INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
·
IF 6.953
Meng Zhang,Guohui Wang,Dong Wang,Yuqi Zheng,Yanxin Li,Wenqiao Meng,Xin Zhang,Feifan Du,Shaoxiang Lee
In this paper, Ag-Metal−organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing. The performance of bilayer dressing was evaluated. The lower layer (PACS) had uniform pore size distribution , good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity . The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility. As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion. In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation . Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer. In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells. In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
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JOURNAL OF MOLECULAR LIQUIDS
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2021
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IF 6.165
Long Wang,Hanyu Gao,Shimin Song,Weiguang Zhou,Na Xue,Yimiao Nie,Bo Feng
The ions activation of quartz is a thorny problem that deteriorates the flotation of metal ore. Polymer inhibitors have exhibited excellent depression performance in the selective flotation of metal-ion activated minerals. In this study, the inhibitory role of sodium alginate (NaAl) in the flotation of Ca 2+ -activated quartz was thoroughly explored by zeta potential, dynamic light scattering (DLS), Fourier transform infrared (FTIR) analysis, X-ray photoelectron spectroscopy (XPS) analysis and adsorption test. The flotation results suggested that NaAl could inhibit the flotation of Ca 2+ -activated quartz in sodium oleate (NaOl) system to different degrees, depending on the addition sequence of NaOl and NaAl. More significant depression of Ca 2+ -activated quartz could be achieved when NaAl was added prior to NaOl. It was found that prominent mutual interaction existed among Ca 2+ , NaOl and NaAl in the bulk solution, probably forming calcium alginate–calcium oleate crosslink product, which was not affected by the addition sequence of these two reagents. However, the interfacial behaviors of these two reagents on Ca 2+ -activated quartz surfaces differed under different reagent conditions. The addition of NaAl after NaOl could not only partially desorb the pre-adsorbed NaOl from mineral surfaces, but also decrease the mineral surface hydrophobicity by polymer coating, which therefore deteriorated the flotation of Ca 2+ -activated quartz. In contrast, when NaAl was added prior to NaOl, the pre-adsorption of NaAl made the further adsorption of NaOl rather difficult, which was likely attributed to the reticulated structure of NaAl and the associated steric hindrance effect. As a result, the flotation of Ca 2+ -activated quartz was tightly depressed.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2020
·Vol. 138
·期 6
·49800
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IF 2.52
Lu Wu,Longwei Li,Lujun Pan,Hai Wang,Yuezhen Bin
The preparation and application of hydrogel has been a hot research field in recent years. Here in, a composite hydrogel based on poly(vinyl alcohol) (PVA), carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA), and oxidized multiwall carbon nanotubes (OMWCNTs) was successfully prepared. Hydrogen and imine bonds of the hydrogel endowed the composite hydrogel with self-healing property and pH sensitivity. The fracture strength of the hydrogel was enhanced to about 0.8 MPa with the help of OMWCNTs, which was about 2.5 times compared with the one without OMWCNTs. Meanwhile, a new conductive network inside the hydrogel was constructed by OMWCNTs, which improved the conductivity of the hydrogel from 1.75 × 10 −4 to 7.02 × 10 −4 S/cm. The sensing test of the hydrogel showed that it could produce profound feedback signals for the deformation caused by external force and response to human body movements, such as finger bending, swallowing, and speaking.
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ACS Omega
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2021
·
IF 3.512
Shuhua Chang,Dawei Qin,Rongjun Yan,Mengli Zhang,Binglin Sui,Hui Xu,Zhaomin Zheng,Xiaoli Hou,Yonggang Wang,Chenggang Qi
pH- and temperature-sensitive nanogels (NGs) were prepared from sodium alginate (SA) and N-isopropylacrylamide (NIPAM), as the sensitivity at pH 5.5 and 31 °C. SA was pH-modified with glutamic acid (Glu) and ethylenediamine (EDA). The products Glu-SA (Glu-modified SA) and EGSA (EDA- and Glu-modified SA) were characterized by ninhydrin color reaction, infrared spectroscopy, and zeta potential, and the best reactant ratio was selected. Moreover, temperature-sensitive, pH-sensitive EGSA-NGs possessing a semi-interpenetrating network structure were prepared by radical polymerization using N-isopropylacrylamide. The morphology of EGSA-NGs was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM). The cytotoxicity test shows the low cytotoxicity and high biocompatibility of the NGs. The newly prepared NGs were also subjected to pH-sensitive temperature-sensitive in vitro drug-loading and drug-release experiments. The pH-sensitive and temperature-sensitive experiments showed that the particle size of EGSA-NGs was reduced at pH 5.5 and above 31 °C. The drug-loading and drug-release experiments also confirmed this finding, indicating that the newly synthesized NGs could release the drug according to the environmental changes. Therefore, the material has potential application value in solid tumor targeted therapy.
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CARBOHYDRATE POLYMERS
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2020
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IF 7.182
Zhicai Yu,Jinru Liu,Hualing He,Shengnan Ma,Jinyin Yao
A novel fire-preventing triple-network (TN) hydrogel was prepared and laminated on cotton fabric to improve fire-resistant performance of cellulose fabric. The TN hydrogel composed of Poly (N-isopropylacrylamide) (PNIPAAm)/sodium alginate (SA)/ Poly (vinyl alcohol) (PVA) exhibited excellent swelling ratio, swelling-deswelling behavior and antibacterial property. Results indicated that introduction of SA could improve water retention capabilities of TN hydrogels. Thermogravimetric experiments showed that the thermal stability of hydrogels was best at a SA: PVA ratio of 2:1. Furthermore, the obtained hydrogel-cotton fabric laminates displayed efficient flame retardancy. Compared to original fabric, hydrogel-fabric laminates were nearly undamaged when exposed to fire for 12 s. This result is attributed to energy absorption as water is heated and evaporates in the hydrogel. The present work provides a new concept to prepare fire-resistant polymer fabric, which may be used in fire-protective clothing to protect the skin from burn injuries.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Yanmin Shen,He Wang,Weikun Li,Zijun Liu,Yuhua Liu,Hongliang Wei,Jingjing Li
In this work, novel sodium alginate–based double-network hydrogel beads were prepared and applied for the water-retention and slow release of fertilizers (WSF). The WSF beads were prepared by ion-crosslinking and the free radical polymerization of acrylic acid, acrylamide, and polymerizable β-cyclodextrin in the presence of urea-loaded halloysites. The WSF beads were characterized using SEM, FTIR , and TGA . Their swelling capacity and water retention were measured by a weighing method and their slow-release behavior was studied by spectrophotometry. The water retention and slow release results showed that the fertilizer displayed improved urea release and water retention properties, indicating that halloysite nanotubes clearly improved the performance of fertilizers. In addition, the experimental data of the slow release of urea in water and soil better fitted the Korsmeyer-Peppas model compared with the Higuchi model, a zero-order model or a first order mode. The release behavior of the fertilizer beads followed a Fickian diffusion mechanism.
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Soft Matter
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2020
·Vol. 16
·期 13
·3319-3324
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IF 3.14
Guangfeng Wu,Kaiyun Jin,Li Liu,Huixuan Zhang
Self-healing hydrogels as renewable materials have attracted significant attention recently. However, traditional self-healing hydrogels require a long time for self-healing and cannot be used at low temperatures. Besides, their poor biocompatibility limits the application of hydrogels. Herein, we have prepared a hydrogel composed of polyvinyl alcohol (PVA) and modified sodium alginate. Due to the dynamic recombination of borate bonds, these hydrogels show a strong self-healing ability, with the shortest self-healing time up to 15 seconds. Also, glycerin (GI) was added into the hydrogel to increase the cold resistance of the hydrogel. At −25 °C, the hydrogel still displayed good frost resistance and elasticity. NaCl and other inorganic salts were added to endow the hydrogel with good electrical conductivity. The hydrogel also had good skin-like properties and could activate the capacitive screen of an electronic device.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Jian Chen,Jinbo Ouyang,Xionghui Cai,Xiaohong Xing,Limin Zhou,Zhirong Liu,Di Cai
The removal of ciprofloxacin (CIP) from aqueous system is of great significance for water treatment. Here, millimeter-sized sodium alginate/H 3 PO 4 activated corncob-based biochar composite beads (SA-PB) were prepared by a facile phase inversion method. These beads were characterized with SEM, EDS, FTIR, XRD and Raman. Results showed that SA-PB beads were successfully prepared and endowed the merits from alginate and biochar. SA-PB containing 80 wt% PB (SA-PB80) exhibited excellent CIP sorption capacity, which is much higher than pure SA and those containing 20 wt% and 50 wt% PB. Kinetic results showed that the sorption process could be fitted to pseudo-second-order model. The isotherm data indicated that sorption behavior conformed to the Langmuir model. Furthermore, SA-PB exhibited high tolerance to ionic strength and favorable reusability, and SA-PB also has plentiful desirable advantages such as biodegradability, economy and easily separable for solid-liquid system as well as its efficient CIP capture performance.
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Polymers
·
2019
·Vol. 11
·期 9
·1476
·
IF 3.164
Yali Ji,Huimin Zhang,Canfu Zhang,Zhiyi Quan,Min Huang,Lili Wang
Highly luminescent silicon quantum dots (SiQDs) were prepared via one-pot hydrothermal route. Furthermore, the optimal synthetic conditions, dependence of the emission spectrum on the excitation wavelength and fluorescent stability of SiQDs were investigated by fluorescence spectroscopy. SiQDs exhibited bright blue fluorescence, and photoluminescence (PL) lifetime is 10.8 ns when excited at 325 nm. The small-sized SiQDs (~3.3 nm) possessed uniform particle size, crystal lattice spacing of 0.31 nm and silicon (111), (220) crystal planes. Luminescent SiQDs/sodium alginate (SA)-carboxymethylcellulose sodium (CMC) nanocomposite bio-polymer films were successfully fabricated by incorporating SiQDs into the SA-CMC matrix. Meanwhile, SiQDs not only impart strong fluorescence to the polymer, but also make the composite films have favorable toughness.Keywords:biopolymer;silicon quantum dots;nanocomposite polymer films;fluorescent;mechanical property
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Pharmaceutics
·
2019
·Vol. 11
·期 10
·524
·
IF 4.773
Kaixiang Zhou,Xiaofang Wang,Dongmei Chen,Yuanyuan Yuan,Shuge Wang,Chao Li,Yuanyuan Yan,Qianying Liu,Liwei Shao,Lingli Huang,Zonghui Yuan,Shuyu Xie
TheStaphylococcus aureus(S. aureus) cow mastitis causes great losses to the cow industry. In order to improve the treatment effect of tilmicosin against cow mastitis, the combination of solid lipid nanoparticle (SLN) technology with in situ hydrogel technology was used to prepare the self-assembly tilmicosin nanogel (TIL-nanogel). The physicochemical characteristics, in vitro release, antibacterial activity and in vivo treatment efficacy of TIL-SLNs and TIL-nanogel were studied, respectively. The results showed the loading capacity (LC), encapsulation efficiency (EE), size, zeta potential and poly dispersion index (PDI) of TIL-nanogel were 23.33 ± 0.77%, 67.89 ± 3.01%, 431.57 ± 12.87 nm, 8.3 ± 0.06 mv and, 0.424 ± 0.032, respectively. The TIL-nanogel showed stronger sustained release in vitro than TIL-SLNs and commercial injection. The cure rate of half dosage and normal dosage of TIL-nanogel was 58.3% and 75.0%, which was higher than that of commercial injection (50.0%) at normal dosage. The results suggest that the treatment dosage of tilmicosin for cow mastitis could be reduced by TIL-nanogel. The novel TIL-nanogel will be beneficial by decreasing the usage of tilmicosin and the treatment costs of cow mastitis.Keywords:tilmicosin;solid lipid nanoparticles;sodium alginate-chitosan nanogel;Staphylococcus aureus;cow mastitis
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Theranostics
·
2019
·
IF 8.063
Kaiqi Lv,Qingju Li,Ling Zhang,Yingchao Wang,Zhiwei Zhong,Jing Zhao,Xiaoxiao Lin,Jingyi Wang,Keyang Zhu,Changchen Xiao,Changle Ke,Shuhan Zhong,Xianpeng Wu,Jinghai Chen,Hong Yu,Wei Zhu,Xiang Li,Ben Wang,Ruikang Tang,Jian'an Wang,Jinyu Huang,Xinyang Hu
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been widely used for treating myocardial infarction (MI). However, low retention and short-lived therapeutic effects are still significant challenges. This study aimed to determine whether incorporation of MSC-derived sEVs in alginate hydrogel increases their retention in the heart thereby improving therapeutic effects. Methods: The optimal sodium alginate hydrogel incorporating sEVs system was determined by its release ability of sEVs and rheology of hydrogel. Ex vivo fluorescence imaging was utilized to evaluate the retention of sEVs in the heart. Immunoregulation and effects of sEVs on angiogenesis were analyzed by immunofluorescence staining. Echocardiography and Masson's trichrome staining were used to estimate cardiac function and infarct size. Results: The delivery of sEVs incorporated in alginate hydrogel (sEVs-Gel) enhanced their retention in the heart. Compared with sEVs only treatment (sEVs), sEVs-Gel treatment significantly decreased cardiac cell apoptosis and promoted the polarization of macrophages at day 3 after MI. sEVs-Gel treatment also increased scar thickness and angiogenesis at four weeks post-infarction. Measurement of cardiac function and infarct size were significantly better in the sEVs-Gel group than in the group treated with sEVs only. Conclusion: Delivery of sEVs incorporated in alginate hydrogel provides a novel approach of cell-free therapy and optimizes the therapeutic effect of sEVs for MI.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Jie Zhang,Jihong Hu,Datong Wu,Jianfeng Ma,Yongxin Tao,Yong Qin,Yong Kong
Sodium alginate (SA) was electrodeposited onto the surface of a glassy carbon electrode (GCE), and then l -lysine ( l -Lys), l -alanine ( l -Ala) and l -cysteine ( l -Cys) were simultaneously introduced to the surface of SA via electrostatic attractions. γ-MnO 2 film was deposited potentiostatically onto the multi-templates immobilized SA from an aqueous mixture of K 2 SO 4 and MnSO 4 . The templates of l -Lys, l -Ala and l -Cys were then oxidized and removed by cyclic voltammetry (CV) while maintaining the crystalline structures of SA and MnO 2 . Finally, the molecularly imprinted SA/MnO 2 was successfully applied in the simultaneous recognition of the isomers of Lys, Ala and Cys by differential pulse voltammetry (DPV). This work opens a new avenue in the construction of SA-based multi-templates molecularly imprinted systems for electrochemical simultaneous recognition of the isomers of several chiral amino acids .
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