Journal of Advanced Research
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2021
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IF 10.479
Min Mu,Haifeng Chen,Rangrang Fan,Yuelong Wang,Xin Tang,Lan Mei,Na Zhao,Bingwen Zou,Aiping Tong,Jianguo Xu,Bo Han,Gang Guo
Introduction Numerous options for treatment of glioblastoma have been explored; however, single-drug therapies and poor targeting have failed to provide effective drugs. Chemotherapy has significant antitumor effect, but the efficacy of single-drug therapies in the clinic is limited over a long period of time. Thus, novel therapeutic approaches are necessary to address these critical issues. Objectives The present study, we investigated a tumor-specific metal-tea polyphenol-based cascade nanoreactor for chemodynamic therapy-enhanced chemotherapy. Methods HA-EGCG was synthesized for the first time by introducing epigallocatechin-3-gallate (EGCG) into the skeleton of hyaluronic acid (HA) with reducible disulfide bonds. A rapid and green method was developed to fabricate the metal-tea polyphenol networks (MTP) with an HA-EGCG coating ( [email protected] /HA-EGCG) based on Fe 3+ and EGCG for targeted delivery of doxorubicin hydrochloride (DOX). GL261 cells were used to evaluate the antitumor efficacy of the [email protected] /HA-EGCG nanoreactor in vitro and in vivo . Results [email protected] /HA-EGCG nanoreactors were able to disassemble, resulting in escape of their components from lysosomes and precise release of DOX, Fe 3+ , and EGCG in the tumor cells. HA-EGCG depleted glutathione to amplify oxidative stress and enhance chemodynamic therapy. The results of in vivo experiments suggested that [email protected] /HA-EGCG specifically accumulates at the CD44-overexpressing GL261 tumor sites and that sustained release of DOX and Fe 3+ induced a distinct therapeutic outcome. Conclusions The findings suggested the developed nanoreactor has promising potential as a future GL261 glioblastoma therapy.
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ACS Omega
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2022
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IF 4.132
Nan Zhang,Chaoren Yan,Changji Yin,Xiaoling Hu,Ping Guan,Yuan Cheng
Numerous therapeutic agents and strategies were designed targeting the therapies of Alzheimer’s disease, but many have been suspended due to their severe clinical side effects (such as encephalopathy) on patients. The attractiveness for small molecules with good biocompatibility is therefore restarted. Epigallocatechin-3-gallate (EGCG), extracted from green tea, is expected to be a promising small-molecule drug candidate, which can remodel the structure of preformed β-sheet-rich oligomers/fibrils and then effectively interfere with neurodegenerative processes. However, as the structure of non-fibrillary aggregates cannot be directly characterized, the atomic details of the underlying inhibitory and destructive mechanisms still remain elusive to date. Here, all-atom molecular dynamics simulations and experiments were carried out to elucidate the EGCG-induced remodeling mechanism of amyloid β (Aβ) fibrils. We showed that EGCG was indeed an effective Aβ fibril inhibitor. EGCG was capable of mediating conformational rearrangement of Aβ1–42 fibrils (from a β-sheet to a random coil structure) and triggering the disintegration of fibrils in a dose-dependent manner. EGCG redirected the structure of Aβ by breaking the β-sheet structure and hydrogen bonds between peptide chains within the Aβ protofibrils, especially the parallel β-strand (L17VFFAEDVGS26). Moreover, reduced solvent exposure and multisite binding patterns all tended to induce the conformation conversion of Aβ17–42 pentameric protofibrils, destroying pre-formed fibrils and inhibiting continued fibril growth. Detailed data analysis revealed that structural features of EGCG with abundant benzene ring and phenolic hydroxyl moieties preferentially interact with the parallel β-strands to effectually hinder the interaction of the interpeptide chain and the growth of the ordered β-sheet structure. Furthermore, experimental studies confirmed that EGCG was able to disaggregate the preformed fibrils and alter the protein structure. This study will enable a deeper understanding of fundamental principles for design of structural-based inhibitors.
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高影响因子
CHEMISTRY OF NATURAL COMPOUNDS
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2019
·Vol. 55
·期 6
·1080-1084
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IF 0.567
Yu Pan,Li Dong-dong,Ni Jun-jun,Xia Chao-jie,Wang Zhen-zhong,Xiao Wei,Ding Gang,Zhao Lin-guo
Four novel betulinic acid (BA) derivatives modified at the C-3 position were prepared by the Mitsunobu reaction and subsequently evaluated for antitumor activity against four common cancer cell lines in vitro. The results from the MTT assay revealed that the four tested compounds showed remarkable cytotoxic activity against four cancer cell lines, much better than BA. Western blotting results indicated that the four compounds, especially compound 2c , caused a significant up-regulation expression of the caspase-12 in CT26 cell. Our results showed that configuration inversions of chiral C-3 of BA could also produce BA derivatives with potent antitumor activity.
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ELECTROCHIMICA ACTA
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2016
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IF 4.803
Zhangxing He,Yingqiao Jiang,Wei Meng,Jing Zhu,Yang Liu,Lei Dai,Ling Wang
In this paper, LiTi 2 (PO 4 ) 3 @N-doped carbon anode has been synthesized by in situ carbon coating approach. The well-proportioned N-doped carbon layer and loose nanoporous structure was obtained by using urea as nitrogen source and pore former. LiTi 2 (PO 4 ) 3 @N-doped carbon as anode demonstrates much better rate capability than LiTi 2 (PO 4 ) 3 @carbon in ALIBs. The optimized anode delivers the discharge capacity of 93.7 mAh g −1 and 74.2 mAh g −1 at rates of 10C and 20C, 22.5 mAh g −1 and 50.0 mAh g −1 larger than that of LiTi 2 (PO 4 ) 3 @carbon. Moreover, LiTi 2 (PO 4 ) 3 @N-doped carbon exhibits excellent cycling performance with capacity retention of 84.3% at 5C after 1000 cycles. As verified, the well-proportioned N-doped carbon layer could reduce charge transfer resistance and improve electrical conductivity. The loose nanoporous structure could shorten pathway and facilitate diffusion for Li ion. Therefore, LiTi 2 (PO 4 ) 3 @N-doped carbon gets the superior electrochemical properties benefiting from those two characteristics.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Zhongyin Chen,Hui Cai,Xiao Zhang,Meng Zhang,Ge-Fei Hao,Zhichao Jin,Shichao Ren,Yonggui Robin Chi
To discover protoporphyrinogen oxidase (PPO) inhibitors with robust herbicidal activity and crop safety, three types of substituted 3-(pyridin-2-yl)phenylamino derivatives bearing amide, urea, or thiourea as side chain were designed via structure splicing strategy. Postemergence herbicidal activity assessment of 33 newly prepared compounds revealed that many of our compounds such as 6a, 7b, and 8d exhibited superior herbicidal activities against broadleaf and monocotyledon weeds to commercial acifluorfen. In particular, compound 8d exhibited excellent herbicidal activities and high crop safety at a dosage range of 37.5–150 g ai/ha. PPO inhibitory studies supported our compounds as typical PPO inhibitors. Molecular docking studies revealed that compound 8d provided effective interactions with Nicotiana tabacum PPO (NtPPO) via diverse interaction models, such as π–π stacking and hydrogen bonds. Molecular dynamics (MD) simulation studies and degradation studies were also conducted to gain insight into the inhibitory mechanism. Our study indicates that compound 8d may be a candidate molecule for the development of novel herbicides.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2017
·Vol. 29
·期 3
·1817-1822
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IF 2.019
Wang Zixing,Yuan Changlai,Zhu Baohua,Feng Qin,Liu Fei,Miao Lei,Zhou Changrong,Chen Guohua
A novel microwave dielectric ceramics Bi(Sc 1/3 Mo 2/3 )O 4 with low firing temperature were prepared via the solid reaction method. The specimens have been characterized using scanning electron microscopy, X-ray diffraction, Raman spectroscopy and DC conductivity. The Bi(Sc 1/3 Mo 2/3 )O 4 ceramics showed B-site ordered Scheelite-type structure with space group C2/c. Raman analysis indicated that prominent bands were attributed to the normal modes of vibration of MoO 4
2− tetrahedra. The dielectric loss of Bi(Sc 1/3 Mo 2/3 )O 4 ceramics can be depended strongly the bulk conductivity by DC measurement. The superior microwave dielectric properties are achieved in the Bi(Sc 1/3 Mo 2/3 )O 4 ceramic sintered at 875 °C/4 h, with dielectric constant ~ 25, Q × f ~ 51,716 GHz at 6.4522 GHz and temperature coefficient of resonance frequency ~ − 70.4 ppm/°C. It is a promising microwave dielectric material for low-temperature co-fired ceramics technology.
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JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
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2024
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IF 2
Zhen Qin,Qiang-qiang Chu,An-lan Ding,Chuan-Ying Li,Mao-yan Zhang
Sirtuin 3 involved in development of various diseases, but its role in inflammatory bowel disease is still unknown. We used inflammatory bowel disease biopsies, colitis animal model, and vitro cells RAW264.7 to study the role of Sirtuin 3 in the pathophysiology of inflammatory bowel disease. Sirtuin 3 negatively correlated with intestinal TNF-α. Sirt3 was less pronounced in pediatric and adult inflammatory bowel disease patients compared with corresponding control group. Sirtuin 3 activator Honokiol suppressed dextran sulfate sodium induced colonic manifestations, while Sirt3 inhibitor caused opposite results. Honokiol inhibited colonic oxidative stress by and reduced intestinal permeability. Honokiol repressed inflammatory response by reducing macrophage infiltration, pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 levels, and inhibiting activation of NF-κB p65 in the colitis mice. However, Sirt3 inhibitor amplified colonic oxidative stress and inflammatory response. In vitro study, Sirt3 inhibitor or siRNA Sirtuin 3 activated NF-κB p65 and enhanced TNF-α, IL-1β, and IL-6 secretion from LPS stimulated RAW264.7, while Honokiol remarkably attenuated these pro-inflammatory cytokines secretion. Finally, knockdown of Sirt3 in Caco-2 cells enhanced TNF-α induced intestinal barrier integrity injury. Sirtuin 3 negatively regulates inflammatory bowel disease progression via reducing colonic inflammation and oxidative stress. Sirtuin 3 is a promising therapeutic target in clinical application for inflammatory bowel disease therapy.
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Cell Metabolism
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2024
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IF 27.7
Wei Wei,Yali Liu,Yuanlong Hou,Shuqi Cao,Zhuo Chen,Youying Zhang,Xiaoying Cai,Qingyuan Yan,Ziguang Li,Yonggui Yuan,Guangji Wang,Xiao Zheng,Haiping Hao
The brain and gut are intricately connected and respond to various stimuli. Stress-induced brain-gut communication is implicated in the pathogenesis and relapse of gut disorders. The mechanism that relays psychological stress to the intestinal epithelium, resulting in maladaptation, remains poorly understood. Here, we describe a stress-responsive brain-to-gut metabolic axis that impairs intestinal stem cell (ISC) lineage commitment. Psychological stress-triggered sympathetic output enriches gut commensal Lactobacillus murinus, increasing the production of indole-3-acetate (IAA), which contributes to a transferrable loss of intestinal secretory cells. Bacterial IAA disrupts ISC mitochondrial bioenergetics and thereby prevents secretory lineage commitment in a cell-intrinsic manner. Oral α-ketoglutarate supplementation bolsters ISC differentiation and confers resilience to stress-triggered intestinal epithelial injury. We confirm that fecal IAA is higher in patients with mental distress and is correlated with gut dysfunction. These findings uncover a microbe-mediated brain-gut pathway that could be therapeutically targeted for stress-driven gut-brain comorbidities.
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高影响因子
OPTICAL MATERIALS
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2024
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IF 3.8
Qian Qiao,Tongge Zhao,Jian Zheng,Huiting Yin,Yuan Zhang,Jinhao Zang,Xun Yang,Haoyu Li,Taotao Rao,Xuan Yu,Xiaoming Yu
Self-powered poly (3-hexylthiophene)/zinc oxide (P3HT/ZnO) heterojunction ultraviolet photodetectors decorated by silver nanoparticles (Ag NPs) were fabricated by sol-gel and spin-coating techniques. The ultraviolet photoresponse performance of the P3HT/ZnO heterojunction photodetectors influenced by the position of plasmonic Ag NPs was investigated. The responsivity and detectivity of the P3HT/Ag/ZnO photodetector with placed Ag NPs at the interface of ZnO and P3HT layers enhanced to 1.92 and 1.15 times compared to the reference devices. When the Ag NPs embedded into ZnO layer , the responsivity, detectivity and external quantum efficiency were 16.42 mA/W, 5.97 × 10 11 Jones, and 5.36 %, respectively, which were 5.77 times, 4.64 times and 5.77 times to that of the pristine P3HT/ZnO photodetector. The enhancement mechanism of plasmonic metallic nanoparticles to the performance of the photodetectors was discussed in details. This study presents a simple route to high performance self-powered photodetectors.
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ChemCatChem
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2024
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IF 3.8
Siyang Yan,Ruilin Feng,Jiaxu Liu,Chenxi Bai,Yanlong Qi
Graphical The dehydration of 2,4-pentanediol to unsaturated alcohol was performed over ceria-based catalysts with high selectivity. A stereocatalytic effect of CeO 2 catalyst was observed for the production of trans -3-penten-2-ol, with negligible content of cis -3-penten-2-ol. The transformation of biobased alkanediols over heterogeneous catalysts is a major object. Here, a series of catalysts were prepared for 2,4-pentanediol dehydration to 3-penten-2-ol. Ceria-based catalysts had a unique property of showing high efficiency. More importantly, a stereocatalytic effect was observed for CeO 2 , yielding trans -3-penten-2-ol with a high selectivity. Raman, XPS, TPD, and TPR were carried out to clarify the catalyst structure, and the relationship between the catalyst structure and catalytic performance were studied. The amount of Lewis acid sites can hardly be correlated with the total concentrations of the oxygen vacancies. It was suggested that the geometry structure of the active sites played a crucial role in trans -3-penten-2-ol production. The oxygen vacancies originating from CeO 2 consisted of active sites with a geometrical structure, which were different from those created by Pr doping CeO 2 . In addition, the Pr doping enhanced the oxygen migration, which resulted in side reactions, consequently, giving a lower selectivity to trans -3-penten-2-ol.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
·
IF 2.1
Mingya Wang,Hongxia Pan,Yongzheng Liu,Jun Chen,Duanlin Cao,Linxiu Zhao
3(5)-Nitropyrazole is obtained by rearrangement of 1-nitropyrazole in high boiling organic solvents. In this paper, the solubility of 3(5)-nitropyrazole in 12 high boiling solvents (anisole, benzonitrile, mesitylene, o-dichlorobenzene, 1-octanol, benzyl alcohol, 2-ethylhexyl acetate, dimethyl glutarate, cyclohexanone, N,N-dimethylformamide, N-methylformamide, and isophorone) was determined using the static gravimetric method over the temperature range of 283.15–323.15 K. The experimental results revealed that the solubility of 3(5)-nitropyrazole exhibited a positive correlation with temperature. Under ambient conditions at 298.15 K, the solubility decreased in the following order: N,N-dimethylformamide (37.705 × 10–2), N-methylformamide (20.131 × 10–2), cyclohexanone (13.469 × 10–2), isophorone (11.957 × 10–2), dimethyl glutarate (6.667 × 10–2), benzyl alcohol (3.909 × 10–2), benzonitrile (2.915 × 10–2), 1-octanol (1.916 × 10–2), 2-ethylhexyl acetate (1.220 × 10–2), o-dichlorobenzene (0.666 × 10–2), anisole (0.688 × 10–2), and mesitylene (0.246 × 10–2). The solubility of 3(5)-nitropyrazole was fitted using the Apelblat equation, λh equation, NRTL model, and van’t Hoff model. The fitting results were evaluated using average relative deviation and RMSD. The NRTL model exhibited the best overall performance. The use of Hansen solubility parameters for solubility prediction and analysis has certain limitations.
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JOURNAL OF MATERIALS SCIENCE
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2025
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IF 3.9
Gao Minjie,Yang Zongmei,Song Senchuan,Liu Xigui,Wang Fei
A series of Pd/N-doped graphene catalysts were designed for the efficient and highly selective synthesis of muscone through the hydrogenation of 3-methylcyclopentadecenone (XT). The catalysts were characterized using FT-IR, BET, XPS, XRD, Raman and SEM–EDS. All results indicated the uniform dispersion of Pd on NG. By optimizing reaction conditions, the hydrogenation of XT achieved a high yield and selectivity of muscone, producing a 99% yield at 2 MPa H 2 and 90 °C in 10 h using a 10 wt% Pd/N-doped graphene catalyst functionalized with melamine (Pd/NmG), which significantly outperformed conventional Pd/C catalysts. Graphical abstract
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