Soft Science
·
2026
·Vol. 6
·期 3
·N
·
IF 15.9
Kaiyan Luo,Yupeng Hu,TengZhou,Xiaonan Liu,Maoxia Lu,Zhi Lei,Daohai Zhang,Wei Gong
The rapid development of information technology has given rise to an urgent demand for high-efficiency electromagnetic wave absorbing materials. It is a challenge for wave-absorbing materials that address the electro-magnetic synergistic effect to develop high-efficiency electromagnetic wave (EMW) materials that can not only reduce the electromagnetic interference generated by electronic devices in daily use but also exhibit a certain degree of stealth in the military field. To study and prepare high-efficiency EMW materials, this paper uses the solvothermal method to prepare NiCo-HHTP, and systematically investigates their electromagnetic wave absorption performance and absorption mechanism. The research shows that the composite material NCH1 obtained in this experiment achieves a minimum reflection loss (RLmin) value of -56.99 dB and an effective absorption bandwidth of 6.51 GHz at a relatively thin matching thickness of 2.9 mm. The polarization effect endows it with good conductive loss, and the magnetic central metal gives it a certain degree of magnetic loss. The synergistic effect of dielectric loss and magnetic loss makes the material exhibit a good wave-absorbing effect. This simple and efficient preparation method provides a new strategy for the preparation and application of metal-organic framework materials in EMW absorption.
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Soft Science
·
2026
·Vol. 6
·期 4
·N
·
IF 15.9
Yunshi Li,Yuejun Jiang,Weilin Lu,Yalin He,Hong Wang,Cong Xu,Hanfeng Qin,Hao Tian,Yingfeng Tu,Yingjia Li,Lihan Shen
Because of their distinct physical and chemical characteristics, soft materials with low modulus, great deformability, and large compliance have progressively emerged as a significant area of study. However, the responsiveness of traditional soft materials is inherently limited by passive diffusion and equilibrium thermodynamics. Thus, by incorporating stimuli-responsive artificial materials into motile bacterial species with anticancer properties, a soft biohybrid bacterial system has been created, converting soft materials from static scaffolding into adaptable, living systems. Specifically, the surface of Escherichia coli DH5α is modified by liposomes co-loaded with glucose oxidase and Tirapazamine (TPZ). The soft biohybrid bacterial system uses anaerobic targeting to deliver anticancer drugs and catalyzes glucose in the tumor microenvironment, consuming local oxygen in the process. The enhanced hypoxic microenvironment fully activates TPZ, significantly boosting its cytotoxic effect on tumor cells. Moreover, the soft biohybrid bacterial system further induces strong immunogenic cell death, which enhances the therapeutic effect while minimizing side effects on normal tissues. This innovative strategy offers a promising solution to overcome the therapeutic challenges associated with traditional soft materials.
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Soft Science
·
2025
·Vol. 5
·期 1
·N
·
IF 9
Lina Wang,Wen Wang,Rongtai Wan,Mutian Yao,Wenna Chen,Liuyu Zhang,Jingkun Xu,Ximei Liu,Baoyang Lu
Highly sensitive strain sensors are crucial for monitoring subtle plant growth changes and show diverse applications in plant sensing. However, the prevailing integrated fabrication methods for such sensors tend to be costly and complex, impeding their fundamental design and practical usage. Herein, we develop a simple and effective multimaterial all-3D printing technique to manufacture integrated strain sensors with a multilayered structure. Such an all-3D-printed strain sensor exhibits excellent sensing performance enabling precise detection of minor strains in plant growth, including high stretchability (> 300%), high sensitivity (~12.78) with good linearity (0.98), and good long-term stability over 3,000 loading/unloading cycles. We further validate the potential applications of our 3D-printed integrated strain sensor for accurate and continuous monitoring of bamboo growth in both horizontal and vertical directions over 14 days. Our all-3D-printed strain sensor offers a promising avenue for integrated strain sensing systems toward plant growth monitoring.
研究领域:
植物学
·
传感器技术
·
材料科学
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生物传感
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Soft Science
·
2025
·Vol. 5
·期 2
·N
·
IF 9
Mengjie Huang,Shun Liu,Yalin Chi,Jianwei Li,Hongling Sun,Lin Dong,Hu Liu,Chuntai Liu,Changyu Shen
Conductive hydrogels have drawn significant attention as smart sensing systems for flexible electronics. However, challenges remain in fabricating multimodal electronics that simultaneously achieve ultrastretchability, conformal adhesion, environmental adaptability, self-healing, and high-performance sensing for electrophysiological signal detection. In this study, a nanocomposite organohydrogel with these features is developed by incorporating chitosan-encapsulated MXene nanosheets into a polyacrylamide network within a phytic acid (PA)/glycerol (GL)/water trisolvent system, aiming to create a multimodal sensing platform. The synergy between hydrogen bonds and electrostatic interactions endows the organohydrogel with exceptional properties, including ultrastretchability (2,800%), robust adhesion (70.6 kPa on paper), and self-healing ability. The combination of PA and GL not only enhances the organohydrogel’s environmental adaptability (-30 to 60 °C) to meet diverse application requirements but also improves its conductivity. These remarkable features enable the organohydrogel to function as a multimodal sensor capable of detecting multiple stimuli (strain and temperature) with high sensitivity and strong robustness against external disturbances. Moreover, it serves as a reliable electrode for electromyography signal detection, providing a high signal-to-noise ratio and low interfacial impedance. By integrating deep learning algorithms, the organohydrogel sensing system achieves 100% accuracy in ball sports identification, showcasing its potential for multimodal sensing platforms.
研究领域:
生物医学工程
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材料科学
·
人工智能
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高影响因子
Soft Science
·
2025
·Vol. 5
·期 4
·N
·
IF 9
Hailong Xu,Chenyang Jing,Zhijian Xu,Haoyang Zhan,Fang Ye,Qiang Chen,Meng Zhu,Luo Kong,Xinliang Li,Xia Chai,Yuchang Qing,Xiaomeng Fan,Fa Luo
With the ever-deepening understanding of nano-electromagnetic interactions and the advancements of fabrication methodologies of nanomaterials, diverse electromagnetic platforms utilizing nanomaterials have been developed for next-generation electromagnetic safeguarding applications. This study presents the design and fabrication of bioinspired porous Ti2CTX/Si3N4 composites featuring an aligned lamellar structure, aimed at facilitating the effective absorption and dissipation of electromagnetic radiation. The layered configuration of Ti2CTX/Si3N4 composites facilitates the repeated reflection of electromagnetic waves between neighboring Ti2CTX layers, hence enhancing the energy dissipation of these waves. At a Ti2CTX concentration of merely 0.21 wt.%, the effective absorption bandwidth of Ti2CTX/Si3N4 composites encompasses the whole X-band (8.2-12.4 GHz), with a minimum reflection loss of -53 dB achievable at a sample thickness of 5 mm. Simultaneously, the fabricated Ti2CTX/Si3N4 composites demonstrate advantages in lightweight characteristics and robust mechanical properties, offering significant insights for the application of Ti2CTX in nano-electromagnetic engineering, particularly in the realm of electromagnetic pollution mitigation.
研究领域:
材料科学
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纳米技术
·
电磁工程
·
复合材料
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高影响因子
Soft Science
·
2026
·Vol. 6
·期 1
·N
·
IF 15.9
Wenlei Zhang,Zhuohao Liu,Jiulong Liu,Chenyu Chai,Peidong Xue,Gang Li,Zhongyun Yuan,Lei Yang
Electrochemically anodized stainless steel (SS) shows promise as a free-standing electrode in flexible supercapacitors due to its low cost, eco-friendly nature, and binder-free characteristics. However, unsatisfactory cycling stability limits its practical use in wearable electronics. Herein, we introduce a conductive carbon film deposited on the surface of the anodized SS electrode as a protective layer via electron cyclotron resonance sputtering. By optimizing the deposition bias voltage and deposition time, the resulting flexible electrode exhibits a specific capacitance of 271.6 mF·cm-2 at a current density of 1 mA·cm-2, representing a 2.24-fold increase over the uncoated counterpart, with 88.7% capacitance retention after 8,000 cycles. The enhanced performance is closely related to the conductivity of the surface coating, which depends on the sp2/sp3 ratio (the relative proportion of graphitic to diamond-like carbon bonding). The carbon film-coated anodized SS electrode is combined with an activated carbon on carbon cloth electrode and a gel electrolyte to produce a flexible supercapacitor. The energy storage device exhibits a wide operating potential window of 1.8 V, a high energy density of 51.70 mWh·cm-3, and a power density of 0.50 W·cm-3, accompanied by robust flexibility and mechanical stability. These findings may pave the way for the development of high-performance, flexible, and cost-effective supercapacitors compatible with large-scale semiconductor device manufacturing.
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Soft Science
·
2026
·Vol. 6
·期 1
·N
·
IF 15.9
Ya Liang,Yubin Zhang,Na Li,Xiaojiao Shi,Yuxuan Qiao,Tifeng Jiao\u003Csup\u003E*\u003C\u002Fsup\u003E,Zhihui Qin\u003Csup\u003E*\u003C\u002Fsup\u003E
Hydrogels with good ionic conductivity and high stretchability hold great promise for flexible sensors, but are challenged by the low toughness and poor crack resistance, which severely limit their performance under complex mechanical conditions. Herein, we report an ionically conductive polyoxometalates (POMs)-composited hydrogel fabricated by incorporating chitosan oligosaccharide-modified silicotungstic acid (COS@SIW) nanocomplexes into a polyacrylamide (PAM) network. The incorporation of COS effectively enhances the interfacial bonding between COS@SIW and the PAM matrix through abundant electrostatic and hydrogen-bonding interactions among COS, SIW, and PAM chains, facilitating efficient stress transfer and energy dissipation. As a result, the obtained POM-composited hydrogel exhibits integrated mechanical properties, including ultrahigh stretchability (2,423%), high toughness (3.77 MJ·m-3), and excellent crack resistance (fracture energy of 8.3 kJ·m-2). Moreover, the hydrogel demonstrates a high ionic conductivity of 0.17 S·m-1, attributed to the intrinsic proton mobility of SIW. The resulting hydrogels exhibit superior strain sensitivity with a wide working range, rapid response, and excellent reliability, enabling their application as wearable sensors for monitoring diverse human motions. Furthermore, the hydrogel can function as a bioelectrode for accurate and reliable detection of electrocardiogram signals. This work provides a new strategy for designing ionically conductive hydrogels with high stretchability, toughness, and superior crack resistance, offering promising opportunities for advanced wearable sensing platforms.
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CHINESE CHEMICAL LETTERS
·
2019
·
IF 3.839
Yanhui Sun,Aiyan Zhan,Shuang Zhou,Xiao Kuang,Hongyan Shen,Hongzhuo Liu,Youjun Xu
Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases. Hence, mitochondria-targeting delivery strategies are highly significant and critically needed. In this study, we developed a small library of peptides simulating the mitochondria-targeting peptide SS-31, a promising tetra-peptide with antioxidant character, and subsequently evaluated the toxicity, antioxidant ability and mitochondrial delivery of nanoparticles. Among the designed peptides, RF-2 ( d -Arg-Dmt-Arg-Phe-NH 2 ) showed controlled toxicity and excellent protection against gentamicin-induced hair cell damage, as compared with SS-31. More importantly, RF-2-modified PLGA nanoparticles demonstrated high colocalization with mitochondria and comparable specific subcellular accumulation, when compared with SS-31. Taken together, the obtained results supported RF-2 as a mitochondria-targeting peptide with high potential as a targeted carrier.
研究领域:
生物医学工程
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细胞生物学
·
药理学
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高影响因子
Natural Product Communications
·
2020
·
IF 0.468
Bo Tao,Zong-ning Yin
Thiolated hyaluronic acid was synthesized, and a quantification method was established to determine the content of the thiol group. Three thiol compounds, 2-nitro-5-mercapto-benzoic acid (TNB), 2- mercaptonicotinic acid (2-MNA), and mercaptopyridine (MPD), were tested for their efficiency in forming adducts with hyaluronic acid (HA) through disulfide bonds. Our results showed that MPD exhibited the highest disulfide exchange efficiency when the reaction was conducted at the optimal pH value. The synthesized hyaluronic acid-SS-mercaptopurine (HA-SS-MP) was characterized by 1H-nuclear magnetic resonance spectroscopy. The HA-SS-MP micelle showed a particle size of 264.4 nm in aqueous solution. An in vitro release experiment demonstrated that the releasing rate of 6-MP from HA-SS-MP in the release medium containing glutathione (GSH) was much higher than that in the release medium without GSH. Cell uptake experiments demonstrated the CD44 targeting of hyaluronic acid. Cytotoxicity tests in mouse melanoma cells (B16F10) showed that HA-SS-MP can kill melanoma cells effectively and with lower cytotoxicity, compared with the active ingredient, 6-MP.
研究领域:
药学
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肿瘤学
·
生物化学
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Guan-Hai Wang,Hua Chen,Yin-Yu Cai,Li Li,Hui-Kang Yang,Qin Li,Zhi-Jiang He,Jian-Tao Lin
The nucleus is one of the most important cellular organelles, where gene encode and transcribe at that location. However, nucleus-targeting gene delivery are rare been reported. It is important to develop a high-efficiency nucleus-targeting gene vector that can deliver targeted gene into nucleus directly for destroy of cancer cells. Here, special nucleus-targeting and size changeable deliver system based on TAT-SS-PAMAM-D3 with TAT functional on the surface and disulfide linked between D2 and D3 is designed to perform highly efficient nucleus-targeting gene delivery for effective cancer cell killing in vitro. CLSM observations reveal that more TAT-SS-PAMAM-D3 are enter into the nucleus when compare to SS-PAMAM-D3. The TAT modified vector can also act as gene deliver to reach high gene transfection efficiencies, high apoptosis and low viability in HeLa cells. This TAT functionalized and disulfide linking in the carrier may become a prospective vector for cancer gene treatment and also offered a different strategy for designing a better gene delivery system.
研究领域:
遗传学
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肿瘤学
·
分子生物学
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PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2022
·
IF 4.966
Guoguang Chen,Qiqi Zheng,Jie Dai,Jia Liu,Jun Yin,Xiaoqing Xu,Aiping Chen,Lili Ren
Currently, the drawbacks of the chemotherapy drugs are still demonstrated poor water solubility, systemic toxicity and even multidrug resistance (MDR) in clinical applications. To address these problems, an amphiphilic block polymer self-assembled reduction sensitive micelle , mPEG-SS-PzLL/TPGS/DOX, was synthesized for efficient anticancer therapy. The polymer had a biodegradable backbone and disulfide bond can be cleaved by reduced glutathione (GHS) in tumor cells, which led to fast release of the DOX . TPGS was designed for an increaseing drug accumulation and a reduction in drug efflux. In follow-up research, we found that mPEG-SS-PzLL/TPGS/DOX micelles achieved a high encapsulation efficiency of 96.1%. Photomicrographs gotten by TEM showed homogeneous and spherical-shaped particles with the particl size of 83.7 ± 3.2 nm. The in vitro release in high reducing conditions reached 96% within 48 h. Furthermore, the mPEG-SS-PzLL/TPGS/DOX micelles caused stronger cytotoxicity to 4 T1 cells and promising therapeutic efficacy for BALB/c mice bearing 4 T1 tumors. Therefore, an excellent drug delivery system was created by combing restore sensitivity with multidrug resistance strategy while maximize drug accumulation in tumor cells. Alternatively, this study offers a bright perspective for cancer therapy with chemotherapeutics.
研究领域:
药学
·
肿瘤学
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Polymers
·
2019
·Vol. 11
·期 10
·1716
·
IF 3.164
Feng Guo,Guiying Li,Songmei Ma,Hengquan Zhou,Xinyi Chen
A temperature, glutathione (GSH), and H2O2multi-responsive composite nanocarrier (MSN-SS-Fc@β-CD-PNIPAM) based on β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared. The surface of the mesoporous silica was first modified by ferrocene (Fc) via a disulfide bond (–SS–) to form an oxidizing and reducing site and then complexed with a β-CD-PNIPAM star shaped polymer through host–guest interactions as a nano-valve to provide temperature responsive characteristics. The structure and properties of the complex nanoparticles were studied by FTIR, TGA, EDS, Zeta potential, and elemental analysis. Doxorubicin (DOX) and Naproxen (NAP), as model drugs, were loaded into nanocarriers to assess drug loading and release behaviour. The release of drugs from nanocarriers was enhanced with an increase of the GSH, H2O2concentration, or temperatures of the solution. The kinetics of the release process were studied using different models. This nanocarrier presents successful multi-stimuli responsive drug delivery in optimal stimuli and provides potential applications for clinical treatment.Keywords:disulfide bond;ferrocene;multi-responsive;nanocarrier;MSNs
研究领域:
材料科学
·
药物递送
·
生物医学工程
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高影响因子
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