Advanced Science
·
2025
·
IF 14.1
Qifei Yang,Shu Lou,Yuan Zhang,Zhurun Fang,Changyue Xing,Wentao Wang,Minxuan Han,Zhendong Wang,Ben Zhong Tang,Ming Zhang
Infectious bone defects present dual challenges: eliminating bacteria and regenerating tissue, which are further complicated by biofilm formation, antibiotic resistance, and chronic inflammation. Here, a near-infrared-II (NIR-II) responsive fibrous scaffold (AIE NPs@BP NSs@FSs) that employs a sequential “Kill–Modulation–Build” therapeutic strategy—referring to infection clearance, immune regulation, and bone repair is developed. Upon NIR-II irradiation, aggregation-induced emission nanoparticles (AIE NPs) produce localized hyperthermia, which eliminates bacteria and biofilms, offering a non-antibiotic solution that reduces the risk of resistance development. Moreover, black phosphorus nanosheets (BP NSs) scavenge reactive oxygen species (ROS) and reprogram macrophages toward a pro-regenerative M2 phenotype. This immunomodulatory shift enhances endothelial migration, neovascularization, and osteogenic differentiation of bone marrow stem cells. With excellent biocompatibility and biomimetic architecture, the scaffold supports coordinated antibacterial, immunoregulatory, and osteoinductive responses. This work provides a promising platform for treating complex infected bone defects by combining photothermal therapy with immune and regenerative modulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RESEARCH
·
2018
·Vol. 26
·期 3
·270-277
·
IF 1.767
Ruan Zheng,Yuan Pan,Jing Titao,Xing Tao,Yan Lifeng
A novel pH-sensitive carborane and cyanine dye conjugated polypeptide and its micelles has been designed and synthesized for potential near infrared fluorescence imaging-guided boron neutron capture therapy (BNCT). The amphiphilic polymer we synthesized with tertiary amine as functional group could self-assemble to micelle nanoparticles at neutral pH, and responsive to acidic solution for the disassembly of the micelles for drug release. The tertiary amine sensitive induced process was observed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). The efficiency of cell killing ability is studied by MTT assays and fluorescence microscope measurement, indicating a new intelligent system for potential NIR imaging-guided therapy.
研究领域:
生物医学工程
·
材料科学
·
癌症治疗
·
生物成像
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2016
·Vol. 5
·期 2
·313-321
·
IF 3.614
Zheng Ruan,Le Liu,Wei Jiang,Shuya Li,Yucai Wang,Lifeng Yan
pH-Sensitive doxorubicin conjugated polymeric micelles entrapped with near infrared (NIR) photosensitizer BODIPY (which works as an imaging agent at the same time) were designed and synthesized by ring opening polymerization of N-carboxyanhydride with mPEG-NH2 as the initiator, following reaction with doxorubicin to form the hydrazone-bond linker for pH responsiveness. Then the NIR dye (BODIPY) was loaded in the micelles for both bioimaging and photodynamic therapy (PDT). A significant cytotoxicity of NIR imaging-guided combined PDT and chemotherapy could be found by MTT assays, which was also confirmed with a fluorescence microscope, indicating a new kind of polymeric nanoparticle for potential theranostic treatment of cancers. In addition, the energy density of the laser for the PDT is extremely low.
研究领域:
药学
·
生物医学工程
·
癌症研究
·
材料科学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
ChemNanoMat
·
2022
·Vol. 8
·期 10
·e202200205
·
IF 3.82
Miao He,Jian Yang,Ke Li,Qinghua Wang,Jinlou Gu
Graphical The nanoscale zeolitic imidazole framework-8 (ZIF-8) is adopted to co-assemble a temperature-sensitive free radical initiator (AIPH) and a photothermal molecule (ICG) to realize the NIR-triggered tandem photothermal and oxygen-independent photodynamic therapy. This as-prepared ICG/AIPH@ZIF-8 nanoplatform displays an excellent killing effect of cancer cells in both normoxia and hypoxia. Due to the limited penetration depth of visible light and insufficient oxygen supply in hypoxic tumor tissues, the development of near-infrared (NIR) triggered and oxygen-independent photodynamic therapy (PDT) to generate active radicals is necessary for cancer treatment. Herein, we developed a NIR-triggered photothermal therapy (PTT) and oxygen-independent PDT system based on metal-organic frameworks (MOFs), which integrated indocyanine green (ICG) and 2,2’-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) as NIR-triggered photothermal units and temperature-sensitive free radical initiator into ZIF-8, respectively. AIPH was introduced into ZIF-8 via a one-pot strategy with high loading capacity (125 mg g −1 ). Through the irradiation of 808 nm laser, the ICG units could efficiently absorb NIR light to rapidly raise the local temperature to 44 °C within 3 minutes. Meanwhile, the local high temperature further induced the AIPH to continuously generate toxic alkyl radicals (R−C⋅). The combination of PTT and free radical therapy is significantly better than the single treatment mode. More importantly, the NIR-triggered synergistic therapy could induce extensive apoptosis of cancer cells in hypoxic conditions, which sheds new light on the development of MOFs-based photochemical therapy platform in the actual tumor microenvironment.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
光疗
✓ 已验证
DOI
高影响因子
Materials Express
·
2024
·Vol. 14
·期 8
·1113-1125
·
IF 0.7
Yang Guang-Hui,Yi Shao-Zhen,Du Shu-Rong,Gao Jia-Lin,Wan Xue-Juan
Combining PNIPAM with a biocompatible NIR-II photothermal agent to prepare near-infrared-responsive hydrogels holds significant importance in the field of biomedical applications. In this study, PNIPAM/Bacterial cellulose (BC)/MXene composite hydrogels were prepared by in-situ
polymerization, where Nb2C MXene serving as a near-infrared photothermal agent and BC acting as enhancing filler. The composite hydrogels possess a semi-interpenetrating network structure, where PNIPAM serves as the crosslinking network backbone, and BC act as a semi-interpenetrating
network, which significantly enhances the mechanical strength of the composite hydrogels. The tensile strength and compressive strength reach 35 KPa and 500 KPa, respectively, which is an order of magnitude higher than that of pure PNIPAM hydrogel. The introduction of BC and MXene did not
significantly affect the thermo-sensitivity of the composite hydrogel which can rapidly undergo a phase transition and release internal moisture above LCST. Morover, the composite hydrogel exhibits excellent photothermal performance, with its temperature rapidly increasing to around 70 °C
under the irradiation of 1064 nm laser. The degree of temperature fluctuations can be accurately regulated by modifying the laser intensity and exposure time. Additionally, it demonstrates good photothermal cycling stability and significant potential for photothermal therapy.
研究领域:
生物材料学
·
纳米医学
·
组织工程
·
光热治疗
·
高分子科学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Jiahuan Liu,Xiaowan Li,Shangyu Xie,Ruirui Ma,Hongfei Wang,Shu-Rong Ban,Chengwu Zhang,Lixia Guo
Titanium has been widely used as a bone implant material due to its high mechanical strength and good biocompatibility. However, implant-related infections and insufficient osteogenic activity can lead to implant failure or delay patient recovery. With that in mind, we fabricated one multifunctional implant coating material, PDA-NOate@CuS. In the as developed material, CuS, deposited in the outermost layer, not only significantly improved the photothermal properties of polydopamine (PDA), but also released Cu ion to effectively prevent bacterial adhesion. The NO-donor (NOate) with near-infrared irradiation, generated NO which strenthened antibacterial effect of materials. The in vitro antibacterial experiments proved that PDA-NOate@CuS displayed excellent S.aureus and E. coli inhibitory effect. MC3T3-E1 cells experiments results showed that PDA-NOate@CuS promoted cell adhesion, growth and mineralization. Moreover, in vivo study demonstrated that titanium implant coated with Ti@PDA-NOate/CuS markedly enhanced osseointegration, inhibited infection, with good biocompatibility. Present study paves ways for developing novel materials for implant modification, which would benefit the treatment of orthopedic disease.
研究领域:
生物材料
·
骨科
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Ying Chen,Rongfei Wei,Lanjiao Li,Xiangling Tian,Fangfang Hu,Hai Guo
High-performance near-infrared (NIR) light sources are highly sought after in advanced spectroscopy techniques, driving the development of NIR phosphor-converted light-emitting diodes (pc-LEDs). Escalating the luminescence intensity and thermal stability of NIR-emitting phosphors, which is a core component of NIR pc-LEDs, is of paramount importance. Herein, chemical unit cosubstitution and cosolvent addition tactics were implemented to simultaneously boost the NIR luminescence performance of the synthesized phosphors. The replacement of [Sc3+-Sc3+] for [Ca2+-Zr4+] in Ca4ZrGe3O12:Cr3+ likely reduces the antisite defects and offers a more rigid crystal structure. As a result, the emitting intensity is reinforced significantly, along with a remarkable improvement in thermal stability, acquiring 65% of the initial luminescence at 423 K compared with 42% for the primal sample. Moreover, the introduction of H3BO3 further enhances NIR luminescence while maintaining a favorable thermal resistance. The encapsulated NIR pc-LED carries an impressive output power of 71.8 mW at 300 mA and a conversion efficiency up to 15.6% at 10 mA. The practical presentations in food checking, imaging, and detection manifest that Ca3.5ScZr0.5Ge3O12:Cr3+,H3BO3 is a promising material for spectroscopy-based technologies.
研究领域:
材料科学
·
光学
·
无机化学
✓ 已验证
DOI
高影响因子
Laser & Photonics Reviews
·
2023
·Vol. 18
·期 1
·2300717
·
IF 11
Yuzhen Wang,Gaochao Liu,Zhiguo Xia
Near-infrared (NIR) II region (1000–1700 nm) lighting sources possess special potential for temperature sensing and quantitative composition analysis. However, it is a challenge to tune the luminescence toward such long wavelength NIR-II emission. Herein, Cr 4+ ions occupation is designed and verified in olivine-type CaYGaO 4 as [CrO 4 ] tetrahedron by site occupancy confinement. Under 620 nm red light excitation, the phosphors display broadband NIR-II emission centered at 1330 nm with a full width at half maximum (FWHM) of 233 nm, resulting from spin-allowed 3 T 2 to 3 A 2 transition of Cr 4+ ions in T d symmetry. The optical thermometry application is demonstrated by decoding the spectral shift and decay times varying with temperature, and the maximum relative sensitivities are 5.82% and 0.78% K −1 , respectively. Furthermore, a flexible film containing CaYGaO 4 :Cr 4+ is fabricated to implement the non-invasive detections of fillet temperature and NH 3 concentration in ammonia. This work represents a step toward developing next-generation NIR-II luminescence materials and widens non-invasive detection applications.
研究领域:
材料科学
·
光学工程
·
生物医学工程
·
无创检测技术
·
分子成像
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2015
·Vol. 3
·期 17
·4445-4451
·
IF 4.696
Jin Wang,Haoran Zhang,Bingfu Lei,Zhiguo Xia,Hanwu Dong,Yingliang Liu,Mingtao Zheng,Yong Xiao
Red-emitting CaAlSiN3:Eu2+ phosphors with different doping contents have been synthesized by solid-state reaction using calcium hydride as a calcium source. The emergence of persistent luminescence in CaAlSiN3:Eu2+ was originated from electron traps introduced by the partial substitutions of O in N sites to form positive trap levels at low Eu2+ concentration. The broad thermoluminescence emission bands indicated multiple trap levels, in which the shallow traps were mainly responsible for the red persistent luminescence; besides, the deep trap electrons could be efficiently released under extra NIR (980 nm) stimulation, resulting in enhanced photoluminescence and phosphorescence. It is expected that the enhanced emission under UV-NIR simultaneous excitation may be a promising technique to investigate the trap distributions in optical energy storage materials.
研究领域:
材料科学
·
发光材料
·
光学物理
·
固态化学
✓ 已验证
DOI
高影响因子
Nanoscale
·
2024
·Vol. 16
·期 16
·8151-8161
·
IF 5.8
Ning Li,Linping Li,Yanping Qiu,Xuhui Liu,Jiatong Zhang,Yangqin Gao,Lei Ge
The rational design of the dimension and geometry of a plasmonic semiconductor cocatalyst is vitally important for efficient utilization of near-infrared (NIR) light and superior photocatalytic hydrogen generation. Herein, hollow cubic CuSe@CdS composites with different sizes and strong localized surface plasmon resonance (LSPR) were prepared by selenizing size-tunable Cu2O templates and loading CdS nanoparticles. The size of hollow cubic CuSe can affect the surface area and the conduction band potential through the size effect, regulating the carrier behavior of the CuSe@CdS heterojunction. The CuSe@CdS composites show enhanced and wide absorption in the full spectrum due to the LSPR effect of CuSe. Meanwhile, the composites show excellent photocatalytic hydrogen capacity in the full spectrum in a 0.35 M Na2S/0.25 M Na2SO3 sacrificial reagent solution. The best hydrogen production rate of CSCE2 is 1.518 mmol g−1 h−1 (5.54 times higher than that of CdS) under Vis light (780 > λ > 420 nm) irradiation and 0.28 mmol g−1 h−1 under NIR light (λ > 780 nm) illumination. Interestingly, the photocatalytic activity for H2 under Vis-NIR light (λ > 420 nm) is about 3 times (up to 4.45 mmol g−1 h−1) higher than that without NIR light assistance, due to the photothermal effect. Various analyses and DFT calculations demonstrate that the p–n heterojunction formed in the composites consists of p-type CuSe and n-type CdS, which achieves efficient carrier transfer and separation under the synergistic effect of the size effect and the photothermal effect. In addition, the expansion of the photocatalytic performance to the NIR range is mainly due to the “hot-electron” injection mechanism induced by the LSPR effect of CuSe. The reasonable design coupled with the plasmonic materials offers a new path to achieving the highly efficient conversion of solar energy to hydrogen energy.
研究领域:
材料科学
·
光催化
·
纳米技术
·
可再生能源
·
等离激元学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 10
·3654-3661
·
IF 5.7
Yaowu Wang,Guocheng Pan,Jianfeng Wang,Yinyan Li,Zhenping Wu,Shiqing Xu,Gongxun Bai
Light-emitting diodes (LEDs) combined with near-infrared (NIR) phosphors are rapidly becoming important light sources for food safety, anti-counterfeiting and biological imaging due to non-destructive and non-toxic advantages. Single-phase materials with multi-mode luminescence under different stimuli are crucial for the development and applications of smart NIR phosphors. Here, we have developed multifunctional Cr3+ activated MgGa2O4 (MGO:Cr3+) phosphors with simultaneous photoluminescence and mechanoluminescence for NIR sensing. Under 470 nm excitation, the phosphors can produce emission bands from 650 to 850 nm. Meanwhile, the flexible devices based on phosphors can exhibit strong emissions in response to mechanical deformation, such as shock and friction. In addition, optical manometers based on luminescence from phosphors can achieve pressure sensing from 7 to 64 KPa. More intriguingly, we combined the MGO:Cr3+ phosphor with a blue LED chip to fabricate an NIR phosphor-converted LED for anti-counterfeiting and biological tissue penetration. Our results suggest that the multifunctional NIR phosphors with simultaneous photoluminescence and mechanoluminescence have potential applications in various sensing devices.
研究领域:
材料科学
·
光学传感
·
光子学
·
发光材料
·
智能传感器
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2023
·
IF 3.6
Chuang Liu,Ziyang Liu,Jie Wang,Yanjie Bai,Xun Sun,Qiang Yang,Xinlong Ma,Huan Zhou,Lei Yang
Efficient hemorrhage control of severe wound injuries is an urgent medical need, deserving agents with promising blood coagulation and biocompatible characteristics. Current work developed polydopamine (PDA) functionalized porous starch powder (PS-PDA) for emergency bleeding treatment. The micro-morphology and elements, chemical groups, and porosity of PS-PDA were systematically characterized. Its comparison with porous starch (PS) revealed the promising potential of this composite in medical practice. On one hand, PS-PDA showed superior surface area and biomineralization affinity over PS, along with comparable hemo/cyto-compatibility. On the other hand, the photothermal effect of PDA under near Infrared (NIR) light paved the possibility to accelerate blood coagulation in situ. In vivo studies indicated PS-PDA can significantly reduce blood loss and improvement of hemostasis efficiency accompanied by NIR light exposure. These results suggest that this newly developed PS-PDA powder can serve as a promising hemostatic material for bleeding wound control.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）