JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Huijiao Fu,Xiaoqiao Guo,Feng Fang,Cao Zhou,Yuanyuan Chen,Xuanbo Zhang,Bingchen Zhang,Xinran Li,Qiwen Liu,Jie Liu,Wei Chen,Ling Yu,Zhiqiang Yu,Xuefeng Wang
Cisplatin serves as the cornerstone medication in ovarian cancer (OC) chemotherapy; however, numerous resistance factors exist, resulting in unsatisfactory clinical treatment outcomes. Concurrently, OC frequently establishes an immunosuppressive microenvironment, which further exacerbates the challenges of cisplatin chemotherapy. Hence, it is particularly significant to explore a therapeutic approach capable of overcoming cisplatin resistance while reversing the immunosuppressive microenvironment of OC. Here, we synthesized a novel cisplatin polyprodrug (PTP) containing thioketal units, which self-assembled with a stimulator of interferon genes (STING) small-molecule agonist (SR-717) to form redox-smart-responsive PTP@SR-717 nanoparticles (NPs), enabling synergistic chemo-immunotherapy. Specifically, PTP@SR-717 NPs enhanced the anti-tumor effect of cisplatin through three key mechanisms: (i) Pre-target factors: Enhancing intracellular cisplatin uptake and reducing GSH-mediated detoxification to promote platinum accumulation. (ii) On-target factors: Utilizing molecular damage-associated molecular patterns (DAMPs) triggered by cisplatin to activate the STING pathway, thereby synergistically amplifying the STING-TBK1-IRF3 signaling and efficiently triggering an immune response. (iii) Post-target factors: Combining chemotherapy and immunotherapy to harness the immune system for tumor eradication. In conclusion, this study presents an effective approach to addressing the challenges associated with cisplatin in the clinical treatment of OC.
研究领域:
肿瘤学
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药理学
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Fan Yongbo,Qu Wanbo,Qiu Haifa,Gao Shuaibing,Li Lu,Lin Zezhou,Yang Yuxuan,Yu Junyi,Wang Lin,Luan Saiwei,Li Hao,Lei Lin,Zhang Yang,Fan Huiqing,Wu Haijun,Yu Shuhui,Huang Haitao
Electrostatic capacitors are critical components in the power system of electric vehicles (EVs). The current commercially available solutions are largely based on ferroelectric oxides of which the permittivity decrease with increasing electric field. Here, we propose a high entropy modulation design in a quantum paraelectric-ferroelectric/antiferroelectric matrix, which enables a stable and field-independent energy charge/discharge response across a wide voltage range. By effectively synergizing the high efficiency (η) of quantum paraelectrics and the high polarization of the ferroelectric/anti-ferroelectric matrix with the entropy regulator, a high recoverable energy density (W rec ) of 13.3 J cm − 3 with an η of 92.4% is achieved in the bulk state of the perovskite material, promising for device scale-up. Versatile polar regions as well as a defect-less microstructure is achieved by the optimized compositional design and material processing. On a mesoscopic level, the electrical microstructure of the material is engineered to provide a large breakdown strength ( E b ) of 750 kV/cm, which is confirmed by the resolved electrochemical information and finite-element simulation. The proposed strategy provides a new path for designing high performance next generation energy storage/power converting dielectrics. This demonstration of quantum paraelectrics for energy storage application is expected to stimulate extensive efforts in the area.
研究领域:
材料科学
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能源技术
·
物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
·
IF 4.7
Wei Zhu,Sai Zhu,Shan Jiang,Jiuyu Yin,Yonggui Wu,Xiaomei Luo
Background Cisplatin (CIS), a widely administered chemotherapeutic agent, is associated with acute kidney injury (AKI). Lansoprazole (LPZ), commonly prescribed to mitigate chemotherapy-induced gastrointestinal complications, may further elevate AKI risk. Paeoniflorin (Pae), a bioactive compound derived from traditional Chinese medicine, demonstrates renal protective properties in AKI, yet its mechanism against CIS and LPZ induced AKI remains undefined. Methods A composite AKI model was established in vivo and in vitro using CIS and LPZ. The protective effect of Pae on the injury of renal tissue or renal tubular cells in mice was observed, followed by Pae pretreatment. The target of Pae was found through network pharmacology, and the binding ability of the target was verified by CETSA experiment and molecular docking. Finally, the target gene was knocked out or over expressed to verified whether Pae regulates necroptosis through this target. Results It was found that renal injury could be exacerbated by LPZ in the CIS induced AKI. Pae could alleviate CIS and LPZ induced AKI. The target gene of Pae was TNFAIP3, which played an important role in necroptosis. The TNFAIP3 could bind well to Pae in molecular docking and CETSA experiment. The necroptosis and inflammatory responses in AKI induced by CIS and LPZ could be also inhibited by Pae in vivo and in vitro. Overexpression of TNFAIP3 played the same cellular protective role as Pae preconditioning. In contrast, Pae could not continue to play a protective role after TNFAIP3 was knocked down. Conclusion The traditional Chinese medicine Pae holds promise as a potential therapeutic agent for AKI, with TNFAIP3 representing an effective therapeutic target in this pathology.
研究领域:
药理学
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分子生物学
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肾脏病学
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转化医学
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肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Bin Wang,Yazhen Yao,Wanli Wang,Yujie Xu,Yi Sun,Qiang Li,Han Hu,Mingbo Wu
Hard carbon has emerged as a promising anode material for rechargeable sodium-ion batteries, owing to its abundant precursor sources and remarkable reversible charge storage capacity. The key to achieving an extended sodium storage capacity lies in the plateau capacity largely associated with the closed-pore structure, yet a comprehensive understanding in this area remains incomplete. In our study, we utilized electron paramagnetic resonance (EPR) spectra to discern the spin state of unpaired electrons within hard carbon materials, enabling the identification of sodium storage plateau regions. Hard carbon anodes with plateau capacity predominantly exhibit delocalized spins, evident in the EPR spectrum by limited spin density and a linewidth exceeding 100 G. These spins originate from the extended aromatic structure within small-sized but curved nano-graphite and the closed-pore walls, which are crucial for plateau capacity. Conversely, hard carbon anodes exclusively possessing slope capacity are characterized by localized spins, presenting a typical narrow and intense Lorentzian EPR signal. These localized spins arise from the edge defects of the nano-graphite structure, serving as favourable sites for sodium adsorption. Our development of a methodology to discern hard carbon plateau capacity behavior based on EPR spectra presents a facile and rapid approach for advancing high-performance hard carbon materials.
研究领域:
材料科学
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电化学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2019
·Vol. 26
·期 23
·23981-23993
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IF 2.914
Li Lincheng,Zhong Dengjie,Xu Yunlan,Zhong Nianbing
In order to improve the adsorption efficiency of the adsorbent and solve the problem of separation difficulty, a novel superparamagnetic micro-nano-bio-adsorbent (PDA/Fe 3 O 4 /BC) was prepared by in situ self-assembly of polydopamine (PDA). The results of scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectrometer (FT-IR), X-ray photoelectron spectrometer (XPS), and vibrating sample magnetometer (VSM) characterization showed that the size of bio-adsorbent was about 200 nm. PDA and Fe 3 O 4 modifications increased the specific surface area of adsorbent, changed the surface functional group of biochar (BC), and made the adsorbent have super-high magnetization (294.76 emu g −1 ). PDA/Fe 3 O 4 /BC was applied to treat Cr wastewater. The results show that the adsorption of Cr by PDA/Fe 3 O 4 /BC includes single-layer and multilayer adsorption. The adsorption follows the pseudo-second-order kinetic model. The adsorption is spontaneous and endothermic, and its maximum adsorption capacity and activation energy are 25.25 mg g −1 at 318 K and 23.108 kJ mol −1 , respectively. After adsorption treatment, PDA/Fe 3 O 4 /BC still possesses high magnetization (233.04 emu g −1 ). PDA/Fe 3 O 4 /BC can treat actual electroplating wastewater with Cr(VI) concentration from 20 mg L −1 to less than 0.2 mg L −1 , which met the PRC discharge standard (GB/21900-2008) of electroplating pollutants.
Graphical abstract
研究领域:
环境科学
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环境工程
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纳米材料
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水污染治理
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应用化学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 133
·期 1
·
IF 1.768
Caideng Yuan,Mingtong Cui,Longlong Feng,Jingpeng Wang,Yan Peng
An amino-functionalized nano-adsorbent (DETA-MNPs) was prepared by a process involving: (1) synthesis of superparamagnetic Fe 3 O 4 nanoparticles; (2) introduction of amino groups after which ATRP initiator was anchored; (3) grafting of glycidyl methacrylate (GMA) via SI-ATRP; and (4) ring-opening reaction of epoxy groups with diethylenetriamine (DETA). The nano-adsorbent was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microscope (TEM), and vibrating sample magnetometer (VSM) and applied to remove Cu(II) in batch experiments. The effects of pH, Cu(II) concentrations, solution ionic strength, and contact time were investigated. The results show that the DETA-MNPs are spherical with cubic spine structure, high saturation magnetization (41.9 emu g −1 ), and an average diameter of 10 nm. The maximum Cu(II) adsorption capacity achieves 83.33 mg g −1 at pH 5.0 by Langmuir model. The adsorption process is highly pH-dependent and reaches equilibrium within 20 min. Furthermore, the DETA-MNPs exhibit excellent dispersibility and reusability. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 132 , 42859.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
Metals
·
2015
·Vol. 5
·期 4
·2401-2412
·
IF 0.883
Yongli Li,Chunxia Zhu,Jinqing Kan
Superparamagnetic nanomaterials are showing great prospects in medical treatments with targeting medicines. A new conductive superparamagnetic nanocomposite, γ-Fe2O3/polyaniline-curcumin (γ-Fe2O3/PANI-curcumin), was prepared by using the interaction between an amino group in polyaniline and a ketone group in curcumin. The γ-Fe2O3/PANI-curcumin nanocomposite showed superparamagnetism (30 emu·g−1) and electrochemical activity, based on the results of magnetization curve and cyclic voltammetry (CV). Transmission electron microscope (TEM) indicated that the particle size of γ-Fe2O3/PANI-curcumin was between 10 and 50 nm. Fourier transform infrared spectra (FT-IR) and X-ray diffraction (XRD) were used to characterize the γ-Fe2O3/PANI-curcumin nanocomposite, confirming that curcumin was immobilized into the γ-Fe2O3/PANI chain. This study provided an academic foundation for developing a new material for immobilizing an anticancer drug.Keywords:curcumin;maghemite;nanocomposites;polyaniline;superparamagnetism
研究领域:
材料科学
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医学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Zhi-Ting Cao,Zhi-Yao Chen,Chun-Yang Sun,Hong-Jun Li,Hong-Xia Wang,Qin-Qin Cheng,Zu-Qi Zuo,Ji-Long Wang,Yang-Zhong Liu,Yu-Cai Wang,Jun Wang
Chemotherapy resistance has become a major challenge in the clinical treatment of lung cancer which is the leading cancer type for the estimated deaths. Recent studies have shown that nanoparticles as drug carriers can raise intracellular drug concentration by achieving effectively cellular uptake and rapid drug release, and therefore reverse the acquired chemoresistance of tumors. In this context, nanoparticles-based chemotherapy represents a promising strategy for treating malignancies with chemoresistance. In the present study, we developed cationic lipid assisted nanoparticles (CLAN) to deliver polylactide-cisplatin prodrugs to drug resistant lung cancer cells. The nanoparticles were formulated through self-assembly of a biodegradable poly(ethylene glycol)- block -poly(lactide) (PEG-PLA), a hydrophobic polylactide-cisplatin prodrug, and a cationic lipid. The cationic nanoparticles were proven to significantly improve cell uptake of cisplatin , leading to an increased DNA-Pt adduct and significantly promoted DNA damage in vitro . Moreover, our study reveals that cationic nanoparticles, although are slightly inferior in blood circulation and tumor accumulation, are more effective in blood vessel extravasation. The CLANs ultimately enhances the cellular drug availability and leads to the reversal of cisplatin resistance.
研究领域:
肿瘤学
·
药剂学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Minghao Wang,Haomin Yu,Jiawei Jiang,Wencong Xu,Guofeng Xu,Si Wu
Cis-trans isomerism plays a crucial role in regulating the thermal properties and phase transitions of materials, which is essential for the development of advanced functional materials. By influencing melting points and glass transition temperatures, cis-trans isomerism enables precise control over material performance in applications such as thermal sensors, self-healing coatings, thermal sensors, and temperature-responsive films. Here we report the impact of cis-trans isomerism in double bonds on the thermal and phase transitions of oleic acid (OA) and elaidic acid (EA) and their derived polymers, with a focus on glass transition temperature ( T g ) and melting point ( T m ). A series of molecules and copolymers with varying cis and trans double bond ratios are synthesized to examine how these isomeric configurations affect thermal behavior. Thermal and structural properties are characterized using differential scanning calorimetry (DSC) and nuclear magnetic resonance (NMR) spectroscopy. The results show a clear correlation between isomeric composition and the polymers' T g and T m , illustrating that the incorporation of cis-trans isomers can be effectively used to fine-tune thermal properties. This research offers valuable insights into the design of advanced polymeric materials with tailored thermal characteristics, paving the way for applications in various high-performance sectors.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER COMPOSITES
·
2024
·
IF 4.8
Junhong Li,Yunsong Pang,Jun Wang,Min Yang,Xiaoliang Zeng,Linlin Ren,Rong Sun
The multifunctional composite elastomers serve as thermal interface materials for heat dissipation in electronic devices when their thermal transport performance is enhanced. The common method for enhancement, continuously raising the thermal conductive filler loading only can improve thermal conductivity of composite elastomers but reduces compliance, resulting in elevated contact thermal resistance with solid surfaces, compromising thermal transport. To address this, we propose grafting short dangling chains onto the composite elastomer matrix to further promote compliance under a certain filler loading. Characterization results demonstrate that the grafted chains effectively reduce relaxation time, enabling faster deformation for the material under pressure. This approach enhances interfacial compatibility, widening the thermal transport path at contact interfaces to contact thermal resistance by 94% (from 17.8 to 1.07 mm 2 W/K), significantly improving overall thermal transport. Additionally, we discussed the feasibility of employing composite elastomers as thermal interface materials for efficient chip heat dissipation. Highlight The grafted dangling chains can promote the composite elastomers softness. The softness promotion can help reduce thermal contact resistance. A series of theories are employed to learn the mechanisms of the promotion. The resulting composite elastomers can be used as thermal interface materials.
研究领域:
材料科学
·
热管理技术
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2025
·
IF 2.3
Yaxin Ren,Zhijun Zhang
An effective collector is crucial for enhancing coal flotation efficiency. The effect of a mixed collector based on petrochemical by-products on coal flotation was investigated. The investigation included various addition orders and was conducted using flotation tests, particle size distribution analysis, GC-MS, FTIR and contact angle measurements. The Mixed addition order exhibited superior performance in flotation compared to the K+Y and Y+K orders at all tested dosages. Particle size distribution analyses revealed that the mixed collector offered better dispersion in water than individual the Y-oil and K-oil, with droplet sizes below 100 µm. FTIR and contact angle measurements indicated that coal treated with the Mixed addition order demonstrated optimal reagent adsorption and the highest level of surface hydrophobicity. Aromatic compounds in the collector interacted with the hydrophobic areas of the coal surface, while partially covering some of the hydrophilic regions between these hydrophobic sites. Conversely, heteropolar components engaged with the hydrophilic regions on the coal surface to enhance adsorption. Despite these improvements, some hydrophilic sites remained after treatments with the Y+K and K+Y orders, which continued to affect the coal flotation properties.
研究领域:
矿物加工工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Tingyu Zhao,Ruirui Cui,Kaixin Guo,Min Zhang,Xu Wang,Jun Zhang,Chaoyong Deng
In this work, by doping the B-site of BaTiO 3 with Mg elements, we have prepared BaMg x Ti 1- x O 3- x (BM x T) films with superparaelectric behaviors. The microstructures, polarization behaviors, breakdown strength, leakage current density, and energy storage performance are investigated systematically of the BM x T films. The breakdown strength of the film reaches 7.5 MV/cm when x = 0.18, at the same time, excellent energy storage density (67.7 J/cm 3 ) and energy storage efficiency (94.9 %) are obtained, which is attributed to the doping of the acceptor element Mg. By doping Mg with a lower chemical valence state to form defect dipoles in the lattice, the breakdown strength and polarization properties of the film are improved while reducing the crystallinity of the film, forming a hysteresis loop with superparaelectric properties. This work provides a feasible route to design superparaelectric materials with simple compositions for high-performance capacitive energy-storage.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）