Advanced Healthcare Materials
·
2025
·
IF 9.6
Yanxue Si,Ruitao Cha,Pai Zhang,Fengshan Zhou,Wenbing Yuan,Xingyu Jiang
5-Aminosalicylic acid (5-ASA) is the first-line drug for ulcerative colitis (UC), which encounters therapeutic constraints due to the poor water solubility and absorption by the upper gastrointestinal. Here, a cyclodextrin-based metal-organic framework (CD-MOF) is used as a carrier for 5-ASA (ASA@CM) to enhance its solubility. To improve the targeted release 5-ASA, ASA@CM is incorporated into sodium alginate/ L -arginine complex (SA-LA) to obtain the desired microspheres (ASA@CM/SL) by electrospray. ASA@CM/SL safeguards 5-ASA against the harsh gastrointestinal environment and provides favorable delivery to the colon. The anti-inflammatory and anti-oxidant activity is studied by measuring inflammatory factors and reactive oxygen species (ROS). The therapeutic effect of ASA@CM/SL on UC mice induced with dextran sulfate sodium is assessed. The biosafety by evaluating cytotoxicity and organ toxicity is studied. ASA@CM/SL shows excellent therapeutic effects for UC, as evidenced by its alleviation of inflammatory response and restoration of disrupted intestinal barriers. ASA@CM/SL features low cytotoxicity and low organ toxicity. This study provides a potential strategy for improving 5-ASA solubility and delivery efficiency, which may also be applied to broadly tackle various small hydrophobic molecules to treat UC and other intestinal diseases.
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Inorganics
·
2025
·Vol. 13
·期 7
·211
·
IF 3
Wen Li,Di Yin,Wanxin Liu,Yi Li,Yijin Wu
The electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) coupled with water electrolysis for green hydrogen production is a promising strategy to address energy crises and environmental pollution. Despite the suitable adsorption energy for HMF due to their partially filled d-band electronic structures, Ni- or Co-based oxides/hydroxides still face challenges in insufficient activity and stability. In this study, a porous heterogeneous nickel cobalt oxide/hydroxide growth on nickel foam (NF), which is defined as NF@NiCo-H/O, was developed via immersion in concentrated alkali solution. Compared with the single-component NiCo oxides, the NF@NiCo-H/O catalyst exhibits a lower application potential of only 1.317 V, 1.395 V, and 1.443 V to achieve current densities of 20, 50, and 100 mA cm−2, respectively, in an alkaline solution containing HMF. Additionally, it demonstrates rapid reaction kinetics with a Tafel slope of 27.6 mV dec−1and excellent cycling stability. Importantly, the presence of more high-valent Ni3+-O species on the catalyst surface contributes to its exceptional selectivity for 2,5-furandicarboxylic acid (86.7%), Faradaic efficiency (93.1%), and conversion rate (94.4%). This catalyst provides some theoretical guidance for the development of biomass electrooxidation catalysts for sustainable energy and chemical production.
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Catalysts
·
2026
·Vol. 16
·期 2
·116
·
IF 4
Chen Chen,Chenhao Yang,Hongke Li,Yiran Liu,Yao Chen,Yunlei Zhang
Electrocatalytic hydrogenation (ECH) represents an environmentally friendly pathway for converting 5-hydroxymethylfurfural (HMF) into the high-value chemical 2,5-bis(hydroxymethyl)furan (BHMF). However, its selectivity and Faradaic efficiency are often constrained by competitive hydrogen evolution at the cathode and insufficient supply of active hydrogen at the surface. To address this challenge, this study developed an Ir-decorated copper oxide nanowire catalyst (denoted as CuIr) featuring a hydrogen-rich adsorption (Hads) surface. The incorporation of Ir significantly enhances the catalyst’s water dissociation capacity, creating abundant Hadssources that selectively accelerate HMF hydrogenation while suppressing side reactions. Under a mild applied potential of −0.45 V vs. RHE and a current density of approximately −20 mA cm−2, the optimal CuIr40catalyst achieved near-complete conversion of HMF (99%), a BHMF yield of 99%, and a high Faradaic efficiency of 97% within 120 min of electrolysis. Mechanistic studies reveal that this catalytic leap stems from the synergistic functional interaction between Cu and Ir sites in substrate activation and hydrogen supply. This work presents a novel strategy for designing efficient electrocatalysts for biomass hydrogenation by regulating surface Hadsconcentration.
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MATERIALS CHEMISTRY AND PHYSICS
·
2026
·
IF 5.2
Senyu Yang,Wenjuan Jin,Jialan Han,Xinyan Wang,Zhichao Pei,Yuxin Pei
The photosensitizer hypericin (Hyp) and the newly synthesized superhydrophobic nitrate-ester-group-capped Pillar[5]arenes (PNO) were employed to fabricate a sunlight-activated photodynamic antimicrobial mask by π-π and π-alkyl interaction via a simple co-spraying strategy. The superhydrophobic PNO layer effectively repels bacterial adhesion, while hypericin generates reactive oxygen species (ROS) under sunlight irradiation. This endows the as-prepared mask with excellent physical anti-adhesion barrier and efficient photodynamic inactivation against bacteria.
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Pathogens
·
2026
·Vol. 15
·期 6
·567
·
IF 3.8
Zixiang Wang,Qianwen Deng,Ziyu Huang,Zixing Lin,Haohui Zhu,Janak L. Pathak,Ying Wang,Min Nie
Porphyromonas gingivalis(P. gingivalis) is a primary pathogen in periodontitis, yet its elimination is limited by complex anatomical structures. Photodynamic therapy (PDT) is a promising adjunct, but its antimicrobial efficacy is compromised in the acidic microenvironment induced byP. gingivalis. Given that 2′,4′,5′,7′-tetraiodofluorescein (TIF) exhibits robust and stable photodynamic activity under acidic conditions, this study investigated the antibacterial effect of TIF-mediated PDT (TIF-PDT) againstP. gingivalis.P. gingivalisATCC 33277 was treated with TIF (5, 10, 20, and 40 μM), light (525 nm), or both. Reactive oxygen species (ROS) generation was assessed at pH 4.5 or 7.4. Bacterial viability and membrane integrity were evaluated by colony-forming unit (CFU) assay and LIVE/DEAD staining. CFU assays demonstrated that TIF-PDT groups achieved an approximately 4-log reduction in bacterial viability compared to the DEMI, Light, and TIF groups, with no dark cytotoxicity and light-alone effects. LIVE/DEAD staining revealed bright yellow fluorescence in the TIF-PDT (40 μM), indicating membrane damage and significantly lower survival rates than controls. TIF-PDT at 10, 20, and 40 μM produced ROS under both neutral and acidic conditions, exhibited low dark cytotoxicity, and demonstrated potent antibacterial activity againstP. gingivalisin vitro, suggesting its potential as an acid-tolerant photosensitizer for periodontitis adjunctive therapy.
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Catalysts
·
2026
·Vol. 16
·期 3
·264
·
IF 4.5
Chenfeng Li,Jiahao Ju,Beizhan Li,Jilei Xu,Xin Su,Zuoyi Xiao,Qingda An,Jiahui Huang
5-Methoxymethyl-2-furfural (MMF) serves as a crucial biobased platform molecule that can be transformed into various high-value chemicals and biobased polyester monomers. However, the current production of MMF still faces several challenges, such as low yield and prolonged reaction time. In this study, we prepared a series of amide-modified strongly acidic resin catalysts and discovered that they have a higher efficiency in converting fructose to prepare MMF in 1-Butyl-3-methylimidazolium chloride ([BMIM]Cl) and methanol. Among the synthesized catalysts, DB757-NMP demonstrated superior performance, achieving an MMF yield of approximately 61.5% under the optimized conditions, with a combined yield of HMF and MMF reaching about 66.6%. The catalyst formation mechanism was analyzed using FTIR, and NMR, confirming the transformation of proton between NMP and the sulfonic acid groups of the resin, which collectively promoted the conversion of fructose to MMF. In addition, we investigated main reasons for catalyst deactivation and successfully restored catalytic activity through regeneration. The regenerated catalyst could be reused for three times with only a slight decrease in MMF yield. The results suggested that DB757-NMP is a more sufficient and recyclable catalyst for the production of MMF from fructose. This work presented a simple and environmentally benign approach for the synthesis of MMF.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Liu Gui,Liu Pengfei,Meng Deming,Zhao Taotao,Qian Xiaofeng,He Qiang,Guo Xuefeng,Qi Jizhen,Peng Luming,Xue Nianhua,Zhu Yan,Ma Jingyuan,Wang Qiang,Liu Xi,Chen Liwei,Ding Weiping
The hydrogenation of CO 2 or CO to single organic product has received widespread attentions. Here we show a highly efficient and selective catalyst, Mo 3 S 4 @ions-ZSM-5, with molybdenum sulfide clusters ([Mo 3 S 4 ] n+ ) confined in zeolitic cages of ZSM-5 molecular sieve for the reactions. Using continuous fixed bed reactor, for CO 2 hydrogenation to methanol, the catalyst Mo 3 S 4 @NaZSM-5 shows methanol selectivity larger than 98% at 10.2% of carbon dioxide conversion at 180 °C and maintains the catalytic performance without any degeneration during continuous reaction of 1000 h. For CO hydrogenation, the catalyst Mo 3 S 4 @HZSM-5 exhibits a selectivity to C 2 and C 3 hydrocarbons stably larger than 98% in organics at 260 °C. The structure of the catalysts and the mechanism of CO x hydrogenation over the catalysts are fully characterized experimentally and theorectically. Based on the results, we envision that the Mo 3 S 4 @ions-ZSM-5 catalysts display the importance of active clusters surrounded by permeable materials as mesocatalysts for discovery of new reactions.
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NEURON
·
2023
·
IF 16.2
Jianzhi Zeng,Xuelin Li,Renzimo Zhang,Mingyue Lv,Yipan Wang,Ke Tan,Xiju Xia,Jinxia Wan,Miao Jing,Xiuning Zhang,Yu Li,Yang Yang,Liang Wang,Jun Chu,Yan Li,Yulong Li
Summary The coincidence between conditioned stimulus (CS) and unconditioned stimulus (US) is essential for associative learning; however, the mechanism regulating the duration of this temporal window remains unclear. Here, we found that serotonin (5-HT) bi-directionally regulates the coincidence time window of olfactory learning in Drosophila and affects synaptic plasticity of Kenyon cells (KCs) in the mushroom body (MB). Utilizing GPCR-activation-based (GRAB) neurotransmitter sensors, we found that KC-released acetylcholine (ACh) activates a serotonergic dorsal paired medial (DPM) neuron, which in turn provides inhibitory feedback to KCs. Physiological stimuli induce spatially heterogeneous 5-HT signals, which proportionally gate the intrinsic coincidence time windows of different MB compartments. Artificially reducing or increasing the DPM neuron-released 5-HT shortens or prolongs the coincidence window, respectively. In a sequential trace conditioning paradigm, this serotonergic neuromodulation helps to bridge the CS-US temporal gap. Altogether, we report a model circuitry for perceiving the temporal coincidence and determining the causal relationship between environmental events.
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CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Fei Wang,Li Li,Chaohui Yang,Zhongxing Cai,Ziyi Guo,Siyu Hou,Xiaoya Xie,Yinghao Chen,Jing Huang,Long Zhang
A series of GdPO 4 :5%Eu 3+ micro/nanomaterials with different morphologies and crystal structures were successfully prepared by the one-step solvothermal method using only the gadolinium source, the phosphoric acid source and ethanol as solvents, without any surfactants or templates, without further calcination and by adjusting only the ratio of phosphoric acid and gadolinium sources. They all have good dispersion and homogeneity. The morphology of the products was mainly regulated by the ratio of H 3 PO 4 to Gd(NO 3 ) 3 · 6H 2 O, with ratios of 2:1, 8:1, 16:1, 24:1, 32:1, 40:1 and 48:1 mL/g resulting in the formation of square, pillow, star, carambola, hollow cylinder, drum and jujube shaped GdPO 4 :5%Eu 3+ micro/nanomaterials, respectively. Ratios of 2:1–24:1 and 32:1–48:1 allow for the direct solvothermal synthesis of monoclinic and hexagonal phase gadolinium phosphate, simultaneously. In addition to their crystal structure and morphology, chemical bonding, thermal stability and specific surface area, their luminescence properties and magnetic resonance imaging (MRI) tracing properties have also been studied in comparison. Interestingly, the GdPO 4 :5%Eu 3+ micro/nanoparticles in the carambola shape had a higher photoluminescence intensity and relaxation rate of 0.7709 mM −1 s −1 (r 1 ) among all the morphologies. The possible mechanisms by which various morphologies of GdPO 4 :5%Eu 3+ were prepared in different ratios were analyzed, and the reasons for their effects on the fluorescence and MRI tracer properties were further investigated. This study is of reference significance for the simple-regulated synthesis of rare earth inorganic gadolinium-containing micro/nanomaterials and provides a reliable guarantee for the expansion of their multifunctional applications in UV–Vis luminescence and MRI tracing for implants.
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 97
·期 7
·1695-1704
·
IF 3.709
Bao Guo,Jidong Liu,Shixiong Tang,Yida Liu,Zenan Tian,Jianhua Lv
BACKGROUND Whether waste polyethylene terephthalate (PET) can be effectively recycled is one of the main challenges of the current environmental problems. The hydrolysis of dimethyl terephthalate (DMT) to terephthalic acid (TPA) over Nb-modified HZSM-5 zeolite was studied. Nb/HZSM-5 zeolites with different loadings were prepared and characterized by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, NH 3 -temperature programmed desorption and pyridine adsorption infrared spectroscopy. The effects of different reaction conditions on the conversion of DMT and TPA yield were investigated. RESULTS The yield of TPA strongly depends on the reaction conditions and the loading of Nb. The niobium phase exists in the form of Nb 2 O 5 on the zeolite and interacts with the surface of HZSM-5 to produce the active site of Brønsted acid. The yield of TPA is closely related to the concentration of Brønsted acid sites. On 0.6Nb/HZSM-5 catalyst, the yield of TPA is highest, at about 94%. CONCLUSION Nb/HZSM-5 catalyst has excellent catalytic activity and high stability for DMT hydrolysis. In addition, the product TPA prepared in this study can be directly applied to the current PET production supply chain, providing a promising catalytic route. © 2022 Society of Chemical Industry (SCI).
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Guangyu Xu,Fanyuan Zhang,Zhenghui Li
In this study, the solubility of 5-chloropyrazin-2-amine in four aqueous solutions (methanol, ethanol, n-propanol, and ethylene glycol (EG)) plus water was determined by a gravimetric method at temperatures ranging from T = 278.15 to 323.15 K at 101.2 kPa pressure. Experimental results indicated that 5-chloropyrazin-2-amine solubility positively increased with increasing temperature at a given solvent composition and decreased with increasing mass fraction of water in each system. The order of solubility from high to low on the mole fraction scale was as follows: methanol (0.02007, 323.15 K) > ethanol (0.01308, 323.15 K) > n-propanol (3.827 × 10–3, 323.15 K) > water (1.569 × 10–3, 323.15 K). Similarly, the solubility of 5-chloropyrazin-2-amine was higher in (methanol + water) than in the other three cosolvent mixtures. The solid phase crystal of 5-chloropyrazin-2-amine was tested by X-ray powder diffraction (XPRD) and the results showed no polymorphic transformation, solvate formation, or crystal transition during entire experiments. The experimental solubility values of 5-chloropyrazin-2-amine were correlated by three thermodynamic models. The results show that the largest relative average deviation (RAD) and root mean square deviation (RMSD) data were no more than 5.38% and 2.34 × 10–4, respectively. The Jouyban–Acree model gave the best correlation result in this study.
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ACS Applied Nano Materials
·
2022
·
IF 6.14
Junrong Zeng,Wenhao Chen,Gaowei Zhang,Liang Yu,Liubiao Zhong,Ya Liu,Sanfei Zhao,Yejun Qiu
Affected by the slow kinetic oxygen evolution reaction (OER), the cell voltage of water splitting is usually beyond 1.5 V, causing high energy consumption to produce hydrogen. Herein, heterostructural Ni3N–NiMoN nanowires supported on carbon cloth (Ni3N–NiMoN/CC) are successfully fabricated, and they can act as bifunctional electrocatalysts, exhibiting a low overpotential of 74 mV at 100 mA cm–2 for hydrogen evolution reaction (HER) and a low potential of 1.39 V at 50 mA cm–2 for 5-hydroxymethylfurfural oxidation reaction (HMFOR), respectively. The HMFOR//HER device constructed by Ni3N–NiMoN/CC achieves a very low cell voltage of ∼1.29 V at 10 mA cm–2, which is 0.32 V lower than that of the OER//HER device. Specially, a value-added product of 2,5-furandicarboxylic acid is obtained. Additionally, density functional theory calculations are carried out. This work provides a promising strategy to further reduce the cell voltage to generate hydrogen by replacing OER with biomass oxidation.
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