CEMENT AND CONCRETE RESEARCH
·
2026
·
IF 14
Zedong Zhou,Hangxi Liu,Juanlong Li,Yiru Yan,George Dan Miron,Barbara Lothenbach,Biwan Xu,Ming Fang,Xiaoli Tan,Bin Ma
Calcium silicate hydrate (C-S-H), the principal binding phase in Portland cement, plays a critical role in the immobilization of heavy metals, yet a quantitative and mechanistic understanding of Cu 2+ uptake by C-S-H remains incomplete. This study investigates the immobilization behavior of Cu 2+ by C-S-H with systematically controlled Ca/Si ratios (0.6–1.6) and develops a thermodynamically consistent sublattice solid-solution model. The C-S-Hs were synthesized under sorption equilibrium conditions and characterized to determine their structural evolution with Ca/Si ratio. Cu 2+ sorption was subsequently examined on pre-synthesized C-S-Hs, combined with spectroscopic analyses to elucidate Cu coordination environments. The results show that Cu 2+ is immobilized predominantly through structural incorporation at low Cu 2+ loadings rather than hydroxide precipitation. With increasing Cu 2+ concentration, Cu 2+ progressively intercalates into the interlayers of C-S-H, partially replacing interlayer Ca 2+ and forming Si-O-Cu linkages associated with Q 2 silicate sites. The Ca/Si ratio strongly controls both uptake capacity and binding mechanism. High Ca/Si ratios promote silicate-chain polymerization through conversion of Q 1 to Q 2 units, whereas extremely low Ca/Si ratios induce redistribution between Q 2 and Q b 2 species. At intermediate Ca/Si ratios, Cu 2+ is mainly stabilized as hydroxyl-associated species. Once the sorption capacity is exceeded, excess Cu 2+ transforms into CuO under alkaline conditions. Based on these observations, a CASH+Cu thermodynamic model incorporating five Cu-bearing endmembers was developed and calibrated using both aqueous and solid-phase data. The model quantitatively reproduces Cu uptake, solution chemistry, and phase assemblages, providing a predictive framework for Cu 2+ retention in cementitious systems.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Lu-feng Wang,Ya-nan Zhang,Mao-qing Chen,Yingxuan Liu,Yong Zhao
Given the dual role of copper ions (Cu 2+ ) as essential micronutrients and harmful pollutants, the demand for developing sensitive and selective sensors capable of trace-level Cu 2+ monitoring in water bodies is urgently needed. In this paper, an ultra-sensitive surface plasmon resonance (SPR) optical fiber Cu 2+ sensor is proposed, which consists of a multimode fiber (MMF) and a 1 cm single-hole dual-core micro-structured fiber (MOF). Femtosecond laser micromachining is employed to fabricate microfluidic channel within the MOF, followed by polydimethylsiloxane (PDMS) infusion to induce an effective refractive index (RI) difference between dual cores to construct a Michelson interferometer (MI) for temperature monitoring. Simultaneously, a gold film is deposited on the MOF surface served as the SPR excitation channel, and multilayers Schiff base-functionalized hydrogel composites are immobilized onto the gold film through electrostatic layer-by-layer (LBL) self-assembly. The specific chelation between Cu 2+ with Schiff base ligands triggers hydrogel swelling, thereby inducing significant resonance wavelength shifts in the SPR spectrum. Experimental results demonstrate that the sensitivity of Cu 2+ has increased by 6 times, with the maximum sensitivity reaching −504.96 nm/(mg/L) and the limit of detection (LOD) as low as 11.0149 nM. The MI channel exclusively responds to PDMS variations due to temperature, exhibiting insensitivity to Cu 2+ concentration fluctuations, thereby eliminating the temperature cross-talk in the SPR channel. The proposed method provides a new thought for the integrated design of sensitive and specific sensors, which has great potential in food safety, environment and biology monitoring.
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高影响因子
International Journal of Nanomedicine
·
2026
·
IF 8.7
Feixiao Ma,Anqi Ji,Beng Ma,Pingjuan Yang,Jiayi Li,Shuxin Liao,Haonan Yao,Xuanhu Xie,Zhiwei Wang,Linlin Shi,Shegan Gao,Xin Hou
Purpose Esophageal cancer (EC) ranks among the most prevalent and lethal malignancies worldwide, and conventional therapeutic modalities, including surgery, radiotherapy, and chemotherapy, are constrained by inherent limitations. Recent advances in nanomedicine have opened new avenues for EC treatment. To achieve efficient and precise tumor eradication, this study developed a pH-responsive composite nanoplatform featuring a hollow architecture to enable high-efficiency loading of photosensitizers and realize multimodal synergistic therapy against EC through the integration of photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT).Methods A pH-responsive Cu2-xSe/PDA/IR820 composite nanoplatform was constructed by coating hollow Cu2-xSe nanoparticles with polydopamine PDA and loading the near-infrared photosensitizer IR820. Morphology, crystalline phase, elemental composition, and surface chemistry were characterized by TEM, XRD, XPS, and FT-IR. Photothermal conversion efficiency was quantified under 808 nm laser irradiation. IR820 release kinetics were monitored under different pH conditions of 5.0, 6.0, and 7.0 to assess pH-responsive behavior. In vitro studies on KYSE-150 EC cells included viability by CCK-8 assay, apoptosis by flow cytometry, ROS generation by DCFH-DA probe, mitochondrial membrane potential by JC-1 staining, and cellular uptake analysis. In vivo antitumor efficacy and biosafety were evaluated in an AKR tumor-bearing C57BL/6J mouse model via intratumoral injection and 808 nm laser irradiation, followed by tumor volume measurement, histopathological analysis with H&E, Ki-67, and TUNEL staining, and systemic toxicity assessment.Results The hollow Cu2-xSe/PDA/IR820 nanoparticles exhibited a uniform size of approximately 164 nm, excellent colloidal stability, and a high photothermal conversion efficiency of 44.56% under 808 nm laser irradiation. IR820 release displayed pronounced pH sensitivity, with a cumulative release of 23.07% at pH 5.0 within 30 minutes. In vitro, the nanoplatform combined with laser irradiation reduced KYSE-150 cell viability to 1.2% at 100 μg/mL, with an IC50 value of 18.74 μg/mL, induced 28.57% apoptosis, elevated intracellular ROS levels, decreased mitochondrial membrane potential, and depleted glutathione to 335 μmol/gprot. In vivo fluorescence imaging confirmed effective tumor accumulation via the EPR effect, with peak signal at 24 hours post-injection. Combined PTT/PDT/CDT treatment significantly suppressed tumor growth, reducing final tumor volume to 17.8% of the control group, and induced extensive apoptosis and necrosis in tumor tissues. Systemic biosafety evaluations revealed no significant hematological or histopathological abnormalities.Conclusion Hollow Cu2-xSe/PDA/IR820 composite nanoparticles loaded with IR820 were successfully fabricated and demonstrated remarkable advantages in multimodal combination therapy against EC.
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PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 19
·3967
·
IF 4.6
Zuoyi Liu,Bo Hu,Minjia Meng
A surface molecularly imprinted ratiometric fluorescent sensor (Eu/CDs@SiO2@IIPs) was constructed for the selective and visual detection of Cu2+. The sensor integrates blue-emitting carbon dots as an internal reference and a custom-designed Eu(III) complex, Eu(MAA)2(2,9-phen), as both the functional and fluorescent monomer within a surface-imprinted polymer layer, enabling efficient ratiometric fluorescence response. This structural design ensured that all fluorescent monomers were located at the recognition sites, thereby reducing background fluorescence interference and enhancing the accuracy of signal changes. Under optimized conditions, the sensor exhibited a detection limit of 2.79 nM, a wide linear range of 10–100 nM, and a rapid response time of 3.0 min. Moreover, the uncoordinated nitrogen atoms in the phenanthroline ligand improved resistance to interference from competing ions, significantly enhancing selectivity. Practical applicability was validated by spiked recovery tests in deionized and river water, with results showing good agreement with ICP-MS analysis. These findings highlight the potential of Eu/CDs@SiO2@IIPs as a sensitive, selective, and portable sensing platform for on-site monitoring of Cu2+in complex water environments.
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DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Tingting Yu,Zhenyu Wei,Weihai Li,Junjie Liu,Yingchun Miao,Xin Liang
Research on clean energy materials represents a necessary response to the urgent global needs for sustainable development and environmental impact mitigation. Chloride-ion batteries (CIBs) with metal chlorides as cathodes have been widely noticed due to their high theoretical gravimetric energy density. However, the significant volume changes during charging and discharging, the poor electrical conductivity and the dissolution of metal chlorides limit the application of metal chloride electrodes. Herein, a Cu 2+ -coordinated sodium alginate (SA)/carbon (C) layer can be formed on the surface of cuprous chloride (CuCl) particles by treating the ball-milled composite of CuCl, SA, and carbon material with water first and then with ethanol. After water treatment, the trace quantity of basic cupric chloride (Cu 2 (OH) 3 Cl) that is formed on the surface of CuCl particles facilitates the in-situ cross-linking with SA. Benefiting from the cross-linking of Cu²⁺ with SA and the chemical and hydrogen bonding between SA and graphene oxide (GO), the CuCl/SA-H₂O/GO cathode delivers a maximum initial discharge capacity of 248 mAh g⁻¹ (92 % of the theoretical capacity) at 100 mA g⁻¹ and retained a reversible capacity of 58 mAh g⁻¹ after 50 cycles.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2017
·
IF 2.536
Ying-Peng Zhang,Yu-Ying Dong,Yun-Shang Yang,Hui-Chen Guo,Bi-xia Cao,Shi-Qi Sun
A new pyrazoline-based probe D was designed and synthesized, which can be used as a highly sensitive, selective and reversible recognizing fluorescent to detect Cu 2 + . The recognition properties of this compound was investigated by UV–vis absorption and fluorescence spectrophotometry. The results showed that the probe D forms a 1:1 complex with Cu 2 + and displayed a linear fluorescence response to Cu 2 + with a detection limit of 1.94 × 10 − 7 M. In addition, the probe have a good biocompatibility in living cells.
研究领域:
化学
·
生物学
·
医学
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高影响因子
JOURNAL OF FLUORESCENCE
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2024
·
IF 2.6
Gong Yafei,Fu Yan,Lou Dawei
Abnormal tryptophan (Trp) metabolism can be used as an important indicator of chronic hepatitis, paranoia, Parkinson’s disease and other diseases. Deficiency or excessive accumulation of Cu 2+ can cause diseases such as Wilson’s disease and Alzheimer’s disease. Eu-based metal-organic framework (Eu-MOF) was successfully prepared for fluorescence sensing of Trp and Cu 2+ in an aqueous solution (pH = 7.4). Eu-MOF showed high selectivity and sensitivity for Trp and Cu 2+ with detection limits of 0.22 µM and 0.09 µM and K sv of 6.17 × 103 M − 1 and 2.37 × 10 4 M − 1 respectively. Trp and Cu2+ had overlapped UV absorption spectra with that of Eu-MOF and competed for the excitation light source. Trp also attenuated the antennae effect of organic ligands on Eu-MOF, thus quenching the red fluorescence of Eu-MOF. This study provides insights into the application of MOFs in bioanalysis and diagnostics.
研究领域:
生物分析
·
诊断学
·
材料科学
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yurou Feng,Amatjan Sawut,Rena Simayi,Xieraili Maimaitiyiming,Xueying Jiao
With the advancement of science and technology, the issue of wastewater pollution has escalated, necessitating urgent attention to wastewater treatment . In this study, a highly efficient adsorbent for Cu 2+ was successfully synthesized through in situ self-assembly using Ca 2+ as the cross-linking agent in ZIF-8@ALG composite hydrogel. The results demonstrated that the incorporation of Ca 2+ as the cross-linker enhanced both adsorption capacity and swelling properties of ZIF-8@ALG composite hydrogel. Adsorption performance evaluation revealed that the hydrogel followed pseudo-second-order kinetic model for Cu 2+ adsorption and Freundlich isotherm model with a theoretical maximum adsorption capacity of 309.57 m g −1 . Thermodynamic analysis indicated that Cu 2+ adsorption onto the hydrogel occurred spontaneously with heat absorption. Furthermore, excellent reusability was observed after five cycles of usage without significant loss in adsorption efficiency. Overall, these findings highlight the potential application of ZIF-8@ALG composite hydrogel as an effective solution for wastewater remediation and recovery of heavy metal ions.
研究领域:
环境科学
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材料科学
·
化学工程
·
环境污染治理
·
重金属去除
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高影响因子
Energy Storage Materials
·
2019
·
IF 0
Yunjie Li,Xiucai Sun,Zhenjie Cheng,Xiao Xu,Jun Pan,Xianfeng Yang,Fang Tian,Yanlu Li,Jian Yang,Yitai Qian
Transitional metal chalcogenides , one important family of promising candidates as electrode materials for sodium-ion batteries, gradually convert to Cu 2 S or Cu 2 Se in the discharge/charge processes, due to electrochemically driven copper diffusion. Thus, their performances after the electrochemical activation, actually come from copper chalcogenides . In this regard, the thorough investigation on the electrochemical properties of copper chalcogenides is important and necessary for the rational design of transitional metal chalcogenides . Here, mesoporous Cu 2-x Se nanocrystals synthesized by a simple solvothermal reaction, are used as a model. They experience the complicated intercalation reaction and the conversion reaction upon cycling, as supported by in-situ / ex-situ techniques and first-principle calculations. All these reactions are highly reversible, leading to 96.1% of the theoretical capacity. These nanocrystals preserve 88% of the initial capacity after 3000 cycles at 5 A g −1 . Even at 10 A g −1 , the capacity is still kept as 92.1% of that at 0.1 A g −1 . In full cells, the nanocrystals without any pre-sodiation and pre-activation, present a lifespan up to 2000 cycles at 0.5 A g −1 and a capacity retention about 74.2%.
研究领域:
材料科学
·
电化学
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纳米科技
·
能源存储
·
无机化学
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JOURNAL OF FLUORESCENCE
·
2026
·
IF 3.4
Liu Long,Chen Jiayi,Ye Meijun,Huang Wen,Liao Xiang,Wu Hanqing,Xu Jingshui
Heavy metal Cu 2+ from industrial discharge continuously accumulates in ecosystems, posing threats to human health and ecological balance. Researchers successfully synthesized a novel fluorescent probe, TPA-OPD , via a Schiff base reaction between triphenylamine and o-phenylenediamine. TPA-OPD exhibits rapid, highly selective, and sensitive fluorescence quenching in response to Cu 2+ , along with excellent anti-interference capability. The binding mechanism between Cu²⁺ and TPA-OPD was confirmed by Job’s plot, Fourier-transform infrared spectroscopy, mass spectrometry, nuclear magnetic resonance, and Gaussian calculations. TPA-OPD effectively detects Cu 2+ in real-world environmental samples such as tap water and river water, demonstrating strong potential for monitoring Cu 2+ pollution. Graphical None = 95% H2O, 1 = Cu²⁺, 2 = Na⁺, 3 = K⁺, 4 = Cs⁺, 5 = Mg²⁺, 6 = Al³⁺, 7 = Ca2+, 8 = Ba²⁺, 9 = Cd²⁺, 10 = N₂H₆²⁺, 11 = Sr²⁺, 12 = NH₄⁺, 13 = Co2+, 14 = Zn2+, 15 = Ag+, 16 = Ni²⁺, 17 = SO₄²⁻, 18 = CO32-, 19 = Cl- , 20 = NO₃⁻, 21 = CH₃COO⁻
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yunxue Sun,Xuetao Zhang,Lijie Xu,Xinru Zhao,Yimei Bai,Xingshuang Zhang,Jing Zhang,Meng Gao,Guanchen Xu
Multifunctional film design combines AIE-H 2 O 2 probe and silica-Cu 2+ sensor. • Dual ratio sensing enables visual detection of H 2 O 2 vapor and Cu 2+ simultaneously. • Flexible film realizes encryption/decryption for anti-counterfeiting smart labels. • Film exhibits mild antimicrobial effect and food preservation function. • Integrated sensing & antibacterial features in intelligent packaging. Fluorescent sensing films are considered as powerful tools for portable detection of various analytes due to their advantages of being non-invasive, real-time and easily integrable. The multifunctional design of fluorescent film sensors plays a crucial role in expanding their practical applications in complex detection scenarios. Here, a flexible ratiometric fluorescent sensing film (PAN@SD-S@CS-TB) with mild antibacterial performance was designed for dual sensing of hydrogen peroxide (H 2 O 2 ) and Copper (II) (Cu 2+ ). Specifically, a silica nanosphere-based Cu 2+ probe was incorporated into the film fiber through co-electrospinning, and subsequently, the fiber surface was functionalized with aggregation-induced emission (AIE)-featured H 2 O 2 sensing molecules. Based on different fluorescence responses, the blue-emission of the film could be quenched upon interaction with H 2 O 2 vapor, whereas the red-emission exhibited “turn-off” behavior in the presence of Cu 2+ . This multifunctional fluorescence film was convenient for the sensitive, selective and visual detection of H 2 O 2 and Cu 2+ , with the detection limits of 27.6 ppb and 80.3 μM, respectively. Based on the multiple-responsive performance of the film, an intelligent anticounterfeiting label was constructed for information encryption and decryption. Moreover, PAN@SD-S@CS-TB demonstrated real-time detection capability in food products. Meanwhile, it exhibited certain antimicrobial properties on food surfaces, which could extend the shelf life and maintained the food freshness. The film with integrated functions of sensing and antibacterial revealed huge advantages in intelligent packaging. This study provided a novel avenue for the development of multifunctional film systems and offered great application values across various fields. Download: Download high-res image (220KB) Download: Download full-size image
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高影响因子
ANALYST
·
2018
·Vol. 143
·期 21
·5145-5150
·
IF 3.864
Yunxiao Jia,Tianxia Sun,Yingnan Jiang,Weiyi Sun,Yu Zhao,Jingwei Xin,Yiting Hou,Wensheng Yang
Gold nanoclusters have attracted widespread attention because of their unique optical and physical properties. However, traditional synthesis methods are complicated and require additional reducing agents, while the yield is often very low. Such resource and time-consuming synthesis processes limit their further application. Herein, a rapid sonochemical route is used to synthesize fluorescent Au nanoclusters in large quantities using glutathione (GSH) both as a capping and reducing agent. These Au nanoclusters are synthesized quickly (∼40 min) due to the presence of ultrasonic waves, and show orange red photoluminescence (Em = 598 nm), small size (∼2 nm) and good dispersion in aqueous solution. Moreover, GSH, as a protecting agent on the surface of resultant Au nanoclusters, has many functional groups including carboxyl and amino groups because of which the nanoclusters show high photo-, storage-, metal- and pH-stability. A stable Au nanoclusters-based nano-sensor is designed for highly sensitive and selective label-free detection of Cu2+ with a low limit of detection of 7 ppb (based on S/N = 3). The fluorescent probe can be used in versatile nanothermometry devices, because their photoluminescence intensity correlates strongly with temperature and varies considerably over a wide temperature range (20–80 °C). Therefore, the novel fluorescent sensing probe has great application prospects in Cu2+ detection and temperature sensing.
研究领域:
纳米医学
·
分析化学
·
生物传感
·
分子影像
·
环境监测
·
热疗监测
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高影响因子
危险品化学品经营许可证（带存储）