Catalysts
·
2023
·Vol. 13
·期 5
·847
·
IF 3.9
Zhen Li,Wenxuan Jiang,Jingwen Huang,Yawen Wang,He Guo
This paper aims to investigate the promotion of persulfate (PS) activation by ZnO in discharge plasma systems for the degradation of ofloxacin (OFX). Scanning electron microscopy and transmission electron microscopy showed that ZnO nanoparticles were successfully prepared by a hydrothermal method. With an increase in the PS dosage, the removal efficiency of OFX first increased and then decreased. With an increase in the ZnO dosage, the removal efficiency of OFX showed a similar trend. Under the optimum 595 mg/L PS dosage and 295 mg/L ZnO dosage, the removal efficiency of OFX by plasma, plasma/ZnO, and plasma/ZnO/PS systems reached 53.6%, 82.8%, and 98.9%, respectively. Increasing the input power was beneficial to the degradation of OFX. ESR results showed that the addition of ZnO could further stimulate PS to produce more ·OH and ·SO4−than that of plasma alone. The capture agent experiment proved that ·OH, ·SO4−, ·O2−, and1O2all participated in the degradation of OFX. A total organic carbon (TOC) removal of 49.6% was obtained in the plasma/ZnO/PS system. Based on liquid chromatography-mass spectrometry (LC-MS) and the Toxicity Estimation Software Tool (TEST), degradation pathways and toxicity were analyzed. Compared to other technologies, it can be concluded that the plasma/ZnO/PS system is a promising technology for pollutant remediation.
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BIOMEDICAL CHROMATOGRAPHY
·
2015
·Vol. 30
·期 3
·426-431
·
IF 1.723
Jing Nie,Yang–Guang Wang,Xiao–Feng Gao,Xiao–kun OuYang,Li–Ye Yang,Di Yu,Wei–jian Wu,Hong–Ping Xu
( S )-(−)-Ofloxacin and ( R )-(+)-ofloxacin concentrations in the plasma of Pagrosomus major after drug treatment were detected by chiral high-performance liquid chromatography, and various pharmacokinetic parameters were calculated from these data. The elimination half-life of ( S )-(−)-ofloxacin was significantly shorter than that of the ( R )-(+) enantiomer. ( S )-(−)-Ofloxacin also had a significantly lower maximum plasma concentration, area under the concentration–time curve from zero to infinity, and mean residence time than ( R )-(+)-ofloxacin. However, the apparent volume of distribution and total body clearance of ( S )-(−)-ofloxacin were greater than those of ( R )-(+)-ofloxacin. The ratio of the ( S )-(−)- to ( R )-(+)-ofloxacin plasma concentration was always <1.0. Together, these data suggest that ( S )-(−)-ofloxacin was preferentially excreted and ( R )-(+)-ofloxacin was preferentially absorbed. Although the difference in pharmacokinetic parameters was small, the metabolic behavior of the ofloxacin enantiomers in P. major was enantioselective. Copyright © 2015 John Wiley & Sons, Ltd.
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CRYSTAL GROWTH & DESIGN
·
2022
·
IF 4.01
Su-Su Meng,Yue-Ming Yu,Fan-Zhi Bu,Cui-Wei Yan,Zhi-Yong Wu,Yan-Tuan Li
A cocrystallization tactic of double optimization and synergistic enhancement efficacy has been proposed, aiming at maximizing the benefits of phenolic acid nutriment syringic acid (HSA) to perfect biopharmaceutical features of antibacterial drug ofloxacin (OA). This strategy utilizes the salt-forming function and cocrystallization ability of HSA interplaying with OA to assemble into a salt cocrystal, thus ameliorating OA’s physicochemical properties in vitro, which, in turn, can optimize its pharmacokinetic characteristics in vivo, making OA’s pharmaceutical peculiarities be doubly optimized on both in vivo and in vitro levels. Ulteriorly, the antibacterial potency of OA is heightened by stimulating the auxiliary antibacterial ability of HSA, fulfilling the cooperativeness of OA and HSA in antibacterial efficacy. Taking this tactic as orientation, the first OA– nutriment salt cocrystal, viz., [HOA+-SA–]-HSA-H2O, is directionally synthesized and structurally identified. Single-crystal X-ray diffraction substantiates that the salt cocrystal has a bilayer hole structure, wherein, a hexahelical hydrogen-bonding motif of [HOA+-SA–] salts situates outside with a double spiral of neutral HSA and H2O molecules inside, thus endowing the salt cocrystal with the capacity to simultaneously enhance solubility and permeability compared with OA itself, which achieves positive correlations with theoretical investigations. Intriguingly, the strengthened in vitro properties of the salt cocrystal have been effectually turned into in vivo pharmacokinetic advantages, displaying an advanced peak plasma concentration and protracted half-life along with raised relative bioavailability. More meaningfully, the antibacterial capacity of the salt cocrystal has also attained significant enhancement owing to the congenerous antibacterial action of OA and HSA. Therefore, this investigation not only offers a novice strategy for optimizing in vitro/vivo pharmaceutical characteristics and concurrently elevating antibacterial efficacy of OA through formation of the salt cocrystal but also fulfills a breakthrough in developing new salt cocrystal systems of antibacterial drugs.
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MARINE ENVIRONMENTAL RESEARCH
·
2026
·
IF 3.4
Yurou Jiang,Wangxinze Shu,Jiyuan Wan,Jinke Yan,Qian Liu,Yong Jiang
Dimethylsulfoniopropionate (DMSP) is a key organic sulfur compound in marine food webs and the main precursor of the climate-active gas dimethyl sulfide (DMS), yet its water-column cycling under the joint influence of emerging pollutants remains poorly constrained. A 19-day microcosm experiment was conducted to examine the long-term effects of single and combined exposure to nanoplastics (NPs) and the antibiotic ofloxacin on planktonic microbial communities and DMSP cycling in coastal seawater. Combined exposure induced much stronger inhibitory effects than either single pollutant, markedly weakening the late-phase biomass recovery observed under the antibiotic-only treatment. DMSP dynamics exhibited a biphasic disruption pattern: an initial transient accumulation was followed by persistently low concentrations later in the experiment, coinciding with pronounced declines in microeukaryotic and total biomass. Combined metagenomic and flow cytometric analyses revealed a “functional decoupling” scenario, in which the surviving community displayed elevated relative abundances of DMSP biosynthesis- and degradation-related genes, while the sharp reduction in microeukaryotic biomass and overall community size constrained the maintenance and renewal of the water-column DMSP pool. Co-occurrence network analysis further showed that co-exposure simplified the microbial network from a more distributed, complex structure to a highly centralized one, with fewer nodes and keystone taxa and decreased robustness indices along the pollution gradient. Together, these findings indicate that the co-occurrence of nanoplastics and antibiotics can disturb DMSP-related functions by eroding community structural stability and functional redundancy, providing experimental evidence for the vulnerability of coastal DMSP cycling to mixed-pollutant stress.
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CHEMOSPHERE
·
2022
·
IF 8.943
Tao Zhang,Pan Wu,Gary Owens,Zuliang Chen
Since ofloxacin (OFX) is one of many common antibiotics, which effluxes into aquatic environment in relatively high concentration, it has become of significant environmental concern due to the potential for increased antibiotic resistance. In this study, an innovative functional Fe/Ni@ZIF-8 composite was successfully used for the Fenton-like oxidation of OFX, with a OFX removal efficiency >98% under optimal conditions. FTIR analysis confirmed that OFX removal occurred via adsorption to Fe/Ni@ZIF-8 by a combination of π-π bond intercalation and electrostatic interaction, while XPS revealed that the Fe/Ni NPs in Fe/Ni@ZIF-8 were also involved in oxidation. Furthermore, LC-MS analysis identified the presence of several OFX degradation products post exposure, which indicted that Fe/Ni NPs in Fe/Ni@ZIF-8 reacted with H 2 O 2 to form •OH, leading to Fenton-like oxidation of OFX. Thus overall, OFX removal by Fe/Ni@ZIF-8 involved both adsorption to ZIF-8 and Fenton-like oxidation by Fe/Ni NPs. A synergistic mechanism for OFX removal by Fe/Ni@ZIF-8 was thus proposed. The removal efficiency of the synthesized catalysts remained high (above 65%) even after a 5th reuse cycle, which reflected the high stability of Fe/Ni@ZIF-8. Overall, this study demonstrated that Fe/Ni@ZIF-8 had significant potential for the removal of OFX from wastewaters with a removal efficiency >90%.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Hao Li,Yi Liu,Feng Jiang,Xing Bai,Huijie Li,Di Lang,Lin Wang,Bo Pan
Cellulose and lignin derived biochars with significant differences in persistent free radicals (PFRs), oxygen-containing functional groups, and defective structure were prepared to explore the mechanism of biochar mediated persulfate (PS) activation. EPR spin trapping and quenching technique coupled with degradation experiments confirmed that the defective structures could activate PS to generate superoxide anions (O 2 •− ), which was converted to singlet oxygen ( 1 O 2 ), especially in the acidic condition. 1 O 2 dominated the degradation of ofloxacin (OFL, a fluoroquinolone antibiotic). An improved iodometric measurement was applied for direct quantification of adsorbed PS on biochar. The amounts of adsorbed PS were consistent with the degradation of OFL and the measured electric current during the reaction indicated that PS adsorption was a prerequisite for PS activation, which may be neglected in previous studies. The results of this study highlighted the key roles of defective structure and adsorption of PS on biochar for the activation of PS.
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ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Chang Liu,Yuan Chen,Hong Lin,Limin Cao,Kaiqiang Wang,Xiudan Wang,Jianxin Sui
Background Due to the serious issue of ofloxacin (OFL) abuse, there is an increasingly urgent need for accurate and rapid detection of OFL. Immunoassay has become the “golden method” for detecting OFL in complex matrix beneficial to its applicability for a large-scale screening, rapidity, and simplicity. However, traditional antibodies used in immunoassay present challenges such as time-consuming preparation, unstable sensitivity and specificity, and difficulty in directional evolution. In this paper, we successfully developed an OFL detection method based on a shark-derived single-domain antibody (ssdAb) to address these issues. Results Using phage display technology and a heterologous expression system, OFL-specific clones 1O11, 1O13, 1O17, 1O19, 1O21, and 2O26 were successfully isolated and expressed in soluble form. Among all OFL-specific ssdAbs, the 1O17 ssdAb exhibited the highest binding affinity to OFL in a concentration-dependence manner. The limit of detection (IC 10 ) of 1O17 ssdAb was calculated as 0.34 ng/mL with a detection range of 3.40–1315.00 ng/mL, and its cross reactivity with other analogs was calculated to be less than 5.98 %, indicating high specificity and sensitivity. Molecular docking results revealed that 100Trp and 101Arg located in the CDR3 region of 1O17 ssdAb were crucial for OFL binding. In fish matrix performance tests, the 1O17 ssdAb did not demonstrate severe matrix interference in OFL-negative fish matrix, achieving satisfactory recovery rates ranging from 83.04 % to 108.82 % with high reproducibility. Significance This research provides a new and efficient OFL detection recognition element with significant potential in immunoassay applications, broadening the application scenarios of ssdAbs. It offers valuable insights into the structure-activity relationship between ssdAbs and small molecules, laying a theoretical foundation for the further directional modification and maturation of ssdAbs in subsequent applications.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yang Yu,Xinlu Liu,Fei Huang,Qingyu Huang,Chuang Yang,Yongjun Zhang
3D-printed monolithic catalysts have garnered significant attention in wastewater treatment due to their structural flexibility and mass transfer control. However, catalyst stability remains a critical challenge for peroxymonosulfate (PMS) activation processes. In this study, a random forest model was employed to investigate the stability and optimize the selection of bimetallic (Fe and Ni) active components. FeNi 3 alloy was synthesized on 3D-printed monoliths by electrodeposition, achieving excellent stability. The 3DE-FeNi monolithic catalyst exhibited excellent performance, achieving a 98.6% conversion of OFX by PMS activation. Numerical simulations and experimental characterizations were used to explore the mass transfer mechanisms. This study provides an effective strategy for precisely manufacturing structured catalysts with high catalytic stability, which can be applied to a range of chemical reactions.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 415
·期 1
·157-166
·
IF 4.478
Yang Zuan,Hu Jing,Zhang Xiaoyu,Yang Huimin,Meng Peiran,Zhao Huanying,Sun Yue
Sensitive determination of ofloxacin (OFL) is very essential for human health and environmental protection. Here, a novel composite of gold nanoparticles(nAu)@MXene(Ti 3 C 2 T x )/poly- p -aminobenzene sulfonic acid (PABSA) was fabricated on the surface of glassy carbon electrode (GCE) and used to sensitively determine OFL. The results of experiments showed that the obtained nAu@Ti 3 C 2 T x /PABSA/GCE electrode could be used as an electrochemical sensor to directly detect ofloxacin (OFL) by differential pulse voltammetry (DPV). Under the optimal conditions, the proposed electrode displayed a broader linear range and a lower detection limit (LOD) for OFL determination when it was compared to those similar sensors. The linear range was from 5.0 × 10 −8 to 5.0 × 10 −4 mol/L and the LOD was 3.7 × 10 −8 mol/L ( S / N = 3). The nAu@Ti 3 C 2 T x /PABSA/GCE electrode also showed good selectivity, repeatability, and reproducibility. Finally, the proposed electrode was used to detect OFL in commercial samples by the standard addition method. The obtained recovery was from 97.3% and 105.7% showing its potential applications in actual sample analysis. Graphical Abstract
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MOLECULES
·
2022
·Vol. 27
·期 13
·4312
·
IF 4.927
Xiaowei Wang,Yingjie Zhao,Yiqi Sun,Dahuan Liu
Residual antibiotics in wastewater have gained widespread attention because of their toxicity to humans and the environment. In this work, Cu-doped ZIF-8s (Cu-ZIF-8s) were successfully synthesized by the impregnation of Cu2+in ZIF-8 and applied in the removal of ofloxacin (OFX) from water. Remarkably, excellent adsorption performance was obtained in Cu-ZIF-8s, especially for Cu-ZIF-8-1, in which the adsorption capacity (599.96 mg·g−1) was 4.2 times higher than that of ZIF-8 and superior to various adsorbents reported previously. The adsorption kinetics and adsorption isotherm follow the pseudo-second-order model and the Langmuir model, respectively. Furthermore, the removal efficiencies of OFX in Cu-ZIF-8-1 reached over 90% at low concentrations. It was revealed that electrostatic interaction and complexation play important roles in the adsorption process. In addition, the material can be regenerated by simple methods. Therefore, the obtained Cu-doped MOFs may have a promising application in the treatment of antibiotic-containing wastewater.Keywords:adsorption;complexation;metal-organic frameworks;ofloxacin
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Journal of Nanomaterials
·
2022
·
IF 3.791
Wenke Xiao,Xiaojuan Zhang,Lingyun Hao,Yuan Zhao,Qing Lin,Zhao Wang,Wenli Song,Dong Liang
It is essential to design multifunctional contact lenses for selective recognition and utilization of the eye drop ofloxacin (OFL). Modified silicone hydrogel (MSL) contact lenses were firstly synthesized via ultraviolet curing by using (hydroxymethyl)methyl aminomethane, polydimethylsiloxane, methacryloxypropyl terminated polydimethylsiloxane, and N,N-dimethylacrylamide as monomers and N-vinyl-2-pyrrolidinone (NVP) as a modifier. The synthesized MSL contact lenses were characterized via Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle and mechanical property tests. The results showed that compared with silicone hydrogel (SL) contact lenses, the MSL contact lenses had a more porous structure and good swelling and mechanical properties. The molecularly imprinted polymer/ofloxacin-modified silicone hydrogel (MIP/OFL-MSL) contact lenses were firstly synthesized via free radical polymerization, using ofloxacin (OFL) as the template molecule. Moreover, compared with chlorogenic acid and myricetin molecule, the MIP/OFL-MSL contact lenses exhibited an adsorption capacity for OFL that reached 2.86 mg/g. The antibacterial test showed that the MIP/OFL-MSL contact lenses displayed an inhibition ring size of 15.2 mm and 17.8 mm for Staphylococcus aureus and Escherichia coli, respectively.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 10
·1-9
·
IF 5.479
Yi Haoyang,Yan Zhiyu,Wang Lumei,Zhou Xiaotong,Yan Rui,Zhang Dongwei,Shen Guoqing,Zhou Shanshan
A fluorometric method is described for the determination of ofloxacin (OFL). It is based on the use of the fluorescent intercalator SYBR Green I (SG-I). The OFL-aptamer has G-quadruplex structures and can be recognized by SG-I. It results in strong fluorescence of SG-I. If OFL is present, OFL will bind to its aptamer to form stable complexes. This induces the despiralization of partial dsDNA regions, leads to changes in the structure of the aptamer. Thus, SG-I is released from the OFL-aptamer into solution. Hence, the fluorescence of SG-I drops. Fluorescence decreases linearly in the 1.1 to 200 nM OFL concentration range, and the limit of detection is 0.34 nM. The method shows good selectivity to much interference including analogues, hormones, pesticides. It is also effortless and fast with the times of measurement of <40 min. In addition, good recoveries of 91.3–119.0% were found for tap water, river water and artificial urine spiked with OFL with relative standard deviation (RSD) of ≤11.6%.
A sensitive fluorometric method is developed for ofloxacin (OFL) detection in aqueous samples based on the fluorescence intensity change of SYBR Green I (SG-I) with or without OFL.
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