JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Liangyun Yu,Jiajun Li,Jingjing Zhang,Xue Chen,Meng Yuan,Qi Zhang,Baocai Xu,Zhiliang Yao,Qin Xu
The accurate measurement of nitrophenols (NPs) in fine particulate matter (PM 2.5 ) is critical because NPs are identified as the main constituents of brown carbon in PM 2.5 , which influence the global radiative forcing and regional climate. Herein, we presented a specific and ultrasensitive photoelectrochemical (PEC) sensor (MIPs/Bi 2 WO 6 @GH/ITO) for 4-nitrophenol (4NP) detection by electrodepositing molecularly imprinted polymers (MIPs) polypyrrole on indium tin oxide coated glass (ITO) electrode modified with dual 3D structural Bi 2 WO 6 @graphene hydrogel (GH) composites. The composites were successfully synthesized through the simple one-step hydrothermal method with 3D flower-like Bi 2 WO 6 efficiently distributed on the 3D porous networks of GH. Under optimum conditions, the PEC sensor exhibited a wide linear range of 5.0 × 10 −12 –1.0 × 10 −7 M for 4NP with a low detection limit of 5.78 × 10 −13 M. MIPs/Bi 2 WO 6 @GH/ITO was further successfully applied for 4NP assay in PM 2.5 . The results indicated that the developed PEC sensor had broad applications for NPs detection in the environmental fields.
研究领域:
环境科学
·
材料科学
·
分析化学
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产品关联
DOI
高影响因子
BUILDING AND ENVIRONMENT
·
2019
·
IF 4.82
Ye Bian,Shijie Wang,Li Zhang,Chun Chen
Electrospinning is a versatile technique to fabricate nanofiber filters with high PM 2.5 removal efficiency and relatively low pressure drop. The eletrospun nanofiber filters may therefore be applied in buildings to reduce indoor exposure to PM 2.5 and the associated adverse health effects . This study investigated the influence of various filter parameters, including fiber diameter , filter thickness, and packing density, on the PM 2.5 removal efficiency. In this work, 25 nylon electrospun nanofiber filters with different filter parameters were prepared, and the PM 2.5 removal efficiency of each sample was measured at five different face velocities. In total, 125 sets of measured data were obtained. The results show that the PM 2.5 removal efficiency of nylon electrospun nanofiber filters was negatively associated with the fiber diameter, and positively associated with the thickness of the filter. However, there was no clear correlation between PM 2.5 removal efficiency and packing density. This investigation further developed a semi-empirical model for predicting the PM 2.5 removal efficiency of nylon nanofiber filters. The accuracy of the model was satisfactory with a median relative error of 7.9%.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Yadong Zhang,Rui Wen,Jingyi Ren,Fan Zhang,Huanting Pei,Jinshi Zuo,Yuxia Ma
Introduction: Exposure to fine particulate matter (PM2.5) is known to be associated with cardiovascular diseases. Sesamin (Ses) is a natural phenolic compound found in sesame seeds and sesame oil. Ferroptosis is a novel mode of cell death characterised by iron-dependent lipid peroxidation. This study aims to explore whether PM2.5 can induce ferroptosis in H9C2 cells and to investigate the precise protective mechanism of Ses.Methods: Based on transcriptomic data, PM2.5 may induce ferroptosis in cardiomyocytes. The ferroptosis inducer erastin and ferroptosis inhibitor ferrostatin-1 (Fer-1) were used to illustrate the mechanisms involved in PM2.5-induced H9C2 cell injury. Using network pharmacology, the pharmacological mechanism and potential therapy targets of Ses were explored for the treatment of PM2.5-induced cardiomyocyte injury. H9C2 cells were cultured and pretreated with Fer-1 or different concentrations of Ses, and then cardiomyocyte injury model was established using erastin or PM2.5. Indicators of oxidative responses, including total superoxide dismutase, reduced glutathione, glutathione peroxidase and malondialdehyde, were measured. The expression levels of ferroptosis-related proteins were determined through Western blot analysis.Results: Results demonstrate that PM2.5 induces ferroptosis in H9C2 cells and Ses exerts a protective effect by suppressing ACSL4-mediated ferroptosis.Discussion: Overall, these findings elucidate a novel mechanism by which Ses ameliorates the detrimental effects of PM2.5 on cardiomyocytes.
研究领域:
心血管疾病
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药理学
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毒理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Kunyi Zhao,Bo Lin,Ling Ma,Qi Zan,Rui Wang,Ruijin Li,Yu Wang,Shaomin Shuang,Chuan Dong,Li Fan
Elucidating the intrinsic relationship between viscosity and lipid droplet (LD)-related diseases remains challenging, due to the lack of sufficient attention and effective tools. So far, the visualization of abnormal LD viscosity in PM 2.5 exposure-induced lung injury model, and malignant tumor tissues containing clinical cancer patient samples has not been achieved. Herein, we developed a novel LD-targetable and viscosity-sensitive fluorescent probe DPTP , based on diphenylamine-thiophene structure with multiple rotatable single bonds. DPTP displays an excellent selectivity and sensitivity toward viscosity changes in the range of 0.89–945 cP. Meanwhile, DPTP has excellent LD-targetable ability, and can monitor the increased viscosity level in the ferroptosis, inflammation, and heavy metal-induced cell injury models, respectively. Furthermore, facilitated with DPTP , we have successfully revealed a rise of LD viscosity in ambient PM 2.5 exposure-induced lung injury, and non-alcoholic fatty liver (NAFL) models. Significantly, the visualization of LD viscosity has also been achieved in tumor tissues containing surgical specimens of cancer patients for the first time, making DPTP a promising tool for cancer diagnosis and imaging-guided surgery.
研究领域:
生物化学
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分子生物学
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毒理学
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癌症研究
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药理学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
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2019
·
IF 5.667
Yixian Zhang,Haolan Zhang,Zhengwei Mao,Changyou Gao
Although the negative impacts of particulate matter (PM2.5) on human health have been well recognized, very few efforts have been paid to find new strategies to suppress the toxicity of PM2.5 both in vitro and in vivo. In this study, reactive oxygen species (ROS)-responsive nanoparticles made of poly(1,4-phenleneacetonedimethylene thioketal) (PPADT) were used to load immunosuppressant drug tacrolimus (FK506) with a drug loading efficiency of around 44%. The PPADT particles showed very good ROS-responsiveness and were degraded in an oxidation environment. By exhausting intracellular ROS, they could effectively suppress the toxicity of A549 lung epithelial cells and RAW264.7 macrophages induced by the PM2.5 particulates collected from three different regions in China. Moreover, the inflammatory response of PM2.5 could also be significantly suppressed, showing much better performance than the free FK506 drugs both in vitro and in vivo. This concept-proving research demonstrates the promising application for the ROS-sensitive drug release particles in dispelling the toxicity and suppressing the inflammation of PM2.5 pollutes, shedding a new light in the design and applications of stimuli-responsive systems in the bionanotechnology and healthcare fields.
研究领域:
纳米技术
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生物医学工程
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环境科学
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药学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
·
2021
·Vol. 47
·期 4
·1-1
·
IF 4.101
Shuo Yang,Xiao-Long Huang,Jin Chen,Li-Na Mao,Xu Liu,Wen-Sheng Yuan,Xiao-Jie Wu,Guang-Wei Luo
Fine particulate matter (PM2.5) with an average aerodynamic diameter of <2.5 µm can cause severe lung injury. Oxidative stress and inflammation are considered the main outcomes of PM2.5 exposure. Curcumin is a well‑known antioxidant; however, its effect on PM2.5‑induced oxidative injury in airway epithelial cells remains unclear. In the present study, it was demonstrated that pre‑treatment with curcumin significantly reduced the PM2.5‑induced apoptosis of BEAS‑2B human bronchial epithelial cells by decreasing the level of intercellular reactive oxygen species. Western blot analysis revealed that curcumin increased the expression of nuclear factor erythroid 2‑related factor 2 (NRF2) and regulated the transcription of downstream genes, particularly those encoding antioxidant enzymes. Moreover, curcumin reduced the PM2.5‑induced expression and production of inflammatory factors, and induced the expression of the anti‑inflammatory factors, interleukin (IL)‑5 and IL‑13. Taken together, the present study demonstrates that curcumin protects BEAS‑2B cells against PM2.5‑induced oxidative damage and inflammation, and prevents cell apoptosis by increasing the activation of NRF2‑related pathways. It is thus suggested that curcumin may be a potential compound for use in the prevention of PM2.5‑induced tissue injury.
研究领域:
药理学
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毒理学
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细胞生物学
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环境健康
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产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2023
·
IF 6.8
Qingyun He,Wuduo Zhao,Peiru Luo,Lingyun Wang,Qiannan Sun,Wenfen Zhang,Dan Yin,Yanhao Zhang,Zongwei Cai
As one of the most important transportation hubs and industrial bases in China, Zhengzhou has suffered from serious PM 2.5 pollution for a long time. However, the investigation of contamination status and possible exposure risks of environmentally persistent free radicals (EPFRs) in PM 2.5 from Zhengzhou is rare. In this work, a comprehensive study of pollution levels, seasonal variations, sources, and potential health risks of PM 2.5 -bound EPFRs in Zhengzhou was conducted for the first time. The atmospheric concentrations of EPFRs in PM 2.5 from Zhengzhou ranged from 1.732 × 10 12 spin m −3 to 7.182 × 10 14 spin m −3 between 2019 and 2020. Relatively serious contamination was noticed in winter and spring. Primary fossil fuel combustion and Fe-mediated secondary formation were apportioned as possible sources of PM 2.5 -bound EPFRs in Zhengzhou. Moreover, to avert the bias of the toxicity assessment induced by utilization of incompletely extracted EPFRs from sample filter, simulatively generated EPFRs were applied to toxicological evaluations (cell viability and reactive oxygen species assays). Corresponding experimental dosages were based on the estimated adults’ annual exposure amounts of EPFRs in real PM 2.5 samples. The results elucidated that EPFRs might cause growth inhibition and oxidative stress of human lung cells, suggesting the possible exposure-induced health concerns for local people in Zhengzhou. This study provides practical information of real contamination status of PM 2.5 -bound EPFRs in Zhengzhou, which is favorable to local air pollution control and reduction of exposure risks on public health in central China.
研究领域:
环境科学
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公共卫生
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毒理学
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空气污染
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 20
·2475-2485
·
IF 3.4
Yi Wang,Yu Miao,Yuxin Cai,Enfu Wang,YiPeng Liang,Jinhuan Zhong,Wenbiao Zhang,Jingda Huang
Development of water-soluble polymer air filtration materials attracts considerable attentions due to their environmentally friendly performance and high efficiency, but the balance of mechanical strength, efficiency and pressure drop still is a severe challenge. Focusing on this issue, polyvinyl alcohol (PVA), bamboo activated carbon (BAC) and sodium lignosulfonate (Ls) were combined to construct an electrospinning system with two filtration functions. In the PVA@Ls@BAC system, the 3D network constructed by the electrospun PVA based nanofibrous could effectively intercept PM2.5, and the introduced Ls enhanced the mechanical strength of PVA nanofibrous due to its good rigidity. In addition, the added negatively charged BAC facilitated the electrostatic adsorption of PM2.5 while also improved the heat resistance of the system. Moreover, polydimethylsiloxane (PDMS) was introduced to enhance the water resistance of the system. The resulting electrospun PVA@Ls@BAC@PDMS composite nanofibrous air filtration membrane exhibited excellent air filtration performance (98.67%), water repellency (123.7° of WCA), and reusable performance, as well as having good mechanical property and the tensile fracture strain reaching 112%. Because of its good performance and simple preparation process, the electrospun PVA@Ls@BAC@PDMS composite nanofibrous air filtration membrane has great application space. Graphical
研究领域:
材料科学
·
环境工程
·
纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Xu Zhang,Xiangbo Ji,Zifang Peng,Yanhao Zhang,Zongwei Cai,Shusheng Zhang
Due to the complicated sample matrix and low concentration, analysis of small-molecule emerging environmental pollutants generally required complex sample preparation and long instrumental detection. It guarantees the sensitivity but is not conducive to rapid screening. In this work, a p -aminoazobenzene ( p -AAB) with excellent energy absorption capability was used to modify multilayer Ti 3 C 2 T X (MXene) to prepare novel material p -AAB/MXene. The modification significantly improved the laser absorption of original material, and made p -AAB/MXene could be employed as matrix for surface-assisted laser desorption/ionization-time of flight-mass spectrometry (SALDI-TOF MS) analysis of small-molecule emerging pollutants. More importantly, p -AAB/MXene could be used as adsorbent to enrich target compounds, then directly sent to SALDI-TOF MS detection without any other sample pre-treatment. Dual characteristics of enrichment material and matrix made p -AAB/MXene-based SALDI-TOF MS method successfully be applied to rapid and accurate detection of emerging environmental pollutants, p -phenylenediamine-quinones (PPDQs) and diamide insecticides (DAIs), in food (beverage) and environmental (PM 2.5 ) samples. High sensitivity (LOD at ng mL -1 level) and satisfactory precision (RSD < 11%) indicated the qualified analytical performance of developed approach. The determined concentrations also elucidated the broad occurrence of PPDQs and DAIs in beverages and PM 2.5 . The results further confirmed the SALDI-TOF MS using p -AAB/MXene as both adsorbent and matrix had considerable potential for efficient and time-saving analysis of trace and ultra-trace small-molecule emerging environmental organic pollutants in complicated samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Exploration
·
2024
·
IF 0
Qi Gao,Jian Gan,Pixiang Wang,Yuxiang Huang,Daihui Zhang,Wenji Yu
Air pollution is caused by the perilous accumulation of particulate matter (PM) and harmful gas molecules of different sizes. There is an urgent need to develop highly efficient air filtration systems capable of removing particles with a wide size distribution. However, the efficiency of current air filters is compromised by controlling their hierarchical pore size. Inspired by the graded filtration mechanisms in the human respiratory system, microporous ZIF-67 is in situ synthesized on a 3D interconnected network of bamboo cellulose fibers (BCFs) to fabricate a multiscale porous filter with a comprehensive pore size distribution. The macropores between the BCFs, mesopores formed by the BCF microfibers, and micropores within the ZIF-67 synergistically facilitate the removal of particulates of different sizes. The filtration capabilities of PM2.5 and PM0.3 could reach 99.3% and 98.6%, respectively, whereas the adsorption of formaldehyde is 88.7% within 30 min. In addition, the filter exhibits excellent antibacterial properties (99.9%), biodegradability (80.1% degradation after 14 days), thermal stability, and skin-friendly properties (0 irritation). This study may inspire the research of using natural features of renewable resources to design high-performance air-filtration materials for various applications.
研究领域:
材料科学
·
环境工程
·
化学工程
·
生物医学
✓ 已验证
DOI
Polymers
·
2018
·Vol. 10
·期 12
·1386
·
IF 2.935
Yan Hong,Chunyu Liu,Xuechun Cao,Yu Chen,Chen Chen,Yan Chen,Zhijuan Pan
Metal-organic frameworks (MOFs) have been regarded as an ideal material for the development of functional textiles with filtration function. Such functional textiles with filtration function can be further used to develop personal protective equipment, such as protective masks. This paper focuses on the comparisons of different processes when applying MOFs to conventional textiles. Two different processes existing in the literature, namely the electrospinning method and hot-pressing method, are discussed in this paper. Materials loaded with MOFs developed with these two processes are evaluated and compared, regarding the adsorption of dyes in water and the removal of pollutants. Experiment results indicate that the hot-pressing method is more advantageous when applying MOF to textiles, in terms of adsorption and removal efficiency.Keywords:MOFs;electrospinning;hot-pressing;PM2.5;PM10;PM1.0
研究领域:
材料科学
·
环境科学
·
纺织工程
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Jingnan Lu,Ran Wang,Manzi Hu,Kezhou Cai,Xinglan Du,Jieshun Cheng,Haimei Hu,Hui Zhou,Baocai Xu
Benzo( a )pyrene (B( a )P) is a structurally stable and carcinogenic compound, and B( a )P deposition and transport from smoking environment particulates to smoked meat products is a global challenge. In this study, a novel photosensitive bifunctional composite gel (ST/SiO 2 -Mn) was successfully synthesized as a reliable material for reducing PM 2.5 -B( a )P in the smoke environment. B( a )P removal experiments demonstrated that the adsorption and filtration properties of the gel effectively reduced the emission of PM 2.5 -B( a )P in smoke environment. The ST/SiO 2 -Mn gel removed 88.5 % of PM 2.5 -B( a )P in 240 min, which further led to a 59.7 % decrease in B( a )P on the sausage surface. In addition, photocatalytic experiments demonstrated that the ST/SiO 2 -Mn composite could effectively remove B( a )P, and 50 μg/mL B( a )P could be completely degraded within 20 min. Free radical trapping experiments showed that superoxide radicals (•O 2 -) contributed significantly to the degradation process. In conclusion, this study provides valuable insights for effective PM 2.5 -B( a )P degradation without increasing economic burden.
研究领域:
食品安全
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）