INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Kaipei Luo,Shaoping Yin,Ruixia Zhang,Hua Yu,Guangji Wang,Juan Li
The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver. In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer. mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase . mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro . More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo , with a TIR of 75.9%. The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
·
分子靶向治疗
·
药物递送系统
·
转化医学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Xi-Ming Song,Xin Zhou,Chunxue Yuan,Yu Zhang,Qiang Tong,Ying Li,Luxia Cui,Daliang Liu,Wei Zhang
We reported a novel Fe 2 O 3 /rutile TiO 2 nanorod (NR) arrays with the heterogeneous structure for photoelectrochemical (PEC) cells, which were fabricated on fluorine-doped tin oxide glass (FTO) substrates that serve as model architecture via a hydrothermal method. Fe 2 O 3 was revealed as an inexpensive and eco-friendly semiconductor sensitizer to make TiO 2 respond to visible light . By using this photoanode, the photoelectric conversion and water splitting properties of PEC cells based on the one-dimensional (1D) Fe 2 O 3 /TiO 2 heterostructures were investigated in detail under simulated sunlight. Meanwhile, the optimization of photovoltaic performance was also achieved by regulating the amount of Fe 2 O 3 . The open circuit voltage and short circuit current of the Fe 2 O 3 /TiO 2 solar cell can reach 0.435 V and 1.840 mA/cm 2 , respectively. In addition, theoretical analysis of the photoelectric effect is preliminarily explored on the basis of the flat band potential results.
研究领域:
材料科学
·
物理化学
·
能源科学
·
纳米科技
·
光催化
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Fangyuan Zhang,Mei Hong,Jing Bai,Zhi Liu,Aiyuan Jia,Zhisheng Liu,Can Shi,Yangxue Li
Levofloxacin (LEV) infiltrated in groundwater has threatened the safety of drinking water . For in-situ remediation of LEV-contaminated groundwater, there exists a main challenge of exploiting proper high efficient backfill medium in utilizing charming permeable reactive barriers (PRBs). Herein, three porous shapeable three-component hydrogen-bonded covalent organic aerogels (H C OA-1, H C OA-2 and H C OA-3) were fabricated based on a multiple-linking-site strategy to evaluate for adsorptive removal of LEV. The three H C OAs exhibited satisfactory performance in LEV adsorption that could integrate high adsorption capacity, good antiion interference, excellent recyclability and wide pH tolerance. The different regularity of kinetics and isotherms of three H C OAs signified that electrostatic effect, pore preservation, hydrogen bonding probably govern the adsorption process in combination, coupling with π-π electron-donor-acceptor (EDA), dipole-dipole and hydrophobic-hydrophobic interaction besides. In addition, the response surface methodology (RSM) was employed for studying the single and synergetic effects of selected variables and optimizing operation conditions. Furthermore, a laboratory PRB column packed with processable H C OA-2 was set up to investigate the LEV removal, and the breakthrough data was explained by Adams-Bohart, Thomas, BDST and Yoon-Nelson models. We believe could hopefully bring H C OAs into the real in-situ remediation of such challenging and persistent LEV-polluted groundwater with further massive-scale efficiently.
研究领域:
环境科学
·
材料科学
·
水污染控制
·
环境功能材料
·
污染物吸附
·
可持续修复技术
✓ 已验证
DOI
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Zhi Yang,Shufang Ma,Yu Shi,Xiaodong Hao,Lin Shang,Bin Han,Bocang Qiu,Bingshe Xu
Nanowires (NWs)-based heterojunction photodetectors (PDs) have been widely applied in the fields of remote sensing, night vision, environmental monitoring, and optical communications with high light absorption coefficient and photoelectric conversion efficiency. Here, S-GaAs NWs/Si heterojunction was developed to form a broadband self-powered PDs by growing GaAs NWs on Si substrate through the sulfur-catalyzed assisted chemical vapor deposition (CVD) technology. Compared with the pure GaAs NWs, the sulfur-assisted catalysts could not only inhibit Ostwald ripening of Au seeds to improve the crystalline quality of NWs but also form a thin Ga–S bond passivation layer to reduce surface defects and enhance the optoelectronic performance of the PDs. The fabricated GaAs NWs/Si heterojunction PDs exhibit excellent performances with the large responsivity of 10.3 mA W −1 and high detectivity of 9.59 × 10 12 cm Hz 1/2 W −1 . Additionally, the designed PDs have the broadband wavelength photoresponse from visible to near infrared and fast response speed (rise/fall time of 3.8/21.8 ms). Importantly, the develop strategy of hybrid heterojunction PDs can be extended to other semiconductor materials for facilitating the practical application of high-performance optoelectronic devices .
研究领域:
半导体材料
·
纳米电子学
·
光电子学
·
凝聚态物理
·
功能材料
·
器件物理
✓ 已验证
DOI
高影响因子
Nanoscale
·
2015
·Vol. 8
·期 5
·2811-2818
·
IF 7.394
Jia-Mei Yang,Feng-Xia Wang,Ge-Bo Pan
Blend films with long nanowires of zinc octaethylporphyrin (ZnOEP) embedded in an insulating polymer of poly(methyl methacrylate) (PMMA) have been successfully fabricated by a one-step spin-coating process. Concerning photoactive blends based on small-molecule semiconductors, this is quite a novel strategy and allows us to greatly reduce the issues related to low device performance, such as phase-separation, poor connectivity of the semiconducting layer, and higher densities of interfacial defects. Intensive studies on the correlation between the film morphology and device performance have revealed that excellent photodetector performance is derived from efficient charge transport and good connectivity observed in highly crystalline, interconnected ZnOEP nanowires embedded in an insulating PMMA matrix. To the best of our knowledge, this is the first demonstration of a blend-film-based organic photodetector, which exhibits high sensitivity, high stability, high Ion/Ioff ratio, excellent mechanical flexibility, and a broadband responsivity region extending up to 1050 nm. The unique characteristics of facile fabrication, high sensitivity, excellent mechanical stability, and broadband responsivity can make the blend film of ZnOEP and PMMA promising in large-area flexible photodetectors.
研究领域:
材料科学
·
纳米科技
·
有机电子学
·
光电子学
·
柔性电子器件
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 112
·111217-111225
·
IF 3.289
Sijie Zhao,Huiru Yang,Cai Zuo,Lu Sun,Liwei Ma,Hua Wei
Star-shaped polymers are attractive as drug carriers due to the integration of relatively easy synthesis compared to the preparation of hyper-branched dendrimers and their potential ability to form unimolecular nanoparticles with enhanced stability to survive the high dilution-associated deformation and subsequently premature drug release in the body fluids and blood during circulation. Clearly, the star structure exerts a significant effect on their bioproperties and potential applications. In this study, three star-shaped amphiphilic copolymers with the same polymer compositions but different star structures were synthesized to investigate the effect of star architecture on their properties as well as potential applications as drug carriers. Three different branched alcohols, 2-(hydroxymethyl) propane-1,3-diol, pentaerythritol and dipentaerythritol with 3, 4, and 6 respective hydroxyl groups were chosen as the starting core to generate the target star-shaped amphiphilic block copolymers composed of hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(oligoethyleneglycol methacrylate) (POEGMA) with 3, 4, and 6 corresponding star arms by a combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Dynamic light scattering (DLS) measurements and pyrene fluorescence probe technique confirmed the capability of the resultant star-shaped amphiphilic copolymers to form unimolecular micelles with average diameters smaller than 50 nm in an aqueous phase. A comparison of the drug loading capacity revealed that the micelles of 4-star-PCL–POEGMA (4s-PCL–POEGMA) exhibited the highest drug loading content (DLC) of all the three formulations. More importantly, in vitro doxorubicin (DOX) release study showed unique pH-mediated drug release behaviors, i.e., dramatically accelerated release at pH 6.0 but a much slower profile at pH 7.4, from these generally recognized “pH-insensitive” 4-arm star-shaped micelles. An acid-triggered degradation and an acid–base titration were performed to further reveal that such interesting pH-responsive drug release behaviors were attributed primarily to the hydrophilic corona of OEG brushes. This study is believed to provide a new insight into the structure–bioproperties relationship of star-shaped polymers, thus should be useful for the future design and development of novel star-shaped polymers for controlled drug delivery.
研究领域:
高分子药剂学
·
纳米医学
·
药物控释
·
生物材料
·
药剂学
·
肿瘤治疗
·
纳米载体
✓ 已验证
DOI
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2020
·
IF 6.984
Shusheng Pan,Ziyue Rao,Yujie Wu,Zhiyu Liu,Jun Ge,Shan Zhang
In this study, a temperature self-regulating solar reactor based on VO 2 thermochromic coating is demonstrated. The temperature of solar reactor can be stabilized at 68.8 °C, which is corresponded to the critical point of metal-to-insulator transition of VO 2 . By employing the solar reactor, the orthorhombic phase CsPbI 3 microwires have been synthesized through solution phase reaction route. Strong emission peaks at 490 nm and 470 nm have been observed in CsPbI 3 microwires under ultraviolet and soft X-ray excitation, respectively. The high performance photodetector based on CsPbI 3 microwire show a detectivity of 1.09 × 10 14 Jones, responsivity of 4.72 A/W, rapid rise and decay time of 0.96 and 0.93 s at 325 nm. Our results demonstrate that the temperature self-regulating solar reactor can be applied for energy-saving solution phase reactor for synthesizing high quality inorganic materials.
研究领域:
材料科学
·
纳米光电子学
·
无机功能材料
·
能源材料
·
半导体器件
✓ 已验证
DOI
高影响因子
Small
·
2017
·Vol. 13
·期 25
·1700364
·
IF 8.643
Xuhai Liu,Dejian Yu,Fei Cao,Xiaoming Li,Jianping Ji,Jun Chen,Xiufeng Song,Haibo Zeng
All-inorganic photodetectors based on scattered CsPbBr 3 nanoplatelets with lateral dimension as large as 10 µm are fabricated, and the CsPbBr 3 nanoplatelets are solution processed governed by a newly developed ion-exchange soldering mechanism. Under illumination of a 442 nm laser, the photoresponsivity of photodetectors based on these scattered CsPbBr 3 nanoplatelets is as high as 34 A W −1 , which is the largest value reported from all-inorganic perovskite photodetectors with an external driven voltage as small as 1.5 V. Moreover, the rise and fall times are 0.6 and 0.9 ms, respectively, which are comparable to most of the state-of-the-art all-inorganic perovskite-based photodetectors. All the material synthesis and device characterization are conducted at room temperature in ambient air. This work demonstrates that the solution-processed large CsPbBr 3 nanoplatelets are attractive candidates to be applied in low-voltage, low-cost, ultra highly integrated optoelectronic devices.
研究领域:
材料科学
·
光电子学
·
纳米科技
·
半导体器件
·
凝聚态物理
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2016
·Vol. 23
·期 4
·2539-2548
·
IF 3.195
He Hui,Hou Xunan,Ma Beibei,Zhuang Linzhou,Li Chuanfa,He Shihong,Chen Shuixia
Viscose fiber was oxidized with sodium periodate to prepare a reactive dialdehyde viscose fiber (DAVF) containing abundant aldehyde groups. A solid amine adsorbent (DAVF-PEI) with high amino density for CO 2 capture was then prepared by modifying DAVF with polyethylenimine (PEI). Response surface methodology (RSM) based on a three-level, three-factorial design was used to optimize the synthesis conditions of DAVF, in which multiple linear regression equations of aldehyde content and fiber mass loss degree were constructed. The well-designed DAVF was then employed as a support to graft with PEI via Schiff base reaction to prepare a solid amine fiber (DAVF-PEI) for CO 2 adsorption. The experimental results verified that DAVF-PEI possessed good thermo-stability and high CO 2 adsorption capacity (4.11 mmol/g). DAVF-PEI also showed promising regeneration performance, which could maintain almost the same adsorption capacity for CO 2 after ten adsorption and desorption recycles.
研究领域:
材料化学
·
环境科学
·
高分子科学
·
化学工程
·
吸附分离
·
碳捕集技术
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2019
·Vol. 30
·期 11
·2781-2789
·
IF 2.162
Tingjun Zhong,Richard J. Mandle,John W. Goodby,Lanying Zhang,Cuihong Zhang
In this work, the thiol-ene click reaction is employed to fabricate polymer-dispersed liquid crystal (PDLC) films by photoinitiated polymerization. The PDLC films are prepared by systematic variation of key conditions: variety and content of -ene monomer, liquid crystal (LC) content, curing time, and curing light intensity. We find that both the morphologies and electro-optic properties of these films are adjustable. When increasing the length of alkyl main chain of -ene monomers, the driving voltages reduce, but in turn, the contrast ratio decreases. Increasing -ene monomer content raises the driving voltages as well as the response time, and the increase of LC content lowers the driving voltages but has a negative effect on the contrast ratio. The changes to the curing conditions (both curing time and UV light intensity) can be used to modify the driving voltages, response time, and contrast ratios of PDLC films. These comparative studies will elucidate new insights in commercial applications of intelligent PDLC films.
研究领域:
材料科学
·
高分子化学
·
软物质物理
·
光电功能材料
·
智能材料
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Yuanfeng Pan,Jingchun Wang,Pingxiong Cai,Huining Xiao
In this work, the stepwise synthesis of interpenetrating polymer network (IPN) strategy was developed in an attempt to fabricate novel hydrogels consisting of sugarcane bagasse cellulose (SBC), carboxymethylcellulose (CMC) and poly (N-isopropylacrylamide) (PNIPAm) as a dual-responsive drug carrier. The pretreated and dissolved SBC was pre-crosslinked using epichlorohydrin in the presence of CMC, followed by in-situ free-radical polymerization of NIPAm in the presence of N,N′-Methylene-bis(acrylamide) as a crosslinking agent. The carboxyl groups in CMC and PNIPAm chains rendered the resulting hydrogel pH and thermal responsive. The results from scanning electron microscopy, infrared spectroscopy , thermogravimetric analysis and mechanical property testing demonstrated the successful formation of the IPN with proper structure and mechanical strength . The swelling experiments at different temperatures and pH showed the dual–sensibility of the hydrogels. Moreover, bovine serum albumin (BSA) was used as a model drug and loaded in the hydrogel; and the drug release behavior was revealed in phosphate buffer solution (PBS) and simulated gastric fluid (SGF). The results indicated that the dual-responsive IPN hydrogel is of great potential for the controlled release of drug.
研究领域:
高分子材料
·
药物递送
·
生物医学工程
·
智能响应材料
·
药剂学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
·
2018
·Vol. 56
·期 19
·1281-1286
·
IF 2.499
Yan Jie Wang,Chen Yu Li,Zhi Jian Wang,Yiping Zhao,Li Chen,Zi Liang Wu,Qiang Zheng
Development of tough hydrogels has greatly expanded their applications as load-bearing materials. However, the elastic modulus of tough hydrogels is usually lower than 1 MPa. It remains a challenge to design tough hydrogels with high modulus. We report here a series of tough double-network (DN) hydrogels with ultrahigh elastic modulus (up to 200 MPa) by forming robust hydrogen bonds between the first poly(acrylic acid) network and the second poly( N -isopropyl acrylamide) network. The dense cooperative hydrogen bonds greatly reduce the segmental mobility and thus improve the rigidity of gel matrix. Owing to the dynamic nature of hydrogen bonds, the modulus of hydrogels is strongly influenced by temperature and pH, affording the gels shape memory property. The strategy by forming robust noncovalent bonds between interpenetrating networks should be applicable to other systems for designing tough and versatile hydrogels with diverse promising applications. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018 , 56 , 1281–1286
研究领域:
高分子物理
·
生物材料
·
软物质科学
·
智能响应材料
·
组织工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）