BIOMATERIALS
·
2026
·
IF 12.9
Yilin Zhang,Dongyan Li,Hui Xiao,Xiuyuan Luo,Yi Xie,Sen Hou,Lizhen Wang,Yubo Fan,Jing Ji,Linhao Li
Corneal alkali burns cause persistent inflammation, leading to corneal vascularization and fibrosis, which severely impair vision. Here, we developed a temporary adhesive and detachable Janus silk-based patch to capture and remove inflammatory mediators from the ocular surface. The lower silk layer of the Janus patch incorporates of polyamidoamine and heparin, offering adsorption capacity for inflammatory mediators on the ocular surface. The upper hyaluronan layer imparts lubrication, alleviating foreign-body sensation and reducing shear stress from blinking. The integration of the silk and hyaluronan layers is achieved through interfacial diffusion, liquid–liquid phase separation, and photopolymerization, resulting in a stable interpenetrating network interface. After water annealing, the Janus patch exhibited excellent transparency, mechanical strength, and swelling resistance, remaining attached to the rat ocular surface for 3–5 days. Adsorption tests confirmed that the patch effectively captured small-molecule dyes, proteins, and free DNA. In the rat corneal alkali burn model, imaging and histological evaluations showed significant reductions in vascularization and fibrosis after 3 days of treatment, along with improved corneal transparency. RNA sequencing revealed that patch treatment effectively inhibited the PI3K–AKT inflammatory pathway. This inflammation-removing patch represents an innovative treatment for corneal alkali burns with significant clinical potential.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Wenxiang Zhu,Jiawei Chen,Qiuling Huang,Zhimin Liao,Xiaobo Wang,Xiaoyu Zhou,Wei Huang,Dengming Zhou,Xuanchu Duan
Chronic inflammation is closely linked to retinal ganglion cell (RGC) damage in glaucoma. However, naturally derived biomaterials often lack sufficient anti-inflammatory activity and fail to effectively support RGC survival. In this study, we developed a stem cell-loaded, nanovesicle-integrated sericin-based hydrogel, SerMA-PC@PNVs, designed to enhance the survival of RGCs in glaucomatous conditions. Nanovesicles (NVs) derived from periodontal ligament stem cells (PDLSCs) were obtained via ultracentrifugation and liposome extrusion. These NVs were loaded with procyanidins (PC) and functionalized with acrylate-polyethylene glycol-N-hydroxysuccinimide (AC-PEG-NHS). The modified NVs (PC@PNVs) were then covalently grafted onto methacrylated sericin (SerMA) through a photo-cross-linking reaction to form the SerMA-PC@PNVs hydrogel scaffold. In vitro studies demonstrated that the SerMA-PC@PNV scaffold enhanced the secretion of neurotrophic factors by encapsulated PDLSCs. Both in vitro and in vivo results confirmed that the SerMA-PC@PNVs/PDLSCs hydrogel effectively reprogrammed microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, thereby creating a neuroprotective microenvironment favorable for RGC survival. Mechanistically, RNA sequencing of retinal tissues revealed significant regulation of pathways associated with the “inflammatory response” and “apoptotic process”. Single-cell RNA sequencing further demonstrated an increase in RGC populations and a reduction in neutrophils and microglia following treatment. Microglial subclustering analysis validated the hydrogel’s regulatory effects on “inflammatory response” signaling. In conclusion, the SerMA-PC@PNVs/PDLSCs can promote the survival of glaucoma-damaged RGCs by regulating the inflammatory response.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2026
·
IF 11.8
Yi Huang,Sihang Liu,Shuai Yin,Lian Xiao,Yugang Zhao,Zhi Tao,Haiwang Li
Understanding droplet-liquid pool interactions in immiscible systems is critical for advancing fluidic encapsulation strategies. Here, we uncover a previously unreported ‘endocytosis’ phenomenon in which an aqueous droplet impacts a deep immiscible pool and spontaneously engulfs the pool liquid, forming a stable double-layered liquid structure. This process origins from the focusing of capillary waves at the droplet-pool interface and followed by a pinch-off of a central oil column via Rayleigh-Plateau instability. We propose a dimensionless criterion for central column formation, determined by whether viscous dissipation of the droplet's kinetic energy. By introducing a UV-crosslinkable precursor, gelatin methacryloyl (GelMA) into the droplet, we succeed in encapsulating pool liquid into hydrogel capsules with tunable core-shell ratios by simply adjusting the impact velocity. This enables precise control of release mechanism: thick-shell capsules exhibit non-Fickian sustained release, while thin-shell capsules display delayed burst Case II release upon swelling. The proposed ‘endocytosis’ phenomena offer a surfactant-free, single-parameter controlled strategy compared to conventional liquid encapsulation methods, which offers a new opportunity for on-demand release in drug delivery and responsive materials.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jinxuan Jia,Lu Fan,Zhuhao Wu,Xiaocheng Wang,Yuanjin Zhao
An autotrophic, photosynthetic 3D-bioprinted core-shell scaffold (MA-SHC-PDA) has been developed for treating infected wounds. • The microalgae core enables sustained oxygen production under light, whereas the NIR-responsive PDA shell simultaneously triggers SHC carbon release and eradicates bacteria. • The MA-SHC-PDA scaffold alleviates hypoxia, suppresses infection, and accelerates infected wound healing. Bioengineered scaffolds have demonstrated significant potential in enhancing wound healing; while there remains ample room for improvement in mitigating localized hypoxia and preventing infections at wound sites. Here, we introduce a microfluidic in situ 3D bioprinted autotrophic photosynthetic scaffold for promoting the healing of infected wounds. The scaffold incorporates oxygen-producing microalgae (MA) along with its essential nutrients (agarose and sodium bicarbonate). Its exterior is coated with a photothermal material, forming a core-shell structured scaffold capable of autonomously cultivating microalgae while exhibiting excellent oxygen-producing activity and photothermal performance. By employing 3D bioprinting to apply this living autotrophic scaffold to infected wounds, we have achieved effective alleviation of local hypoxia, reduction of oxidative stress, and concurrent inhibition of bacterial infections. These combined effects significantly promoted neoangiogenesis, collagen accumulation, and tissue regeneration in infected wounds. Thus, our autotrophic photosynthetic 3D-bioprinting scaffolds hold substantial potential and value for clinical applications in wound healing.
✓ 已验证
产品关联
DOI
高影响因子
Science China-Chemistry
·
2026
·
IF 9.8
Lai Xiangting,Sun Qian,Zhang Meng,Jiang Zhongtian,Xiong Xueru,Wang Kaojin,Wu Gang,Sun Guoxing,Jia Yong-Guang,Zhu Xiaoxia
Hydrogel matrices for flexible electronic devices need to meet multiple criteria, including robust mechanical properties, appropriate skin adhesion, and high conductivity. Conventional hydrogels, however, often suffer from limitations such as hysteresis fatigue, poor adaptability, and structural fragility. In this work, we designed a series of polymerizable, water-soluble molecular slide-ring (MSR) units with precise host-guest molar ratios. These MSRs are based on bile acid guests functionalized with hydrophilic poly(ethylene glycol) chains of varying lengths, which specifically recognize host acrylate β-cyclodextrins. Subsequent photopolymerization of the MSRs with acrylamide yielded a range of SR hydrogels exhibiting wide tensile fracture strains and low hysteresis. Furthermore, the incorporation of nanoclay particles of laponite-RDS led to a composite slide-ring hydrogel system with improved toughness, high strength, and stable sensing performance. The composite hydrogel-based sensors not only demonstrate excellent skin adhesion and minimal skin irritation, but also monitor human motion and electrocardiogram signals with high sensitivity in both humans and mice, highlighting their potential for flexible wearable electronics. This study addresses key synthetic challenges associated with traditional slide-ring hydrogels and establishes a new paradigm for developing high-performance slide-ring materials using versatile MSRs.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Jun Zhang,Huiting Lian,Guangming Liu,Qingmei Liu,Bin Liu,Xiaofeng Wei
This study reports an integrated dual-signal microfluidic immunosensor for point-of-care detection of ovalbumin-specific IgE (OVA-sIgE) in interstitial fluid. A pH-responsive composite material, ZIF-8 encapsulating phenolphthalein and surface-conjugated with antimouse OVA-sIgE (ZIF-8@PP∼Abs), was synthesized and characterized. Structural and elemental analyses confirmed the successful synthesis and antibody functionalization, while the composite retained strong alkaline-triggered colorimetric response due to ZIF-8 decomposition and subsequent phenolphthalein release. Carbon dots (CDs) show concentration-dependent fluorescence, which is effectively quenched by ZIF-8@PP∼Abs. A paper-based chip coimmobilized with CDs and OVA antigen enabled simultaneous colorimetric and fluorescent detection. The colorimetric pathway operates as a “turn-on” system through alkaline-induced color change, while the fluorescent pathway functions as a “turn-off” system via CDs quenching by ZIF-8@PP∼Abs. Quantitative analysis using the green channel─identified as the most sensitive through RGB decomposition─showed linear responses across 0.06–8.00 ng/mL OVA-sIgE, with detection limits of 0.026 ng/mL (colorimetric) and 0.032 ng/mL (fluorescence). The dual-signal design, featuring built-in cross-verification, demonstrates high reliability through favorable spike-and-recovery results. ROC analysis shows AUC values of 0.9999 for both signals, with a significant reduction in false positives. To achieve operational integration, a custom-designed negative-pressure-driven microfluidic chip was developed, incorporating all necessary steps into a negative-pressure valve-controlled microfluidic chip. The chip demonstrated robust fluid handling, repeatable operation, and user-friendly functionality. The integrated sensor exhibited excellent selectivity, strong anti-interference capability against common interstitial fluid constituents. This work presents a practical, accurate, and reliable platform for decentralized allergy testing, merging advanced nanomaterials, dual-mode transduction, and microfluidic engineering.
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2026
·Vol. 12
·期 8
·4330-4341
·
IF 6
Sun Yikun,Li Mingjun,Hao GuiPeng,Yang Zhen,Yang Lei
Postoperative re-tear remains a prevalent challenge in rotator cuff repair. To address this, we developed a bioactive glass composite rotator cuff patch (BCP) with heterogeneous structural design to promote tendon−bone interface regeneration. The BCP features an outer barrier of hydrophobic poly (lactic acid) (PLA) electrospun membrane, which prevents infiltration of inflammatory fibrotic tissue. The inner structure, fabricated via a dual-nozzle 3D printing strategy, comprises gelatin methacryloyl (GelMA) hydrogel layers differentially loaded with zinc-doped (ZnBG) or strontium-doped (SrBG) bioactive glass, targeting the tendon and bone regions, respectively. Bioactive glass enables sustained ion release within the physiological environment, establishing distinct ionic microenvironments across the tissue interface. In vitro , ZnBG-released ions significantly promoted the proliferation and migration of tendon-derived stem cells, upregulated mature tendon matrix expression, and inhibited fibrotic scarring. Conversely, SrBG-released ions enhanced the osteogenic differentiation and mineralization potential of bone marrow mesenchymal stem cells. In vivo evaluation further demonstrated that the BCP effectively facilitated organized collagen regeneration and improved the quality of its integration with bone. Additionally, the BCP favorably modulated the local immune microenvironment toward a reparative phenotype. In summary, this study presents an innovative biomaterial strategy for achieving comprehensive structural and functional regeneration of the tendon−bone interface following rotator cuff injury.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2026
·
IF 6.7
Yu Liu,Qizheng Bi,Xiaoning Chu,Zhihao Dang,Junmin Hui,Zhuo Liu,Congkui Tian
The detection of leucine aminopeptidase (LAP) activity is essential for diagnosing liver cancer and liver injury. This study presents a novel fluorescence-based method designed for the sensitive detection of LAP through cascade catalytic reactions. Leucine-histidine (LeH) was synthesized using histidine and leucine as substrates for LAP. Notably, histidine (His) effectively inhibited the Cu 2+ -catalyzed oxidation of o-phenylenediamine (OPD) to fluorescent 2,3-diaminophenazine (oxOPD), resulting in a diminished fluorescence signal. Given that LAP hydrolyzes LeH to release His, which subsequently inhibits the Cu 2+ -OPD system, LAP activity can be quantitatively assessed by measuring fluorescence changes during the hydrolysis process. The exceptional performance of the Cu 2+ -OPD system in quantifying His allowed for highly sensitive LAP detection, achieving a detection limit as low as 0.05 U/L. Furthermore, the strategy was successfully implemented to evaluate LAP activity in cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2026
·
IF 10.4
Haifei Cao,Yicheng Ding,Xingzhi Liu,Junchao Luo,Junjie Niu,Huan Zhao,Xichao Zhou,Xiaozhong Zhou,Yong Xu,Huilin Yang,Qin Shi
Spinal cord injury (SCI) disrupts the local microenvironmental niche, resulting in persistent neuroinflammation, vascular dysfunction, and impaired neuronal regeneration, presenting a significant challenge for tissue repair. In this context, hydrogels offer a versatile strategy for targeted and sustained therapeutic delivery and localized microenvironmental modulation. To facilitate niche restoration following SCI, we developed a bioinspired platform by integrating KTPSLEQRTVYAKGGIKRGK-brain-derived neurotrophic factor mimetic peptides (TPS-BDNF) into a dopamine-modified gelatin methacryloyl hydrogel. In vitro and in vivo studies demonstrated that the proposed hydrogel exhibits optimal injectability, shear-thinning behavior, and intrinsic antioxidant and anti-inflammatory properties, thereby facilitating minimally invasive delivery and localized microenvironment modulation. Furthermore, the TPS-BDNF endows the multifunctional hydrogel with sustained neurotrophic and pro-angiogenic cues that promote the restoration of the neurovascular niche and subsequent functional recovery after SCI. In summary, the bioinspired hydrogel offers a promising, clinically translatable approach to synergistic niche remodeling for the restoration of neuronal function following SCI. Statement of significance The gelatin methacryloyl (GelMA) /dopamine/Polyethylene glycol-conjugated KTPSLEQRTVYAKGGIKRGK-brain-derived neurotrophic factor mimetic peptides (TPS-BDNF) (GDP) hydrogel represents a significant advance for spinal cord injury (SCI) therapy by simultaneously promoting neurogenesis and angiogenesis while delivering strong anti-inflammatory and antioxidant effects. By integrating TPS-BDNF with a GelMA-based matrix, GDP remodels the lesion microenvironment, enhances endogenous neural stem cell mobilization and neuronal differentiation, and improves functional recovery in SCI animals, all with injectable, controllable release and minimal systemic toxicity. This platform holds strong potential for translation to human SCI treatment. Download: Download high-res image (372KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Tong Qi,Xiao Wang,Yijing Han,Chengqi He
The regeneration and functional rehabilitation of peripheral nerve defects remain major clinical challenges. Piezoelectric materials have the potential to restore both nerve morphology and function. Conventional grafts struggle to repair nerves with complex structures. To address this issue, band-aid–inspired tissue-adhesive membranes were designed to accommodate diverse nerve diameters and branching structures. Electrospinning was used to prepare a Janus membrane that served as a suture-free piezoelectric nerve repair membrane. The inner layer comprised oriented adhesive hydrogel fibers fabricated from gelatin methacryloyl and tannic acid, whereas the outer layer comprised piezoelectric silk fibroin fibers that provided barrier function and structural support. In vivo experiments demonstrated that this membrane streamlined surgery, enabled rapid and facile bridging of complex peripheral nerve defects, and significantly facilitated morphological and functional nerve recovery. This finding holds significant promise for advancing personalized, simplified, and more effective clinical management of peripheral nerve defects. Additionally, it is anticipated to treat defects in other tissues and organs, specifically those with irregular morphologies.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 35
·48286-48296
·
IF 7.8
Liu Di,Zhang Ruoyu,Zhai Fei,Ji Zhongying,Shi Xinyan,Lyu Yang,Wang Xiaolong
Conventional microfluidic chips fabricated from polydimethylsiloxane (PDMS), glass, and silicon suffer from intrinsically fixed surface wettability, tedious post-modification, and inhomogeneous wetting inside enclosed three-dimensional (3D) microchannels, which severely restrict their applications in biphasic fluid manipulation. Herein, we develop a photocurable poly(vinyl alcohol) (PVA)-based hydrogel featuring a triple synergistic network for digital light processing (DLP) 3D printing of integrated microfluidic devices. Under acidic catalysis, glutaraldehyde (GA) undergoes acetalization with PVA to form the first crosslinked network, which consumes hydrophilic hydroxyl groups and introduces hydrophobic alkyl segments. Subsequently, the hydrogel framework is co-constructed by a PVA hydrogen-bonding physical network and a UV-initiated covalent network derived from acrylamide (AAm), acrylic acid (AAc), and poly(ethylene glycol) diacrylate (PEGDA), ultimately yielding a triple-crosslinked network. By adjusting the GA loading, the water contact angle of the hydrogel can be continuously tuned from 15.42 ° (hydrophilic) to 111.66 ° (hydrophobic). Benefiting from the interpenetrating multi-network architecture, the tensile strength increases from 48.76 kPa to 118.27 kPa, and the elastic modulus increases from 14.72 to 63.84 kPa. DLP 3D printing enables the direct fabrication of monolithic microfluidic chips with smooth microchannels down to approximately 160 μm in width, without requiring any post-treatment. Fluorescence characterization confirms that the hydrophilic channels allow stable laminar flow of deionized water, while the hydrophobic channels enable low-friction transport of mineral oil. This work establishes a comprehensive strategy integrating molecular design, wettability programming, and 3D additive manufacturing, providing a scalable platform for applications in fluid transportation, biochemical detection, environmental monitoring, and wearable microfluidics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Zhang Yongfeng,Dong Ting,Xie Kaifang,Lin Jia-Horng,Han Guangting,Chen Que,Chi Shan,Lou Ching-Wen
Photothermal aerogel fibers offer promise for intelligent
thermal management in extreme cold environments, yet their scalable
production is hindered by slow gelation kinetics, poor mechanical
strength, and limited dyeability. Herein, we report an in situ photo-cross-linking
strategy for the fast gelling fabrication of dyeable photothermal
aerogel fibers, using thermoplastic polyurethane (TPU) as the sheath
and methacrylated chitosan (CSMA) aerogel as the core. The photosensitive
CSMA core cross-links within 15 s under UV irradiation, enabling fast
sol–gel transition in a deionized-water coagulation bath within
1 min. The trade-off between dyeability and photothermal performance
is addressed by incorporating cesium tungsten bronze (CWO) nanoparticles
into the TPU sheath layer or in situ polymerizing polypyrrole (PPy)
in the CSMA core layer, whereby light-blue TPU/CWO@CSMA fibers and
near-white TPU@CSMA-PPy fibers were developed. Both fibers exhibit
excellent mechanical properties (tensile strength 3.1–3.3 MPa,
elongation >1600%) and low thermal conductivity (0.047 ± 0.0004
W·m –1 ·K –1 ), achieving
a good synergistic optimization of passive thermal insulation and
active photothermal heating performance. They also display good dyeability
for multicolored fabrication while maintaining strong photothermal
performance. TPU/CWO@CSMA fibers heat to 66.7 ° C under 1-sun
illumination and reach 19.2 ° C at −20 ° C via CWO’s
LSPR effect. TPU@CSMA-PPy fibers show mild, controllable warming (≈16
° C at −7 ° C; 20 ° C at 0 ° C) with slower
cooling. Outdoor tests confirm fabric temperatures remain in a mild
25–34 ° C range without overheating. This work overcomes
the long-standing technical bottleneck of conventional photothermal
aerogel fibers that are typically restricted to single, undyeable
colors, demonstrating promising potential for personal thermal management
and related applications.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）