JOURNAL OF CONTROLLED RELEASE
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2023
·
IF 10.8
Yupeng Wang,Yuwei Cong,Manying Cai,Xiaoling Liang,Lina Wang,Dongfang Zhou
Polyprodrug nanomedicines hold great potential for combating tumors. However, the functionalization of polyprodrug nanomedicines to improve therapeutic efficacy is restricted by conventional polymerization methods. Herein, we fabricated a charge-conversional click polyprodrug nanomedicine system by metal-free azide-alkyne cycloaddition click polymerization (AACCP) for targeted and synergistic cancer therapy. Specifically, Pt(IV) prodrug-backboned diazide monomer , DMC prodrug-pendent diazide monomer, dialkyne-terminated PEG monomer and azide-modified folate were click polymerized to obtain the target polyprodrug (P1). P1 could self-assemble into nano-micelles (1-NM), where PEG was the hydrophilic shell with folate on the surface, Pt(IV) and DMC prodrugs as the hydrophobic core. Taking advantage of PEGylation and folate-mediated tumor cell targeting, 1-NM achieved prolonged blood circulation time and high tumor accumulation efficiency. Tumor acidic microenvironment-responsive cleavage and cascade activation of pendant DMC prodrug induced surface charge conversion of 1-NM from negative to positive, which promoted tumor penetration and cellular internalization of the remaining 1-NM. After internalization into tumor cells, the reduction-responsive activation of Pt(IV) prodrug to Pt(II) further showed synergetic effect with DMC for enhanced apoptosis . This first designed charge-conversional click polyprodrug nanomedicine exhibited targeted and synergistic efficacy to suppress tumor proliferation in living mice bearing human ovarian tumor model.
研究领域:
纳米技术
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药学
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肿瘤学
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
Magnetochemistry
·
2026
·Vol. 12
·期 7
·74
·
IF 2.8
Bin Chen,Ge Gao,Yuhua Liu,Wei Ding,Hong Li
Conventional water treatment relies on sequential flocculation and disinfection, which inflates infrastructure costs and heightens the risk of disinfection byproduct formation. Here, we report a magnetic lignin-based flocculant (LS-DMC-AM@Fe3O4) that integrates flocculation, sterilization, and rapid magnetic separation within a single material. The composite was synthesized by thermally initiated graft copolymerization of methacryloyloxyethyl trimethylammonium chloride (DMC) and acrylamide (AM) onto sodium lignosulfonate (LS), followed by incorporation of Fe3O4nanoparticles (NPs) at 15 wt% loading; the product exhibited a saturation magnetization of 12.8 emu g−1. LS-DMC-AM@Fe3O4achieved 98.2% kaolin turbidity removal at 1 mg L−1and 98.6%E. coliremoval at 8 mg L−1, and displayed a markedly broader effective dosage window than its non-magnetic analog. We attribute this broadened window to Fe3O4-enhanced membrane disruption, which liberates anionic intracellular contents that buffer excess cationic charge and thereby suppress restabilization. The bactericidal efficiency reached 90% at 18 mg L−1, 1.6-fold higher than LS-DMC-AM, governed by a synergistic dual mechanism: quaternary ammonium contact-killing coupled with Fe3O4NP-induced intracellular reactive oxygen species (ROS) accumulation. Under an external magnetic field, flocs underwent rapid phase separation and displayed enhanced shear-regrowth capacity (E. colifloc recovery factor: 53% vs. 26%); Fe3O4NPs were recovered at >95% efficiency over two cycles. Despite higher unit production costs, LS-DMC-AM@Fe3O4delivers competitive per-unit-volume treatment economics through its ultralow effective dosage and magnetic seed recyclability. These results establish a viable strategy for engineering multifunctional, recyclable flocculants from industrial lignin waste.
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DOI
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 20
·4170-4180
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IF 4.726
Chong Cheng,Ai He,Chuanxiong Nie,Yi Xia,Chao He,Lang Ma,Changsheng Zhao
This study reports a highly efficient, convenient and universal protocol for the fabrication of robust antifouling and antibacterial polymeric membranes via one-pot cross-linked copolymerization of methyl acryloyloxygen ethyl trimethyl ammonium chloride (DMC) and poly(ethylene glycol) methyl ether methacrylate (PEGMA). The infrared testing and X-ray photoelectron spectroscopy gave obvious evidence that abundant DMC and PEGMA chains had enriched on the membrane surface. The surface and cross-sectional SEM images indicated that the addition of DMC and PEGMA had a little effect on the membrane roughness and inner structure. Meanwhile, the systematic investigations into the water contact angle, protein adsorption, ultrafiltration and bacterial inhibition indicated that the composite membranes showed improved hydrophilicity, decreased protein adsorption, increased water flux and antifouling property, as well as greatly enhanced antibacterial ability. Furthermore, it was found that the cross-linked copolymerization could further endow the composite membrane with multi-chemical properties, for instance the charged interface. As a model system, Ag nanoparticle-PDMC multilayers were coated onto the positively charged PES–DMC6 membranes via layer by layer assembly, and the successful surface coating confirmed their versatile ability and also provided a more effective and durable antibacterial coating to the composite membranes. All these results suggest that the robust antifouling and antibacterial composite membranes can be prepared via the proposed one-pot cross-linked copolymerization, and it is believed that this approach has great potential to be applied in various biomedical or industrial fields where antifouling and antibacterial properties are highly demanded.
研究领域:
材料科学
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化学工程
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生物医学工程
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高分子科学
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产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2018
·
IF 0
Zhongwei Fu,Yunyun Zhong,Yuehong Yu,Lizhen Long,Min Xiao,Dongmei Han,Shuanjin Wang,Yuezhong Meng
A new class of TiO2-doped CeO2 nanorods was synthesized via a modified hydrothermal method, and these nanorods were first used as catalysts for the direct synthesis of dimethyl carbonate (DMC) from CO2 and CH3OH in a fixed-bed reactor. The micromorphologies and physical–chemical properties of nanorods were characterized by transmission electron microscopy, X-ray diffraction, N2 adsorption, inductively coupled plasma atomic emission spectrometry, X-ray photoelectron spectroscopy, and temperature-programmed desorption of ammonia and carbon dioxide (NH3-TPD and CO2-TPD). The effects of the TiO2 doping ratio on the catalytic performances were fully investigated. By doping TiO2, the surface acid–base sites of CeO2 nanorods can be obviously promoted and the catalytic activity can be raised evidently. Ti0.04Ce0.96O2 nanorod catalysts exhibited remarkably high activity with a methanol conversion of 5.38% with DMC selectivity of 83.1%. Furthermore, kinetic and mechanistic investigations based on the initial rate method were conducted. Over the Ti0.04Ce0.96O2 nanorod catalyst, the apparent activation energy of the reaction was 46.3 kJ/mol. The reaction rate law was determined to be of positive first-order to the CO2 concentration and the catalyst loading amount. These results were practically identical with the prediction of the Langmuir–Hinshelwood mechanism in which the steps of CO2 adsorption and activation are considered as rate-determining steps.
研究领域:
催化
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化学工程
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材料科学
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环境化学
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DOI
PubMed
FUEL
·
2021
·
IF 6.609
Qiao Wang,Wanchen Sun,Liang Guo,Shaodian Lin,Peng Cheng,Hao Zhang,Yuying Yan
The laminar burning speed, Markstein length and cellular instability of three oxygenated fuels, polyoxymethylene dimethyl ether 3 (PODE 3 ), dimethyl carbonate (DMC) and n-butanol (NB), were experimentally studied using spherical flame propagation method. Both of the three fuels are potential alternatives for petrochemical gasoline and diesel. Laminar burning speeds and Markstein lengths were measured at ambient pressure and elevated temperature (363 K-423 K) with three extrapolation models including linear and non-linear employed to extract the unstretched flame speed. Onset of flame cellular instability of the three fuels was determined at high pressure (0.5–0.75 MPa) which was favored to the occurrence of cellular instability. Three well-validated mechanisms for PODE 3 , DMC and NB respectively were used to numerically analyze the flame structure and then understand the underlying effect of the molecular structure of oxygenated fuels on laminar flame propagation. Results show that PODE 3 has the highest laminar burning speed among the three, supporting by both thermal effect and kinetic effect. While the laminar burning speed of NB is higher than that of DMC, which is due to the combined effect of thermal factor and kinetic factor. The molecular structure of oxygenated fuels exerts an influence on the laminar flame propagation through the fuel-specific cracking pathway and resulting formed intermediates with different reactivity. The absence of C–C bond within PODE 3 and DMC leads to the formation of substantial oxy-intermediates (CH 2 O) with high reactivity during fuel decomposition. PODE 3 has the most stable flame among the three because of the strong stretching of PODE 3 flame. The flame stability of DMC and NB is approximately similar especially at high initial pressure.
研究领域:
燃烧科学
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化学工程
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燃料化学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·Vol. 35
·期 38
·2503713
·
IF 19
Caiyan Shen,Dichang Guan,Wenchao Liu,Yanbing Cao,Zhongdong Peng,Yu Ren,Litao Kang,Jinhao Meng,Zhichen Xue,Ke Du
The development of fluorine-free electrolytes offers a promising route for more environmentally sustainable lithium-ion batteries (LIBs). However, the low solubility of fluorine-free lithium salts in conventional carbonate solvents limits this progress. Additionally, while strongly coordinating solvents enhance salt dissolution, their use can lead to co-intercalation in graphite, complicating electrolyte design. Herein, lithium bis(oxalate)borate (LiBOB) is chosen as lithium salt, and a synergistic electrolyte design strategy is employed, combining a strongly coordinating solvent (tris(2-methylpropyl) phosphine oxide, TMP) and weakly coordinating solvent (dimethyl carbonate, DMC). This approach enables the use of fluorine-free lithium salts while ensuring compatibility with graphite by modulating the primary coordination shell. Furthermore, this solvation structure enables the formation of an inorganic-dominated cathode electrolyte interphase (CEI) on the LiMn 2 O 4 (LMO) and a solid electrolyte interphase (SEI) on the graphite, improving lithium-ion conductivity and overall electrochemical performance. Additionally, compared to lithium hexafluorophosphate (LiPF 6 ), fluorine-free lithium salt minimized the formation of HF by-products, suppressing transition metals (TMs) dissolution. As a result, 1 Ah LMO||graphite pouch cell with fluorine-free electrolyte retains 92.8% of its capacity after 200 cycles, demonstrating excellent cycling stability and delivering high-rate capacity of 0.8486 Ah at 2 C, compared to 84.8% retention and 0.652 Ah with the conventional electrolyte.
研究领域:
电化学
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能源材料
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电池技术
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可持续化学
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材料科学
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产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Chen Hua,Kaimin Chen,Zun Wang,Xuhong Guo
Cationic latexes have received wide attention due to their special properties and potential applications in wood coatings, fabric treatment, etc. However, the practical application of cationic latexes was hindered due to their poor stability, especially the alkali resistance stability. In this work, various stable cationic polyacrylate latexes were prepared by an efficient route. Three cationic comonomers, i.e., methacrylatoethyl trimethyl ammonium chloride (DMC), 2-(dimethylamino)ethyl methacrylate (DMAEMA), and 2-aminoethyl methacrylate hydrochloride (AEMH), were used in the aqueous semi-continuous seeded emulsion polymerization of methyl methacrylate (MMA) and butyl acrylate (BA) using cetyl trimethyl ammonium bromide (CTAB) and 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIBI) as the cationic emulsifier and initiator, respectively. The alkali resistance of the latex could be significantly improved by the addition of cationic monomer DMC and be simply tuned by adjusting DMC dosage. The improved stability of the latex might originate from the higher charge density on the surface of the latex by the introduction of DMC. Moreover, the effects of initiator dosage, emulsifier dosage and different cationic comonomers on the latex preparation and the film properties were also systematically investigated. This work not only introduces an efficient route to prepare cationic latexes with superior stability, but also paves the way for latexes to be used in applications such as textile finishing, paper industry, and biomedical field, etc.
研究领域:
材料科学
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化学工程
·
高分子化学
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产品关联
DOI
高影响因子
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