FOOD CHEMISTRY
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2024
·
IF 8.5
Guijiao Zhao,Chenhuan Wang,Min Kang,Lin Hao,Weihua Liu,Zhi Wang,Xiaodong Shi,Qiuhua Wu
Developing effective methods for highly sensitive detection of phenolic endocrine disruptors (EDCs) is especially urgent. Herein, a magnetic hydroxyl-functional porous organic polymer (M-FH-POP) was facilely synthesized by green diazo-couple reaction using basic fuchsin and hesperetin as monomer for the first time. M-FH-POP delivered superior adsorption performance for phenolic EDCs. The adsorption mechanism was hydrogen bonds, hydrophobic interaction and π-π interplay. With M-FH-POP as adsorbent, a magnetic solid phase extraction method was established for extracting trace phenolic EDCs (bisphenol A, 4- tert -butylphenol, bisphenol F and bisphenol B) in water and fish before ultra-high performance liquid chromatography tandem mass spectrometry analysis. The method displayed low detection limit (S/N = 3) of 0.05–0.15 ng mL −1 for water and 0.08–0.3 ng g −1 for fish. The spiked recoveries were 88.3 %–109.8 % with the relative standard deviations of 2.4 %–6.4 %. The method offers a new strategy for sensitive determination of phenolic EDCs in water and fish samples.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Jun-Qiu Zhang,Xiao-Fang Shen,Jun Liu
Malachite green (MG), a widely used antiparasitic agent, poses health risks to human due to its genotoxic and carcinogenic properties. Herein, a stable dual-emission fluoroprobe of carbon dots/copper nanoclusters is prepared for highly selective detection of MG based on the inner filter effect. This probe exhibits characteristic emission bands at 435 and 625 nm when excited at 376 nm. After adding MG, the both emission signals were significantly quenched, and the ratio of fluorescence intensity (F 435 /F 625 ) was linearly related to the concentration of MG in the range of 0.05–40 μmol L −1 with a limit of detection of 18.2 nmol L −1 . Meanwhile, the two signals exhibit linear relationships with the concentration of MG, respectively, and the corresponding detection results were consistent. The fluoroprobe was successfully used for the detection of MG in fish samples with the recoveries ranging from 96.0% to 103.8% and a relative standard deviation of <3.3%.
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FOOD CONTROL
·
2025
·
IF 6.3
Huan Huang,Guocheng Zhou,Zhiyuan Meng,Ting Li,Linfeng Sun,Zhonglong Wang,Yiqin Yang
Biogenic amines (BAs), such as cadaverine (Cad), putrescine (Put), and spermine (Spe), serve as critical indicators of meat freshness. In this study, we developed a novel flavonol-derived fluorescent probe, 4-(3-((4-cyanobenzoyl)oxy)-4-oxo-2-(2,4,6-trimethoxyphenyl)-4H-chromen-7-yl)benzoic acid ( CTBA ). CTBA exhibited a sensitive and selective fluorescence response to BAs, with a pronounced emission peak at 510 nm that intensified proportionally with BA concentration. For Cad, the probe demonstrated a linear detection range of 0–45 μM, achieving a low limit of detection (LOD) of 0.36 μM. The interaction mechanism between CTBA and cadaverine was validated through 1 H NMR and high-resolution mass spectrometry (HRMS). Furthermore, a composite fluorescent film was fabricated by spin-coating CTBA with ethyl cellulose (EC), leveraging hydrogen-bonding interactions. This film was successfully applied for real-time monitoring of freshness in fish, and prawn. Our work introduces a pioneering bifunctional material capable of dual-purpose packaging and freshness detection, offering significant potential for enhancing food safety protocols.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Wenwen Liu,Miao Li,Songyi Lin,Tongtong Shi,Yoshimasa Nakamura,Liang Song,Yue Tang
This study developed an emulsion delivery system using fish skin gelatin (FSG) and pectin (PEC) as complex emulsifiers to encapsulate benzyl isothiocyanate (BITC). The stability and BITC release profile of the FSG-PEC emulsion were evaluated in vitro and in vivo . Results indicated that the FSG-PEC emulsion significantly enhanced BITC bioavailability compared to water emulsion and single emulsifier systems, achieving targeted delivery. The BITC-loaded FSG-PEC emulsion significantly increased high-density lipoprotein cholesterol levels, reduced low-density lipoprotein cholesterol, cholesterol, and triglyceride levels, alleviated liver enzyme injuries, lowered creatinine and blood urea nitrogen levels, relieved oxidative stress induced by hyperglycemia, enhanced liver antioxidant capacity, reduced pro-inflammatory factor content in the liver, and improved liver tissue and islet damage in T2DM mice. This research not only provides a theoretical foundation for the delivery and controlled release of lipophilic active substances but also lays the groundwork for further exploration of their functional activities in vivo .
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Tianxing Fang,Qingyi Wei,Erwen Wu,Hongbin Pu
Malachite green (MG), with teratogenic and reproductive toxicity, is widely misused as an antimicrobial agent, posing a serious threat to animal and human health. Therefore, this study developed a novel recyclable Surface-enhanced Raman scattering (SERS) hydrogel substrate, TiO 2 /MXene/PAA-PAM@AuNPs (TMPA), by forming a dual hydrogen-bond network using a PAA-PAM hydrogel matrix with TiO 2 /MXene and embedding AuNPs, for detecting MG residues in aquatic products. This hydrogel exhibits high sensitivity, with a detection limit for MG of 8.13 × 10 −6 mg/L. Additionally, it can completely degrade surface-adsorbed MG within 60 min under light irradiation, achieving self-cleaning and enabling reuse for more than seven cycles, and can be stored for over 50 days while maintaining its SERS activity due to the support and preservation provided by the hydrogel network. Additionally, this substrate can rapidly detect MG residues on or within fish, offering a new strategy for monitoring MG residues in aquatic products.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Ping Shi,Xin Wang,Sajid Ali,Li-Yan Zeng,Xin-hui Xian,Jin-ling Huang,Sheng-yun Qin,Yuan-Sen Liu,Hafiz Umer Javed
This study explores the development of chitosan (CS) films enhanced with citric acid-based deep eutectic agents (CA-DEA) to address the dual challenges of sustainable food packaging and effective fish preservation. CA-DEA was synthesized using citric acid (CA) and choline chloride (ChCl) in molar ratios of 1:1, 2:1, 3:1, and 4:1, with the synthesis confirmed through FTIR analysis. Among these, the 4:1 molar ratio, identified as the most effective formulation for its superior antibacterial properties against E. coli (17.3 ± 0.78 mm) and S. aureus (23.625 ± 0.09 mm), was further evaluated at varying concentrations (0.5%, 1%, 1.5%, and 2%) to examine its effects on the structure and functional properties of CS films. Mechanical testing revealed that films with 0.5% CA-DEA achieved the highest tensile strength (TS; 47.98 ± 2.40 MPa), while higher concentrations led to decreased TS (13.59 ± 1.37 MPa), likely due to over-plasticization. The incorporation of CA-DEA enhanced the films' antibacterial, antioxidant, and UV-barrier properties, significantly improving their bioactivity. As a bioactive coating on tilapia fillets, the incorporation of CA-DEA formulation effectively reduced water loss, preserved protein, controlled TVB-N levels, and extended shelf life, showing the most effective preservation results. This study highlights CA-DEA’s multifunctionality as a bioactive plasticizer, offering a sustainable alternative to conventional packaging and advancing eco-friendly preservation technologies for perishable aquatic products.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Chen Li,Chao Ai,Boyu Chen,Yanan Zhao,Hui Wang,Lei Chen,Hui Teng
The nutritional efficacy of fish oil is significantly limited by its high susceptibility to oxidative degradation and low bioavailability. In this study, a non-covalent complex composed of anthocyanins (ANC) and whey protein (WP), was rationally designed and utilized to develop a fish oil emulsion system aimed at enhancing oxidative stability and bioaccessibility. The fluorescence spectroscopy (INF), Fourier transform infrared spectroscopy (FTIR) and Far UV circular dichroism (CD) demonstrated specific molecular interactions were generated between ANC and WP. Upon emulsification, the WP-ANC complex at 0.4 wt% acted as an effective emulsifier, yielding emulsions with reduced droplet size and enhanced antioxidative stability. Comparative analysis revealed that WP-ANC stabilized emulsions exhibited superior inhibition of lipid oxidation compared to those stabilized solely by WP, thereby significantly enhancing the stability of fish oil. Under simulated in vitro gastrointestinal digestion, the emulsion formulated with 0.4 % ANC and WP promoted lipid droplet breakdown, suppressed oxidative degradation during digestion, decreased the release rate of free fatty acids, and consequently enhanced the bioavailability of fish oil.
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2025
·
IF 3.6
Yue Guoliang,Cai Zhenling,Meng Chun,Mao Yuhong
Efficient immobilized lipase systems are essential for industrial lipid modification, yet the combined effects of enzyme loading, support properties, and post-immobilization stabilization on catalytic performance remain underexplored. In this study, Thermomyces lanuginosus lipase (TLL), Candida antarctica lipase B (CalB), and their mixture (T + C) were respectively immobilized on two structurally distinct commercial supports (A & B)—differing in hydrophobicity, surface area, and pore size—at varied loading densities. Adsorption followed monolayer kinetics, with support B enabling higher enzyme up to 44.1 mg/g wet for T + C. Co-immobilized T + C systems exhibited enhanced catalytic activity compared to individual lipases, particularly in esterification and transesterification, benefiting from the complementary substrate specificities of TLL and CalB. Chemical crosslinking with chitosan and glutaraldehyde significantly reduced lipase desorption and improved thermal stability. The optimized system Cr-B-T + C-M (crosslinked support B-TLL + CalB with medium enzyme loading) efficiently catalyzed fish oil transesterification at 60 °C for 18 h, increasing the EPA + DHA content from 30.5% to 54.8%. All immobilized lipases retained over 80% of their initial catalytic activity after three reuses (60 °C and 18 h). These results highlight the synergistic benefits of co-immobilization and crosslinking on tailored supports, offering a versatile strategy for developing stable and efficient lipase biocatalysts for high-value lipid processing.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Zhuxian Gao,Zelan Wang,Yuanyuan Li,Caihu Li
Cationic dyes like crystal violet (CV) and methylene blue (MB) pose severe environmental and biological risks, demanding rapid, on-site detection. Conventional colorimetric methods often suffer from high detection limits and poor robustness. Metal-organic frameworks (MOFs) such as ZIF-8 show promise for dye adsorption, but integrating them into processable, transparent matrices for visual sensing remains a challenge, driving the need for advanced hybrid materials. ZIF-8 nanoparticles were synthesized and uniformly embedded within a poly (methylmethacrylate) (PMMA) matrix through a melting mix approach, yielding a transparent composite material. This ZIF-8/PMMA hybrid served as a highly effective visual sensor for the rapid detection of CV and MB in aqueous solutions. A systematic optimization of critical parameters (pH, contact time, temperature, and ionic strength) demonstrated that the sensor has robustness under diverse environmental conditions. Notably, the sensor achieved exceptional visual detection limits of 0.1 mg L −1 (CV at 583 nm) and 0.08 mg L −1 (MB at 664 nm), surpassing conventional colorimetric methods. Density functional theory (DFT) calculations revealed that van der Waals interactions dominated the adsorption mechanism between ZIF-8 and the target dyes. When applied to fish tissue samples, the method exhibited excellent accuracy (recovery rates: 92–107 %) and reproducibility (RSD: 8.9–12.8 %), with a strong linear response (R 2 > 0.99) for both analytes. The selective adsorption performance of ZIF-8 combined with the optical transparency and processability of PMMA provides a groundbreaking environmental protection platform for on-site monitoring of cationic dyes in complex biological matrices.
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Frontiers in Nutrition
·
2025
·
IF 5.1
Jinpeng Gong,Boya Liu,Tao Huang,Lu Wei,Yupeng Ma,Hao Chen,Jing Gan,Junbo Ge
Osteoporosis, a prevalent metabolic bone disease, poses a significant challenge for bone repair in aged populations. Soy-derived osteogenic peptide (SOP) holds promise but its clinical translation is hampered by rapid enzymatic degradation and poor oral bioavailability, representing a major challenge that necessitates the development of a protective delivery system. To address this, we developed a novel composite hydrogel based on fish gelatin and sodium alginate (SA/FG) as an oral delivery vehicle to overcome these limitations. Systematic characterization revealed that the SA/FG formulation offers distinct advantages: the incorporation of an optimal amount of SA significantly enhanced the mechanical strength and stability of the hydrogel, addressing the common weakness of single-network gelatin hydrogels, while maintaining a high water content (~90%) and a superior rehydration capacity (83.65% in distilled water). In a glucocorticoid-induced zebrafish osteoporosis model, the SOP-loaded SA/FG hydrogel significantly increased skull bone mass by 120.17% and improved larval swimming behavior, markedly outperforming the free SOP group. This study presents the first report of an SA/FG composite hydrogel for effective oral delivery of an osteogenic peptide. The system demonstrates great potential as a functional food or supplement for preventing and treating osteoporosis, offering an innovative strategy to enhance peptide stability and bioavailability through a biocompatible, double-network carrier.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Zhihang Xu,Hong He,Jian Du,Peng Shan,Chenglong Fu,Jinwen Hu,Yehan Tao,Chao Li,Yanna Lv,Haisong Wang
Anthocyanin-based pH-responsive indicators are promising for food freshness monitoring, but UV exposure during transportation and retail display causes chromophore degradation and fading. Herein, core–shell sodium alginate/cinnamaldehyde/zein/anthocyanin nanoparticles (SCZC) were fabricated via a multiscale protection strategy. Anthocyanins were confined in a hydrophobic zein core through hydrophobic and π–π interactions, while cinnamaldehyde-assisted interfacial densification and a sodium alginate shell provided diffusion barriers against external stresses. After incorporation into a carboxymethyl cellulose (CMC) matrix, the CMC film containing 0.4 g SCZC nanoparticles (C/SCZC-0.4) exhibited improved UV and visible-light stability, with ΔEab values of only 5.21 after 4 h of UV irradiation and 5.22 after 8 days of visible-light exposure. Compared with the free-anthocyanin CMC film (C/C), C/SCZC-0.4 reduced anthocyanin migration in water from 84.34% to 35.65%, while improving oxygen barrier performance and tensile strength to 2.32 cm 3 ·μm·m −2 ·day −1 ·kPa −1 and 30.0 MPa. The label retained pH/ammonia responsiveness and visually distinguished seafood freshness. Download: Download high-res image (208KB) Download: Download full-size image
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Foods
·
2026
·Vol. 15
·期 2
·345
·
IF 5.1
Zixin Li,Yin Wang,Yong Jiang,Lili Chen,Meilan Yuan,Li Zhao,Chunqing Bai
Low-salt cured fish is prone to deterioration due to lipid oxidation and microbial proliferation during refrigeration. Chlorogenic acid (CGA), with excellent antioxidant and antimicrobial activity, is a promising candidate for the preservation of cured fish. However, its instability in the presence of environmental factors significantly confines its direct application. In this research, CGA was encapsulated in liposomes and utilized as a dip-coating for cured fish. The effects of varying concentrations of CGA-loaded liposomes (L-CGA) coating on the physicochemical quality and microbial diversity of cured fish were rigorously compared to those treated with CGA solutions, blank liposomes, and distilled water throughout 32 days’ storage at 4 °C. The results showed that L-CGA exhibited a higher lipid oxidation-inhibiting capacity (generation of hydroperoxides and their secondary oxidation products) than the corresponding free CGA at fixed concentrations. Furthermore, the liposomal formulation showed significantly enhanced inhibitory activity against dominant spoilage-associated bacterial genera (e.g.,Staphylococcus,Macrococcus, andRothia), with the L-CGA loaded at 800 mg/L of CGA showing optimal effectiveness. This enhanced preservation effect can be attributed to the protective and controlled release properties of the liposomes, which facilitate improved preservation outcomes for CGA. These findings demonstrate that L-CGA could be used as a promising preservative for low-salt cured fish or some similar products.
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危险品化学品经营许可证（带存储）