INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2022
·Vol. 23
·期 4
·2080
·
IF 6.208
Zhaoqian Fan,Yukun Qin,Song Liu,Ronge Xing,Huahua Yu,Kecheng Li,Pengcheng Li
The exploration of novel, environmentally friendly, and efficient nematicides is essential, and modifying natural biomacromolecules is one feasible approach. In this study, 6-O-(trifluorobutenyl-oxadiazol)-chitosan oligosaccharide derivative was synthesized and characterized by FTIR, NMR, and TG/DTG. Its bioactivity and action mode against root-knot nematodeM. incognitawere estimated. The results show that the derivative shows high nematicidal activity against J2s, and egg hatching inhibitory activity at 1 mg/mL. The derivative may affect nematode ROS metabolism and further damage intestinal tissue to kill nematode. Meanwhile, by synergism with improving crop resistance, the derivative performed a high control effect on the nematode with low phytotoxicity. These findings suggested that chitosan oligosaccharide derivatives bearing fluoroalkenyl groups are promising green nematicides.Keywords:chitosan oligosaccharide;nematicide;Meloidogyne incognita;trifluorobutenyl group
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ACS Omega
·
2022
·
IF 4.132
Chunpo Gao,Yanan Wang,Jiasheng Shi,Yanyan Wang,Xiaoli Huang,Xilu Chen,Zhiyong Chen,Yunfeng Xie,Yanzhao Yang
Chitosan is a typical hydrophilic biomass building block widely used in material science and engineering. However, its intrinsic amphiphilicity has been seldom noted so far. Herein, a series of glutaraldehyde-crosslinked chitosan cryogels with superamphiphilicity are fabricated at moderately frozen conditions through a freezing–thawing process. The micron-sized porous cryogel samples display a 0° contact angle toward both water and oil, 0° water contact angle under oil, and over 120° oil contact angle underwater. By comparing the wetting behavior of the tablet compressed by pure chitosan powders, the superamphiphilicity of the chitosan sample is proven to be independent on crosslinkers. This special wettability endows the chitosan cryogels with high separation efficiency for various surfactant-stabilized oil-in-water emulsions under continuous flow mode driven by gravity as well as a peristaltic pump.
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CARBOHYDRATE POLYMERS
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2022
·
IF 10.723
Jinghui Jiang,Xiaoxia Chen,Gong-Liang Zhang,Hongshun Hao,Hong-Man Hou,Jingran Bi
To improve the mechanical and barrier properties of cellulose and chitosan (CS) and to allow the application of volatile antibacterial benzyl isothiocyanate (BITC) in active packaging, a double-layer nanocomposite film was prepared. Cellulose nanofibers (CNF) were crosslinked with CS via genipin to build the substrate. Quaternized cellulose nanocrystals (QCNC) were synthesized for carrying BITC as the coating material . By the layer-by-layer self-assembly approach, CS-CNF/QCNC-BITC film was fabricated. This film possessed the tensile strength of 33.75 MPa, low permeabilities of oxygen (6.9 × 10 −17 m 3 /s·m·Pa) and moisture (1.2 × 10 −11 g/s·m·Pa), and good antibacterial activity with the inhibition zone diameters of 4.9, 4.2 and 2.7 cm against Escherichia coli , Salmonella typhimurium and Staphylococcus aureus . The total viable count , total volatile basic nitrogen and thiobarbituric acid-reactive substances of the chicken wrapped CS-CNF/QCNC-BITC were only 4.4 log CFU/g, 17.7 mg/100 g and 0.44 mg/kg at 14 days, indicating a potential application of CS-CNF/QCNC-BITC for food packaging.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Chen Huang,Fusheng Sun,Xuxi Ma,Chao Gao,Nan Yang,Katsuyoshi Nishinari
Food-grade microgel-stabilized emulsions have been attracting much attention due to their promising applications in food formulations. In this study, the use of hydrophobically modified chitosan microgels ( h -CSMs) as particle emulsifiers to stabilize high internal phase emulsions (HIPEs) was demonstrated for the first time. Four hydrophobically modified chitosan ( h -CS) were obtained by grafting deoxycholic acid (DA) with chitosan (CS) at grafting rates of 4.64%, 13.21%, 15.12% and 30.29%, respectively. The selected modified chitosan were further cross-linked with sodium tripolyphosphate (TPP) to form h -CSMs. It was found that, compared to pure CS and the modified h -CS, the h -CSMs have higher hydrophobicity , and can stabilize oil-in-water HIPEs effectively. The interfacial properties of the h -CSMs, and the formation, microstructure and rheological properties of HIPEs were characterized by dynamic interfacial adsorption, contact angle, visual observation, laser confocal microscopy and rheological measurements, respectively. The results show that stable HIPEs with oil concentration up to 90 wt% can be formed using very low h -CSM particle concentration (only 0.05 wt% for the HIPE with 90 wt% oil), and the HIPEs stabilized by h -CSMs displayed higher rheological compliance than other solid particle stabilized HIPEs at high oil volume fraction. The strong emulsification properties of the h -CSMs are attributed to their increased hydrophobicity, the enhanced exposure of hydrophobic groups during microgelation process, and the viscoelasticity of h -CSMs.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Long Xia,Juguo Dai,Xiaohong Wang,Mingjin Xue,Yiting Xu,Conghui Yuan,Lizong Dai
Multifunctional cotton fabrics (M-CF) have important application prospects in intelligent home decoration and material packaging. In this work, nanoparticles (AgNC@BP) were prepared by coating the surface of silver nanocubes (AgNCs) with borate polymer. Subsequently, M-CF with electromagnetic wave (EMW) absorption, mechanical enhancement, flame-retardancy and antibacterial performances were prepared by immersing cotton fabrics (CF) into AgNC@BP/crosslinked chitosan (CS) solution. Expectantly, AgNC@BP endows AgNC@BP/CS-CF with good flame retardancy and low combustion heat release. That is, the char length of AgNC@BP/CS-CF is 7.9 cm after the vertical burning test (UL-94 V) and the peak heat release rate (pHRR) of AgNC@BP/CS-CF is reduced by 21.4% compared to pure CF. Meanwhile, the tensile strength of AgNC@BP/CS-CF is 18.8% higher than that of CF. Synchronously, the introduction of AgNC@BP can also endow M-CF with better EMW absorption, mechanical and antibacterial properties . In conclusion, this work provides a tactic for fabricating M-CF.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2022
·Vol. 110
·期 10
·2231-2240
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IF 3.405
Kun Liu,Xiaopei Wu,Honglian Dai
Scaffold design is particularly important and necessary for soft tissue repair such as nerve tissue repair. In this article, we designed and manufactured a macroporous chitosan-based hydrogel with excellent cell compatibility and antioxidant properties. Here, the chitosan (CS) based hydrogel is obtained by repeated freezing and thawing using citric acid (CA) as a cross-linking agent. We have evaluated the effects of citric acid content on the physical and chemical properties of hydrogels through mechanical properties and scanning electron microscopy. CA-CS hydrogel shows a macroporous structure, as the citric acid increases, the mechanical strength increases and the pore size decreases. In vitro cell experiments show that CA-CS hydrogel partakes positive effects on cell survival, adhesion and proliferation, as well as antioxidant properties. All results provide a basis for the construction of porous chitosan-based hydrogels, while demonstrating a promising approach to deal with oxidative stress in nerve injury.
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Advanced Healthcare Materials
·
2022
·Vol. 12
·期 16
·2201651
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IF 11.092
Yunhao Yu,Rui Tian,Yu Zhao,Xudong Qin,Liefeng Hu,Jun-Jie Zou,Ying-Wei Yang,Jian Tian
Microvascular dysfunction caused by hyperglycemia leads to slow healing of diabetic wounds and significantly increases the risk of bacterial infection. The misuse of antibiotics can also lead to bacterial resistance, making the management of diabetic wounds more challenging. Thus, developing new antibacterial agents or strategies to overcome antibiotic resistance is highly pursued. Herein, novel supramolecular photothermal nanoparticles (MCC/CS NPs), assembled from mono-carboxyl corrole (MCC) and chitosan via hydrogen bonding and π – π stacking, are developed and used for treating bacterial wound infection. The MCC molecules possess good photothermal performance and the chitosan with inherent bioactivity can exert moderate antibacterial effects. The aggregation of MCC in MCC/CS NPs induced by chitosan-templated self-assembly further quenches molecular fluorescence and realizes an extraordinary photothermal conversion efficiency of 66.4%. Moreover, the highly positively charged MCC/CS NPs can selectively target bacteria via electrostatic interactions. Under near-infrared laser irradiation, the MCC/CS NPs achieve potent photothermal and inherent antimicrobial synergistic effects against Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Furthermore, the bacteria-infected diabetic wound model confirms that the MCC/CS NPs can effectively kill drug-resistant bacteria, accelerate wound healing and angiogenesis, and show good biocompatibility, representing a novel and efficient photothermal antibacterial nanoplatform.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Lumin Yang,Xiaoduo Zhao,Xiaozhu Liao,Rui Wang,Zengjie Fan,Shuanhong Ma,Feng Zhou
The lubrication deficiency in joints is a major cause of osteoarthritis. One of the most commonly used treatment means is to inject artificial lubricants, but there is a potential risk of infection during the injection process. Therefore, developing artificial lubricants with dual functions of friction-reduction and antibacterial is urgent. In this work, a novel polysaccharide-derived lubricant with simultaneous anti-bacteria and water-lubrication properties, called CS-MPC-N, is developed by grafting 2‑methacryloyloxylethyl phosphorylcholine (MPC) and nisin peptide onto backbone of chitosan (CS). Compared to the control CS, CS-MPC-N exhibits good lubrication and friction-reduction properties because of its excellent water solubility. Especially, CS-MPC-N shows low friction coefficient (0.03 ∼ 0.05) at the sliding interfaces of artificial joints materials or even natural articular cartilages. Moreover, CS-MPC-N can effectively inhibit the proliferation of Staphylococcus aureu, exhibiting excellent antibacterial effect. This kind of novel polysaccharide-derived lubricant is expected to be used in treating infectious arthritis.
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NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 32
·15628-15634
·
IF 3.925
Yuzhe Zhang,Jie Hua,Hao Wu,Yizi Shao,Peiyang Gu,Zhongyu Li
The separation and recovery of neodymium from industrial pollutants and environmental sewage has become a problem of concern. However, there are still several difficulties in the practical treatment process including low pH values, low concentrations of rare earth elements, and coexistence of multiple trivalent ions, which are long-term challenges for neodymium recovery. In this paper, the synthesis of a composite membrane prepared using chitosan as an efficient adsorbent for Nd3+ is reported. The introduction of polyethylenimine into the composite membrane provided abundant protonated amino nitrogen atoms and endowed the composite membrane with excellent buffering capacity under extremely acidic conditions. Carbon nanofiber aerogels in the composite membrane can effectively improve the specific surface area and mechanical properties. Moreover, the introduction of ion imprinting technology can effectively improve the specific adsorption of Nd3+ on the composite membrane, which makes the composite membrane able to easily separate Nd3+ from other coexisting ions. The adsorption capacity of single metal adsorption for Nd3+ is 43.63 mg g−1. The composite membrane also showed good reusability, and the regeneration efficiency reached 86% after 5 cycles. The results show that the composite membrane can be used for the separation and enrichment of Nd3+ in solution.
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Heritage Science
·
2022
·Vol. 10
·期 1
·1-12
·
IF 2.843
Liu Zhen,Liu Kun
Chinese ink has very special significance for presentation of artistic effects and preservation of works of art; however, wasted nonrenewable resources, potential toxicity, and complex and inefficient production technologies have limited the development of inks for traditional Chinese culture. Herein, environmentally friendly, practical and antibacterial Chinese ink was prepared by facile heating-stirring of gelatin and the natural polysaccharide chitosan. The internal composition, viscosity, morphology, particle size and antibacterial properties of the ink were characterized by Fourier transform-infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy and bacteriostatic zone tests. The results showed that commercial ink (CM) spread easily on Xuan paper and led to imperfect artwork, while the chitosan and gelatin ink (CG) showed good adhesion and stability on Xuan paper. Based on this study, we believe that the good performance of CG ink should be attributed to restrictions arising from its internal chitosan and gelatin network, which restrict diffusion. Finally, the author used CG ink to display traditional Chinese calligraphy and landscape painting and believes that it has significant application prospects and will be used in large-scale production.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Tian-Cai Sun,Bing-Yu Yan,Xu-Chao Ning,Chao Hui,Lei Xu,Yi-Ning Ding,Xing-Long Yang,Seeram Ramakrishna,Yun-Ze Long,Jun Zhang
Burns and scalds are thermal injuries caused by a large amount of heat accumulation in local tissues. The first cooling emergency is a key step. However, it is hard that in outdoors to find clean water to cool the scald tissue sites. Moreover, most dressings are concentrated on the treatment process today, neglecting the emergency treatment of temperature reduction. In this study, we imported refrigeration in the electrospinning process while using dirty water, rainwater and even urine of outdoors, so that the cooled sterile fibers were directly deposited on the burn and scald wounds, and the cooling emergency was achieved through the dual cooling mechanism. Since this fiber which is made up of cheap fish gelatin contains CuS adopting the green method, it can generate heat and effectively kill bacteria under the irradiation of an illumination lamp at the front end of a spinning device. As a result of the direct deposition, there is an excellent fit between the fibrous membrane and the skin, which reduces the air gap to achieve a better and quick cooling and heating effects. On the same Chitosan/Platelet-derived Growth Factor fiber membrane, this method of cooling first and heating second can shorten the recovery time from 30 days to 21 days. Thus, this treatment strategy has a great potential application prospect in the field of outdoor burn treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Dao-Qiang Lu,Dahai Liu,Justin Liu,Wen-Xing Li,Yilong Ai,Jun Wang,Daogang Guan
Chitosan-based nanogels are effective carriers for drug delivery due to their biocompatibility and biodegradability. However, the chemically cross-linked nanogels usually require complicated procedures or tough conditions. Herein, we report a simple approach to generate chitosan-based nanogels by photo-crosslinking of poor solvent-induced nanoaggregates without requiring any emulsifying agent, catalyst, or external crosslinker. O-nitrobenzyl alcohol-modified carboxymethyl chitosan was synthesized and self-crosslinked into the nanogels in a mixed solution of ethanol and water under 365 nm light irradiation due to UV-induced primary amine and o-nitrobenzyl alcohol cyclization. The nanogels (CMC-NBA NPs) and lactobionic acid-decorated nanogels (LACMC-NBA NPs) displayed a uniform diameter (~200 nm) and excellent stability under physiological conditions. Notably, the nanogels exhibited a high loading content (~28 %) due to π-π stacking and electrostatic interactions between doxorubicin (DOX) and the carriers. These DOX-loaded nanogels showed rapid drug release under slightly acidic conditions. The cell and animal experiments confirmed that LACMC-NBA NPs increased cellular uptake, improved cytotoxicity in tumor cells, and enhanced growth inhibition in vivo than CMC-NBA NPs. Thus, these photo-crosslinked nanogels possess great potential for DOX delivery.
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