Food & Function
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2025
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IF 5.4
Le Wang,Houzhen Lu,Haitao Gui,Zifu Ni,Zhongke Sun,Zihua Wang,Zhihua Wang,Xuanyan Liu,Qipeng Yuan
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease (IBD) posing a significant health threat. This study explored the protective effects of D-tagatose against DSS-induced colitis in mice and its underlying mechanisms using H&E staining, AB-PAS staining, immunofluorescence, immunohistochemistry, ELISA, qPCR, western blotting, and other assays. D-Tagatose improved colitis by increasing body weight and colon length, with decreased DAI (disease activity index) and histopathological scores. The results showed that D-tagatose inhibited the secretion of myeloperoxidase (MPO), inflammatory enzymes (iNOS and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) as well as increased the content of anti-inflammatory cytokines (IL-10) in vitro. In addition, D-tagatose enhanced the expression of tight junction proteins (ZO-1 and Occludin) and mucin (MUC-2). Furthermore, D-tagatose was able to modulate the gut microbiota dysbiosis caused by DSS-induced UC and increased the content of short-chain fatty acids (SCFAs). This study indicated that D-tagatose attenuated DSS-induced UC by modulating inflammatory cytokines, restoring intestinal barrier function, maintaining gut microbiota homeostasis, and enhancing SCFA production. These findings provide D-tagatose as a safe and effective novel functional food strategy for the prevention and treatment of UC.
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DESALINATION
·
2025
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IF 9.8
Huiling Chen,Xiubei Yang,Guiping Yang,Yuhe Mu,Chengbing Yu,Wei Zhang,Gaofeng Zeng
The remediation of toxic dye pollutants via covalent organic frameworks (COFs) presents a promising yet challenging strategy for sustainable water purification, as conventional powdered COFs face critical limitations in recyclability and secondary contamination risks. Herein, we introduce a paradigm-shifting approach combining template-assisted electrospinning with room-temperature dynamic covalent chemistry to fabricate hierarchically porous TAPT-TFPT COF hollow fibers, which address these bottlenecks. The synthesized fibers exhibit crystallographically ordered 2.2 nm pores, a high surface area (1402 m 2 g −1 ), and reliable chemical/thermal stability. These structural merits translate to unprecedented Congo red (CR) adsorption performance with a maximum capacity of 3670 mg g −1 (3–15 times higher than state-of-the-art COFs), size-selective removal efficiency, and comprehensive adsorption metrics including rapid kinetics (95 % removal in 6 h), pH adaptability (50–99 % efficiency across pH 2–12), and cyclic stability (90 % retention after 5 cycles). Mechanistic analyses reveal chemisorption-dominated Langmuir monolayer adsorption governed by pseudo-second-order kinetics, with molecular recognition driven by synergistic pore-size matching, multivalent hydrogen bonding, and π-π interactions. This work establishes an ambient aqueous synthesis platform for macroscopic COF architectures while redefining performance benchmarks for industrial-scale water treatment technologies.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Xuyuan Sun,Minmin Liu,Ying Wang,Zhengyuan Dai,Li Li,Yaping Ding
A molecularly imprinted electrochemical sensor (MIECS) based on dual functional monomers was designed for the trace analysis of ramipril (RAM). The molecularly imprinted polymer (MIP) film was prepared by electropolymerization, p-aminobenzoic acid (p-ABA) and 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) were used as dual functional monomers, and RAM was used as template molecule. Compared with sensors that only use a single functional monomer (p-ABA or AMT), the synergistic effect of dual functional monomers enhances the selectivity of MIECS. Under optimal conditions, the MIECS demonstrated a low detection limit of 23.9 fM within a wide linear range from 10 −13 M to 10 −6 M. Its application was validated by the successful detection of RAM in tablets with satisfactory recovery.
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POWDER TECHNOLOGY
·
2025
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IF 4.6
Yakun Yin,Shaohua Wang,Wen Shi,Youpo Mise,Zejia Wang,Xuejiao Zhou,Juan An,Hongdan Wang,Wentang Xia,Wenqiang Yang
This study introduces an automated rotating cathode roller electrolysis system designed to eliminate cathode residue and ensure consistent production of high-quality dendritic copper powder (DCP). We systematically evaluated Cu, Mo, 316 L stainless steel (316 L), Ti, and Ta cathodes to unravel their impact on DCP morphology, residue accumulation, and energy efficiency. After 10 deposition cycles (10 min/cycle), Cu cathodes accumulated severe residue (89.62 g m −2 ), causing particle coarsening, a 51 % increase in apparent density, and 60 % higher energy consumption. The residue formation mechanism involves the initial deposition of a dense copper layer that bonds firmly to the Cu substrate, evolving into a residual layer after scraping. Ti initially showed low residue but degraded cyclically. Mo formed weakly adherent deposits that fragmented during scraping. In stark contrast, 316 L and Ta exhibited near-zero residue accumulation, consistently producing superior DCP with low apparent density (0.37–0.69 g cm −3 ) and fine particle size (10.02–29.82 μm). Surface characterization revealed that the presence of protective oxide layers on 316 L and Ta surfaces is key to inhibiting residue formation and corrosion. Ta emerged as the optimal cathode, achieving zero residue, exceptional corrosion resistance, stable high-quality DCP output, and minimal energy consumption during long-term operation.
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WATER RESEARCH
·
2025
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IF 12.4
Shui Wang,Wenjing Qiao,Wei Li,Shengqiang Ying,Lianghua Lu,Jingjing Wang,Yi Yang,Jun Yan,Jiandong Jiang
Trichloroethene (TCE) and toluene are ubiquitous co-contaminants in groundwater and soil, yet effective strategies for their concurrent remediation remain challenging due to inhibitory interactions and substrate competition. In this study, we obtained two anaerobic enrichment cultures capable of detoxifying TCE and toluene with degradation rates of 141.7 ± 57.5 and 317.6 ± 1.3 µmol/(L·d), respectively. The 16S rRNA gene amplicon sequencing and quantitative PCR revealed that Dehalococcoides spp. dechlorinated TCE to ethene, while Azoarcus - Aromatoleum spp. mediated the toluene degradation under nitrate-reducing condition, with growth yields of 2.5 ± 1.3 × 10 8 copies/µmol Cl − released and 1.3 ± 0.2 × 10 9 copies/µmol toluene consumed, respectively. The enrichment cultures were successfully immobilized, maintaining degradation efficiencies comparable to those of free cells when individually exposed to respective contaminants. Under co-contamination scenario, complete TCE dechlorination was achieved only with immobilized cultures, as the immobilization matrix mitigated the toxicity from denitrification intermediates. When incorporated into sand columns to construct permeable reactive barriers (PRBs) simulating the groundwater flow system, the immobilized cultures completely degraded TCE and toluene (up to 547 μM) individually within 17 days. A hydrodynamically zoned bioremediation strategy was implemented for co-contamination removal, achieving 91.2% upstream TCE dechlorination and 78.98% downstream toluene oxidation. Elevated TCE loading (338 μM) without sufficient hydraulic retention time caused accumulation of dechlorination intermediates, whereas subsequent reduced TCE (169 μM) restored complete dechlorination to ethene. Toluene degradation remained suboptimal due to inhibitory effects from upstream TCE and its dechlorination intermediates. This study provides valuable technical insights and practical guidance for designing and implementing zoned bio-PRBs to address challenging groundwater co-contamination problems.
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Shuwen Zhu,Huiqing Fan,Lin Lei,Yongbo Fan,Weijia Wang
Developing triethylamine (TEA) sensors using metal oxide semiconductors (MOS) presents challenges such as achieving high sensitivity, low operating temperatures, and reliable detection of trace TEA. In this study, a novel two-step solvothermal synthesis strategy was developed for the sequential fabrication of δ-MnO 2 nanosheets and δ-MnO 2 /WO 3 (WMn) heterojunction composites. The resulting WMn heterostructure features a unique morphology, where δ-MnO 2 nanosheets are encapsulated within a WO 3 matrix, forming well-defined layered interfaces and abundant active sites. This tailored structure significantly enhances the TEA sensing performance. In particularly, WMn1 sensor achieves an ultrahigh response of 515.37 to 20 ppm TEA at 140 °C. The sensor also exhibits an exceptionally low detection limit of 15.91 ppb, along with rapid response/recovery kinetics and long-term stability. The superior performance is attributed to the formation of n–p heterojunction and the synergistic effects of electronic and chemical sensitization, which optimize charge carrier dynamics, reduce interfacial resistance, and enhance surface reactivity. By focusing on interface engineering in heterojunction-based gas sensors, this study contributes to the strategic design of high-performance sensing materials, with potential applications in environmental monitoring and industrial safety.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Xue Wang,Lu Liu,Di Wu,Yuxin Hu,Hongzhuo Liu,Yizhou Sun,Guangqi Yan
Noninfectious uveitis (NIU) remains a significant cause of vision impairment, typically managed with glucocorticoids. However, current glucocorticoid implants present considerable side effects, including elevated intraocular pressure and cataracts. To overcome these limitations, we synthesized a novel prodrug, dexamethasone gallate (DG), which possesses the powerful anti-inflammatory ability of dexamethasone (DEX) and exhibits strong antioxidant activity of gallic acid (GA) that helps protect ocular tissues against oxidative stress. DG was formulated into cyclodextrin microparticle suspension eye drops, designed to progressively disintegrate and penetrate ocular tissues effectively. In experimental autoimmune uveitis (EAU) models, DG suspension eye drops demonstrated comparable therapeutic efficacy to conventional DEX eye drops at reduced dosages, significantly reducing anterior and posterior ocular inflammation. Notably, DG formulations substantially minimized intraocular pressure elevation and glucocorticoid-related adverse effects. These findings support the potential of DG suspension eye drops as a safer, efficient, and patient-friendly therapeutic alternative for treating NIU.
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Frontiers in Pharmacology
·
2025
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IF 4.8
Hanbin Chen,Guanghong Li,Lin Deng,Nan Xu,Simon Ming-Yuen Lee,Xiaowei Nie,Jin-Song Bian
Introduction: Pain is a complex phenomenon involving physiological and psychological responses to noxious stimuli. Long-term opioid or NSAID use leads to reduced efficacy and tolerance. Initially a thermosensitive receptor, TRPV1 is increasingly recognized as a target for analgesic intervention.Methods: Our investigation is focused on the exploration of novel TRPV1 antagonists derived from natural sources through computational screening methodologies, aiming to assess their efficacy as analgesic agents.Results: Among the compounds screened, a promising TRPV1 antagonist named pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside (PINO) has exhibited superior stability in its interaction with TRPV1 through virtual screening and molecular dynamics simulation. A dosage of 20 mg/kg of PINO had been shown to reduce the writhing response in acetic acid-induced mice, elevate the thermal pain threshold in the hot water tail-flick and hot plate assays, and concurrently increase the mechanical pain threshold in CFA-induced inflammatory pain models in mice. Moreover, in a murine Lewis lung carcinoma cell line LL-induced bone cancer pain model, PINO also effectively raised the thermal and mechanical pain thresholds in mice. Furthermore, PINO had been found to attenuate the production and gene expression of pro-inflammatory cytokines. The underlying mechanism was attributed to the suppression of NF-κB and MAPK signaling cascades.Discussion: This innovative compound represents a prospective avenue for the management of acute, chronic, and bone cancer pain, providing a viable alternative analgesic option for individuals suffering from such conditions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Mingxiao Feng,Qianyu Wang,Minzhen Lei,Dawei Zhang,Qian Yu,Chunyan Yan
Neuroinflammation is closely linked to Alzheimer's disease, where the deposition of amyloid-beta activates microglia, triggering multiple processes that lead to neuronal damage and cognitive decline. However, studies have shown that water extract of Pinellia ternata can improve cognitive function and reduce inflammatory response in the brain injury of mice. Herein, a water-soluble polysaccharide, PTTBP-2-2. with a molecular weight of 11.7 kDa, consisting of D-Glc, D-Gal, D-Xyl, and L-Ara, was isolated from P. ternata . Methylation analysis, partial acid hydrolysis, and nuclear magnetic resonance revealed that the of PTTBP-2-2 backbone consisted of →4)- α -D-Glc p -(1→, →4,6)- α -D-Glc p -(1→, and →6)- α -D-Gal p -(1 → residues, with side chains substituted at O -2, O -3, and O -6 positions of →4)- α -D-Glc p -(1→. In vitro experiments demonstrated that PTTBP-2-2 significantly reduced nitrous oxide levels in BV2 microglia cells and suppressed the expression of pro-inflammatory genes, including COX2 , iNOS , TNF-α , IL-1β , and IL-6 . These factors are key mediators of neuroinflammation. Mechanistic investigations revealed that the anti-neuroinflammatory activity of PTTBP-2-2 was mediated through the regulation of NF-κB and Nrf2/HO-1 signaling pathways. Overall, PTTBP-2-2 shows potential as a therapeutic agent for the treatment of neuroinflammation.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
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IF 4.6
Peng-cheng Zhao,Xiao-xing Wang,Lv-qi Xie,Zi-ting Li,Xue Li,Zi-qin Dai,Xi-yang Tang,Zhi-hong Yao,Xin-sheng Yao,Yi Dai
Oligosaccharides (OSs) are abundant in natural products (NPs), yet their rapid and effective characterization, especially for absorbed OSs, remains challenging. In this study, an enhanced data acquisition and analysis strategy using three derivative labels was proposed and successfully applied to characterize the in vitro and in vivo profiles of OSs in Mori Fructus fruit (MF). For data acquisition, Data Independent Acquisition (DIA) was performed to maximize the MS information of OSs, followed by Mass Defect Filtering (MDF) using Metabolynx XS™ to automatically exclude irrelevant ions and generate Precursor Ion List (PIL) of potential OSs. A PIL-based Data Dependent Acquisition (DDA) was subsequently implemented to obtain clear MS 2 spectra. For data analysis, fragmentation behaviors of OS reference standards were evaluated to obtain Characteristic Fragment Ions (CFIs) and Neutral Losses (NLs) that served as criteria for eliminating false-positives. Ultimately, 79 OSs (44 neutral-reducing OSs, 11 nitrogen-reducing OSs, 20 acid-reducing OSs, and 4 neutral non-reducing OSs) were characterized in MF extract. In addition, 68 OS prototypes were detected in intestinal contents and 15 OS prototypes were observed in plasma. In conclusion, this novel strategy enabled stepwise screening, classification and systematic characterization of OSs in NPs in vitro and in vivo .
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FOOD HYDROCOLLOIDS
·
2025
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IF 12.4
Pan Wang,Bangfeng Yin,Ping Zou,Zhenjia Zheng,Dan Wang,Peiyou Qin,Wenting Zhao,Yuanyuan Zhao,Ye Liu,Xiaoyan Zhao
To address the limitation of resveratrol (Res) related to its low bio-accessibility and poor stability, Res-pectin complexes with varying degrees of esterification were developed. The encapsulation efficiency of Res in these complexes was determined, revealing the following order: Res-L106 > Res-L13 > Res-H121 > Res-H115. Upon non-covalent interaction with pectins, Res exhibited enhanced stability, reduced crystallinity, and modified microstructure. The complexes exhibited stable particle sizes across a pH range of 4 to 8, with the Res-L106 complex showing minimal sensitivity to variations in ionic strength and temperature. All complexes exhibited improved antioxidant activities compared to pectins alone, with the Res-L106 complex displaying the highest activity. The complex enhancing the bio-accessibility of Res follows the order of Res-L106 > Res-L13 > Res-H121 > Res-H115. Additionally, all complexes promoted the production of short-chain fatty acids (SCFAs), with butyric acid being the predominant product. Notably, the Res-L106 complex exhibited the highest SCFAs-producing capacity. In conclusion, this study provides valuable insights into the design and optimization of strategies to enhance the bioavailability of Res, highlighting the potential of low-esterified pectin as an effective delivery carrier for bioactive compounds.
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ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Weijie Zhang,Lintao Wang,Wei Pei,Jie Dang,Yewen Zhang,Xiang Liu,Abdullah Maqsood,QinQin He,Min Li
Introducing defects into Metal–organic frameworks (MOFs) is an effective measure to increase adsorption sites, which is of great significance for improving phosphorus (P) adsorption performance. In this study, various defect-containing cerium (Ce)-based MOFs (Ce-MOFs) were prepared by introducing different types and equivalents of monocarboxylates. Among them, butyric acid (BA)-regulated Ce-MOF (Ce-MOF(40BA)) exhibited excellent adsorption performance with a maximum phosphate adsorption capacity of 117.28 mg P/g. When the initial phosphate concentration was 3 mg P/L, the adsorption equilibrium could be reached within 10 min with a phosphate removal rate of 96.6%. Thermogravimetry analysis (TGA) showed that the average coordination number of Ce-MOF (40BA) was only 4.33 compared to six of the pristine Ce-MOF, indicating an abundant defect content. By increasing defects, mesopores were introduced, enriching the material’s pore structure and achieving a mesopore proportion up to 58.81%. X-ray photoelectron spectroscopy (XPS) analysis revealed that the introduction of defects created numerous unsaturated metal centers, leading to a significant increase in Ce(III) contents. Further density functional theory (DFT) calculations indicated that the defective Ce-MOF had a lower binding energy compared to the pristine Ce-MOF, making it more favorable for phosphate adsorption. This study provides a strategy for preparing efficient defect-containing MOF adsorbents. The excellent adsorption performance of Ce-MOF(40BA) in practical wastewater bodies makes it a promising material for solving water eutrophication.
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