitro experiments demonstrated [email protected] membranes inhibited the apoptotic process caused by high level of H 2 O 2 , decreased intracellular oxidative stress , suppressed inflammation-related gene/protein expression, and inhibited macrophage M1 polarization. The nanostructured HAp stimulated osteogenic differentiation, and the loading of MnO 2 NSs played a synergistic effect. In addition, the barrier function of PLA could hamper the epithelium overgrowth, providing the development space for periodontal regeneration. By scavenging H 2 O 2 , generating O 2 , eliminating inflammation, and regulating immune response, [email protected] membranes efficiently promoted bone regeneration. Our results confirmed that composite membranes have great potential for application in GBR, and provide a reference for future design of bone repair materials.
研究领域:
生物材料
·
组织工程
·
再生医学
·
骨科
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）