CHEMOSPHERE
·
2019
·
IF 5.108
Chenglong Yu,Erping Bi
Use of reclaimed water for irrigation is a main way for pharmaceutical compounds such as diclofenac getting into the soil environment. However, the role of minerals, especially iron oxides , in the diclofenac adsorption to soils with low soil organic matter (SOM) is still in the lack of evaluation. In this study, adsorption of diclofenac onto six minerals (five nature minerals-hematite, goethite , magnetite, kaolinite and aluminium oxide and one engineered mineral-activated aluminia) and five reference soils was investigated by column chromatography. Adsorption of diclofenac onto minerals and soils was totally reversible and interactions such as H-bonding were the primary mechanisms. Adsorption affinity of iron oxides was much higher than that of nature silicon and aluminum oxides. Diclofenac tended to be adsorbed by mineral surface -OH groups with high thermodynamic stability, which were dehydroxylated at high temperature. Compared with the SOM-dominated sorption of naphthalene , adsorption of diclofenac onto soils was controlled by bonding with surface -OH groups of iron oxides. Adsorption coefficients of diclofenac onto soils can be well predicted by contents of extracted Fe by diethylenetriamine pentaacetic acid (DTPA) instead of total iron oxides contents, suggesting that the bonding was adsorption site-dependent. These findings highlighted the importance of iron oxides in the adsorption of diclofenac (an anionic pharmaceutical compound) in soils with relatively low SOM (e.g., 1.03-3.45%). It also indicated that contents of effective surface -OH groups and DTPA-Fe were the promising parameters to develop the predictive models for diclofenac adsorption onto minerals and soils, respectively.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Li Zhang,Yongsheng Fu,Zhenran Wang,Gaofeng Zhou,Runyu Zhou,Yiqing Liu
In this work, the degradation kinetics and mechanism of diclofenac (DCF) using peracetic acid (PAA) activated by zero valent copper (ZVC) were systematically investigated. It was found that PAA could be catalyzed effectively by ZVC to produce HO • , CH 3 COO • and CH 3 COOO • , which were responsible for the removal of DCF. Based on the XPS, XRD and FESEM characterization results of ZVC before and after reaction, the corrosion of ZVC was occurred to produce Cu + under acidic condition, which was the main activator for PAA, H 2 O 2 and O 2 . The recommended pH for this reaction system was 3.0, and DCF degradation was enhanced gradually with increasing ZVC dose and PAA dose. The existence of Cl - , CO 3 2– , Fe 3+ , Cu 2+ and dissolved organic matter (DOM) promoted DCF degradation in ZVC/PAA system, while SO 4 2- and NO 3 – had almost no influence on DCF removal. Six intermediates were identified in this system, and the probable degradation mechanism of DCF was thus proposed, including seven transformation pathways, i.e., hydroxylation, amidation, dechlorination-cyclizaiton, dechlorination-hydrogenation, dechlorination-hydroxylation, decarboxylation and formylation. This study provides a new method for PAA activation and DCF removal from the polluted water.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2020
·Vol. 413
·期 1
·193-203
·
IF 3.637
Yang Liwei,Li Lele,Li Fen,Zheng Hejie,Li Tongtong,Liu Xiaoqiang,Zhu Jichun,Zhou Yanmei,Alwarappan Subbiah
Herein, a photoelectrochemical (PEC) aptasensing platform was designed by integrating surface oxygen vacancy (OV) defects, Ti 3+ self-doping, the heterojunction, and resonance energy transfer (RET) effect into one platform for the detection of diclofenac sodium (DCF). Briefly, OV defects were introduced on TiO 2 nanospheres with simultaneous Ti 3+ self-doping, followed by a well-separated deposition of FeVO 4 nanoparticles on TiO 2 to obtain a Ti 3+ -O-TiO 2 /FeVO 4 heterojunction. The surface modification of OVs, Ti 3+ doping, and deposition of FeVO 4 were confirmed by SEM, XPS, EPR, DRS, and PEC measurements. The surface OVs and doping of Ti 3+ species created a new donor (defect) energy level under the conduction band of TiO 2 , which minimized the bandgap and thereby improved the visible light absorption of TiO 2 . Moreover, the capture of photo-excited electrons by surface OVs could hinder the electron-hole recombination. Due to the intimate surface contact and perfect energy matching between TiO 2 and FeVO 4 , the formation of heterojunction decreased the bandgap and facilitated the electron-hole separation of TiO 2 . All these above events contributed to the enhancement of the PEC signals, which were then quenched by the RET effect between Ti 3+ -O-TiO 2 /FeVO 4 and Au nanoparticle (AuNP)–labeled cDNA that had been attached to its complementary DCF aptamer on Ti 3+ -O-TiO 2 /FeVO 4 |ITO. The addition of target-DCF detached AuNP-labeled cDNA from the electrode to recover the photocurrent, resulting in a “signal-on” PEC aptasensor that exhibited a 0.1–500-nM linear range and a detection limit of 0.069 nM for DCF, attributed to the excellent amplification of the proposed aptasensing platform.
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Journal of Composites Science
·
2025
·Vol. 9
·期 12
·663
·
IF 3.7
Xiaoyi Gou,Zia Ahmad,Zaijin You,Zhou Ren
The removal of water pollutants with high selectivity and efficiency is still a huge challenge owing to the complex composition of contaminated water. The preparation, modification of Pickering emulsion microspheres, and their application in the adsorption and removal of non-steroidal anti-inflammatory drugs (diclofenac) in water were studied. Poly(2-(diethylamino)ethyl methacrylate-divinylbenzene), (P(DEAEMA-DVB)) microspheres were prepared by Pickering emulsion polymerization. The P(DEAEMA-DVB) polymer was modified with glycidyl trimethylammonium chloride (GTAC) and phenyl glycidyl ether (PGE) to prepare the adsorbent poly(quaternized and phenyl-functionalized) (P(QP-DVB)) with a substantial quantity of quaternary ammonium functional groups. The non-steroidal anti-inflammatory drugs in aqueous solution was mainly adsorbed by the anion exchange interaction with quaternary ammonium species. The adsorption kinetics coincided with the pseudo-second-order kinetic model, and the adsorption isotherm conformed to the Langmuir isotherm model. The optimized P(QP-DVB) particles exhibited well-defined spherical morphology and a uniform particle size distribution ranging from 15 to 30 µm. Nitrogen adsorption/desorption characterization revealed a high specific surface area of 674 m2g−1and a pore size distribution from 2 to 25 nm. In addition, the aforementioned microsphere underwent chemical regeneration and exhibits good reusability, thereby reducing both the economic costs and environmental impacts.
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Journal of Water Process Engineering
·
2026
·
IF 6.6
Lei Cui,Kun Ye,Hao-Yang He,Bing Li
Polyquaternium modified hydrochar was prepared via free radical grafting. • PQHC exhibits high adsorption capacities for MO/DS (660.89/615.32 mg·g −1 ). • PQHC maintains high performance in real water matrices (tap and river water). • Adsorption mechanism was dominated by electrostatic attraction and anion exchange. The widespread use of anionic pharmaceuticals and dyes has led to serious water pollution. As a biosorbent for water treatment, hydrochar shows poor affinity for anionic contaminants due to its negative surface charge, limiting its practical applicability. In this study, a novel cationic polyquaternium-functionalized hydrochar (PQHC) was synthesized via radical graft polymerization of (3-methacrylamidopropyl)trimethylammonium chloride (MAPTAC) onto hydrochar for removal of these anions. PQHC maintained a stable positive charge over a broad pH range (2−12), and achieved exceptional adsorption capacity for representative anionic pollutants such as diclofenac sodium (DS) and methyl orange (MO). The adsorption capacities for DS and MO maximized to 615.32 and 660.89 mg·g −1 , respectively. Kinetic studies demonstrated exceptionally rapid adsorption, with the uptakes of MO and DS (at 400 and 200 mg·L −1 , respectively) attaining 97.8% and 95.8% of their equilibrium values within the first 5 min. Characterizations revealed a multifaceted adsorption mechanism centered on electrostatic attraction and Cl − /pollutant anion exchange, synergistically enhanced by hydrogen bonding and n/π-π interactions. In addition, PQHC removed both pollutants at high rates in tap water and river water. Thus, this work develops a rapid and efficient biosorbent for capturing anionic pollutants from complex wastewater, and proposes a facile and efficient modification method for preparing cationic-functionalized hydrochars with great potential for practical water treatment applications. Download: Download high-res image (213KB) Download: Download full-size image
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2018
·
IF 2.88
Tao Liu,Zhihai Xie,Qing Liu
A sensitive, simple and novel method was developed to determine diclofenac sodium (DS) using silver nanoparticles (AgNPs) as probe by resonance light scattering (RLS) technique. It was found that DS could quench the RLS intensity of AgNPs . Moreover, the decrease in RLS intensity was linearly correlated to the concentration of DS over the range of 0.01–2.0 μg mL −1 . DS can be measured in a short time (5 min) without any complicated or time-consuming sample pretreatment process. Parameters that affect the RLS intensities such as pH, concentration of AgNPs, reaction time, electrolyte concentration , and coexisting substances were systematically investigated and optimized. The results showed that the method had a very good selectivity and could be used conveniently for the determination of DS. The limit of detection (LOD) was 2.85 ng mL −1 (3σ), and the relative standard deviation (RSD) was less than 3.6% ( n = 6). Possible mechanism for the RLS changes of AgNPs in the presence of DS was discussed and the method was successfully applied for the analysis of tablets and urine samples.
研究领域:
分析化学
·
纳米技术
·
药物分析
·
环境监测
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JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Xian-Rui Zhang,Xian-Ying Xie,Yan Liu,Lu-Ting Jiang,Hong-Mei Yang,Lei Gao
This study aimed to overcome the poor aqueous solubility of diclofenac (DIC), a BCS Class II drug, through the strategic formation of amine salts. Three novel salts with diisopropylamine (DIP), butanolamine (BUTA), and tromethamine (TRIS) were successfully synthesized and comprehensively characterized. Single-crystal X-ray diffraction revealed distinct hydrogen-bonded networks for each salt, ranging from cyclic tetramers (DIC-DIP) to extended three-dimensional frameworks (DIC-BUTA, DIC-TRIS). Solid-state characterization by PXRD, DSC and FTIR spectroscopy confirmed the formation of new, phase-pure crystalline materials, with FTIR clearly showing the disappearance of the carboxylic C=O band and the appearance of carboxylate bands, confirming proton transfer. The salts demonstrated dramatically enhanced equilibrium solubility and intrinsic dissolution rates (IDR) compared to the parent DIC, particularly in water. The most significant improvements were observed for DIC-BUTA and DIC-DIP, achieving solubility increases of 213.0-fold and 146.4-fold, and IDR increases of 276.0-fold and 222.7-fold, respectively. The superior dissolution performance of DIC-BUTA and DIC-DIP is correlated with their moderate hydrogen-bond networks (5 and 3 donor bonds, respectively) and lower crystal densities (1.326 and 1.262 g/cm³), which facilitate easier lattice disruption and solvation. Conversely, the densely packed, highly hydrogen-bonded structure of DIC-TRIS resulted in the highest lattice stability but the most modest solubility enhancement. All salts exhibited congruent dissolution without phase transformation. This work establishes DIC-BUTA and DIC-DIP as the most promising candidates for developing rapid-release oral formulations of diclofenac and provides fundamental insights into the structure-property relationships governing salt solubility.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 5
·11959-11977
·
IF 5.19
He Haonan,Zhao Junfeng
In this study, the degradation efficiency and reaction mechanisms of diclofenac (DCF), a nonsteroidal anti-inflammatory drug, by the combination of ferrate (Fe(VI) and peroxymonosulfate (PMS) (Fe(VI)/PMS) were systematically investigated. The higher degradation efficiency of DCF in Fe(VI)/PMS system can be obtained than that in alone persulfate (PS), Fe(VI), PMS, or the Fe(VI)/PS process at pH 6.0. DCF was efficiently removed in Fe(VI)/PMS process within a wide range of pH values from 4.0 to 8.0, with higher degradation efficiency in acidic conditions. The increasing reaction temperature (10 to 30 ℃), Fe(VI) dose (6.25 to 100 µM), or PMS concentration (50 to 1000 µM) significantly enhanced the DCF degradation. The existences of HCO 3 ¯, Cl¯, and humic acid (HA) obviously inhibited the DCF removal. Electron paramagnetic resonance (EPR), free radical quenching, and probing experiments confirmed the existence of sulfate radicals (SO 4 • ¯), hydroxyl radicals ( • OH), and Fe(V)/ Fe(IV), which are responsible for DCF degradation in Fe(VI)/PMS system. The variations of TOC removal ratio reveal that the adsorption of organics with ferric particles, formed in the reduction of Fe(VI), also were functioned in the removal process. Sixteen DCF transformation byproducts were identified by UPLC-QTOF/MS, and the toxicity variation was evaluated. Consequently, eight reaction pathways for DCF degradation were proposed. This study provides theoretical basis for the utilization of Fe(VI)/PMS process. Graphical abstract
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CHEMOSPHERE
·
2021
·
IF 7.086
Xiaoyi Xu,Zhimin He,Hui Tang,Yidong Sun,Shuyuan Zhang,Dezhi Shi,Fangying Ji
In this study, using furfuryl alcohol as the precursor carbon and mesoporous silica as the template, and furfuryl alcohol-derived mesoporous carbon (FMC) was prepared. The specific surface area of FMC was 1022.61 m 2 /g, the pore volume was 1.71 cm 3 /g, and the mesoporous volume was 98.8%. Based on the adsorption kinetics of pharmaceuticals onto the FMC in synthetic urine, equilibrium adsorption was reached in 120 min, and it followed a pseudo-second-order model. The adsorption isotherms were well-fitted by the Sips isotherm model, and the saturated adsorption capacities of diclofenac and oxytetracycline in fresh urine were 411.8 mg/g and 465.9 mg/g, respectively. Batch experiment results showed that pharmaceutical removal was strongly influenced by urine components such as sodium chloride, urea, and ammonium hydroxide. The adsorption of diclofenac and oxytetracycline was influenced by many factors including π-π interactions, hydrogen bonds , and electrostatic forces. FMC exhibited excellent reusability and retained urine nutrients during pharmaceutical adsorption.
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PHARMAZIE
·
2014
·Vol. 69
·期 12
·898-903
·
IF 1.003
Xia Meng-Ming,Wang Li,Pan Pei-Pei,Wang Hai-Yun,Chen Meng-Chun,Chen Yi,Dai Da-Peng,Cai Jian-Ping,Hu Guo-Xin
CYP2C9 is one of four known members of the human cytochrome P450 CYP2C superfamily, with at least 57 CYP2C9 alleles being previously identified. Genetic polymorphisms of CYP2C9 significantly influence the efficacy and safety of some drugs, which might cause adverse effects and therapeutic
failure. The purpose of the present study was to clarify the role of 36 CYP2C9 alleles, 21 novel alleles (*36-*56) found in the Chinese population, in the oxidative metabolism of diclofenac in vitro. Insect microsomes expressing the 36 human CYP2C9 alleles were incubated with 2-100
μM diclofenac for 30 min at 37°C and terminated by the addition of 30 μL 0.1 M HCl. Diclofenac and 4'-hydroxyl (OH)-diclofenac, the major diclofenac metabolite, were analyzed by high-performance liquid chromatography (HPLC). Compared with wild-type CYP2C9*1, most variants
showed significantly altered values in Vmax, Km and intrinsic clearance (Vmax/Km). Only one variant exhibited markedly increased intrinsic clearance value, whereas 31 variants exhibited significantly decreased values. Thus, this study demonstrated
that more attention should be given to subjects carrying these CYP2C9 alleles when administering diclofena.
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ELECTROANALYSIS
·
2015
·Vol. 28
·期 1
·76-82
·
IF 2.138
Otieno Kevin Okoth,Kai Yan,Lan Liu,Jingdong Zhang
A simple but sensitive electrochemical method was proposed for simultaneous determination of paracetamol (PCT) and diclofenac (DCF) based on poly(diallyldimethylammonium chloride) (PDDA) functionalized graphene (GR). Although GR enhanced the electro-oxidation peak currents of PCT and DCF, the peak potential difference between two drugs was reduced. By contrast, PDDA-GR greatly increased the electrochemical currents of both analytes while provided well-separated peak potentials. Thus, the voltammetric behavior and simultaneous electrochemical determination of PCT and DCF were investigated on PDDA-GR. The applicability of the proposed method was verified when it was applied in determination of PCT and DCF in pharmaceuticals and lake water.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Chen Wang,Jinlai Cheng,Lixia Song,Ziyu Zhou,Qinghe Zhao,Yu Zhao,Huajing Wang,Yuqing Tan,Baosheng Zhao,Miyi Yang
A novel therapeutic approach combining acupuncture and diclofenac sodium (DS) administration was established for the potential treatment for rheumatoid arthritis (RA). DS is a commonly used anti-inflammatory and analgesic drug but has short duration and adverse effects. Acupoints are critical linkages in the meridian system and are potential candidates for drug delivery. Herein, we fabricated a DS-loaded multilayer-modified acupuncture needle (DS-MMAN) and investigated its capacity for inhibiting RA. This DS-MMAN possesses sustained release properties and in vitro anti-inflammatory effects. Experimental results showed that the DS-MMAN with microdoses can enhance analgesia and efficiently relieve joint swelling compared to the oral or intra-articular administration of DS with gram-level doses. Moreover, the combination of acupoint and DS exerts a synergistic improvement in inflammation and joint damage. Cytokine and T cell analyses in the serum indicated that the application of DS-MMAN suppressed the levels of pro-inflammatory factors and increased the levels of anti-inflammatory factors. Furthermore, the acupoint administration via DS-MMAN could decrease the accumulation of DS in the liver and kidneys, which may express better therapeutic efficiency and low toxicity. The present study demonstrated that the acupuncture needle has the potential to build a bridge between acupuncture and medication, which would be a promising alternative to the combination of traditional and modern medicine.
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