Nature Communications
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2026
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IF 18.1
Li Haotian,Zhang Jianhua,Zhang Linjun,Zhang Hengjie,Yang Zhen,Gu Zhipeng,Yang Lei,Li Yiwen
Long-term exposure to ultraviolet (UV) radiation can cause sunburn, skin aging, and skin cancers. Conventional sunscreens typically combine organic UV filters and inorganic particles for photoprotection, yet concerns remain regarding skin penetration, systemic effects, and reactive oxygen species generation. Inspired by natural photoprotective mechanisms in plants, we develop a series of all-small-molecule sunscreen hydrogels based on natural polyphenols through a facile one-pot assembly process. The resulting hydrogels exhibit efficient UV shielding with high sun protection factors, strong bioadhesion, antioxidant and antibacterial activities, high visible-light transmittance, and low skin penetration tendency. The hydrogels also demonstrate good environmental stability and effective photoprotection in both mice and Bama miniature pigs. This work highlights the potential of bioinspired all-small-molecule assemblies for efficient and safe photoprotection.
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高影响因子
BMC Complementary Medicine and Therapies
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2026
·Vol. 26
·期 1
·80
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IF 4.4
Gan Xinyu,Liang Mingzhu,Shadekejiang Halinuer,Hong Huan,Lu Jinyu,Li Xu,Zhang Xueqin,Lu Chen
Background Diabetic nephropathy (DN) is a major diabetes complication and a primary cause of end-stage renal failure. Notoginsenoside R1 (NGR1) is known to reduce proteinuria, exert hypoglycemic effects, and enhance renal function in DN patients. However, the exact mechanisms by which NGR1 affects DN are not well understood. Methods An integrative approach combining multi-omics bioinformatics and experimental validation was employed. We analyzed GEO datasets (GSE30122, GSE96804) to identify differentially expressed genes and performed WGCNA to define key modules. Network pharmacology predicted NGR1 targets, which were refined via machine learning (LASSO and Random Forest). Immune infiltration was assessed by CIBERSORT. Molecular docking and dynamics simulations evaluated binding interactions. In vitro functional validation used high glucose (HG)-injured MPC5 podocytes, with MME -specific inhibitor (Thiorphan), confirming target necessity. Results Bioinformatic analysis identified three core targets, MME , PTGS2 , and S100A9 , within the DN pathological network. Functional enrichment revealed their involvement in oxidative stress detoxification, TGF-β-mediated fibrosis, and AGE-RAGE signaling pathways. Immune infiltration analysis indicated an aberrant increase in M0/M2 macrophages and activated mast cells, alongside a reduction in protective γδ T cells, with core targets showing strong correlations with specific immune subsets. Subsequent molecular docking and dynamics simulations indicated that NGR1 exhibited the strongest binding affinity for MME , among the three targets. Corroborating these findings, in vitro experiments confirmed that NGR1 specifically upregulates MME expression transcriptionally and translationally. Crucially, NGR1 counteracted HG-induced oxidative stress, fibrosis, and inflammation. These protective effects were largely abolished upon MME inhibition, demonstrating MME’s essential role in this process. Conclusion This study suggests that NGR1 may exert renoprotective effects in DN potentially through MME modulation, which appears to mitigate oxidative stress, inflammation, and fibrosis. The findings indicate MME could serve as a promising therapeutic target, providing preliminary mechanistic insights for developing targeted DN therapies.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·214
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IF 15
Jin Mengying,Zhang Yahui,Liang Wei,Ao Rigele,Zhou Yuchen,Dang Wanwen,Wu Hongxu,Han Meng,Zhen Yonghuan,An Yang
Background Volumetric muscle loss (VML) leads to severe skeletal muscle dysfunction. While muscle tissue engineering offers a promising strategy, challenges persist due to insufficient neuromuscular innervation and poor reconstruction of neuromuscular junctions (NMJs). Conductive hydrogels can mimic the electrophysiological microenvironment and thus promote structural and functional regeneration, yet commonly used conductive materials still suffer from poor hydrophilicity, non-degradability, and potential cytotoxicity, while their underlying mechanisms remain unclear. Ti 3 C 2 T x MXene, a class of two-dimensional nanomaterials with high conductivity and biocompatibility, shows potential for repairing electroactive tissues. In this study, we developed a novel biomimetic electroactive hydrogel by incorporating Ti 3 C 2 T x MXene nanosheets into adipose-derived decellularized extracellular matrix (adECM). This study aimed to investigate the effects and mechanisms of MXene/adECM hydrogel on muscle regeneration and innervation. Results MXene/adECM hydrogel demonstrated excellent biocompatibility, biodegradability, and conductivity. Compared to the adECM hydrogel, the incorporation of MXene promoted myogenesis, along with increased expression of Desmin, MyoD1, and Myf5. Furthermore, the MXene/adECM hydrogel at the optimal concentration increased the average neurite length by 47.29 μm ( p < 0.05) relative to the adECM group. Transcriptomic analysis combined with a neuromuscular co-culture system indicated that the MXene/adECM hydrogel promoted the formation of neuromuscular junctions (NMJs). The incorporation of MXene upregulated the expression of specific voltage-gated calcium channels at the motor endplate, with transcript levels of Cacna1a and Cacna1s increased to 2.1-fold and 3.1-fold, respectively. It was further observed that calcium signaling was enhanced in the MXene/adECM group, with the peak calcium signal intensity being 2.40 times that of the adECM group. In vivo rat VML model confirmed that, compared to the adECM hydrogel, the MXene/adECM hydrogel promoted an increase in regenerated muscle fiber area, reduced collagen deposition, and elevated the fluorescence intensity of CD31 and Tuj. The co-localization percentage of presynaptic and postsynaptic NMJ markers increased from 27.85 ± 8.69% to 42.21 ± 15.52%. Gait analysis showed significant improvements in print area, swing/stance ratio, and movement velocity. In the MXene/adECM group, the isometric tetanic force (ITF) upon sciatic nerve stimulation was significantly higher than that of the adECM group (0.082 ± 0.012 N vs. 0.057 ± 0.014 N, p < 0.05), approaching the level of the uninjured group. Conclusion Together, these findings demonstrate that the incorporation of MXenes into adECM provides a promising strategy that integrates microenvironmental support with endogenous electrical cues to modulate calcium influx and promote NMJ formation, offering a new paradigm for the treatment of VML. Graphical Study on the therapeutic strategy and underlying mechanism of conductive MXene/adECM hydrogel for volumetric muscle loss (VML) repair. Ti3C2Tx MXene nanosheets were integrated into an adipose-derived decellularized extracellular matrix (adECM) to fabricate a conductive composite hydrogel. Upon implantation, the MXene/adECM hydrogel promoted structural regeneration and reinnervation of the injured skeletal muscle. The bioactive microenvironment and endogenous electrical conductivity facilitated neuromuscular junction (NMJ) formation, accompanied by enhanced calcium influx
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Journal of Translational Medicine
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2026
·Vol. 24
·期 1
·893
·
IF 9.7
Hao Zhihua,Su Xin,Li Jiantao,Jin Jing,Li Zheng,Yan Zhiqiang,Jiao Wenpeng,Jiao Wenjing,Wang Yingying,Ji Chenguang,Wang Xuan,He Yutong
Background Metabolic reprogramming underpins the acquisition of radioresistance in esophageal squamous cell carcinoma (ESCC); however, the specific bioenergetic vulnerabilities and direct pharmacological targets remain to be fully elucidated. This study defines a distinct metabolic phenotype conferring radioresistance and evaluates the natural alkaloid Cepharanthine (CEP) as a mechanism-driven radiosensitizer. Methods Matched clinical cohorts of radiosensitive and radioresistant ESCC patients were analyzed using widely-targeted and targeted metabolomics. Bioenergetic profiling (ECAR/OCR) was performed on established isogenic radioresistant cells. The mechanistic interactions between CEP and its target were mapped via network pharmacology, surface plasmon resonance (SPR), cellular thermal shift assays (CETSA), ubiquitin-proteasomal degradation assays, and Q347A site-directed mutagenesis. In vivo efficacy was validated across human cell-derived xenografts (CDX) and immunocompetent syngeneic (AKR/C57BL/6) mouse models. Results Clinical multi-omics revealed a "metabolic duality" in radioresistant ESCC, characterized by the concurrent hyperactivation of glycolysis and oxidative phosphorylation (OXPHOS). CEP administration disrupted this metabolic network, significantly sensitizing ESCC cells to irradiation [Dose-modifying factor at 37% survival (DMF 37 ) > 1]. Mechanistically, CEP directly engages the kinase domain of p70S6K—a structural interaction dependent on the Q347 residue—and triggers its ubiquitin-proteasomal degradation. This targeted clearance disrupts the upstream PI3K/Akt/mTOR survival axis. Genetic overexpression of wild-type p70S6K, but not the Q347A mutant, rescued the dual hypermetabolic phenotype and reinstated radioresistance. Clinically, elevated p70S6K expression correlated with poor disease-free survival and therapeutic failure. In vivo, CEP synergized with radiotherapy to suppress tumor kinetics in both CDX and syngeneic models, while concurrently enhancing CD8 + T cell infiltration in the immunocompetent microenvironment, with no observable systemic toxicity. Conclusions Radioresistant ESCC relies on a dual hypermetabolic state driven by the PI3K/Akt/mTOR/p70S6K cascade. CEP overcomes this radioresistance by physically binding to and degrading p70S6K, thereby inducing bioenergetic exhaustion and reshaping the anti-tumor microenvironment. These findings provide a solid mechanistic rationale for translating CEP into clinical radiotherapeutic regimens.
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高影响因子
Nature Nanotechnology
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2026
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IF 37.5
Liu Yutong,Zuo Wenhua,Wang Wei,Lin Cong,Weng Qingsong,Zhu Yinggang,Zhang Kai,Du Ke,Ruan Haihui,Pan Feng,Huang Xuejie,Liu Xiang,Yu Hailong,Chen Guohua,Liu Qiang
Stress-induced fractures are recognized as a primary cause of degradation in a wide range of positive electrode active materials during battery operation. However, the state-of-the-art mechanistic understanding and strategy development often overlook the brittle nature of these materials, as well as the dynamic and localized characteristics of mechanical stress during the charge and discharge cycles of the cell. Here we present a shape-memory polymer nanocoating method using initiated chemical vapour deposition to dynamically delocalize concentrated stresses in various positive electrode active materials, including Ni-rich layered oxides with different Ni contents and LiFePO 4 . Fracture simulations and surface-to-bulk physicochemical characterizations collectively show that the balanced stiffness and deformability of the shape-memory polymer nanocoating on the positive electrode material effectively mitigate stress gradients and the consequent surface reconstruction, chemical heterogeneity and intergranular cracking during battery operation. In particular, when a polymeric nanocoated nickel-rich layered oxide positive electrode active material (90 at% of Ni) is tested in non-aqueous lithium metal coin cell configuration at 25 °C, the cells can be consistently charged and discharged over long cycles at moderate (for example, 1,000 cycles at 400 mA g −1 ) and high (for example, 500 cycles at 1 A g −1 ) specific currents.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2026
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IF 4.1
Zheng Chen,Yang Yu-Ma,Xiao Jian-Wu,He Jun-Jie,Lin Bo,He Fu-An
In this work, the novel multifunctional electrospun trimethoxy (1H,1H,2H,2H-heptadecafluorodecyl)silane (TMHFDS)/Ag-TiO 2 /polyvinylidene fluoride (PVDF) mats were prepared. In the preparation process, the AgNO 3 was reduced to be the Ag nanoparticle and then in situ deposited on the TiO 2 nanoparticle to form the Ag-TiO 2 hybrid, which was used as the filler to fabricate the electrospun Ag-TiO 2 /PVDF mats followed by the TMHFDS modification. The successful preparation of the electrospun TMHFDS/Ag-TiO 2 /PVDF mats were proved by the characterizations of scanning electron microscopy, two-dimension energy-dispersive X-ray spectroscopy mapping, Fourier transform infrared spectroscopy, differential scanning calorimeter, and wide-angle X-ray diffraction. The electrospun TMHFDS/Ag-TiO 2 /PVDF mats possessed not only the enhanced crystallinity degree and useful piezoelectric β-crystal content of PVDF than those of the PVDF solid film and the electrospun PVDF mat but also the photocatalytic degradation ability for the oil red O dye. Moreover, for the electrospun TMHFDS(3%)/Ag-TiO 2 (30%)/PVDF mat, its water contact angle reached as high as 156.4° which was 24.6° higher than that of the electrospun PVDF mat before the TMHFDS modification, and its oil absorption capacities for valorous oils ranged between 16.3 g g −1 and 25.1 g g −1 , exhibiting the well oil–water separation ability.
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Journal of Applied Spectroscopy
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2026
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IF 0.7
Zhao Xing,Zhang Peiyue,Leng Xin,Liu Jing,Zhang Yang,Bai Yinjuan,Yang Bingqin
Trace element analysis of ancient human remains plays an important role in reconstructing dietary habits and living environments. However, conventional analytical methods have critical limitations such as destructive sampling, high costs, and inadequate sensitivity. To address these challenges, a reversible fluorescent probe with specific recognition for Cu 2+ was fabricated and characterized in this study for cell detection and bioimaging. Compared with other cations in solution, the probe exhibited exceptional selectivity and sensitivity towards Cu 2+ . The interaction between the probe and Cu 2+ accelerated the ring-opening process, resulting in a new emission band at 525 nm within a specific pH range. A strong linear relationship between the fluorescence intensity and Cu 2+ concentration, ranging from 0.0 to 1.0 equivalents, with a detection limit of 4.52 μM, was observed. In addition, Job plots and infrared spectral analysis revealed that B probe complexed Cu 2+ at a 1:1 ratio. Biological testing revealed that the probe has good biocompatibility and can be effectively used for Cu 2+ cell imaging. Cu 2+ -specific reversible fluorescent probes can be designed and fabricated with good fluorescence response characteristics and combined with fluorescence spectroscopy technology to accurately quantify Cu 2+ in complex ancient human samples.
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高影响因子
Nano-Micro Letters
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2026
·Vol. 18
·期 1
·450
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IF 38.5
Zhang Zhilin,Gu Jiayi,Wang Lina,Cui Xingchen,Zhai Xu,Xu Yue,Liu He,Li Deliang,Li Bingle,Tian Ye,Lu Baoyang,Fu Yu,Wang Tieqiang
The cascade polymerization synergistic toughening mechanism overcomes the problem of mutual constraints between "mechanical strength and response speed" of traditional hydrogels and realizes load-bearing actuation.
The “mass–deformation” dynamic coding law was established, enabling a hydrogel-based 0/1 binary information encoding system derived from mechanical actuation responses.
Actuation–perception integrated logic-gate units were developed to enable intelligent soft robotics through a closed-loop “light-triggered actuation–signal feedback–logic processing–robotic action” control system.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Zhang Yong,Jiao Gongao,Ding Zuozhe,Zhang Dongzhi
Hydrogen Sulfide (H 2 S) gas can cause physiological discomfort at low concentrations and is lethal at high concentrations. It is one of the major pollutants in the petrochemical industry. In this article, carbon-modified WO 3 nanoparticle gas-sensitive sensing materials were synthesized using the hydrothermal method, and high-performance H 2 S gas-sensitive sensing devices were fabricated. At a doping ratio of 2:3, the optimal working temperature for the carbon-modified WO 3 (C-WO 3 ) nanoparticles is 160 °C. It exhibits a response value of 23.7 for 10 ppm of H 2 S gas, with a response and recovery time of 6 s/64 s. The material demonstrates excellent selectivity, repeatability, and long-term stability for detecting H 2 S gas. These outstanding performance characteristics make it a promising candidate for H 2 S gas detection applications. This modification enhances the material’s gas-sensing performance and its resistance to interference. Finally, first-principles calculations revealed the mechanism behind the improvement in the H 2 S gas-sensing performance of carbon-modified WO 3 sensing materials.
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高影响因子
Nature Communications
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2026
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IF 18.1
Ren Lijuan,Hu Xiuli,Wang Shuyu,Shi Jiaqi,Gong Jiaxing,Wang Manyun,Zhou Ji,Wang Jianzu,Lv Xian-Wei,Bielawski Christopher W.,Geng Jianxin
Zinc−air batteries are promising devices for use in safe and cost-effective energy storage applications. However, their practical utility is hindered by sluggish oxygen evolution and oxygen reduction reactions. We show that hybridizing electronically coupled Co single atoms and a CoPd alloy within a three-dimensional macroporous N-doped carbon (CoPd/Co@3D NC) enables high-performance N 2 H 4 -assisted zinc−air batteries, where the oxygen evolution reaction is replaced with the thermodynamically more favorable hydrazine oxidation reaction. Experimental and theoretical data reveal that electronic coupling between the Co single atoms and the CoPd alloy mutually modifies their electronic structures, which, in turn, weakens oxygen adsorption on the Co single atoms and enhances N 2 H 4 adsorption on the Pd sites. The electronic-coupling effect accelerates the rate-limiting steps of the oxygen evolution and hydrazine oxidation reactions. Consequently, N 2 H 4 -assisted zinc−air batteries employing CoPd/Co@3D NC exhibit a small charging/discharging voltage gap of 0.52 V at 100 mA cm −2 , a peak specific power of 151 mW cm −2 , and a specific capacity of 810 mAh g −1 at 10 mA cm −2 ; these values are competitive when compared to those exhibited by conventional zinc−air batteries.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
·Vol. 61
·期 33
·24477-24493
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IF 4.4
Dong Mingming,Yang Shuyong,Zhou Peng,Huang Zewen,Tu Shenghui
The persistence and removal of antibiotic residues in aquatic environments represent a global environmental challenge. In this study, a novel ternary Bi 2 WO 6 /UiO-66/AgI heterojunction photocatalyst was designed and constructed for the deep removal of tetracycline (TC). AgI nanoparticles and Bi 2 WO 6 nanosheets were in situ anchored onto a porous UiO-66 framework, successfully integrating high adsorption capacity, visible-light response, and efficient charge separation. It was demonstrated that the composite, when exposed to visible light, exhibited a significantly enhanced level of TC degradation activity in comparison with its single- and binary-component counterparts. Mechanistic investigations revealed that UiO-66 not only served as an adsorptive substrate to concentrate pollutants but also functioned as an electron transfer mediator, promoting a direct Z-scheme charge transfer pathway between Bi 2 WO 6 and AgI. This configuration effectively suppressed charge-carrier recombination and enhanced the generation of reactive oxygen species ·O 2 − , ·OH and h + ). The proposed reaction pathway was confirmed by radical-trapping experiments and electron paramagnetic resonance (EPR) spectroscopy. Additionally, this composite material demonstrated favourable performance in stability and toxicity assessments. This work provides a new design concept for metal–organic framework-based composite photocatalysts and elucidates their potential application in synergistic adsorption–photocatalytic degradation of organic pollutants in water treatment. Graphical abstract
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JOURNAL OF ANTIBIOTICS
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2026
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IF 2.7
Zhang Zhikun,Mao Yixuan,Wang Xiu,Ji Hongsheng,Li Yu-Ying
Mycoplasma pneumoniae (MP) is an important respiratory pathogen. Growth inhibition and regulation of inflammation in lung are key to the treatment of MP infections. Bortezomib, a proteinase inhibitor, was found to possess both functions in this study. Firstly, bortezomib showed dose-dependent bacteriostatic activity against MP in culture medium. Decreases in glucose catabolism (changes of pH) and colony-forming units (CFUs) were detected at 3 d post-incubation (bortezomib>10 nM). The MP cells incubated with bortezomib of 25 nM exhibited decreases in contents of protein and carbohydrate comparing to normal MP cells. When co-incubated with lung epithelial cells, reductions in MP CFUs and viability of lung epithelial cells were detected. Transcriptome analysis revealed that bortezomib (25 nM) influence the protein digestion and absorption pathways in A549 cells. Meanwhile, bortezomib up-regulated the PI3K-Akt and JAK-STAT pathways and down-regulated the MAPK pathway in MP-infected cells. Western-blot detection revealed that bortezomib reduce the increase in TLR4 triggered by MP, and reduce the level of IκBα. Meanwhile, higher level of extracellular IL-6 was detected in MP-infected cells post bortezomib treatment. In addition, the secretions of bortezomib-treated A549 cells showed promoting effects on M1-polarization of macrophages. In Balb/c mice, oral administration of bortezomib promoted the production of MP-specific antibodies and reduced pulmonary damage at 7th day post infection. In conclusion, bortezomib exerts a direct bacteriostatic effect on MP in vitro, it also plays roles in the regulation of inflammatory pathways during MP infection.
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高影响因子
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