INDUSTRIAL CROPS AND PRODUCTS
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2025
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IF 6.2
Xu Dong,Liping Chen,Danjie Xu,Jian Zhang,Fang Hu,Qingwei Ping
Considering the non-renewable and non-biodegradable characteristics of conventional petroleum-based plastic films, their widespread use contributes significantly to environmental degradation. This study utilizes a green synthesis citrate-based chemical cross-linking strategy to improve the dispersion of ethanol lignin within the film, thereby promoting the development of a natural, safe, renewable, biodegradable, and environmentally friendly biomass-based functional food packaging material. A novel, multifunctional green food preservation film (ELA x C) was synthesized by employing CMC film as the substrate, ethanol lignin (EL) as the functional agent, and citric acid (CA) as the cross-linking agent. The influence of CA addition on the properties of the film was systematically examined. The results indicated that the ELA 0.2 C film exhibited an optimal elongation at a break of 8.0 %, a tensile strength of 28.49 MPa, and outstanding UV-blocking performance, effectively blocking 100 % of UVB and 99.2 % of UVA radiation. Furthermore, the ELA 0.2 C film exhibits antioxidant properties, gas barrier performance, and biodegradability. This film demonstrates significant potential as a multifunctional cling film for apple slices. Moreover, EL can be directly applied as a functional agent without the need for re-dissolution, thereby offering an innovative pathway for the efficient and environmentally sustainable utilization of lignin.
研究领域:
食品科学与技术
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高分子材料
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绿色化学
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可持续包装
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木质素利用
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Xin Jiang,Siyu Yuan,Jie Yang,Hui Liao,Hansong Wu,Baolin Jiang,Kun Qian
Drug cocrystal can not only improve the physicochemical properties of drugs but also exert a synergistic effect without altering the original structure of drugs. Herein, we successfully synthesized a norfloxacin-kaempferol cocrystal hydrate (cocrystal 1 ) from an antibacterial drug and a flavonoid active ingredient. Compared with norfloxacin or kaempferol alone, cocrystal 1 enhanced antibacterial activity against Gram-positive bacteria ( S. aureus ), Gram-negative bacteria ( K. pneumoniae and P. aeruginosa ), and fungus ( C. albicans ). Meanwhile, cocrystal 1 enhanced the antioxidant activity of kaempferol and also improved the solubility of norfloxacin and kaempferol. Moreover, cocrystal 1 enhanced the anticancer activity against human breast cancer cells MDA-MB-231, colon cancer cells SW480 and lung cancer cells H1299.
研究领域:
药学
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药物化学
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晶体工程
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抗菌研究
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癌症药理学
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产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Jing Zhang,Yuxiao Wang,Na Li,Lin Gao,Dongxu Zhang,Hongxun Tao,Rentang Zhang
Previous studies demonstrated that the blackening process could enhance the bioactivity of jujubes while it could also lead to uncontrolled Maillard reactions, potentially compromising product quality. To address this, we investigated how exogenous anthocyanin regulated the Maillard pathway and promoted desirable aroma formation during the fermentation of blackened jujube wine. Results showed that exogenous anthocyanin reduced the 5-hydroxymethylfurfural content in blackened jujube wine from 1.18 mg/L to 0.82 mg/L, suggesting a potential interaction with Maillard intermediates or 5-hydroxymethylfurfural. Moreover, the contents of bioactive compounds increased during the fermentation. HS-SPME-GC-MS analysis identified that a crucial phase for flavor development occurred on day 6 of fermentation, with ester compounds peaking at 7658.19 μg/L. Among these, ethyl caprylate and ethyl caprate were the predominant flavor compounds. The addition of exogenous anthocyanin increased the concentration of total volatile compounds in blackened jujube wine, resulting in a rich fruity and floral aroma at the end of fermentation. These results elucidate the mechanistic role of exogenous anthocyanin in modulating the Maillard pathway and aroma formation, providing a theoretical foundation for optimizing blackened jujube wine quality.
研究领域:
食品科学与技术
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酿酒与发酵技术
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风味化学
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植物化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiaoyi Zheng,Yijie Xie,Linlin Zhao,Xiaojuan Huang,Shige Wang,Yongkang Lai,Peng Fan,Yanbo Zeng,Jiulong Zhao,Zhaoshen Li
This study developed a chitosan (CS)‑sodium tripolyphosphate (TPP)‑zinc (Zn) nanogel for treating Helicobacter pylori ( H. pylori ) through synergistic antibacterial, anti-inflammatory, and mucosal repair mechanisms. The nanogel was synthesized via an emulsion method, leveraging electrostatic interactions between CS amino groups and TPP phosphate ions, followed by Zn incorporation. Characterization revealed uniform spherical nanoparticles (~200 nm) with high Zn content (20.18 %) and controlled hydrogen (H 2 ) and Zn 2+ release (15 h) in acidic environments. In vitro assays demonstrated potent antibacterial activity against H. pylori (95.83 % inhibition at pH = 2; 28.54 % inhibition at pH = 7) attributed to Zn 2+ -mediated enzyme disruption. The nanogel exhibited significant antioxidant capacity, scavenging 82.3 % of PTIO and 65.48 % of DPPH radicals. Biocompatibility testing confirmed minimal haemolysis (<5 %) and high cell viability (>95 %). In vivo studies in H. pylori -infected mice demonstrated a bacterial inhibition rate of 97.54 % through upregulation of β-catenin and tight junction proteins. Concurrently, mucosal repair was enhanced, achieving migration rates of 44.2 ± 5.6 % and 72.34 ± 2.1 % at 12 and 24 h respectively. The nanogel also preserved gut microbiota diversity post-treatment, unlike conventional antibiotics. This multifunctional nanogel platform combines biocompatibility, ease of manufacture and dual therapeutic effects. In summary, this study proposes a multifunctional therapeutic strategy capable of simultaneously addressing H. pylori infection, gastric inflammation and mucosal damage. It offers a paradigm shift from traditional antibiotic-centred therapies, providing a promising strategy for eradicating Helicobacter pylori and restoring gastric injury.
研究领域:
纳米医学
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胃肠病学
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抗菌治疗
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药物递送
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生物材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2025
·
IF 11.5
Baojin Tan,Weilin Yang,Guanglin Zhang,Rong Zeng
Acute lung injury (ALI), a life-threatening inflammatory syndrome driven by macrophage polarization imbalance, triggers uncontrolled cytokine storms and alveolar-capillary barrier collapse. While macrophage-targeted immunomodulation holds therapeutic promise, current strategies suffer from imprecise cellular targeting and inadequate functional reprogramming. To address this, we developed an inhaled biomimetic apoptotic body-mimicking nanoplatform (CeCPT@PSL). Its phosphatidylserine-containing liposomal (PSL) shell replicates the “eat-me” signaling of apoptotic bodies to enable macrophage targeting and immunomodulation. Inspired by the organelle-regulating capacity of apoptotic cargo, the encapsulated synthetic mitochondrial-targeting nanozyme complexes (CeCPT) execute precision mitochondrial restitution through redox homeostasis restoration. This dual-pathway strategy achieves synergistic therapy by concurrently modulating macrophage function and repairing damaged mitochondria, thereby enhancing macrophage repolarization. In murine ALI models, inhaled CeCPT@PSL concurrently attenuated inflammatory cascades and resolved mitochondrial impairment via targeting lung-macrophage-mitochondrial axis, and restored pulmonary function. This bio-inspired multi-function platform establishes a heuristic strategy wherein artificial nanovesicles recapitulate cellular functions to resolve dysregulated pathological cascades, offering a promising therapeutic avenue for intractable inflammatory diseases.
研究领域:
纳米医学
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免疫治疗
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炎症性疾病
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呼吸医学
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线粒体生物学
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产品关联
DOI
PubMed
高影响因子
PHYTOCHEMICAL ANALYSIS
·
2025
·
IF 2.6
Yan Jiang,Hui Ni,Wen-Jing Zhao,Long Wang,Cai Zhang,Ping Li,Hui-Jun Li
Introduction Multiorigin phenomenon is quite common in Chinese herbal medicine, whereas quality consistency evaluation among the involved plant species is seldom considered. Objectives The present study, taking Taraxaci herba as a typical case, aimed to develop a strategy based on a combination of chemical similarity and in vitro bioequivalence to evaluate the quality consistency of three Taraxacum species. Materials and Methods The chromatographic fingerprints were established through two approaches, namely, high-performance liquid chromatography coupled with photodiode array detector and quadrupole time-of-flight mass spectrometry (HPLC-PDA/QTOF-MS) and gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC-QTOF-MS). The common characteristic peaks from chromatographic fingerprints were quantified. The bioactivities were tested by antioxidant and anti-inflammatory activity assays. Quality consistency of the three Taraxacum species was globally evaluated by using a combination of chemical similarity and in vitro bioequivalence through univariate and multivariate statistical analysis. Results The statistical results showed no classification of the three species based on contents of quantified analytes and in vitro bioactivities, respectively. Conclusion This study not only demonstrated the medicinal interchangeability of three species of Taraxaci herba but also proposed a comprehensive strategy to evaluate quality consistency of multiorigin Chinese herbal medicines by integrating chemical similarity and in vitro bioequivalence.
研究领域:
生药学
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天然产物化学
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中医药学
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分析化学
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药物评价
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产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Xinmeng Wang,Jinxuan Yu,Shengfeng Ye,Binghui Su,Jiangyang Chen,Xiaoping Rao
Pickering emulsions stabilized by bio-based solid particles offer a promising approach for the sustained release and targeted delivery of bioactive substances. In this work, rosin-based carbon dots (RCDs) were synthesized through a simple one-step hydrothermal method and applied to stabilize oil-in-water (O/W) Pickering emulsions encapsulating volatile clove essential oil (CEO). The microstructure, surface charge, encapsulation efficiency, antioxidant activity, antibacterial efficacy, and stability of the emulsions were investigated. The optimized Pickering emulsion demonstrated outstanding functional properties, including an average droplet size of 42.6 nm, a high CEO encapsulation efficiency (72.34%), and potent DPPH radical scavenging activity (88.4%). Antibacterial efficacy significantly surpassed free CEO, showing expanded inhibition zones against both S. aureus and E. coli. Importantly, the emulsion exhibited excellent storage stability, anti-flocculation properties, and thermal tolerance, indicating its suitability for practical applications. This work provides a novel and environmentally friendly strategy for preparing Pickering emulsions using RCDs and expands the potential applications of rosin in the development of encapsulation and sustained-release systems for bioactive compounds.
研究领域:
材料科学
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纳米技术
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食品科学与技术
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药物递送系统
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绿色化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yufeng Chen,Jia-Hong Li,Junqin Li,Ninghong Yin,Ming Song,Zhizhong Hu,Lingyong Song,Yumei Qian,Weize Li,Dinggeng He,Zhong Fan,Luo Hai,Jianbo Liu
Tobacco smoke-induced lung disease remains a major global health threat. Reactive oxygen species (ROS) present in cigarette smoke including superoxide (•O2–), hydroxyl radicals (•OH), and hydrogen peroxide (H2O2) contribute substantially to oxidative injury, yet conventional acetate filters are ineffective at removing these gaseous free radicals. Here, we report manganese-doped hollow cerium oxide (Mn–CeO2) nanospheres as robust antioxidative nanozymes for scavenging gas-phase ROS. Mn–CeO2 exhibits enhanced superoxide dismutase (SOD)-like, catalase (CAT)-like activities and superior •OH scavenging compared with undoped CeO2. After being filled into a commercial cigarette filter, Mn–CeO2 removed over 56.2% of targeted ROS from smoke under our test conditions. In a mouse passive-smoking model, cigarette filters filled with Mn–CeO2 markedly reduced pulmonary inflammation and histological lung injury relative to the controls. Serum biochemical markers showed no significant systemic toxicity. Our research demonstrates that manganese doping significantly improves the ROS scavenging performance of CeO2 nanozymes and suggests a feasible route to reduce cigarette smoke-derived oxidative damage.
研究领域:
纳米技术
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环境健康
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材料科学
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毒理学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Zeyuan Liu,Chao Zhang,Lifang Zou,Xingguang Chen,Baocai Xu
Pork trimmings, a major and underutilized by-product of pork processing, possess considerable potential for further exploitation. In this study, antioxidant peptides were isolated and identified from fermented pork trimmings, and their protective mechanisms against ethanol-induced oxidative damage in HepG2 cells were investigated. Utilizing a strategy integrating peptidomic analysis with molecular dynamics simulations, four novel peptides—VGWGR, LPPPR, LGPRYR, and WGGR—were identified, and their specific molecular interactions with Keap1 were elucidated. Among these, VGWGR exhibited the strongest binding affinity to Keap1, outstanding free radical scavenging capacity in vitro , and significant cytoprotective effects. Mechanistic studies further revealed that VGWGR activates the Keap1/Nrf2 pathway, leading to substantial upregulation of downstream antioxidant proteins (HO-1 and NQO1) and increased activities of endogenous antioxidant enzymes. This study not only enhances the value-added utilization of pork trimmings but also supports the potential of VGWGR as a functional food ingredient.
研究领域:
食品科学与技术
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分子生物学
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生物信息学
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营养生物化学
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肽类研究
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yueguang Wang,Zifeng Huang,Oujun Dai,Xin Lei,Meining Li,Hanlin Zhou,Jie Pang
Inspired by the pore structure of plant leaves, this study fabricates a konjac glucomannan/polylactic acid (KGM/PLA)-based composite film that mimics the passive thermal regulation mechanism of natural stomata, enabling highly efficient cooling. By integrating xanthan gum (XG)-stabilized KGM/PLA matrices and hexadecyltrimethoxysilane-carvacrol@zinc oxide/cellulose nanocrystal nanosheets (HDTMS-CRV@ZnO/CNC NSs), the composite film exhibits potent antibacterial activity (25.22 ± 1.5 mm inhibition zone against Staphylococcus aureus ) and extends produce shelf life by over 7 days. The film also demonstrates outstanding optical properties, achieving 91.06 % solar reflectance (0.3–2.5 μm) and 91.40 % infrared emissivity (8–13 μm), which enables sub-ambient cooling of ∼10 °C under sunlight. Practical tests show the film maintains an internal temperature of 27.18 °C at 35 °C ambient conditions, effectively preserving the freshness of strawberries and tomatoes compared to deteriorated control samples. This work presents an innovative approach to intelligent food packaging, combining preservation functionality and environmental adaptability for sustainable food storage applications.
研究领域:
材料科学
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食品包装技术
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仿生材料
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可持续农业
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热管理
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纳米复合材料
·
抗菌材料
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产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Bo Jie Chen,Hock Eng Khoo,Xia Li,Biyu Peng
The present study examined the effect of α-amylase on complex carbohydrates in longan seeds and assessed the feasibility of using these carbohydrates as tanning agents. Enzymatic and hot-water extracts were purified and analyzed for their structural components and physicochemical properties. Enzymatic extraction with ultrasonic assistance yielded higher levels of bioactive components in longan seed polysaccharides (LSPs) than the non-enzymatic method. Dialdehyde longan seed polysaccharides (DLSPs) were prepared using LSPs and NaIO 4 . The effects of different NaIO 4 concentrations on molecular size, aldehyde content, other chemical compositions, structural characteristics, and tanning performance of DLSPs were evaluated. Increasing NaIO 4 concentrations decreased total sugars, polyphenols, and saponins, while raising protein content. The oxidant broke glycosidic bonds and oxidized o -dihydroxyl groups, forming reactive aldehyde groups. The DLSP-tanned leather exhibited a shrinkage temperature of 76.4 °C and tensile strength of 17.03 MPa. The tanning performance and bioactivity of DLSPs stem from lower molecular weight and high aldehyde and hydroxyl content. These polysaccharide samples exhibited good permeability and cross-linking reactivity within the collagen fiber network. Therefore, DLSPs are a promising new type of chromium-free tanning agents.
研究领域:
高分子科学
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皮革化学
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酶工程技术
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天然产物提取
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可持续材料
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产品关联
DOI
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Jing Liang,Jiayan Xie,Yue Gu,Jianhua Xie,Yi Chen,Bing Zheng,Yue Qiu,Xiaobo Hu,Qiang Yu
Vigna umbellata is an important homologous medicinal and food legume, and its fruit is rich in polyphenols. Acidic, alkaline (highest yield) and enzymatic methods were used to release bound polyphenols from rice bean skin dietary fiber. 44 compounds were identified from the alkaline hydrolysis products. With the increase of polyphenol concentration within a specific range, the scavenging rate of DPPH• and ABTS + • radicals and the reduction ability of ferric ions were increased. Rice bean skin dietary fiber bound polyphenols (RBSDF-BP) showed significant α -glucosidase inhibitory activity. The results showed that Hydrogen bonding and hydrophobic forces were the binding forces for RBSDF-BP to form a stable polyphenol-enzyme complex with α -glucosidase. Molecular docking revealed that the three polyphenols of RBSDF-BP had a strong affinity for the active site in the hydrophobic cavity of the enzyme. This study provides valuable discoveries for the potential application of RBSDF-BP as natural inhibitors of α -glucosidase. Chemical compounds Protocatechuic acid (PubChem CID: 72); Malic acid (PubChem CID: 525); Isoferulic acid (PubChem CID: 736186); p-Hydroxybenzoic acid (PubChem CID: 135); Citric acid (PubChem CID: 311), (+)-Catechin (PubChem CID: 9064), Fumaric acid (PubChem CID: 444972), Gallic acid (PubChem CID: 370), Azelaic acid (PubChem CID: 2266), (−)-Epicatechin (PubChem CID: 72276).
研究领域:
食品科学与技术
·
植物化学
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营养生物化学
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分子对接与模拟
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酶抑制
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功能食品
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抗氧化研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）