Materials Research Express
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2021
·Vol. 8
·期 4
·045012
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IF 1.62
Fei Ge,Rui Qiao,Ping Song,Yugui Tao,Longbao Zhu,Weiwei Zhang,Wanzhen Li,Lin Gui
Tumors area common cause of morbidity and mortality. High treatment efficiency and low drug toxicity are key for effective tumor treatment. Here, the pH-sensitive material ZIF-90 was synthesized by the liquid-phase diffusion method for loading paclitaxel (PTX), and the targeting peptide (RGD) was prepared by the solid-phase synthesis method to modify it (RGD/PTX@ZIF-90). The skeleton of RGD/PTX@ZIF-90 collapses in the acidic tumor microenvironment, thereby releasing PTX and mediating the controlled release of the drug. ZIF-90 below 300 nm was obtained by adjusting the ratio of metal ions and organic ligands in the characterization experiment. In addition, in vitro drug release experiments showed that the drug release rate was greater at pH = 5.5 than at pH = 7.4. The lethal rate of RGD/PTX@ZIF-90 to human breast cancer cells (MCF-7) was 44.5%, which was higher than the lethal rate of PTX alone (37.3%) in the cytotoxicity experiment and apoptosis experiment. Uptake experiments revealed that RGD/PTX@ZIF-90 mainly existed in the cytoplasm of MCF-7, which suggests that the drug had successfully entered the cell to achieve the therapeutic effect. The loading of the nano-medicine carrier ZIF-90 and the modification of the targeting peptide RGD significantly improve the therapeutic effect of PTX and indicate that this system could be used to treat breast cancer.
研究领域:
药学
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肿瘤学
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纳米技术
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药物递送系统
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ANALYTICAL BIOCHEMISTRY
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2022
·
IF 3.191
Yue Xin,Dun Zhang,Yan Zeng,Peng Qi
ATP is a high-energy compound that plays a vital role in biological metabolism. Abnormal changes in ATP concentration are related to various diseases and reflect microbial metabolism in biofilms. In this work, we prepared carbon quantum dots (CDs) with aggregation-induced fluorescence inhibition effect using the bacterial culture medium as raw material with a hydrothermal method . Then, an abiotic fluorescent nanoprobe named [email protected] imidazolate frameworks-90 (ZIF-90) was facilely synthesized by encapsulating CDs into ZIF-90. Owing to the encapsulation of CDs in the hollow structure of ZIF-90, the blue fluorescence emission of [email protected] decreased significantly. In the presence of ATP, the ZIF-90 framework was destroyed due to the strong coordination between ATP and Zn 2+ . The released CDs exhibited stronger fluorescence intensity , which was closely related to the ATP concentration. The convenient synthesis process and rapid ATP-responsive ability make [email protected] highly promising for clinical and environmental analysis .
研究领域:
生物化学
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纳米技术
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分析化学
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生物医学工程
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DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
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2025
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IF 4.7
Zitian Zhuang,Yutong Gu,Wenjie Yang,Xianying Cao,Ling Zhang,Ke Jiang
Combination chemotherapy is a key strategy for improving cancer treatment efficacy and overcoming drug resistance, but it requires smart nanocarriers capable of codelivering multiple drugs and achieving precise release at the tumor site. Herein, we report a ZIF-90-based dual-drug delivery platform (NAR@ZIF-90-DOX) for synergistic cancer therapy. The natural product naringenin (NAR) was encapsulated within ZIF-90 pores via a “one-pot” method, while the chemotherapeutic drug doxorubicin (DOX) was covalently grafted onto the surface through a pH-sensitive Schiff base linkage. This dual-gated design leverages the acidic tumor microenvironment to trigger simultaneous ZIF-90 degradation and Schiff base cleavage. This enables the synchronous and targeted release of both drugs in 4T1 cells, leading to a significantly enhanced synergistic anticancer effect compared to single-drug administration. This work provides a strategy for designing multifunctional, intelligent Metal–Organic Frameworks (MOFs) nanoplatforms for combination chemotherapy.
研究领域:
纳米技术
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药学
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材料科学
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生物化学
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肿瘤学
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PubMed
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xiaolong Sun,Jiahuan Hu,Yufeng Zhou,Xiangyu Zi,Huayue Zhu,Xi Luo,Yongqian Fu
In this study, we endeavored to catalyze the biosynthesis of D -phenyllactic (D-PLA) from L-Phenylalanine (L-Phe) through a one-pot method. However, the crucial enzymes for the biosynthesis of phenylpyruvate (PPA), amino acid oxidase (L-AAD), is a membrane-bound protein. Herein, we proposed a novel co-immobilization strategy of whole cells and enzymes, integrating them into ZIF-90 to achieve efficient biosynthesis of D-PLA. Consequently, we embarked on integrating both enzyme and E. coli into ZIF-90, ultimately obtaining the novel biocatalyst E. coli /LDH@ZIF-90. This achievement facilitated the cascade reaction between LDH and E. coli , enabling a streamlined one-pot bioconversion process. The morphology and structure of E. coli /LDH@ZIF-90 were thoroughly characterized using a range of methods, including XRD, SEM, FT-IR, CLSM, and XPS, which confirmed that the material had been successfully synthesized. Further activity experiments revealed that E. coli /LDH@ZIF-90 exhibited good stability even under harsh conditions. Additionally, the biocatalyst retained 76 % of its initial catalytic activity after completing six cycles. Moreover, when utilized for the biosynthesis of D-PLA, this system demonstrated an impressive conversion rate of 85.2 % after 12 h. The successful cascade catalysis from L-Phe to D-PLA underscored the potential of the enzyme-cell cascade catalytic system, offering valuable insights for its potential industrial applications.
研究领域:
生物技术
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生物化学
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催化
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材料科学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
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2024
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IF 6.1
Wan Huang,Song Zhang,Li Luo,Yalong Pan,Lijun Han,Yao Yu
Multimodal therapy based on nanozyme is expected to become a novel option for tumor treatment. However, the catalytic efficiency of nanozyme and the hypoxia microenvironment of tumors limit the therapeutic effect of nanozyme. Here in this article, we screened a small molecule midazole-2-carboxaldehyde (ICA) to preparation ZIF-90 and embedded gold and platinum nanoparticles to obtain ZAAP. ZAAP possessed a multi-enzymatic cascade of catalytic process including greatly enhanced peroxidase activity via "bionic" catalytic microenvironment (enhanced 23-fold), catalase and glucose oxidase activities, resulting in glucose decomposition to continuously supply H2O2, peroxidases for the catabolism of H2O2 to generate ROS and peroxidase-induced oxygen generation for continuous oxidation of glucose. All the above process built a catalysis cycle which greatly promotes the generation of ROS and oxygen as well as the consumption of glucose, leading to the chemical dynamic therapy function and alleviating the tumor hypoxia. In addition to the photothermal effect of ZAAP, a synergistic treatment of chemical dynamic/ photothermal/ starvation therapy can be achieved and the tumor inhibition rate reached 96.4% within 2 weeks, indicating that ZAAP show great potential in nanozyme based synergistic multimodal tumor treatment.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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材料科学
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2018
·Vol. 42
·期 18
·15061-15067
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IF 3.201
Jing Ma,Bing Yan
We prepared multi-component luminescent hybrid films based on a silicon chip by a covalent functionalization strategy of both metal–organic frameworks (ZIF-90) and lanthanide complexes. Herein the Si chip is firstly covalently modified by aminopropyltriethoxysilane (APTES) via a hydrolysis and condensation reaction, and then ZIF-90 is covalently grafted onto the surface of Si chip through imine condensation with APTES to form the hybrid films (Si-APTES-ZIF-90). Ternary lanthanide complexes with 3-methacryloxypropyltrimethoxysilane (MPTMS) and Phen (1,10-phenanthroline) are introduced to the above film systems through MPTMS as a covalent linker. The final multi-component hybrid films (Phen-Ln-MPTMS-Si-APTES-ZIF-90) display the typical Ln3+ (Ln = Eu, Tb, Sm and Dy) luminescence through the energy transfer from the MPTMS-Si-APTES-ZIF-90 host. Moreover, fine tuning of the luminescence color for these films is discussed by adjusting the excitation wavelength. Phen-Ln-MPTMS-Si-APTES-ZIF-90 (Ln = Eu, Sm, Dy) can exhibit white color emission closely by selective excitation. In addition, the consolidation stability under airflow of the film and the luminescence stability of the film under certain humidity environments are discussed.
研究领域:
材料科学
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化学
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光学
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DOI
高影响因子
Nature Communications
·
2021
·Vol. 12
·期 1
·1-8
·
IF 14.919
Lei Yuting,Zhang Guihua,Zhang Qinglan,Yu Ling,Li Hua,Yu Haili,He Yi
Zeolitic imidazolate frameworks (ZIFs) are very useful as high-capacity iodine (I 2 ) adsorbents. The adsorption performance is usually probed by measuring a statistical average property over an entire sample consisting of a large number of ZIF particles, leaving the interparticle heterogeneity information among individuals. Here we report a dark-field microscopy (DFM) method to visualize gaseous I 2 adsorption on single ZIF-90 particles in situ and in real time. The adsorption of I 2 is found to alter the scattering spectrum of ZIF-90 particles, inducing a distinct color change from bluewhite to yellow. According to correlating the adsorption amount of gaseous I 2 with the change of B value from DFM images, we quantitatively image the adsorption process and estimate the related kinetic parameters at the single particle level. Single particle measurements clarify the large particle-to-particle heterogeneity in adsorption reactivity and significant adsorption activity improvement of ZIF-90 after introduction of linker defects, which provides a microscopic understanding of the structure-activity relationship. We further demonstrate the capacity of this strategy for studying gaseous I 2 adsorption on single ZIF-91 particle as a derivative of ZIF-90 to illustrate the generality.
研究领域:
材料科学
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化学
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PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Dan Zhang,Yue Zhao,Qi He,Zengxi Pan,Guohong Ma
Herein, a superhydrophobic surface was designed and fabricated based on the “lotus effect” construction mechanism. The zeolitic imidazolate framework (ZIF-90) micro-nanoparticles were initially synthesized via a one-pot method, combined with long-chain stearic acid (STA), and subsequently embedded in polyvinyl butyral (PVB) to form a superhydrophobic surface at room temperature. The superhydrophobic surface demonstrated mechanical stability and retained its superhydrophobicity with a water contact angle (CA) greater than 150°, even at a wear distance of 400 cm. The composite coating formed by applying this superhydrophobic surface to magnesium (Mg) alloy exhibited a high corrosion potential (Ecorr = −0.86 V) and a low corrosion current density (icorr = 3.66 × 10–12 A·cm–2) compared to the uncoated Mg substrate (Ecorr = −1.53 V, icorr = 1.14 × 10–4 A·cm–2), indicating that the coating effectively enhances the corrosion resistance of the substrate. Notably, the superhydrophobic composite coating demonstrated corrosion resistance durability with a high charge transfer resistance (Rct = 5.12 × 109 Ω·cm2) after 5 days of immersion in 3.5 wt % NaCl aqueous solution. In addition, the as-prepared superhydrophobic surface also displayed excellent performance in self-cleaning and anti-icing. We believe that this work can facilitate the application of ZIFs on superhydrophobic surfaces and provide a new approach for metal corrosion protection.
研究领域:
材料科学
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防腐蚀技术
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表面工程
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PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Haoran Zheng,Jiayu Guo,Han Wang,Yurou Wang,Wenxiang Zhou,Ke Liu,Qiang Ma,Yanfei Qi
Bacteria are prevalent environmental pollutants. Live bacteria can proliferate and spread under appropriate conditions, presenting higher risks compared to non-viable counterparts. However, detecting live bacteria remains a challenge. Adenosine triphosphate (ATP), an energy currency in organisms, offers a reliable biomarker for the live bacteria sensing. Herein, we developed a zeolitic imidazolate framework-90 (ZIF-90) enhanced ATP sensing platform to detect live bacteria. The nanosystem which based on ZIF-90, encapsulating the DNA decorated magnetic beads (MB@S1) through self-assembly. When the S. aureus aptamers on ZIF-90 bonded to bacteria, the skeleton structure of ZIF-90 was disrupted by ATP leakage from live bacteria, leading to the release of MB@S1. Then, the MB@S1 initiated the hybridization chain reaction (HCR) and they were transduced by CRISPR-Cas12a to amplify the signal twice. The proposed ZIF-90 blocking sensing strategy (ZIF-90 strategy) exhibited remarkable sensitivity with the limit of detection (LOD) down to 0.223 pM for ATP detection, about 500 folds lower than the traditional ATP aptamer blocking sensing strategy (aptamer strategy). Furthermore, we used a smartphone for on-site analysis, realizing the quantification of live S. aureus with the LOD of 2.0 CFU/mL. Therefore, the approach possessed great application potential for public health, environment monitoring, bioanalysis and food safety.
研究领域:
生物化学
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分子生物学
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纳米医学
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环境科学
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食品安全
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产品关联
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PubMed
高影响因子
JOURNAL OF BIOTECHNOLOGY
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2025
·
IF 3.9
Xinyue Zhang,Yanqi Li,Jingjing Bi,Junjie Zhang,Bingzhi Li,Xing Zhang,Jie Zheng,Lei Lin
Chondroitin sulfate (CS) is a structurally complex anionic polysaccharide widely used in medical, cosmetic and food applications. Enzymatic catalysis is an important strategy for synthesizing CS with uniform chain lengths and well-defined structures. However, the industrial application of glycosyltransferases is hindered by limitations such as low expression yields, poor stability, and challenges in reuse. We developed a mild and rapid one-step synthetic method for the efficient immobilization of chondroitin synthase (KfoC). The resulting KfoC@ZIF-90 composite exhibits high catalytic activity, thermal stability, and pH adaptability. Notably, KfoC@ZIF-90 exhibited 5-fold enhanced thermal stability at 40°C and retained 86% relative activity at pH 10, while also maintaining 90% activity in organic solvents, surpassing the performance of free KfoC. Molecular docking analysis revealed that encapsulating KfoC within hydrophilic ZIF-90 reduced its binding energy to the substrate, thereby improving catalytic performance. Furthermore, KfoC@ZIF-90 can be easily separated from the reaction solution by centrifugation, simplifying product isolation and purification while enabling enzyme reuse. These attributes significantly enhance operability and reduce processing costs, making enzymatic CS synthesis more feasible for industrial applications.
研究领域:
生物化学
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合成生物学
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酶工程
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PubMed
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Pingfei Li,Yongqi Liu,Jie Zhang,Tianyi Wang,Shiming Zhang,Xinggang Yang
Owing to the complexity of the tumor microenvironment, monotherapy often suffers from inherent limitations and fails to achieve satisfactory antitumor efficacy. Therefore, multimodal collaborative therapy has become a trend. In this study, CP@ZIF-PQ/Ce6 NPs, a ZIF-90-based multimodal nanosystem loaded with copper peroxide (CP) nanoparticles, the autophagy inhibitor primaquine phosphate (PQ) and the photosensitizer Ce6, were developed. This nanosystem enables the integration of photodynamic therapy (PDT), chemodynamic therapy (CDT), oxygen generation, and autophagy inhibition. Through the combined therapeutic effects of PDT/CDT/O 2 generation/autophagy inhibition, CP@ZIF-PQ/Ce6 NPs enhance the production of reactive oxygen species(ROS), alleviate tumor hypoxia, and block the autophagy-mediated protective pathway in tumor cells. Moreover, the nanosystem exhibits dual pH- and ATP-responsive properties, allowing tumor microenvironment-triggered drug release. CP@ZIF-PQ/Ce6 NPs successfully integrate PDT, CDT, oxygen-generating therapy, and autophagy inhibition, demonstrating potent antitumor activity and favorable biocompatibility both in vitro and in vivo. This study provides an innovative strategy and experimental evidence for multimodal collaborative antitumor therapy to overcome the limitations of monotherapy imposed by the tumor microenvironment. Download: Download high-res image (147KB) Download: Download full-size image
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Ning Ding,Bo Zhang,Imran Mahmood Khan,Mingwei Qin,Shuo Qi,Xiaoze Dong,Zhouping Wang,Junsong Yang
The prevalence of pathogenic bacterial infections with high morbidity and mortality poses a widespread challenge to the healthcare system. Therefore, it is imperative to develop nanoformulations capable of adaptively releasing antimicrobial factors and demonstrating multimodal synergistic antimicrobial activity. Herein, an NIR-activated multifunctional synergistic antimicrobial nanospray MXene/ZIF-90@ICG was prepared by incorporating ZIF-90@ICG nanoparticles onto MXene-NH2 nanosheets. MXene/ZIF-90@ICG can on-demand release the antimicrobial factors MXenes, ICG, and Zn2+ in response to variations in pH and ATP levels within the bacterial infection microenvironment. Under NIR radiation, the combination of MXenes, Zn2+, and ICG generated a significant amount of ROS and elevated heat, thereby enhancing the antimicrobial efficacy of PDT and PTT. Meanwhile, NIR excitation could accelerate the further release of ICG and Zn2+, realizing the multimodal synergistic antibacterial effect of PDT/PTT/Zn2+. Notably, introducing MXenes improved the dispersion of the synthesized antimicrobial nanoparticles in aqueous solution, rendering MXene/ZIF-90@ICG a candidate for application as a nanospray. Importantly, MXene/ZIF-90@ICG demonstrated antimicrobial activity and accelerated wound healing in the constructed in vivo subcutaneous Staphylococcus aureus infection model with NIR activation, maintaining a favorable biosafety level. Therefore, MXene/ZIF-90@ICG holds promise as an innovative nanospray for adaptive multimodal synergistic and efficient antibacterial applications with NIR activation.
研究领域:
纳米医学
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生物材料
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感染生物学
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DOI
PubMed
高影响因子
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