Journal of Translational Medicine
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2026
·Vol. 24
·期 1
·893
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IF 9.7
Hao Zhihua,Su Xin,Li Jiantao,Jin Jing,Li Zheng,Yan Zhiqiang,Jiao Wenpeng,Jiao Wenjing,Wang Yingying,Ji Chenguang,Wang Xuan,He Yutong
Background Metabolic reprogramming underpins the acquisition of radioresistance in esophageal squamous cell carcinoma (ESCC); however, the specific bioenergetic vulnerabilities and direct pharmacological targets remain to be fully elucidated. This study defines a distinct metabolic phenotype conferring radioresistance and evaluates the natural alkaloid Cepharanthine (CEP) as a mechanism-driven radiosensitizer. Methods Matched clinical cohorts of radiosensitive and radioresistant ESCC patients were analyzed using widely-targeted and targeted metabolomics. Bioenergetic profiling (ECAR/OCR) was performed on established isogenic radioresistant cells. The mechanistic interactions between CEP and its target were mapped via network pharmacology, surface plasmon resonance (SPR), cellular thermal shift assays (CETSA), ubiquitin-proteasomal degradation assays, and Q347A site-directed mutagenesis. In vivo efficacy was validated across human cell-derived xenografts (CDX) and immunocompetent syngeneic (AKR/C57BL/6) mouse models. Results Clinical multi-omics revealed a "metabolic duality" in radioresistant ESCC, characterized by the concurrent hyperactivation of glycolysis and oxidative phosphorylation (OXPHOS). CEP administration disrupted this metabolic network, significantly sensitizing ESCC cells to irradiation [Dose-modifying factor at 37% survival (DMF 37 ) > 1]. Mechanistically, CEP directly engages the kinase domain of p70S6K—a structural interaction dependent on the Q347 residue—and triggers its ubiquitin-proteasomal degradation. This targeted clearance disrupts the upstream PI3K/Akt/mTOR survival axis. Genetic overexpression of wild-type p70S6K, but not the Q347A mutant, rescued the dual hypermetabolic phenotype and reinstated radioresistance. Clinically, elevated p70S6K expression correlated with poor disease-free survival and therapeutic failure. In vivo, CEP synergized with radiotherapy to suppress tumor kinetics in both CDX and syngeneic models, while concurrently enhancing CD8 + T cell infiltration in the immunocompetent microenvironment, with no observable systemic toxicity. Conclusions Radioresistant ESCC relies on a dual hypermetabolic state driven by the PI3K/Akt/mTOR/p70S6K cascade. CEP overcomes this radioresistance by physically binding to and degrading p70S6K, thereby inducing bioenergetic exhaustion and reshaping the anti-tumor microenvironment. These findings provide a solid mechanistic rationale for translating CEP into clinical radiotherapeutic regimens.
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Nature Nanotechnology
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2026
·
IF 37.5
Liu Yutong,Zuo Wenhua,Wang Wei,Lin Cong,Weng Qingsong,Zhu Yinggang,Zhang Kai,Du Ke,Ruan Haihui,Pan Feng,Huang Xuejie,Liu Xiang,Yu Hailong,Chen Guohua,Liu Qiang
Stress-induced fractures are recognized as a primary cause of degradation in a wide range of positive electrode active materials during battery operation. However, the state-of-the-art mechanistic understanding and strategy development often overlook the brittle nature of these materials, as well as the dynamic and localized characteristics of mechanical stress during the charge and discharge cycles of the cell. Here we present a shape-memory polymer nanocoating method using initiated chemical vapour deposition to dynamically delocalize concentrated stresses in various positive electrode active materials, including Ni-rich layered oxides with different Ni contents and LiFePO 4 . Fracture simulations and surface-to-bulk physicochemical characterizations collectively show that the balanced stiffness and deformability of the shape-memory polymer nanocoating on the positive electrode material effectively mitigate stress gradients and the consequent surface reconstruction, chemical heterogeneity and intergranular cracking during battery operation. In particular, when a polymeric nanocoated nickel-rich layered oxide positive electrode active material (90 at% of Ni) is tested in non-aqueous lithium metal coin cell configuration at 25 °C, the cells can be consistently charged and discharged over long cycles at moderate (for example, 1,000 cycles at 400 mA g −1 ) and high (for example, 500 cycles at 1 A g −1 ) specific currents.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2026
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IF 4.1
Zheng Chen,Yang Yu-Ma,Xiao Jian-Wu,He Jun-Jie,Lin Bo,He Fu-An
In this work, the novel multifunctional electrospun trimethoxy (1H,1H,2H,2H-heptadecafluorodecyl)silane (TMHFDS)/Ag-TiO 2 /polyvinylidene fluoride (PVDF) mats were prepared. In the preparation process, the AgNO 3 was reduced to be the Ag nanoparticle and then in situ deposited on the TiO 2 nanoparticle to form the Ag-TiO 2 hybrid, which was used as the filler to fabricate the electrospun Ag-TiO 2 /PVDF mats followed by the TMHFDS modification. The successful preparation of the electrospun TMHFDS/Ag-TiO 2 /PVDF mats were proved by the characterizations of scanning electron microscopy, two-dimension energy-dispersive X-ray spectroscopy mapping, Fourier transform infrared spectroscopy, differential scanning calorimeter, and wide-angle X-ray diffraction. The electrospun TMHFDS/Ag-TiO 2 /PVDF mats possessed not only the enhanced crystallinity degree and useful piezoelectric β-crystal content of PVDF than those of the PVDF solid film and the electrospun PVDF mat but also the photocatalytic degradation ability for the oil red O dye. Moreover, for the electrospun TMHFDS(3%)/Ag-TiO 2 (30%)/PVDF mat, its water contact angle reached as high as 156.4° which was 24.6° higher than that of the electrospun PVDF mat before the TMHFDS modification, and its oil absorption capacities for valorous oils ranged between 16.3 g g −1 and 25.1 g g −1 , exhibiting the well oil–water separation ability.
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Journal of Applied Spectroscopy
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2026
·
IF 0.7
Zhao Xing,Zhang Peiyue,Leng Xin,Liu Jing,Zhang Yang,Bai Yinjuan,Yang Bingqin
Trace element analysis of ancient human remains plays an important role in reconstructing dietary habits and living environments. However, conventional analytical methods have critical limitations such as destructive sampling, high costs, and inadequate sensitivity. To address these challenges, a reversible fluorescent probe with specific recognition for Cu 2+ was fabricated and characterized in this study for cell detection and bioimaging. Compared with other cations in solution, the probe exhibited exceptional selectivity and sensitivity towards Cu 2+ . The interaction between the probe and Cu 2+ accelerated the ring-opening process, resulting in a new emission band at 525 nm within a specific pH range. A strong linear relationship between the fluorescence intensity and Cu 2+ concentration, ranging from 0.0 to 1.0 equivalents, with a detection limit of 4.52 μM, was observed. In addition, Job plots and infrared spectral analysis revealed that B probe complexed Cu 2+ at a 1:1 ratio. Biological testing revealed that the probe has good biocompatibility and can be effectively used for Cu 2+ cell imaging. Cu 2+ -specific reversible fluorescent probes can be designed and fabricated with good fluorescence response characteristics and combined with fluorescence spectroscopy technology to accurately quantify Cu 2+ in complex ancient human samples.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·450
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IF 38.5
Zhang Zhilin,Gu Jiayi,Wang Lina,Cui Xingchen,Zhai Xu,Xu Yue,Liu He,Li Deliang,Li Bingle,Tian Ye,Lu Baoyang,Fu Yu,Wang Tieqiang
The cascade polymerization synergistic toughening mechanism overcomes the problem of mutual constraints between "mechanical strength and response speed" of traditional hydrogels and realizes load-bearing actuation.
The “mass–deformation” dynamic coding law was established, enabling a hydrogel-based 0/1 binary information encoding system derived from mechanical actuation responses.
Actuation–perception integrated logic-gate units were developed to enable intelligent soft robotics through a closed-loop “light-triggered actuation–signal feedback–logic processing–robotic action” control system.
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JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Zhang Yong,Jiao Gongao,Ding Zuozhe,Zhang Dongzhi
Hydrogen Sulfide (H 2 S) gas can cause physiological discomfort at low concentrations and is lethal at high concentrations. It is one of the major pollutants in the petrochemical industry. In this article, carbon-modified WO 3 nanoparticle gas-sensitive sensing materials were synthesized using the hydrothermal method, and high-performance H 2 S gas-sensitive sensing devices were fabricated. At a doping ratio of 2:3, the optimal working temperature for the carbon-modified WO 3 (C-WO 3 ) nanoparticles is 160 °C. It exhibits a response value of 23.7 for 10 ppm of H 2 S gas, with a response and recovery time of 6 s/64 s. The material demonstrates excellent selectivity, repeatability, and long-term stability for detecting H 2 S gas. These outstanding performance characteristics make it a promising candidate for H 2 S gas detection applications. This modification enhances the material’s gas-sensing performance and its resistance to interference. Finally, first-principles calculations revealed the mechanism behind the improvement in the H 2 S gas-sensing performance of carbon-modified WO 3 sensing materials.
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Nature Communications
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2026
·
IF 18.1
Ren Lijuan,Hu Xiuli,Wang Shuyu,Shi Jiaqi,Gong Jiaxing,Wang Manyun,Zhou Ji,Wang Jianzu,Lv Xian-Wei,Bielawski Christopher W.,Geng Jianxin
Zinc−air batteries are promising devices for use in safe and cost-effective energy storage applications. However, their practical utility is hindered by sluggish oxygen evolution and oxygen reduction reactions. We show that hybridizing electronically coupled Co single atoms and a CoPd alloy within a three-dimensional macroporous N-doped carbon (CoPd/Co@3D NC) enables high-performance N 2 H 4 -assisted zinc−air batteries, where the oxygen evolution reaction is replaced with the thermodynamically more favorable hydrazine oxidation reaction. Experimental and theoretical data reveal that electronic coupling between the Co single atoms and the CoPd alloy mutually modifies their electronic structures, which, in turn, weakens oxygen adsorption on the Co single atoms and enhances N 2 H 4 adsorption on the Pd sites. The electronic-coupling effect accelerates the rate-limiting steps of the oxygen evolution and hydrazine oxidation reactions. Consequently, N 2 H 4 -assisted zinc−air batteries employing CoPd/Co@3D NC exhibit a small charging/discharging voltage gap of 0.52 V at 100 mA cm −2 , a peak specific power of 151 mW cm −2 , and a specific capacity of 810 mAh g −1 at 10 mA cm −2 ; these values are competitive when compared to those exhibited by conventional zinc−air batteries.
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JOURNAL OF MATERIALS SCIENCE
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2026
·Vol. 61
·期 33
·24477-24493
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IF 4.4
Dong Mingming,Yang Shuyong,Zhou Peng,Huang Zewen,Tu Shenghui
The persistence and removal of antibiotic residues in aquatic environments represent a global environmental challenge. In this study, a novel ternary Bi 2 WO 6 /UiO-66/AgI heterojunction photocatalyst was designed and constructed for the deep removal of tetracycline (TC). AgI nanoparticles and Bi 2 WO 6 nanosheets were in situ anchored onto a porous UiO-66 framework, successfully integrating high adsorption capacity, visible-light response, and efficient charge separation. It was demonstrated that the composite, when exposed to visible light, exhibited a significantly enhanced level of TC degradation activity in comparison with its single- and binary-component counterparts. Mechanistic investigations revealed that UiO-66 not only served as an adsorptive substrate to concentrate pollutants but also functioned as an electron transfer mediator, promoting a direct Z-scheme charge transfer pathway between Bi 2 WO 6 and AgI. This configuration effectively suppressed charge-carrier recombination and enhanced the generation of reactive oxygen species ·O 2 − , ·OH and h + ). The proposed reaction pathway was confirmed by radical-trapping experiments and electron paramagnetic resonance (EPR) spectroscopy. Additionally, this composite material demonstrated favourable performance in stability and toxicity assessments. This work provides a new design concept for metal–organic framework-based composite photocatalysts and elucidates their potential application in synergistic adsorption–photocatalytic degradation of organic pollutants in water treatment. Graphical abstract
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JOURNAL OF ANTIBIOTICS
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2026
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IF 2.7
Zhang Zhikun,Mao Yixuan,Wang Xiu,Ji Hongsheng,Li Yu-Ying
Mycoplasma pneumoniae (MP) is an important respiratory pathogen. Growth inhibition and regulation of inflammation in lung are key to the treatment of MP infections. Bortezomib, a proteinase inhibitor, was found to possess both functions in this study. Firstly, bortezomib showed dose-dependent bacteriostatic activity against MP in culture medium. Decreases in glucose catabolism (changes of pH) and colony-forming units (CFUs) were detected at 3 d post-incubation (bortezomib>10 nM). The MP cells incubated with bortezomib of 25 nM exhibited decreases in contents of protein and carbohydrate comparing to normal MP cells. When co-incubated with lung epithelial cells, reductions in MP CFUs and viability of lung epithelial cells were detected. Transcriptome analysis revealed that bortezomib (25 nM) influence the protein digestion and absorption pathways in A549 cells. Meanwhile, bortezomib up-regulated the PI3K-Akt and JAK-STAT pathways and down-regulated the MAPK pathway in MP-infected cells. Western-blot detection revealed that bortezomib reduce the increase in TLR4 triggered by MP, and reduce the level of IκBα. Meanwhile, higher level of extracellular IL-6 was detected in MP-infected cells post bortezomib treatment. In addition, the secretions of bortezomib-treated A549 cells showed promoting effects on M1-polarization of macrophages. In Balb/c mice, oral administration of bortezomib promoted the production of MP-specific antibodies and reduced pulmonary damage at 7th day post infection. In conclusion, bortezomib exerts a direct bacteriostatic effect on MP in vitro, it also plays roles in the regulation of inflammatory pathways during MP infection.
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Nature Communications
·
2026
·
IF 18.1
Peng Haibao,Zeng Youming,Huang Yang,Lin Chenyu,Lei Zeyu,Sun Peixin,Yang Jiahui,Sheng Shaoqi,Huang Yuxin,Li Xiaohui,Zhao Jiaxu,Zeng Rui,Li Cheng,Yang Wanqi,Di Xiangjie,He Sisi,Wang Yongsheng,Yang Hanting,Yang Wuli,Chi Yudan
The central nervous system is a critical reservoir for cancer metastasis, underscoring the urgent need for effective strategies for targeted drug delivery that minimize systemic side effects. Here, we present a zwitterionic polycarboxybetaine (PCB) designed to achieve selective accumulation within the tumor vasculature of brain metastases, thereby facilitating the rapid release of therapeutics without relying on external stimuli in preclinical models. PCB selectively targets the betaine-γ-aminobutyric acid transporter 1 (BGT1) at the blood-brain-tumor barrier (BBTB), enabling localized enrichment of nanoparticles within the tumor vasculature. The intrinsic mechanical flexibility of PCB activates the Piezo1 ion channel in endothelial cells, resulting in calcium ion influx and enhanced calpain activity, which together facilitate the degradation of VE-cadherin. The burst-release mechanism improves vascular permeability and compromises the integrity of the tumor vascular barrier, allowing for the swift release of encapsulated therapeutics and promoting extensive drug distribution within the tumor microenvironment. Notably, PCB encapsulating either osimertinib or cisplatin demonstrates therapeutic efficacy, intratumoral targeting, and favorable biological safety in disease models. These findings indicate that this zwitterion-functionalized platform effectively surmounts the challenges posed by the BBTB, supporting improved drug delivery and therapeutic efficacy in brain metastases.
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Nature Communications
·
2026
·Vol. 17
·期 1
·6517
·
IF 18.1
Wang Yinlong,Hou Qihang,Lv Xinying,Liu Jiongyan,Wang Huimei,Zhao Yan,Tong Haonan,Liu Yanli,Du Juan,Yang Xiaojun,Wu Shengru,He Shuixiang,Yang Xin
Although fecal microbiota transplantation (FMT) shows promise for ulcerative colitis (UC), its clinical success appears to be contingent upon the degree of donor microbiota engraftment. Using an LD50-based ecological model, our study reveals that inorganic nitrogen utilization capacity (IN-uc) critically determines gut microbial assembly in high oxidative stress environments, which significantly influences microbial engraftment outcomes. Building on this mechanistic insight, we engineer a probiotic-metabolite consortia designed to synergistically increase IN-uc in the gut ecosystem. We find that PM-mix 14 alleviates oxidative stress-mediated colonization barriers of donor microbiota by catalyzing the conversion of excess reactive nitrogen species through multi-step reactions, promotes L-glutamate biosynthesis and ATP production, thereby ensuring greater similarity in the structure and function of the recipient microbiota to those of the donor. In multiple male murine models of colitis, PM-mix 14 supplementation during FMT significantly improves microbial engraftment fidelity, which is correlated with increased anti-inflammatory responses and attenuated colonic pathology. Network meta-analysis of multiple clinical datasets further substantiates the prognostic value of donor gut microbial IN-uc in UC remission. Our findings establish the gut microbial IN-uc as an ecological driver of microbiota engraftment and present a rationally designed microbial therapy that optimizes FMT efficacy through targeted metabolic reprogramming.
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Nature Communications
·
2026
·
IF 18.1
Zhang Chunyu,Sun Haozhe,Liu Xiang,Kong Kejian,Zhou Tiancong,Wang Xi,Duan Haohong
Electrochemical C–S bond construction represents an attractive route to produce valuable organosulfur compounds, yet current approaches suffer from low reaction efficiency and rely on sulfites (SO 3 2− ) as the sulfur source. Here we report a paired electrolysis for hydroxymethanesulfonate synthesis from widespread industrial-waste sulfides (HS − ). Specifically, HS − is oxidized to SO 3 2− by in-situ generated H 2 O 2 at cathode, and methanol is oxidized to formaldehyde at anode, with following C–S coupling to form hydroxymethanesulfonate. By matching HS − concentration with current density and strengthening convective mass transfer between intermediates, we achieve efficient hydroxymethanesulfonate production with Faradaic efficiency of 102.8% and productivity of 282 μmol h −1 in a membrane-free H-cell under optimized conditions (50 mA cm −2 , 0.05 M HS − , stirring in anodic chamber). By constructing a flow reactor, this paired electrolysis enables conversion of HS − -contaminated wastewater (from <10 ppm to 3000 ppm) with Faradaic efficiencies exceeding 100%, while tolerating coexisting anions and heavy metals in real effluents. It also converts waste H 2 S gas with >87% conversion and >74% hydroxymethanesulfonate selectivity over 102 hours of stable operation, demonstrating more cost-effective economics to both industrial and previous electrochemical methods.
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