CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Huihui Shi,Jiaxin Shen,Lin Zhu,Mingrui Zhou,Binghui Li,Zijian Gao,Yunhong Liu,Zhen Li,Ji Zhou,Kuibo Yin,Meng Nie
Constructing advanced fluorescent anti-counterfeiting hydrogels is crucial for highly secure and powerful information encryption. However, lipophilic fluorescent molecules and accessible decryption condition make it challenging in fluorescent hydrogel fabrication and information validity. Herein, we draw an inspiration from the cellular mechanical response regulation to develop a universal swelling-deswelling strategy that embeds lipophilic fluorescent molecules into hydrophilic core–shell poly (stryrene-block-1-vinylpyrrolidone) (SP) and blocks most exogenous stimuli. Benefiting from reversible swelling behavior and rich hydrogen bond binding sites of SP, the proposed strategy could be expanded to multiple lipophilic dyes and prepared dyed SP is suitable for almost all hydrogels. Using lanthanide dyed SP as fluorescent units and dual network hydrogel as matrix, multiple anti-counterfeiting functions including nonvolatile, rewritable, and dual information storage and encryption, are realized by designing hydrogel architectures and regulating photo-responsive behaviors. It is believed that such research would inspire further studies on multifunctional hydrogel development for multi-level anti-counterfeiting and intelligent information encryption.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 219
·期 23
·1800329
·
IF 2.492
Haihuan Wang,Jianghao Zhan,Kechen Xiao,Feng Luo,Jiehua Li,Hong Tan
A self-healing composite hydrogel with thermoresponsive three-stage optical adjustment (opaque-transparent-translucent) is achieved by combining polyampholyte hydrogel (PAH) with a small amount of poly( N -isopropylacrylamide) (PNIPAM) nanogels. The PAH has an upper critical solution temperature to dominate the initial optical stage of reversible opaque-transparent transition and also offers its self-healing properties via reversible ionic bonds. Meanwhile, the PNIPAM shows a lower critical solution temperature by hydrophilic-hydrophobic phase transition and synergistic clustering of PAH, which controls the subsequent optical stage of reversible transparent-translucent transition. Therefore, the PAH/PNIPAM composite hydrogel shows a reversible three-stage optical modulation by controlling temperature from low (<15 °C) to medium (15–30 °C) to high (>30 °C) via double phase transition behavior of PAH/PNIPAM. Through different analytical methods, the synergistic thermoreposensive effects of PNIPAM nanogels and the bulk PAH are demonstrated. Finally, a prototype of a smart window is designed to demonstrate one of its potential applications.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xiaojin Zhang,Yuchen Zhang,Wanglong Zhang,Yu Dai,Fan Xia
Adhesive, tough, and conductive hydrogels have broad application prospects in wearable and flexible sensors. The construction of adhesive-tough hydrogels still remains a challenge. Here, for the first time, we develop Janus adhesive-tough hydrogel by a medium-guided (filter paper absorbing HAuCl 4 ) diffusion method, followed in-situ generation of gold nanoparticles (AuNPs) in gelatin-polyacrylamide (GA) double network hydrogel. The as-generated AuNPs in the adhesive surface restrict the formation of triple helixes of gelatin, thus enhancing the adhesion to various materials such as steel, polytetrafluoroethylene (PTFE), ceramic, wood, stone, rubber, copper, glass, and skin. The tough side maintains double network structure, resulting in high toughness with good recovery ability. The thickness of the adhesive surface can be regulated by adjusting the diffusion time and the concentration of HAuCl 4 . By adding lithium chloride (LiCl), the hydrogel can be applied as strain sensor to monitor human motion such as finger, cervical vertebrae, wrist, and elbow. These findings may contribute to the design of Janus adhesive-tough hydrogels and provide a model for strain sensors.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 6
·期 2
·257-264
·
IF 4.543
Jinhui Li,Zuxiang Xu,Ying Xiao,Guorong Gao,Jing Chen,Jingbo Yin,Jun Fu
Stimulus-responsive hydrogels are assembled into soft devices that transform their shape upon external stimuli. It is very important to understand the macroscopic assembly mechanisms and to modulate the interface stability of assemblies. In this study, polyelectrolyte hydrogels with outstanding mechanical performances and opposite charges were assembled into soft devices via electrostatic association. The interface strength could be tuned by varying the net charge density, which depends on the concentration of charged/chargeable monomers, the pH of the buffer solution, and the ionic strength of the solution. We propose that charge screening at the interface by free counterions causes a reduction of interface strength, whereas charge redistribution is helpful to strengthen the interface of the assemblies. The understanding of macroscopic assembly mechanisms provides significant guidelines for designing novel soft transducers and drivers and engineering their interface strength.
研究领域:
生物材料学
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软物质物理
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高分子化学
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仿生工程
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生物医学工程
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Shuo Xu,Shaorong Yan,Jun You,Xiaochen Wu
Antibacterial hydrogels have emerged as a promising approach for effective wound treatment. However, despite extensive research on the fabrication of antibacterial hydrogels, it remains challenging to develop injectable, biocompatible, transparent, and mass-producible hydrogels with antibacterial properties. In this study, we successfully fabricated an antibacterial drug-loaded composite hydrogel, named CC45/OKG40/HS, through a Schiff base reaction between carboxymethyl chitosan (CC) and oxidized konjac glucomannan (OKG), followed by the encapsulation of stevioside-stabilized honokiol (HS) micelles. The CC45/OKG40/HS hydrogel exhibited several favorable properties, including a short gel time (<10 min), high water content (>92%), injectability, good adhesiveness, self-healing ability, and high transparency. In vitro experiments confirmed its excellent antibacterial properties, antioxidant activities, and high biocompatibility (no cytotoxicity, hemolysis ratio <5%). Furthermore, in vivo evaluation demonstrated that the CC45/OKG40/HS0.5 hydrogel accelerated wound healing by relieving inflammatory responses and enhancing re-epithelization. Given its feasibility for mass production, the findings showed that the CC45/OKG40/HS hydrogel has the potential as an advanced antibacterial wound dressing for commercial use.
研究领域:
生物材料学
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药剂学
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医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2015
·Vol. 22
·期 9
·1-8
·
IF 1.92
Zhou Mi,Ye Xiaofeng,Liu Kaiyue,Hu Jingying,Qian Xin
During the past decade, a series of thermo-responsive hydrogels based on poly( N -isopropylacrylamide) (PNIPAM) were prepared for drug delivery. However, the release performance of those hydrogels was limited because the LCST (lower critical solution temperature) of PNIPAM (about 32 °C) is slightly lower than human body temperature, and the drug loading is complicated. To develop a new drug delivery matrix with the suitable responsive interval, a novel, temperature-sensitive copolymer with two monomers, N -isopropylacrylamide and methylacrylic polyethylene glycol monomethyl ether ester (MPEGMA) [poly(NIPAM- co -MPEGMA)], was synthesized by free radical polymerization. Then, the supramolecular hydrogels with tunable response temperature, whose structures were confirmed by X-ray diffraction (XRD), were fabricated via inclusion complexation with α-cyclodextrin (α-CD) and the copolymers in aqueous solution. The rheology results indicated that response interval could be modulated by controlling the contents of PNIPAM in the copolymers. Compared to the normal PNIPAM ge1, the succinct method of gel preparation streamlined the process of loading and made the drug loading capacity controllable. The release time was proved to be prolonged by the release kinetics of 5-fluoroucrail (5-Fu), which showed feasibility as a drug delivery.
研究领域:
材料科学
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药学
✓ 已验证
产品关联
DOI
高影响因子
Regenerative Engineering and Translational Medicine
·
2025
·
IF 1.9
Pradana F. Josse Pasca,Handayani Salsabila Dwi,Phalosa Ghani,Salsabila Mirza,Wicaksono Ikhsan Adil,Al-Ghifary M. Raafi,Putri Dita Sheilla,Arsyadi,Tuba Syahrul
Background Uncontrolled hemorrhage is a leading cause of preventable mortality in trauma cases, necessitating rapid and effective hemostatic interventions. Conventional methods such as gauze dressings and tourniquets have limitations, including delayed clot formation, bacterial contamination, and potential tissue damage. Recent advancements in biomaterials have highlighted chitosan/β-glycerophosphate (CS/β-GP) hydrogels as promising thermosensitive agents for emergency hemostasis. Objective This literature review explores the potential of chitosan/β-glycerophosphate (CS/β-GP) thermosensitive aerosol hydrogel as a novel hemostatic agent, emphasizing its physicochemical properties, gelation mechanisms, delivery innovations, and strategies to enhance its mechanical strength. Methods Relevant scientific literature was collected from Scopus, PubMed, CrossRef, and Semantic Scholar databases using targeted
研究领域:
生物材料
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生物医学工程
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急诊医学
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高分子科学
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药剂技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2020
·Vol. 36
·期 5
·962-969
·
IF 1.063
Yu Wenting,Xue Bin,Zhu Zhenshu,Shen Ziqin,Qin Meng,Wang Wei,Cao Yi
Injectable hydrogels are ideal biomaterials for delivering cells, growth factors and drugs specifically to localized lesions and subsequent controlled release. Many factors can affect the efficacy of injectable hydrogels. To avoid potential damage to encapsulated cells or drugs, injectable hydrogels should be highly dynamic so that they can undergo shear-thinning at low strain rates and rapidly reform after injection. However, dynamic hydrogels are often mechanically weak, leading to the leakage of encapsulated cells or drugs. Here we demonstrated a convenient method to improve the mechanical strength without jeopardizing the dynamic properties of hydrogels by using metal ion-peptide crosslinkers containing multiple metal ion-ligand bonds. We showed that the dynamic properties of the hydrogels correlated with the intrinsic dynamics of the metal-ligand bonds and were not affected by the formation of multivalent binding. Yet, the mechanical stability of the hydrogels was significantly improved due to the increased thermodynamic stability of the crosslinkers. We further showed that the drug release rates were slowed down by the formation of multivalent crosslinkers. Our results highlight the importance of ligand valency to the mechanical response of hydrogels and provide a universal route to rationally tune the dynamic and mechanical properties of injectable hydrogels.
研究领域:
生物材料学
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化学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Hengye Shi,Yibo Sun,Yiyan Gao,Fei Jia,Guanghui Gao
As a new flexible electronic device, hydrogel sensors express unique value in biomedical, wearable, and smart medical fields. However, hydrogel sensors achieve high sensitivity while supporting bacterial growth, increasing the risk of human infection and shortening the service life of hydrogel sensors. Thus, a conductive antibacterial hydrogel sensor based on polyvinyl alcohol-sodium alginate dual network structure was designed and prepared by freeze–thaw method. The polyhexamethylene-biguanide was introduced into hydrogel with excellent antibacterial effect and antibacterial stability of 7 days for Gram-positive and Gram-negative bacteria. Meanwhile, the remarkable fracture strain (325%) and stress (226 kPa) of hydrogels can create complex three-dimensional structures as well as achieve 3D print effects. Moreover, the hydrogel can not only monitor human movement in real time (such as finger bending, vocalization, etc.), but also detect weak electromyographic signal. Therefore, the antibacterial property, fatigue resistance, and fast response of hydrogel sensor provide a theoretical basis for human health monitoring and the development of the next generation of intelligent medical devices. Graphical Application diagram of PPLS hydrogel.
研究领域:
生物医学工程
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柔性电子器件
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智能医疗设备
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材料科学
·
可穿戴传感器
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Yixiong Duan,Yuchuan Jin,Yiyang Jia,Mingyue Zhao,Lang Bai,Shoujun Zhu,Zhentong Wei,Songling Zhang,Bai Yang,Yunfeng Li
Patient-derived tumor organoids (PTOs) closely recapitulate the histopathology, gene expression, and drug response of patient tumor tissues, thereby making them highly reliable in vitro models in preclinical cancer research. Currently, basement membrane extracts (BME or Matrigel) dominate the in vitro culture of PTO models, although BME hydrogels suffer from batch-to-batch variability, possible contamination of murine host cells, and non-tunable mechanical properties. Here, we design and prepare fully synthetic thermoreversible nanofibrillar hydrogels (TNHs) for the growth and enzyme-free release of ovarian PTOs. PTOs cultured in TNHs exhibit morphological, histological, and gene expression similarities to organoids grown in Matrigel and their corresponding tumor tissues. In addition, the on-demand release of PTOs without loss of cell viability and organoid integrity is achieved upon cooling. The released PTOs show a strong tumorigenic ability by xenografts of PTOs in mice. The results show that the fully synthetic TNHs is a highly promising alternative to BME for the establishment of ovarian PTOs in vitro.
研究领域:
癌症研究
·
组织工程
·
生物材料
·
再生医学
·
类器官技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 37
·12895-12903
·
IF 7.393
Hang Zhou,Li Zheng,Qingyu Meng,Ruixin Tang,Zhaosong Wang,Baokang Dang,Xiaoping Shen,Qingfeng Sun
Elastic polyion hydrogels (EPIHs) as pressure sensors require to be microstructurally modified or micropatterned to improve the sensitivity of the parallel-plate sensing configurations. In this work, we designed a novel lignocellulose/EPIH composite microstructure that featured three unique characteristics including the loosening of the polyion chains, the introduction of complex porous channels and the reduction of the compressive modulus of the system for the purpose of piezoresistive sensitivity improvement. This lignocellulose/EPIH displayed hierarchical porous networks involving huger stiffer pores in lignocellulose (hindering the excessive intertwining of polyanion chains) and resultant smaller softer pores in polyanions, leading to high compressibility (80% strain), a high energy dissipation ratio (65%), and low Young's modulus (104 KPa) below 40% strain. Ultimately, the hybrid hydrogel possessed an increased conductivity change rate when compressing at low pressures (C20/C0 = 1.24) because of the soft, porous structure and the introduction of rGO nanosheets as ion repositories. Using this material, a soft tactile sensor with high sensitivity (9.71 MPa−1 within 22 KPa) was demonstrated to reconstruct and simulate the waves of a series of force signals, showing promising applications in the fields of recreation and sports for human–machine interfaces with relatively broad force ranges.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 133
·期 15
·
IF 1.768
Mi Zhou,Kaiyue Liu,Xin Qian
A series of pH-temperature dual stimuli-responsive random copolymers poly[ N,N -dimethylaminoethyl methacrylate- co -poly(poly(ethylene glycol) methyl ether methacrylate][poly(DMAEMA- co -MPEGMA)] were synthesized by free radical polymerization. The supramolecular hydrogel was formed by pseudopolyrotaxane, which was prepared with the host-guest interactions between α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG) side chains. Fourier transform infrared (FT-IR), nuclear magnetic resonance ( 1 H NMR), and X-ray diffraction (XRD) confirmed the structures of the hydrogels. The pH-temperature dual stimuli responsive properties of the hydrogels were characterized by rheometer. Finally, the controllable drug release behavior of the hydrogel, which was used 5-fluorouracil (5-Fu) as the model drug, was investigated at different temperatures and different pH values. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43279.
研究领域:
高分子材料科学
·
药物递送系统
·
生物医学工程
·
智能响应材料
·
药剂学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）