ENVIRONMENTAL RESEARCH
·
2022
·
IF 8.431
Yusong Yang,Ying Zhao,Yuan Zong,Ruiqi Wu,Mingyi Zhang,Jing Feng,Tong Wei,Yueming Ren,Jun Ma
Developing high-efficiency catalysts for peroxymonosulfate (PMS)-based advanced oxidation processes is important for eliminating pollutants in water. Herein, α-MnO 2 with major exposed {110} and {100} facets prepared via a hydrothermal method were used as catalysts to activate PMS for the degradation of Orange Ⅰ (OⅠ). α-MnO 2 -100, with more abundant surface hydroxyl groups and greater reductive ability, performed remarkably better than α-MnO 2 -110 for degrading OⅠ. OⅠ removal of 86.20% was obtained in the α-MnO 2 -100/PMS system. The apparent rate constant of OⅠ removal over α-MnO 2 -100 was 2.11 times higher than that of α-MnO 2 -110. The effects of PMS concentration, catalyst dosage, OⅠ concentration, initial pH, anions and humic acid (HA) on OⅠ degradation in the α-MnO 2 -100/PMS system were systematically investigated. Quenching experiments and electron paramagnetic resonance (EPR) demonstrated that SO 4 • − , •OH, O 2 • − and 1 O 2 were the reactive oxygen species (ROS) in the α-MnO 2 -100/PMS system. Moreover, the possible degradation pathway of OⅠ in the α-MnO 2 -100/PMS system was proposed. This work provides an ideal metal oxide catalyst for sewage remediation.
研究领域:
环境科学
·
化学工程
·
水处理
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DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2019
·Vol. 150
·期 5
·1244-1255
·
IF 2.372
Zhang Han,Hua Shaofeng,Zhang Lei
Abstract Graphene oxide (GO) has broad application prospects in the field of catalysis, especially as enzyme carrier, owing to its unique intriguing physic-chemical properties. In this paper, the layer structure and oxygen functional group content of GO which may affect the properties of the immobilized enzyme were discussed. GO was prepared from 8000 mesh and nanoscale graphite at different reaction temperatures (40 °C and 95 °C), and used as carriers to immobilize α-amylase by deposition and cross-linking methods, respectively. Several analytical tools, including AFM, FT-IR, UV–Vis, XPS, and Raman, were used to character GOs. The enzyme loading of GO-8000-40 °C-E (of GO-NM-95 °C-GA-E) was 122.1 (49.8) mg/g, which retained 94.7 (82.6) % of the free enzyme activity, the optimum pH, optimum temperature, K m and V max were 7.0 (7.0), 70 (75) °C, 18.837 (39.989) mg/mL and 1.584 (1.842) μmol/(mL·min), respectively. Overall results indicated that 8000 mesh graphite was suitable for the preparation of immobilized enzyme by deposition method, while nano-graphite had an advantage in cross-linking immobilized enzyme. Graphic Abstract
研究领域:
催化
·
材料科学
·
生物化学
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2014
·Vol. 292
·期 12
·3243-3249
·
IF 2.41
Li Xiubing,Xiao Junjie,Wang Xi,Yi Chunwang,Su Shengpei
The pH-responsive inclusion complexation of comblike triblock polymer, P2VP- b -PPEOMA- b -P2VP, with α-cyclodextrin (α-CD) was studied. The triblock polymer was prepared by reversible addition–fragmentation chain transfer polymerization (RAFT) and formed inclusion complexes (ICs) after selective threading of the PEO segment of the triblock polymer through the cavities of α-CD units. For comparison, PPEOMA homopolymer was prepared, and the inclusion complexation with α-CD was also studied. The formed ICs were characterized by XRD and 1 H NMR. The results revealed that P2VP- b -PPEOMA- b -P2VP can form ICs with α-CD even when forming micelles, and the introduction of P2VP had a great influence on the solution property and the stoichiometry of EO to CD of the inclusion complexes depending on the concentration and the pH of the solution.
研究领域:
高分子化学
·
材料科学
·
超分子化学
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DOI
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2021
·
IF 4.86
Zhengyuan Chen,Yuhuan Wu,Bixia Wang,Jiamin Fang,Changlian Gan,Chuanlan Sang,Zhu Dun,Tajie Luosang,Qing Wang,Dawa Zeren,Tianqin Xiong
Clinical studies have shown that Intrahepatic cholestasis is closely related to intestinal injury. The gut-liver axis theory suggests that the intestine and liver are closely related, and that bile acids are important mediators linking the intestine and liver. We compared two cholestasis models: a single injection model that received a single subcutaneous ANIT injection (75 mg/kg), and a multiple subcutaneous injection model that received an injection of ANIT (50 mg/kg) every other day for 2 weeks. We used Transmetil (ademetionine 1,4-butanedisulfonate) to relieve intrahepatic cholestasis in the multiple injection group. In the multiple injection group, we found increased hepatic bile duct hyperplasia, increased fibrosis of the liver, increased small intestine inflammation and oxidative damage, increased harmful bile acids, decreased bile acids transporter levels. After treatment with Transmetil, the liver and gut injuries were relieved. These results suggest that intrahepatic cholestasis can cause disorders of the gut-liver axis.
研究领域:
肝病学
·
胃肠病学
·
药理学
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DOI
PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2022
·
IF 7.419
Xia Gan,Hailing Huang,Jing Wen,Kai Liu,Yuting Yang,Xiaoning Li,Gang Fang,Yonghong Liu,Xueni Wang
Prostate cancer is a disease that often occurs in elderly men. Androgen receptor signaling pathway runs through the occurrence and development of prostate cancer. Thereby, targeting androgen receptor is a crucial strategy for the treatment of prostate cancer. α-Terthienyl, which has been used as photosensitive activator and insecticide, is a natural compound rich in marigold. In the present study, we found α- terthienyl could inhibit the cell viability of four prostate cancer cell lines, especially on LNCaP and 22Rv1 cells which endogenously express androgen receptor. Then we proved that it could inhibit the proliferation of prostate cancer cells and induce apoptosis of prostate cancer cells by plate clone formation assay and flow cytometry respectively. Furthermore, we found α-terthienyl could inhibit androgen receptor nuclear translocation, reduce androgen receptor expression, reduce the mRNA and protein expression of androgen receptor target genes (KLK3, TMPRSS2, PCA3) and nuclear proliferation antigen Ki67 and PCNA. In addition, it inhibited the expression and phosphorylation of Akt protein while increasing the expression of tumor suppressor p27. Besides, we constructed a mouse xenograft prostate cancer model and confirmed that α-terthienyl also inhibited the growth of prostate cancer in vivo. In conclusively, α-terthienyl played an anti-prostate cancer role by inhibiting both the expression of androgen receptor and the transduction of its signal pathway, suggesting that it is a promising natural small molecule for the treatment of prostate cancer.
研究领域:
肿瘤学
·
药理学
·
分子生物学
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DOI
PubMed
高影响因子
Journal of the Korean Ceramic Society
·
2026
·
IF 4.4
Yan Long-Pan,Zhang Guo-Hua
α-Si 3 N 4 and SiC powders were prepared from reaction between SiO 2 and carbon black in different atmosphere. The effects of atmospheres, raw material particle sizes, and C/SiO 2 molar ratio on the syntheses of Si 3 N 4 and SiC powders were investigated. The optimal parameters for preparing α-Si 3 N 4 were determined to be a temperature of 1500 °C for 8 h with a C/SiO 2 molar ratio of 4.0. In addition, the results demonstrated that H 2 atmosphere facilitated SiC synthesis by lowering its formation temperature. SiC powders were synthesized under a flowing H 2 atmosphere at 1500 °C for 5 h. N 2 -H 2 mixed atmosphere inhibited Si 3 N 4 formation while promoting SiC synthesis, with increasing SiC content as the H 2 partial pressure rose. Meanwhile, the size reduction of raw materials was conducive to promoting the formation of Si 3 N 4 and SiC and reducing the granularity of the final product. However, if the particle size of the raw materials was too fine, the product will tend to agglomerate.
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DOI
高影响因子
Journal of Materials Chemistry C
·
2026
·
IF 5.1
Zhiwei Wang,Zihao Song,Wenqi Jiang,Jin Zhu,Xianfei Luo,Yuchen Li,Wenbin Zhu,Gan Jin,Hua-Yu Tang,Xing Gao,Xue-Li Liu
Amine intercalation is an efficient way to fine tune and enhance the properties of layered α-zirconium phosphate (α-ZrP), however, its impact on the proton conduction properties of α-ZrP has been rarely explored. In this contribution, a long-chain alkylamine, dodecylamine (DDA), was successfully intercalated into α-ZrP nanoplates. The intercalation was seen to exert both positive and negative impacts on the proton-transport capabilities of α-ZrP. When the intercalant concentration was low, the hydrophobic long-chain alkyl groups of anchored DDA molecules hindered the diffusion of water, causing suppressed proton conduction. With a high DDA concentration, enhanced proton conduction was observed in the intercalated α-ZrP, due to the existence of expanded interlayer spacing and free DDA, which facilitated the diffusion and accommodation of water molecules, leading to an increase in carrier concentration and the formation of hydrogen-bonding networks. The optimized DDA-intercalated α-ZrP (α-ZrP-DDA (1:4)) showed a proton conductivity of 1.11×10-4 S cm-1 at 303 K and 98% relative humidity (RH), which was one order of magnitude higher than that of α-ZrP. Moreover, a humidity sensor based on α-ZrP-DDA (1:4) was fabricated, which could distinguish deep, normal and fast breathing, indicating its potential for practical monitoring of human breath. Our work demonstrates that amine intercalation is an efficient strategy for modulating proton-transport behavior in α-ZrP, thereby broadening its potential applications.
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产品关联
DOI
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2026
·
IF 5.2
Tao Liu,Xu Zhang,Wei Zhang,Dejin Yang,Jipeng Li,Lin Liu
Objective α-Amanitin (α-AMA), the principal toxin of lethal mushrooms, induces severe liver injury by exacerbating oxidative stress. Glutathione S-transferase A1 (GSTA1), a crucial hepatic antioxidant enzyme, plays an ambiguous role in this process. Methods A mouse model of α-AMA-induced liver injury was established. Hepatic damage was assessed via serum biochemistry (ALT, AST, T-BIL) and histopathology (H&E staining). Oxidative stress markers (SOD, CAT, MDA) were measured. Integrated transcriptomics and metabolomics were employed to identify critical pathways. The interaction between α-AMA and GSTA1 was evaluated using molecular docking and Drug Affinity Responsive Target Stability (DARTS) assays. In vitro mechanisms were further dissected in HUH7 cells using siRNA knockdown, and functional rescue experiments. Results α-AMA caused significant liver injury, evidenced by elevated serum markers, worsened histopathology, and increased oxidative stress (reduced SOD/CAT, elevated MDA). Multi-omics analysis pinpointed GSTA1 and glutathione metabolism as central to the toxicity. Both molecular docking and DARTS assays confirmed a direct interaction between α-AMA and GSTA1. Mechanistically, α-AMA activated the NRF2 pathway, leading to upregulated GSTA1 expression. Paradoxically, GSTA1 silencing alleviated toxicity. This detrimental effect was mediated through GSTA1-driven depletion of cellular glutathione (GSH), resulting in reactive oxygen species (ROS) accumulation. Conclusion This study unveils a novel mechanism where α-AMA hijacks the NRF2-GSTA1 antioxidant axis, transforming GSTA1 from a detoxifier into a key perpetrator of hepatotoxicity via GSH depletion, ROS overproduction. GSTA1 emerges as a promising direct therapeutic target and potential diagnostic biomarker for α-AMA poisoning, highlighting a critical direction for future research.
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2026
·Vol. 48
·期 7
·331
·
IF 4.3
Chen Huan-Feng,Yang Zi-Jun,Chen Hai-Rong,Zhao Hai-Ming,Li Yan-Wen,Cai Quan-Ying,Mo Ce-Hui,Xiang Lei
Mining operations release substantial quantities of organic flotation reagents into aquatic environments. These compounds could subsequently enter soil systems through irrigation, runoff, or overflow, posing significant pollution and potential ecological risks. Nevertheless, the environmental fates of these reagents, particularly foaming agent, in soils remains poorly understood. This study investigated the sorption and degradation of α-terpineol (a typical foaming agent) in six soils with distinct physicochemical properties, using batch experiments coupled with solid-phase extraction and gas chromatography–mass spectrometry. The sorption kinetics followed a pseudo-first-order model, involving intra-particle and liquid film diffusion, while the sorption isotherms were best described by the Langmuir model, indicating monolayer sorption. The sorption process was governed mainly by hydrophobic interactions associated with soil organic matter (OM) and bridging effects facilitated by clay components. Higher OM content, higher clay content, neutral pH, greater abundance of dissolved OM, and higher cation concentrations promoted α-terpineol sorption. The logarithmic organic carbon partition coefficient of α-terpineol mainly ranged from 1.7 to 3.0, suggesting its weak sorption capacity in soils. The degradation kinetics conformed to a first-order model, with the degradation half-lives varying between 9.4 and 69.1 h cross different soils. This degradation was promoted by lower initial compound concentration, reduced moisture, moderate temperature, and enhanced microbial activity. A distinct lag phase in α-terpineol degradation highlighted its potential environmental persistence. These findings provide critical insights into the environmental fate and potential ecological risks of foaming agents in soil.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
·
2014
·Vol. 46
·期 3
·169-175
·
IF 1.566
Hong-Ya Li,Xiao-Li Zhang,Jie-Bing Zhang,Tian-Tian Zhang,Bin-Xia Zhao
The transesterification of phosphatidylcholine with methanol was successfully carried out using a promising solvent methyl tert-butyl ether instead of traditional ether, and the reaction was dramatically enhanced in the presence of tetrabutylammonium hydroxide as the phase-transfer catalyst. Kinetics of the reaction including the effects of the reaction conditions on the conversion of phosphatidylcholine and the apparent rate constant ( k app ) were investigated in detail. On the basis of the experimental evidence, the transesterification mechanism was proposed and a kinetic model was developed, and the experimental data were well described by the pseudo–first-order equation.
研究领域:
生物化学
·
有机化学
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DOI
高影响因子
Materials Science and Engineering B-Advanced Functional Solid-State Materials
·
2026
·
IF 4.6
Tianyuan Xiao,Xinyue Dong,Nan Yang,Yanming Zhang,Xiaoya Ding,Guangming Yin
To address the increasingly serious problem of antibiotic contamination, the hydrothermal method was employed to synthesize In 2 O 3 /α-Bi 2 O 3 photocatalysts. For tetracycline (TC) in aqueous solution, its photocatalytic degradation efficiency driven by visible light was systematically evaluated. The physical structure, optical properties and charge transfer of the composite materials were characterized and analyzed by XRD, PL and EIS. Nanoparticles In 2 O 3 was uniformly loaded on spindle-shaped α-Bi 2 O 3 , and the specific surface area increased to 17.08 m 2 /g. The composite material demonstrated a strong TC photodegradation ability, with a degradation efficiency of 86.99% (catalyst dosage = 30 mg, pH = 6, and initial TC concentration = 5 mg·L −1 ). The experimental results show that its excellent performance is attributed to the formation of heterojunctions, which have improved visible light absorption and efficient charge transfer. Free radical scavenger studies have confirmed that ·O₂ − and h + generated by photocatalysts account for the efficient degradation of TC, thus laying a foundation for the practical application of photocatalysts. This study innovatively constructs an In 2 O 3 /α-Bi 2 O 3 heterojunction with tailored loading ratio, which not only extends the visible-light response range but also promotes directional charge transfer, thus achieving superior photocatalytic degradation of tetracycline.
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·Vol. 44
·期 17
·22003-22007
·
IF 3.057
Zunlan Hu,Tianbin Zhu,Weiwei Wu,Zijun Peng,Feng Hu,Zhipeng Xie
Novel polycrystal α-Si 3 N 4 submicron rods have been successfully prepared from amorphous Si 3 N 4 powders. As-synthesized submicron rods have oblate section, with the size of 110–150 nm in height, 150–300 nm in width and 3 µm to tens of micrometers in length. Underlying growth mechanism was rationally proposed based on the results of X-ray diffraction analyses, scanning electron microscopy and transmission electron microscopy observations. It was demonstrated that the nucleation and crystal growth of α-Si 3 N 4 occurred simultaneously during the fabrication process of submicron α-Si 3 N 4 rods. The growth of α-Si 3 N 4 submicron rods follows vapor-solid-solid mechanism. The submicron rods grew from the surface of amorphous Si 3 N 4 powders in N 2 atmosphere without catalysts. The silicon monoxide vapor [(SiO)g], as a reaction intermediate, reacted with nitrogen [N 2 ] to form α-Si 3 N 4 seeds, further growing into the Si 3 N 4 nanowires. Finally, the Si and N atoms deposited on the surface of Si 3 N 4 nanowires and rearranged to form submicron rods.
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DOI
高影响因子
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