JOURNAL OF CHEMICAL SCIENCES
·
2020
·Vol. 132
·期 1
·1-14
·
IF 1.406
Cheng Si Yuan,Yang Xi Nan,Tao Zhu,Wei Lian Tong,Zhao Wei Wei,Jiang Dao Fa,Jin Yan Mei,Gao Jie,Ma Pei Hua
Abstract The host–guest binding characteristics of cyclopentanocucurbit[6]uril (CyP 6 Q[6]) and cyanine dye trans -4-[4-(dimethylamino)styryl]-1-methylpyridinium iodide ( t -DSMI) have been studied. The results show that CyP 6 Q[6] and t -DSMI form a 1:1 inclusion system, generating strong fluorescence. On this basis, the fluorescent probe t -DSMI@CyP 6 Q[6] has been constructed, and its anion recognition ability has been investigated. In a neutral environment, BF 4 − , H 2 PO 4 − , and I − elicit obvious specific responses from the probe, since they have stronger binding forces. This probe shows greater sensitivity than the previously reported probe t -DSMI@HMeQ[6]. Graphic abstract Since the complex formed by CyP 6 Q[6] and t -DSMI can produce strong fluorescence at pH > 4.6, t -DSMI@CyP 6 Q[6] was constructed to recognize the anions at pH ≅ 5. The results show that in a near neutral environment, BF 4 − , H 2 PO 4 − , and I − elicit obvious specific responses from the probe.
研究领域:
分析化学
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材料科学
·
化学传感器
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DOI
高影响因子
GLIA
·
2024
·
IF 5.4
Kechun Chen,Bingtian Xu,Shuqin Qiu,Lu Long,Qian Zhao,Jiangping Xu,Haitao Wang
We have previously shown that phosphodiesterase 4 (PDE4) inhibition protects against neuronal injury in rats following middle cerebral artery occlusion/reperfusion (MCAO/R). However, the effects of PDE4 on brain edema and astrocyte swelling are unknown. In this study, we showed that inhibition of PDE4 by Roflumilast (Roflu) reduced brain edema and brain water content in rats subjected to MCAO/R. Roflu decreased the expression of aquaporin 4 (AQP4), while the levels of phosphorylated protein kinase B (Akt) and forkhead box O3a (FoxO3a) were increased. In addition, Roflu reduced cell volume and the expression of AQP4 in primary astrocytes undergoing oxygen and glucose deprivation/reoxygenation (OGD/R). Consistently, PDE4B knockdown showed similar effects as PDE4 inhibition; and PDE4B overexpression rescued the inhibitory role of PDE4B knockdown on AQP4 expression. We then found that the effects of Roflu on the expression of AQP4 and cell volume were blocked by the Akt inhibitor MK2206. Since neuroinflammation and astrocyte activation are the common events that are observed in stroke, we treated primary astrocytes with interleukin-1β (IL-1β). Astrocytes treated with IL-1β showed decreased AQP4 and phosphorylated Akt and FoxO3a. Roflu significantly reduced AQP4 expression, which was accompanied by increased phosphorylation of Akt and FoxO3a. Furthermore, overexpression of FoxO3a partly reversed the effect of Roflu on AQP4 expression. Our findings suggest that PDE4 inhibition limits ischemia-induced brain edema and astrocyte swelling via the Akt/FoxO3a/AQP4 pathway. PDE4 is a promising target for the intervention of brain edema after cerebral ischemia.
研究领域:
神经科学
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药理学
·
细胞生物学
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病理生理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Kaiyu Zhao,Kangrui Sun,Yafei Guo,Lingzong Meng,Tianlong Deng
The isopiestic equilibria for the systems {Li 2 B 4 O 5 (OH) 4 + H 2 O}, {LiB 5 O 6 (OH) 4 + H 2 O} and {Li 2 B 4 O 5 (OH) 4 + LiB 5 O 6 (OH) 4 + H 2 O} at 288.15 K and ambient pressure were measured by the isopiestic method using a modified gravimetric isopiestic apparatus. The water activities and osmotic coefficients were determined based on the sodium chloride standard reference solution. On the basis of Pitzer model, an extended Pitzer model was developed to describe the thermodynamic properties of the aqueous systems containing different forms of lithium borates, then the Pitzer single salt parameters β (0) , β (1) , β (2) and C ϕ for the binary systems {Li 2 B 4 O 5 (OH) 4 + H 2 O} and {(LiB 5 O 6 (OH) 4 + H 2 O} and mixing ion-interaction parameters θ B 4 O 5 OH 4 , B 5 O 6 OH 4 and ψ Li , B 4 O 5 OH 4 , B 5 O 6 OH 4 for the ternary system {Li 2 B 4 O 5 (OH) 4 + LiB 5 O 6 (OH) 4 + H 2 O} were fitted with the experimental osmotic coefficients using the Fortran 97 program. Meanwhile, the water activities were calculated by the Pitzer parameters, and the good agreement between the calculated water activities and experimental results of this ternary system indicated that the Pitzer parameters obtained in this work were reliable.
研究领域:
物理化学
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热力学
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无机化学
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2022
·
IF 3.269
Pengshuai Zhang,Ruping Ge,Chunxia Jin,Jixiu Deng,Feiyang Dai,Yameng Wan,Beibei Zhang,Shuwei Yu,Xing Li,En Zhang,Lan Zhang,Lu Zhang
The mole fraction solubility of 1-[4-(4-hydroxyphenyl)piperazin-1-yl]ethenone (1-HPE) in twelve mono-solvent systems namely “2-methoxyethanol (2-ME), methanol (MeOH), ethanol (EtOH), butan-1-ol ( n -BuOH), 2-propoxyethanol (2-PE), propan-2-ol ( i -PrOH), 2-methylpropan-1-ol ( i -BuOH), Acetonitrile (MeCN), ethane-1,2-diol (EG), 2-ethoxyethanol (2-EE), propan-1-ol ( n -PrOH), 2-butoxyethanol (2-BE)” were determined from 283.15 K to 323.15 K under 0.1 MPa. The experimental solubility order follows: 2-ME > 2-EE > 2-PE > 2-BE > MeOH > EtOH > n -PrOH > i -PrOH ≈ n -BuOH > i -BuOH ≈ MeCN > EG. The UNIQUAC model, modified Apelblat model, NRTL model, Wilson model, Jouyban model and NRTL-SAC model equation were used to correlate of 1-HPE solubility, and the average 10 4 RMSD of them was 0.89, 1.21, 0.94, 4.72, 0.60 and 1.25, respectively. Furthermore, Hansen solubility parameters analysis (HSP) was used to evaluate the miscibility of 1-HPE in the selected solvents. Hirshfeld surface (HS) analysis was performed to discuss the electrostatic features and the patterns of intermolecular interactions of 1-HPE. Thermodynamic properties (Δ mix G , Δ mix S , Δ mix H , Δ dis G , Δ dis S , Δ dis H ) were calculated by the UNIQUAC model. The calculated results indicated that the dissolution and mixing process of 1-HPE in the mono-solvents selected in this work was spontaneous and entropy increment.
研究领域:
化学工程
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物理化学
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产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2015
·
IF 2.947
Xuechen Huang,Hanxing Liu,Zhe Song,Hua Hao,Wenqin Zhang,Qi Xu,Chuyu Peng,Ling Huang,Minghe Cao
Dense (1 − x )BaTiO 3− x (Na 1/4 Bi 3/4 )(Mg 1/4 Ti 3/4 )O 3 [(1 − x )BT– x NBMT] polycrystalline ceramics were prepared by solid-state reaction method. The detailed structure analysis was performed by X-ray diffraction (XRD) and Raman spectroscopy , confirming that the Ba and Ti sites were partially replaced by Na + /Bi 3+ and Mg 2+ ions, respectively. An obvious structural variation from tetragonal to pseudocubic was observed for sample with x = 0.08–0.12. The lattice parameter for sample with x ≥ 0.12 decreased linearly with x value. Three changing modes in frequency, width and intensity were observed with x value in the Raman spectra, indicating intense changes of local structure, accounting for evolved dielectric and ferroelectric macroscopic properties. The subgrain microstructures were observed by conventional transmission electron microscopy (TEM) imaging with an energy-dispersive X-ray spectroscopy (EDS) attachment. A large number of core–shell grains were detected by TEM dark field, for x = 0.20, which were attributed to the dissolution–precipitation mechanism. In this present study, (1 − x )BT– x NBMT ceramics are considered promising for high temperature capacitor applications.
研究领域:
材料科学
·
陶瓷
·
介电与铁电材料
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固体化学
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产品关联
DOI
高影响因子
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
·
2017
·Vol. 53
·期 3
·459-461
·
IF 0.603
Liu X. J.,Yan Y. N.,Wang S. Q.,Li X.,Liu X. G.
A new synthetic route to 4-methoxyisophthalic acid, the key intermediate in the synthesis of Picotamide, is reported. The new protocol starts from commercially available and cheap 4-methylphenol and includes four steps: esterification, Fries rearrangement, methylation, and oxidation; the overall yield is 49%. Unlike the traditional Blanc chloromethylation/oxidation scheme, the proposed procedure avoids using volatile and corrosive hydrochloric acid.
研究领域:
有机化学
·
药物化学
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DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2019
·
IF 2.781
Zhiqiang Xu,Xianhua He,Mingwei Liang,Lijuan Sun,Di Li,Kenan Xie,Li Liao
Catalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) over high-performance non-noble metal catalysts is attracting intensive attention. Herein, we report a graphene supported Cu@Ni bimetallic nanowires catalyst by a facile liquid phase reduction method with the assistance of an external magnetic field. The morphology and structure of the composite are studied by SEM, TEM and XPS. The vibrating sample magnetometer (VSM) is used to analyze its magnetic properties . Owing to the synergistic effect of graphene and bimetallic nanowires, the catalyst shows superior catalytic performance and excellent stability. The results of catalysis exhibit an extraordinary rate constant (1.16 min −1 ) and activity factor (5.81 min −1 mg −1 ) at room temperature, which are much higher than a majority of non-noble metal catalysts, even noble metal catalysts. Also, compared with noble metal catalyst, the novel catalyst possesses ferromagnetism , which facilitates the separation of catalyst and reaction system, and guarantees recyclability. Moreover, a possible synergistic catalytic mechanism based on the fact that electron transfer between copper-nickel nanowires and graphene has been proposed. It is believed that the novel catalyst has a great importance for the application of nanowires in the field of catalysis.
研究领域:
催化化学
·
材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 3
·1533
·
IF 4.9
Hongxuan Du,Yaoyao Liang,Jianing Li,Xinyao Yuan,Fenglin Tao,Chengjie Dong,Zekai Shen,Guangchao Sui,Pengchao Wang
Biosensors based on allosteric transcription factors have been widely used in synthetic biology. In this study, we utilized theAcinetobacterADP1 transcription factor PobR to develop a biosensor activating the PpobApromoter when bound to its natural ligand, 4-hydroxybenzoic acid (4HB). To screen for PobR mutants responsive to 4-hydroxyphenylpyruvate(HPP), we developed a dual selection system inE. coli. The positive selection of this system was used to enrich PobR mutants that identified the required ligands. The following negative selection eliminated or weakened PobR mutants that still responded to 4HB. Directed evolution of the PobR library resulted in a variant where PobRW177Rwas 5.1 times more reactive to 4-hydroxyphenylpyruvate than PobRWT. Overall, we developed an efficient dual selection system for directed evolution of biosensors.
研究领域:
合成生物学
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微生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CRYSTAL GROWTH
·
2013
·
IF 1.552
Y.F. Zhang,L. Huang,Y.B. Sun,B. Han,H.S. Cheng
In this work, we reported on the synthesis and characterization of (Z)-4-oxo-4-ureido-but-2-enoic acid and p-toluenesulfonic acid 3-nitrophenyl ester and their detailed crystal structure information were studied. The crystallization of (Z)-4-oxo-4-ureido-but-2-enoic acid results in reduced π -conjugation in the molecule and weaker intra-molecular hydrogen bonding. The main driving force for the molecular self-assembly of (Z)-4-oxo-4-ureido-but-2-enoic acid was found to be the strong intermolecular hydrogen bonds . Compared with (Z)-4-oxo-4-ureido-but-2-enoic acid with six type of strong H-bonds, p-toluenesulfonic acid 3-nitrophenyl ester possesses much lower melting point (110–111°C), average packing energy (−3.7 kcal mol −1 ), molecular deformation energy (−0.6 kcal mol −1 ) and highest torsional angle change (9.3°). This can be ascribed to the week intermolecular interaction between center molecule and adjacent molecules.
研究领域:
化学
·
材料科学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Xiqiang Tian,Muhammad Zahid,Wang Sun,Yujun Zhu
TiO 2 with different morphology as supports can lead to different surface properties and catalytic activities of catalysts. Herein, we reported a novel facile evaporation-induced assisted hydrothermal approach to synthesize three-dimensional hierarchical structure TiO 2 assembled from needle flakes by using Brij-35 as the morphology-directing agent. The morphology of the prepared TiO 2 from flower-like (TiO 2 -FT), sea urchin-like (TiO 2 -SUT), to ball-like (TiO 2 -BT), as well as the size of needle flakes, were controlled by adjusting the amount of Brij-35. These TiO 2 supported palladium catalysts were facilely prepared using a green bio-reductive method with Catalpa Fruit extract as reducing agent, where they showed remarkable catalytic activity in selective hydrogenation of 4-nitrophenol by sodium borohydride. Especially, 1 wt%Pd/TiO 2 -SUT with sea urchin-like exhibited higher reaction rate constant (1.44 min −1 ) than 1 wt%Pd/TiO 2 -FT (1.08 min −1 ) and 1 wt%Pd/TiO 2 -BT (0.72 min −1 ). Furthermore, XRD, N 2 adsorption–desorption, SEM, TEM, CO-FTIR, XPS and CO chemisorption measurements were performed to study the effects of different surface morphologies on the surface properties of catalysts. It reveals that the high catalytic performance of 1 wt%Pd/TiO 2 -SUT can be attributed to its specific hierarchical structure and much higher surface area, improving the uniform dispersion of Pd nanoparticles on the support to expose extra active surface Pd atoms (Pd 0 species) over 1 wt%Pd/TiO 2 -SUT.
研究领域:
材料科学
·
催化
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
·
2019
·Vol. 39
·期 9
·554-563
·
IF 1.774
Yan Yan,Pengchong Wang,Ying Sun,Yalin Dong,Jianfeng Xing
Previously, we reported that 3, 4-oxo-isopropylidene-shikimic acid (ISA) has therapeutic potential in experimental colitis in rats. This study aimed to elucidate the potential mechanisms of ISA on the inflammatory response in rats with 2, 4, 6-trinitrobenzenesulfonic acid-induced colitis. After the induction of colitis, rats were orally administered ISA for 12 days. Then, the expression levels of inflammatory cytokines, cell adhesion molecules, and matrix metalloproteinase (MMP) in the blood and colon tissues, and the protein level of nuclear factor kappa B (NF-κB) p65 in cytoplasm and nucleus of colon tissues were evaluated. As a result, an enhanced inflammatory response was observed in rats with experimental colitis. However, the treatment with ISA significantly ameliorated the inflammatory response, which was manifested as a significant decrease in the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interferon (IFN)-γ, IL-8, TNF-α mRNA, P-selectin, E-selectin, intercellular cell adhesion molecule-1, MMP9 and MMP9 mRNA in rat blood and colon tissues, respectively, and a significant decrease in the levels of IFN-γ/IL-4, and the NF-κBp65 activity coefficient. Therefore, the therapeutic effect of ISA on experimental colitis may be related to its inhibitory effect on the expression of cytokines, adhesion molecules, and MMP9, which may be involved in the inhibition of the activation and nuclear translocation of NF-κBp65.
研究领域:
药理学
·
免疫学
·
胃肠病学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
·
IF 2
Zheng-En Piao,Jingzhou Guo,Dan Wang,Wei Mao,Yuan Pu,Jian-Feng Chen
2-(4-tert-Butylphenyl)-5-(4-biphenyl)-1,3,4-oxadiazole (PBD) is one of the most widely used electron transport layer materials in optoelectronic devices, and studies on the solubility of PBD in various solvents are critical for development of solution-processable roll-to-roll electronic devices. In this study, the isothermal saturation method is used to determine the solubility data of PBD in 12 commonly used organic solvents. The experimental solubility of PBD increases gradually with enhanced temperature for the examined temperature range of 283.15–323.15 K in n-hexane, methanol, ethanol, isopropanol, tetrahydrofuran (THF), acetonitrile, ethyl acetate, N-methylpyrrolidone (NMP), toluene, and chlorobenzene, while the temperature ranges were 293.15–333.15 K and 273.15–303.15 K for dimethyl sulfoxide and dichloromethane, respectively. The obtained solubility values of PBD are correlated by three models including the modified Apelblat equation, λh equation, and Yaws equation. Comparison of the calculated Akaike information criterion values resulted in selecting the optimal model for each solvent. Of the five solvents calculated, n-hexane, methanol, toluene, THF, and NMP, the λh equation provides an optimal fit. Both the modified Apelblat equation and the Yaws equation work well in chlorobenzene. Among the other six solvents, the fit of the Yaws equation is the best. These results of solubility provide the basic data for the synthesis of PBD nanoparticles via high-gravity-assisted antisolvent precipitation processing.
研究领域:
材料科学
·
化学工程
·
物理化学
·
光电子学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）