JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 31
·24185-24197
·
IF 6.7
Zhang Wan-Jie,Dong Yu-Jun,Zhou Shao-Meng,Ying Rui-Ning,Cai Zhuo-Mei,Zhao Jing,Wang Da-Wei,Lin Hong-Yan
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27)
is a
promising target for new herbicide research. To develop new HPPD-inhibiting
herbicides, we used a scaffold-hopping strategy by introducing a quinazolinone
ring and combining it with the classic triketone pharmacophore, designing
and synthesizing a series of novel HPPD inhibitors with a fused-ring
architecture. The results showed that II -series of compounds
exhibited excellent inhibitory activity against Arabidopsis thaliana ( At ) HPPD, with IC 50 values 0.5- to 2.5-fold lower than those of mesotrione. Moreover,
we obtained the crystal structure of At HPPD– II-36 complex at a resolution of 1.8 Å. Importantly, II-36 exhibited high safety to wheat and outstanding herbicidal
efficacy against Echinochloa crus-galli , Digitaria sanguinalis , and Bromus japonicus at a dosage of 30 g ai/ha. Our study
provides a valuable example for designing novel HPPD inhibitors with
enhanced herbicidal activity and improved crop selectivity.
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FUSION SCIENCE AND TECHNOLOGY
·
2026
·
IF 1.2
Hu Wang,Chao Fang,Zhengbao Yu,Jin Liu,Jing Huang,Jing Wei,Weihua Wang,Wei Lu,Xiaowu Yu
The thermal conductivity of epoxy resin decreases sharply to approximately 0.01 W·m−1·K−1 at 4 K, significantly limiting its application in nuclear fusion engineering. To address this limitation, this study prepared epoxy composite reinforced with silver, diamond, or wollastonite at 50 vol % and 70 vol %, and systematically investigated their 4-K thermal conductivity. The results demonstrated that at 70 vol %, the silver epoxy composite achieved a thermal conductivity of 5 W·m−1·K−1, which is more than two orders of magnitude higher than that of the diamond-epoxy composite (0.05 W·m−1·K−1). At 50 vol %, the silver epoxy composite (0.12 W·m−1 ·K−1) exhibited similar thermal conductivity to the wollastonite epoxy composite (0.1 W·m−1·K−1). Increasing the silver filler from 50 to 70 vol % enhanced the thermal conductivity from 0.12 to 5 W·m−1·K−1, representing a 42-fold improvement.Through combined theoretical analysis, microstructural characterization, and finite element analysis, the following conclusions were drawn. The electron conduction–dominated fillers were the preferred choice for the cryogenic thermal conductivity epoxy composite. In the discrete composite, even the electron conduction–dominated filler could not significantly improve the cryogenic thermal conductivity of the epoxy composite; even 50 vol % silver only reached approximately 0.12 W·m−1 ·K−1. The synergistic effect between the filler type and the distribution (electron conduction–dominated filler combined with continuous filler distribution) can substantially enhance the cryogenic thermal conductivity of the epoxy composite. This work provides technical support for the design of high-performance thermal management materials for superconducting magnet cooling systems in fusion reactors.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Qi-Jia Jiang,Ke Cao
A rhodium-catalyzed universal protocol for selective chalcogenation of B(4)-H of o-carboranes with diaryl diselenides, diaryl disulfides, and diphenyl ditelluride has been developed for the first time. A series of B(4)-Se/S/Te-o-carborane derivatives decorated with various kinds of active groups have been synthesized with excellent yields and regioselectivity. Based on control experiments, a plausible mechanism involving radical and direct oxidative addition process is proposed. This work would be an important reference for the design of new reactions for the chalcogenation of boron clusters.
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Heliyon
·
2024
·
IF 3.4
Jintao Xu,Shanlin Zhu,Canyuan Liao,Weijun Zhao,Xingyuan Zhong,Zijun Wang,Jiuping Zhong
High-sensitivity optical temperature measurement has attracted extensive attention in both fundamental studies and practical applications. In this study, a series of upconversion (UC) luminescence phosphors composed of NaGd(PO 3 ) 4 (NGP) doped with 20 at% Yb 3+ and various concentrations of Er 3+ (0.5 at% as the optimal concentration) was synthesized by high-temperature solid-state method. And their crystal structure and the distribution of lanthanide dopants were analyzed using X-ray diffraction with Rietveld refinement verifies. Under 980 nm laser excitation, the obtained phosphors show the characteristic Er 3+ upconversion green and red emission bands through two-photon processes. The fluorescence intensity ratio (FIR) based on the thermal coupled states demonstrates the thermal sensing ability in a wide temperature range of 200–573 K. The thermal sensitivity is relatively high with the maximum absolute thermal sensitivity S a of 0.53 % K −1 (523 K) and the maximum relative thermal sensitivity S r of 2.60 % K −1 . The phosphor NGP:Yb/Er also exhibits high repeatability as the thermal sensors reach 97 %. These findings postulate the potential of NGP:Yb/Er as a promising candidate in optical thermal sensing applications.
研究领域:
材料科学
·
光学
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Acta Crystallographica Section C-Structural Chemistry
·
2014
·Vol. 70
·期 11
·1050-1053
·
IF 0.535
Li X.,Wang Z.-G.,Chen H.-H.,Liu S.-G.
The title compound, C18H28O3, was prepared by the reaction of 2,6-di-tert-butylphenol with methyl acrylate under basic conditions using dimethyl sulfoxide as the promoter. The structure of this antioxidant indicates significant strain between the ortho tert-butyl substituents and the phenolic OH group. In spite of the steric crowding of the OH group, it participates in intermolecular hydrogen bonding with the ester carbonyl O atom.
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ESC Heart Failure
·
2023
·
IF 3.8
Yu Li,Qian He,Chao-Yong He,Chao Cai,Zhen Chen,Jing-Zhu Duan
Aims Diabetic cardiomyopathy (DC) is one of serious complications of diabetic patients. This study investigated the biological function of activating transcription factor 4 (ATF4) in DC. Methods and results Streptozotocin-treated mice and high glucose (HG)-exposed HL-1 cells were used as the in vivo and in vitro models of DC. Myocardial infarction (MI) was induced by left coronary artery ligation in mice. Cardiac functional parameters were detected by echocardiography. Target molecule expression was determined by real time quantitative PCR and western blotting. Cardiac fibrosis was observed by haematoxylin and eosin and Masson's staining. Cardiac apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labelling. Activities of superoxide dismutase, glutathione peroxidase, and levels of malonic dialdehyde and reactive oxygen species were used to assess oxidative stress damage. Molecular mechanisms were evaluated by chromatin immunoprecipitation, dual luciferase assay, and co-immunoprecipitation. ATF4 was up-regulated in the DC and MI mice ( P < 0.01). Down-regulation of ATF4 improved cardiac function as evidenced by changes in cardiac functional parameters ( P < 0.01), inhibited myocardial collagen I ( P < 0.001) and collagen III ( P < 0.001) expression, apoptosis ( P < 0.001), and oxidative stress ( P < 0.001) in diabetic mice. Collagen I ( P < 0.01) and collagen III ( P < 0.01) expression was increased in MI mice, which was reversed by ATF4 silencing ( P < 0.05). ATF4 depletion enhanced viability ( P < 0.01), repressed apoptosis ( P < 0.001), oxidative damage ( P < 0.001), and collagen I ( P < 0.001), and collagen III ( P < 0.001) expression of HG-stimulated HL-1 cells. ATF4 transcriptionally activated Smad ubiquitin regulatory factor 2 (Smurf2, P < 0.001) to promote ubiquitination and degradation of homeodomain interacting protein kinase-2 ( P < 0.001) and subsequently caused inactivation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway ( P < 0.001). The inhibitory effects of ATF4 silencing on HG-induced apoptosis ( P < 0.01), oxidative injury ( P < 0.01), collagen I ( P < 0.001), and collagen III ( P < 0.001) expression were reversed by Smurf2 overexpression. Conclusions ATF4 facilitates diabetic cardiac fibrosis and oxidative stress by promoting Smurf2-mediated ubiquitination and degradation of homeodomain interacting protein kinase-2 and then inactivation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway, suggesting ATF4 as a treatment target for DC.
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ACS Applied Polymer Materials
·
2023
·
IF 5
Siyuan Zhang,Jiao He,Xinjian Cheng
Amphiphilic hyperbranched polymers (AHBPs) possess important characteristics, such as high solubility, low viscosity, and multiple functional groups, making them of significant scientific interest. In this work, a chain transfer agent (CTA) with a styrene unit was synthesized at first. Subsequently, the CTA was polymerized with a coumarin derivative containing a −C=C bond through reversible addition-fragmentation chain transfer-self-condensing vinyl polymerization (RAFT-SCVP) to obtain the hyperbranched polymer HP-1. Finally, using HP-1 as a macromolecular CTA, amphiphilic hyperbranched fluorescent probes AHP-2 and AHP-3 were synthesized via RAFT polymerization of hydrophilic monomers poly[oligo(ethylene glycol) methacrylate] (PEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). The as-prepared AHP-2 and AHP-3 were characterized and confirmed. These macromolecular fluorescent probes enable highly sensitive and specific recognition of 4-nitrophenol (4-NP) with detection limit as 0.59 μM. A unique fluorescence quenching effect, termed “enriching inner filter effect (IFE)”, was revealed through the study of the recognition mechanism of the probes for 4-NP in hyperbranched polymers. This effect has the potential to expand the preparation methods of both fluorescent probes and functional hyperbranched polymers. This work investigates the synthesis methodology of amphiphilic hyperbranched polymers and the performance of fluorescent probes, providing a valuable approach for the development of highly sensitive polymer fluorescent probes in the future.
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Biosensors-Basel
·
2022
·Vol. 12
·期 9
·760
·
IF 5.743
Haijun Du,Yan Zhang,Xin Wang,Huali Hu,Jixing Ai,Huanxi Zhou,Xia Yan,Yang Yang,Zhiwei Lu
The determination of plant growth regulators is of great importance for the quality monitoring of crops. In this work, 4-bromophenoxyacetic acid (4-BPA), one of the phenoxyacetic acids, was detected via the electrochemical method for the first time. A CeO2-decorated electrochemical exfoliated graphene (eGr) composite (CeO2/eGr) was constructed as the sensor for sensitive detection of 4-BPA due to the synergistic effect of the excellent catalytic active sites of CeO2and good electron transference of the eGr. The developed CeO2/eGr sensor displayed a good linearity in a wide range from 0.3 to 150 μmol/L and the lowest detection limit of 0.06 μmol/L for 4-BPA detection. Electrochemical oxidation of 4-BPA follows a mix-controlled process on the CeO2/eGr electrode, which involves 2e in the transference process. This developed CeO2/eGr sensor has excellent repeatability with a relative standard deviation (RSD) of 2.35% in 10 continuous measurements. Moreover, the practical application of the sensor for 4-BPA detection in apple juice has recoveries in the range of 90–108%. This proposed CeO2/eGr sensor has great potential for detecting plant growth regulators in the agricultural industry.Keywords:plant growth regulators;4-bromophenoxyacetic acid;electrochemical determination;lowest detection limit;CeO2/eGr composite
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Sustainability
·
2022
·Vol. 14
·期 21
·14300
·
IF 3.889
Qinghong Wang,Siyu Li,Xin Wang,Zhuoyu Li,Yali Zhan,Chunmao Chen
The extensive use of pharmaceuticals and personal care products (PPCPs) causes high concentrations of pharmaceutical metabolites to exist in aquatic environments. Though the removal of parent PPCPs has raised concerns, the degradation of pharmaceutical metabolites was rarely investigated. In this study, the degradation of 4-acetylaminoantipyrine (4-AAA), a typical dipyrone metabolite frequently detected worldwide in surface water and wastewater, was initially studied using persulfate (PDS)-based advanced oxidation processes (AOPs). Compared with commonly used activation methods of alkali, ultrasonic, ultraviolet, and Fe2+, 4-AAA achieved its best degradation (98.9%) within 30 min in a thermally activated PDS system due to the promotion of both radical production and the reaction rate with the rise in temperature. The optimum degradation of 4-AAA could be achieved with the temperature of 80 °C regardless of initial pH values, indicating a wide suitable pH range. Moreover, over 80% of the degradation of 4-AAA could be achieved with the presence of Cl−(0–16 mM), HCO3−(0–8 mM), and humic acid (0–30 mg/L), further indicating the application potential of the system. Both sulfate radicals (SO4•−) and hydroxyl radicals (•OH) contributed to 4-AAA degradation and the contribution of •OH increased with the pH rising from 3 to 11 due to the transformation from SO4•−when reacting with OH−. Three hydroxylated and ring-opening intermediates were detected during the 4-AAA degradation. The ECOSAR prediction indicated that the acute toxicity of most intermediates decreased than 4-AAA while the chronic toxicity increased, which suggested the transformation of intermediates should be further focused on in SO4•−and •OH based AOPs. This study would provide technical reference for the control of 4-AAA in wastewater treatment processes, raise concerns on the influence of PPCPs metabolites, and throw light on reducing the harm of PPCPs and their metabolites in aquatic environments.Keywords:4-acetylaminoantipyrine (4-AAA);heat activation;persulfate;degradation pathway;toxicity
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MOLECULES
·
2022
·Vol. 27
·期 9
·2738
·
IF 4.927
Lu Xu,Jinmeng Yu,Lu Jin,Le Pan
A series of 30 succinate dehydrogenase inhibitors (SDHIs) of 4-amino coumarin-based derivatives were designed and synthesized. According to the analysis of fungicidal activity in vitro, most of the compounds expressed broad-spectrum antifungal activity against four plant pathogenic fungi (Alternaria alternata, Alternaria solani, Fusarium oxysporum,andBotrytis cinerea) using the mycelium growth inhibition method. The results showed that compounds3nwith the group of 2-ene-3-methyl-butyl and4ewith the group of 2-bromo-1-oxo-hexyl displayed excellent activity againstAlternaria alternataandAlternaria solani, with EC50values of 92~145 μg/mL. Molecular docking showed that the inhibitor3nwas completely locked into the cavity of SDH, forming a conventional hydrogen bond interacting with the amino acid residue TYR58. The present work indicates that these derivatives would serve as novel potential fungicides targeting SDH.Keywords:succinate dehydrogenase;inhibitor;4-amino coumarin;fungicide;antifungal activity;molecular docking
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Frontiers in Chemistry
·
2022
·
IF 5.545
Kuang Yi,Xia Yunlong,Wang Xing,Rao Qingqing,Yang Shengxiang
4-hydroxyl coumarin (HC), an important intermediate during the synthesis procedure of rodenticide and anti-cardiovascular drug, shows highly medicinal value and economic value. To achieve the efficient adsorption of HC from natural biological samples, a novel magnetic surface molecularly imprinted polymer (HC/SMIPs) was constructed by employing methacrylic acid (MAA) as functional monomer, organic silane modified magnetic particles as matrix carrier and HC as template molecule. Due to the numerous specific imprinted cavities on the HC/SMIPs, the maximum adsorption capacity of HC/SMIPs for 4-hydroxycoumarin could reach to 22.78 mg g−1 within 20 min. In addition, HC/SMIPs exhibited highly selective adsorption for 4-hydroxycoumarin compared with other active drug molecules (osthole and rutin) and showed excellent regeneration performance. After 8 cycles of adsorption-desorption tests, the adsorption capacity of HC/SMIPs just slightly decreased by 6.64%. The efficient selective removal and easy recycle of 4-hydroxycoumarin from biological samples by HC/SMIPs made a highly promising to advance the application of imprinting polymers in complex practical environments.
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MATERIALS CHEMISTRY AND PHYSICS
·
2022
·
IF 4.778
Zhijia Zhang,Huifeng Mei,Qiang Wang,Rui Li,Guojun Wang,Hao Wei,Xiao Ouyang
Unlike the organisms in nature, the synthetic materials are difficult to repair the damage via self-regulation. Even the self-healing materials generally require the external stimuli (e.g., temperature, pressure, light, etc ) to repair themselves. In this paper, self-healing polyurethane elastomer was designed and prepared based on 2-ureido-4[1 H ]-pyrimidinone compound by the simple physical blending method. The tensile strength and the elongation at break of the self-healing polyurethane elastomer were 0.65 MPa and 623.1%, respectively. The healing performance was measured by cut-off experiment, showing that the fracture of the self-healing polyurethane elastomer was healed at room temperature without external stimuli and kept excellent mechanic properties. The healing efficiencies of the tensile strength and the elongation at break were achieved to 87.7% (0.57 MPa) and 71.7% (446.7%) after healing at room temperature with 30 h, respectively. When the temperature was up to 80 °C, the healing time curtailed at 1 h. And the tensile strength and the elongation at break were recovered to 0.59 MPa and 532.1%, respectively. These promising results provide a strategy that allows increasing the life cycle of materials, adapting them to a circular economy model, thus reducing the generation of waste.
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