COMPOSITES PART B-ENGINEERING
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2020
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IF 7.635
Jueying Yang,Yu Chen,Lin Zhao,Zhipan Feng,Kelin Peng,Ailing Wei,Yalun Wang,Zongrui Tong,Bin Cheng
The preparation of hydrogel wound dressing materials with high antibacterial activities and good biosafety simultaneously can be relatively challenging. Aiming at solving this crucial problem, a multi-functional chitosan/carboxymethyl chitosan/silver nanoparticles (CTS/CMCTS/AgNPs) polyelectrolyte composite physical hydrogel is constructed by in situ photoreduction of silver ions with α-hydroxy of CMCTS and semi-dissolution acidification sol-gel transition (SD-A-SGT) methods using natural polymers with no chemical reductant involved. The XRD , TEM and IR characterizations reveal a highly uniform structure of the composite hydrogel with good mechanical strength . The composite hydrogel also exhibits good self-healing ability, and the self-healing mechanism of the composite hydrogel prepared by natural polymers with high similarity is put forward on the basis of molecular dynamics simulation. The AgNPs gives the hydrogel excellent antibacterial activities against both S. aureus and P. aeruginosa ., while the preparation method with no chemical reductant and crosslinking agent required endows the hydrogel high biocompatibility. The great application potentials of CTS/CMCTS/AgNPs polyelectrolyte composite hydrogel are demonstrated with its promoting effects on the healing of P. aeruginosa infected wounds as the wound dressing. It is a breakthrough in achieving hydrogels with desired biosafety and antibacterial activities simultaneously. The composite hydrogel is found with great application potentials as wound dressing.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2026
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IF 3.1
Ying Hao,Jingjing Yang,Wenlu He,Qihao Sun,Jintong Zhang,Yulin Chang,Fengyuan Wang,Xiao Wu,Ping Xue,Jingyao Sun
Passive radiative cooling (PRC) provides a sustainable solution for building energy management. However, it still remains a huge challenge to fabricate cost-effective and scalable materials with complementary radiative cooling capabilities. Herein, chitosan (CS)-based hydrogels were fabricated by adding radiative cooling fillers—barium sulfate (BaSO 4 ), titanium dioxide (TiO 2 ), and silicon dioxide (SiO 2 ) to achieve selective enhancement of either solar reflectance or infrared emissivity. Through optimization of filler type and loading, CS/BaSO 4 and CS/TiO 2 hydrogels exhibit a peak solar reflectance of 87% (0.4–1.0 μm), enabling outdoor sub-ambient cooling of 7°C under peak solar radiation. The CS/SiO 2 hydrogel (S3-30) exhibits significantly improved atmospheric window emissivity of 88% (8–13 μm), facilitating efficient nighttime radiative heat dissipation. The imine-crosslinked CS networks provide excellent solid–liquid dual-phase stability, preventing water leakage while maintaining facile processability. More importantly, indoor simulations show that temperature is reduced by 2.2°C–4.2°C in model building, while 12-h outdoor field validation confirms stable sub-ambient performance. This work proposes a facile, versatile and biopolymer-based method to fabricate radiative cooling coatings with complementary functionalities, offering a new pathway toward sustainable thermal management in built environments.
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iScience
·
2026
·Vol. 29
·期 9
·117200
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IF 4.5
Xudong Li,Chengzhe Yang,Xin Li,Lanxin Li,Youbin Li,Tengyue Liu,Qiang Gao,Lanfeng Huang
Summary Large bone defects remain a clinical challenge due to limited regenerative capacity. In this study, carboxymethyl chitosan (CMCS) hydrogels incorporating gradient nano-hydroxyapatite (nHA) were developed to enhance bone repair. The composite hydrogels exhibited improved mechanical properties, controlled degradation, and good biocompatibility. In vitro , nHA-containing hydrogels promoted bone marrow mesenchymal stem cell (BMSC) proliferation and osteogenic differentiation, as shown by increased alkaline phosphatase (ALP) activity, mineralization, and upregulation of runt-related transcription factor 2 (RUNX2), osteocalcin (OCN), and bone morphogenetic protein-2 (BMP-2). In vivo , implantation in a rat distal femoral condyle defect model showed enhanced new bone formation and improved trabecular structure, particularly in the 1% nHA group. These results suggest that gradient nHA-loaded CMCS hydrogels can effectively enhance osteogenesis and support bone regeneration.
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SOLID STATE IONICS
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2026
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IF 3.7
Fang Liu,Bo Liu,Guibao Guo
Phosphoric acid (PA)-doped membranes have emerged as promising electrolyte candidates for high-temperature proton exchange membrane fuel cells (HT-PEMFCs). Nevertheless, their commercial adoption has been limited by durability challenges, particularly PA leaching. Herein, we developed composite proton-exchange membranes by blending phosphonated polyborosiloxane (PA-PBS) with chitosan (CS). The phosphonic groups were grafted onto polyborosiloxane chains via N-C-P bonds, which effectively reduces proton carrier loss. The microporous structure of membranes provides channels for internal water transfer. The membranes exhibit 3.5% weight loss at 150 °C. The membrane with the optimal PA ratio (PA:APTES = 2:1) achieves a proton conductivity of up to 67 mS/cm at 140 °C, and a maximum single-cell output power density of 435.1 mW/cm 2 at 140 °C, demonstrating its potential for high-temperature, low-humidity applications.
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FOOD CHEMISTRY
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2026
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IF 10.4
Xijiao Bian,Zhuqing Liu,Jiaqian Cui,Junwei Tang,Jungang Jiang,Yifan Zhang,Lei Wang
AKDSC reduces the water sensitivity of starch via hydrolysis condensation reaction. • AKDSC enhances the interaction and networking between CH and SL. • The CH/SL- AKDSC exhibits excellent barrier and mechanical properties. • The CH/SL- AKDSC effectively extends the shelf life of cherry tomatoes. To address the environmental pollution caused by petroleum-based plastic packaging, the development of high-performance biodegradable films has become a key research focus in the field of food packaging. In this study, hydrophobically modified starch (AKDSC) was prepared via the esterification reaction of alkyl ketene dimer and subsequently introduced into a chitosan/sodium lignosulfonate (CH/SL) composite system, successfully constructing a multifunctional composite film (CH/SL-AKDSC). The structural characterization results indicated the formation of a denser hydrogen bond network between the phenolic hydroxyl/amino groups in CH/SL and the hydroxyl groups in AKDSC. The performance tests showed that the film exhibited a water contact angle of 105.9°, an oxygen transmission rate as low as 1.18 g/(m 2 ·d), and an ultraviolet shielding rate of over 99%. In a 10-day cherry tomato preservation experiment, the CH/SL-AKDSC film demonstrated good preservation effects, highlighting its practical application potential in green and efficient food packaging. Download: Download high-res image (128KB) Download: Download full-size image
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Yueming Hu,Feijie Wang,Shiqiang Ouyang,Yan Ma,Qianru Meng,Zhongli Liu,Jinghan Zhang,Shufeng Ma,Liqiang Wang
Strawberries are susceptible to water loss, microbial spoilage, and quality deterioration during storage and transportation, resulting in a shortened shelf life. Intelligent packaging integrating active preservation and freshness indication can delay deterioration while providing quality feedback. Humidity variations caused by respiration and transpiration are closely associated with strawberry quality deterioration, yet their conversion into real-time data feedback remains challenging for conventional systems. Herein, a self-powered humidity-sensitive chitosan-based nanofibrous packaging material was fabricated via electrospinning. Deacetylated chitin nanocrystals (D-ChNCs) nanoframe reinforcement and tea polyphenols (TP) functionalization synergistically constructed a CTS/PEO/D-ChNCs/TP three-dimensional nanofibrous network. The heterogeneous interfaces and polar functional groups promoted triboelectric charge accumulation, enabling the triboelectric nanogenerator (TENG) based on this membrane to achieve an open-circuit voltage approaching 180 V. Benefiting from the abundant hydrophilic functional groups and large contact area, the TENG converted packaging humidity variations into voltage signals. As the relative humidity (RH) increased from 50% to 80%, the output voltage decreased linearly (R 2 = 0.993), enabling reliable humidity sensing. The D-ChNCs/TP-functionalized membrane exhibited antioxidant and antibacterial activities, delaying strawberry deterioration for 6 days. Meanwhile, the TENG output signal was strongly correlated with weight loss, firmness, and total soluble solids, enabling self-powered classification of strawberry freshness. Download: Download high-res image (235KB) Download: Download full-size image
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LANGMUIR
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2026
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IF 4.4
Yunxing Li,Xue Cai,Beizhe Chang,Tong Yang,Hang Jiang,To Ngai
Titanium dioxide nanoparticles (TiO2 NPs) are widely used as inorganic UV filters, yet their photocatalytic activity and resulting phototoxicity raise serious safety issues. Here, we report a Pickering double emulsion templating strategy for constructing chitosan-based porous microspheres encapsulating TiO2 NPs (TiO2@CS-PMs), with controllable microstructures and mass loading of TiO2 NPs. The oil-in-water-in-oil double emulsion template confines TiO2 NPs within a cross-linked porous polymer skeleton. Structural confinement, combined with the antioxidant capacity of chitosan (CS), greatly reduces UV-induced reactive oxygen species generation of TiO2 NPs. In vitro assays reveal that TiO2@CS-PMs have good biocompatibility and significantly lower phototoxicity to HaCaT cells than naked TiO2 NPs. The porous architecture promotes optical confinement, and the encapsulation causes interfacial interactions between TiO2 NPs and the CS matrix, resulting in broadened and enhanced UV attenuation. Sunscreen incorporating TiO2@CS-PMs exhibits higher sun protection factors and cellular photoprotection at lower TiO2 NPs doses, while the CS matrix provides antibacterial activity. This work reveals Pickering double emulsion templating porous microstructure as a versatile platform for managing particle photochemistry, providing insights into the development of safer and multifunctional UV filters.
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PubMed
高影响因子
Nanomaterials
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2026
·Vol. 16
·期 9
·550
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IF 4.8
Chong Chen,Zhenyuan Chui,Yaokun Pang
As a green energy technology, triboelectric nanogenerators (TENGs) convert mechanical energy into electricity and have gained significant attention in response to growing global environmental concerns. However, the widespread use of petroleum-based polymers as triboelectric materials in high-performance TENGs raises concerns over plastic pollution. In this work, we report a high-performance biodegradable TENG utilizing chitosan/laser-induced graphene (LIG) composite films as triboelectric layers. Modified chitosan substrates were first converted into LIGs via a convenient one-step CO2laser engraving, subsequently incorporated into chitosan matrices to form homogeneous composite films. A TENG device was designed by pairing the LIG/chitosan composite film with the fluorinated ethylene propylene (FEP) film, and copper electrodes. The introduction of LIG effectively strengthens charge storage and dielectric properties of the chitosan matrix, thereby significantly boosting the triboelectric output performance. Experimental results demonstrate that the as-assembled TENG with an LIG concentration of 1 wt.% achieves a peak open-circuit voltage of 196 V and short-circuit current of 2.1 μA, with a maximum power density of 295 mW/m2. It can drive LED lights and small low-power electronic devices. Furthermore, the designed TENG device exhibits good biodegradability, flexibility, and stability, serving as a self-powered sensor for monitoring human joint movements. This work provides a simple and scalable strategy for integrating laser-induced graphene with biomass-based polymers, offering new insights into the design of high-performance, biobased triboelectric materials.
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POLYMER
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2026
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IF 5.1
Huanyang Yu,Zhicheng Tian,Yan Wang,Weiyu Tian,Xinmeng Shen,Liyan Wang
Developing biodegradable smart packaging materials is a key strategy to address plastic pollution. A biodegradable smart pH-responsive film (CGTR) was developed by using the non-covalent synergistic interaction of tannic acid (TA) and riboflavin (RF) in the chitosan/gelatin (CG) matrix. Performance characterization reveals that the TA/RF interaction not only achieves uniform dispersion within the matrix but also significantly enhances the film's overall performance. The film demonstrates complete UV barrier capability, with a free radical scavenging rate increasing by 57.17 % within 20 minutes and reaching 99.11 % after 180 minutes. Additionally, its water vapor barrier, mechanical strength, and thermal stability have been effectively improved. In summary, CGTR film as an eco-friendly smart packaging material shows great potential in food preservation and visual freshness indicator.
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Bioengineering-Basel
·
2026
·Vol. 13
·期 6
·592
·
IF 4.4
Bilal Ahmad,Changyun Quan,Xiyue Zhang,Haiyan Xia,Zhenhong Yuan,Chenghua Zhu,Yang Zhang,Haixia Yang,Xueqin Huang,Chunyi Tong,Bin Liu,Binjie Xu
C-reactive protein (CRP) is one of the most essential biomarkers for the early detection of inflammation and infection. In this study, we developed a sensitive and selective electrochemical immunosensor for CRP detection, leveraging the unique properties of gold nanoparticles (AuNPs). A nanostructured layer of AuNPs was deposited onto a screen-printed carbon electrode (SPCE), followed by the formation of a self-assembled monolayer (SAM) of L-cysteine and EDC/sulfo-NHS chemistry. The antibody was covalently immobilized onto the modified electrode through optimized dual-crosslinking chemistry. Detection conditions were systematically optimized, with pH 8.0 in Tris buffer providing the best electrochemical response. Electrochemical characterization was performed using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) in a 5 mM K3[Fe(CN)6]/K4[Fe(CN)6] redox probe solution containing 0.1 M KCl. CRP detection was achieved by monitoring the increase in charge transfer resistance (Rct) upon specific binding of the target CRP antigen to the immobilized antibody. Spiked recovery experiments showed spiked recovery rates ranging from 98.01% to 107.14%, with a standard deviation below 4%. Regeneration studies demonstrated high efficiency, confirming the suitability of the sensor interface for repeated and reliable measurements. Under optimized conditions, the immunosensor exhibited excellent analytical performance, including a low limit of detection (LOD) of 0.16 µg/mL, a wide linear detection range of 5–100 µg/mL, high selectivity against 13 potential interferents (including inflammatory cytokines), and good reproducibility with a relative standard deviation (RSD) of 3.69%. The sensor also showed strong stability, retaining more than 95% of its signal after 15 days, and high regeneration efficiency of 97% over seven cycles. These results highlight the strong potential of the proposed immunosensor for point-of-care (POC) applications due to its simple fabrication, cost-effectiveness, user accessibility, and robust analytical performance.
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Journal of Advanced Prosthodontics
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2026
·Vol. 18
·期 3
·191
·
IF 2
Le Na Lau,Chae-Ryeong Cha,Satoshi Imazato,In-Sung Luke Yeo
PURPOSE The impact of chitosan (Ch) surface modification on the osseointegration of niobia-modified yttria-stabilized zirconia (Y,Nb-TZP) implants was assessed using a rabbit tibia model. MATERIALS AND METHODS Y,Nb-TZP and SLA discs and implants were prepared and coated with Ch of 95% degree of deacetylation (DDA). MC3T3-E1 cells and human gingival fibroblasts were cultured onto discs (n = 3) for cell proliferation, adhesion, osteogenic differentiation and gene expression analysis. Specimen surface characteristics were assessed using scanning electron microscopy and confocal laser scanning microscopy. Eight rabbits underwent tibial implant placement and were euthanized at 2 and 8 weeks after surgery (n = 4). Bone-to-implant contact (BIC) and bone area (BA) were quantified through histomorphometric evaluation. One-way ANOVA with Tukey’s post hoc test was used for statistical analysis ( P < .05) unless otherwise specified. RESULTS Ch-coated Y,Nb-TZP discs supported cell attachment, proliferation, and osteogenic differentiation in vitro , with increased osteogenic and early focal adhesion gene expression, compared with uncoated controls. However, in vivo evaluation in rabbit tibiae showed no improvement in bone-to-implant contact or bone area around Ch-modified implants relative to uncoated Y,Nb-TZP or SLA controls, and osseointegration did not occur in the Ch-coated groups. CONCLUSION. Although Ch promoted osteogenic activity in vitro , these effects did not translate in vivo , and the coating failed to enhance osseointegration on Y,Nb-TZP implants. This gap underscores the complexity of host responses and the need to refine Ch properties for further evaluation under clinically relevant conditions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Jiangjie Tang,Ruimin Tang,Liangjian Chen,Chunsheng Shao,Li Yi
Recent advances in osteoimmunology have underscored the crucial role of the host immune response in bone regeneration. In this study, we developed a double-crosslinked carboxymethyl chitosan-alginate-hydroxyapatite composite hydrogel bone scaffold (CAHA) by directional freeze-casting. The content of HA (15 wt%, 25 wt%, 35 wt%, and 45 wt%) has significantly influenced the physical properties of the scaffold, including pore size, porosity, swelling behaviour, Ca 2+ ion release, surface stiffness, and compressive modulus. In vitro experiments indicated that the CAHA scaffold upregulated the expression of anti-inflammatory genes ( p < 0.0001) and downregulated the expression of proinflammatory genes ( p < 0.0001) in RAW 264.7 macrophages, promoting a shift from the M1 phenotype to the M2 phenotype. The M2 phenotype effectively enhanced osteogenic differentiation of MC3T3-E1 cells and angiogenesis in HUVECs. In vivo studies using an air pouch model revealed a greater number of M2 macrophages surrounding the CAHA scaffolds. Tibial defect experiments showed that 8 weeks after implantation, the group treated with the CAHA scaffold containing 45 wt% HA exhibited significant bone healing compared with the control group ( p < 0.05). Thus, the novel CAHA composite hydrogel scaffold shows promise as an immunomodulatory biomaterial for bone tissue engineering.
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