DYES AND PIGMENTS
·
2016
·
IF 4.055
Yue Li,Fengli Zhang,Xiao-Feng Wang,Gang Chen,Xueqi Fu,Wenjing Tian,Osamu Kitao,Hitoshi Tamiaki,Shin-ichi Sasaki
Herein three synthesized chlorophyll derivatives (ZnChl-1, H 2 Chl-2, ZnChl-2) featuring hydrophilic hydroxy/carboxy groups were employed as precursors for fluorescent organic nanoparticles (NPs) with biocompatible Pluronic F127 as the encapsulation matrix for the first time. Such red NPs exhibited broad absorption bands and high hydrophilicity . Three chlorophyll derivatives with different substituent groups show varying degrees of changes after loaded with F127. As a result, ZnChl-2 exhibited the best retainable photoluminescence yield after encapsulation among these chlorophyll derivatives. It reveals that ZnChl-2@F127 is the most suitable NPs for cell imaging by comparing not only different three chlorophyll derivatives, but also free ZnChl-2 and ZnChl-2@F127. Application of ZnChl-2@F127 NPs for cancer cell imaging was successfully demonstrated and such chlorophyll-based NPs showed bright fluorescence signals and low toxicity. These studies indicate that the F127 encapsulated low-costed chlorophyll derivatives NPs are efficient fluorescent dyes for biological imaging. It is further directed towards photodynamic therapy based on chlorophyll derivatives.
研究领域:
生物医学工程
·
材料科学
·
光学成像
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Yang Zhang,Siru Zhou,Zhenglei Li,Haoquan Zhang,Meng Zhang,Jun Wang,Lingling Chen,Hongwei Zhang
Pore forming agent or hydrophilic additives are necessary for the optimization of membrane pore structure and surface physicochemical properties. Although it has been demonstrated that the blending additives tends to locate around membrane pore walls due to segregation and this would further leach out in practical operations, the impact of additives fate on membrane pore structure as well as sieving performance is almost overlooked in literatures. In this study, five kinds of Pluronic copolymers with different molecular architectures were employed for casting PSF UF membranes, and the fate of these copolymers in membrane matrix was explored by combing FTIR and XPS spectra with TG analysis . More importantly, the evolutions of membrane mean pore radius (r*) and radius distribution (σ) after additive leaching were quantitatively investigated based on the modified Steric Pore Model (SPM). In passive solute sieving experiments, the increment of r* and σ possessed positive correlation with the degree of polymerization (DP) of EO segments within the corresponding additive. The results of thermoporosimetry and saline filtration experiments further evidenced that such a correlation should be attributed not only to the steric hindrance of EO segment, but also to its hydration ability. Moreover, the intrinsic polymer geometry (r ST ) was also a crucial factor for understanding the evolutions of membrane pore structure during additive leaching. Especially for membranes having small r ST , both the isopropanol (IPA) treatment and poly-dopamine (PDA) decoration experiments suggested that pore enlargement and the generation of new small cavities would occur simultaneously during additive leaching, making the prediction complicated. Finally, we proposed that the relative synthetic aperture (RSA) could serve as a complementary indicator for understanding and describing the pore enlargement behavior of a blended UF membrane. In an industrial point of view, it also offers a new way to evaluate and predict the long-term performance and stability of a blending modified porous membrane.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Peihong Li,Chunling Zhang,Rui Li,Lijie Qu,Xueyan Dai,Yanlong Sui,Jiazi Hou
Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, α-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127−α-CD hydrogels. This study explored the temperature-dependent sol–gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%–8.0% weight content of F127. The cross-linking points in this system were PEO−α-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127−α-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.
研究领域:
药剂学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
ANALYST
·
2014
·Vol. 140
·期 3
·797-802
·
IF 3.906
Chong Sun,Daoying Wang,Muhan Zhang,Yanxiu Ni,Xiaohui Shen,Youchao Song,Zhiming Geng,Weimin Xu,Fang Liu,Chun Mao
The development of advanced nanomaterials for the highly efficient electrical detection of biological species has attracted great attention. Here, novel polypyrrole-Pluronic F127 nanoparticles (PPy-F127 NPs) with conducting and biocompatibility properties were synthesized and used to construct a L-lactic acid biosensor that could be applied in biochemical assays. The PPy-F127 NPs were characterized by transmission electron microscopy (TEM), elemental analysis and UV-vis spectroscopy. Lactate oxidase (LOx) structure variation on the PPy-F127 NPs was investigated by circular dichroism (CD). The cyclic voltammetric results indicated that LOx immobilized on the PPy-F127 NPs exhibited direct electron transfer reaction with a formal potential value (E0′) of 0.154 V vs. SCE. Moreover, the biosensor had good electrocatalytic activity toward L-lactic acid with a wide linear range (0.015–37.5 mM) and a low detection limit of 0.0088 mM. The regression equation was I (μA) = 0.02353c (mM) + 1.4135 (R2 = 0.9939). The L-lactic acid biosensor had a good anti-interference property towards uric acid (UA), ascorbic acid (AA), glucose and cysteine. The idea and method provide a promising platform for the rapid development of biosensors that can be used in the detection of biological species.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2018
·
IF 0
Xiang-Qian Zhang,An-Hui Lu,Qiang Sun,Xiao-Fei Yu,Jun-Yue Chen,Wen-Cui Li
Ordered carbon spheres with enlarged mesopores have been considered to be desirable carbon electrodes for ionic liquid-based supercapacitors. New synthesis of these materials to use commercially available soft templates is yet to be developed. In this study, we demonstrate that by silica encapsulation of self-assembled polymer nanospheres prepared using commercially available Pluronic F127, mesopore sizes of obtained carbon nanospheres can be enlarged from micropores to large mesopores up to 10.7 nm in size. A linear relationship between the mesopore size and the thicknesses of silica nanocages has been established, which enables us to alter the mesopore sizes in a controlled manner. The two-electrode test in EMI-BF4 electrolyte demonstrates that mesoporous carbon nanospheres show a capacitance of up to 113 F g–1 at 10 A g–1. They also exhibit an excellent energy density (E) of 56 W h kg–1 (working voltage of 4.0 V). Such high capacitance, outstanding rate capability, and excellent power density (P) are owing to enlarged mesoporous channels and large specific surface area allowing rapid mass transportation and full use of the surface area.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Yijie Si,Huanyu Bai,Caifu Yi,Xuebin Song,Chengliang Duan,Daliang Guo,Linxin Zhong,Zhou Sha,Jing Li,Yinchao Xu,Xin Zhang
This study reports a novel method for fabricating carbon paper (CP) self-supporting electrodes via the synergistic modification of phenolic resin with Pluronic F127 and boron-nitrogen co-doped carbon (CNB). Results demonstrated that the soft-templating effect of Pluronic F127, in conjunction with the synergistic heteroatom doping derived from urea (N) and boric acid (B), facilitated the formation of a mesopore-dominated hierarchical pore structure within the CP self-supporting electrodes. The F127-CNB@CP electrode exhibited the tensile and flexural strengths of 11.40 MPa and 633.83 MPa, which are 146% and 77% higher than those of CP electrode, respectively. It also exhibited lower in-plane and through-plane resistivities, which was attributed to attributed to improved interfacial electron transport pathways. Electrochemical tests revealed that the F127-CNB@CP electrode delivered an areal capacitance of 1589.93 mF cm −2 at a current density of 1 mA cm −2 , retains 81.4% of its capacitance at 10 mA cm −2 ，and achieves energy and power densities of 0.22 mWh cm −2 and 4.85 mW cm −2 , respectively. A symmetric supercapacitor assembled with F127-CNB@CP electrode maintains 92.8% of its initial capacitance after 30,000 cycles, delivering an energy density of 0.14 mWh cm −2 and a power density of 0.9 mW cm −2 . This work provides new insights and a theoretical basis for the design of high-performance CP based self-supporting supercapacitor electrodes.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Yan Zheng,XiaoDong Lv,Yong Xu,Xu Cheng,Xin Wang,Rupei Tang
It remains a crucial challenge to achieve efficient cellular uptake in tumor cells for nanoscale drug delivery systems. This work described that two multi-functional pullulan nanogels were prepared by co-polymerization between methacrylated pullulan (Pullulan-M) and different crosslink agents, an acid-labile ortho ester-modified pluronic (L61-MOE) or non-acid-sensitive methacrylated pluronic (L61-M). The prepared nanogels showed a regular spherical structure with the size about 200 nm measured by dynamic light scattering and transmission electron microscopy (TEM). Doxorubicin as a model drug was successfully encapsulated into nanogels. As expected, Pul-L61-MOE showed pH-dependent DOX release, and 25% of DOX was released at pH 7.4 while 84.48% of DOX was released at pH 5.0. In vitro cellular uptake and MTT results indicated that pH-sensitive nanogels (Pul-L61-MOE) displayed higher cellular internalization and cytotoxicity than acid-insensitive nanogels (Pul-L61-M) and free DOX. Flow cytometry assay suggested these nanogels remarkably increased intracellular reactive oxygen species (ROS) level and induced more cell apoptosis by the function of pluronic. Finally, in vivo antitumor results indicated that the multi-functional nanogels exhibit supreme antitumor efficiency, and the tumor growth inhibition (TGI) was 83.37%. Therefore, the pH-sensitive pullulan nanogels can be potential nano-carriers for drug delivery in tumor treatment.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Chong Shen,Bin Peng,Ying Wang,Qin Meng
Milk is often polluted by heavy metal ions due to the growing environment pollution, but few methods have been developed to remove the heavy metal ions. Here a non-toxic sorbent, namely di-acrylated Pluronic P123 (P123-DA) hydrogel, was fabricated for removal of Hg 2+ and Pb 2+ from milk without impairing their nutritive contents. This hydrogel possessed high mechanical stress and maximum adsorption capacity of 35.2 and 53.9 mg/g for Pb 2+ and Hg 2+ . The removal ratio of Pb 2+ and Hg 2+ by P123-DA hydrogel respectively reached 85.3% and 81.9% for the polluted whole milk while was individually 86.3% and 83.8% for the skim milk. Interestingly, the treatment by P123-DA hydrogel didn’t significantly reduce the main nutritive contents in milk. Such hydrogel will be a recyclable, safe and effective tool for reuse of milk that polluted by heavy metal ions.
研究领域:
食品科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Progress in Natural Science-Materials International
·
2023
·
IF 4.7
Kaiting Cheng,Yiming Fang,Liang Bai,Feng Gui,Junchi Ma,Huimin Gao,Yadong Zhao,Xingtao Xu
In everyday life, traditional dressings such as band-aid and gauze are used for dealing with small wounds. However, these dressings have shortcomings such as pain caused by tearing, inapplicability to joints, single functionality, and adverse reactions. Therefore, there is a great need for an inexpensive, comfortable, and multi-functional wound dressing. In this study, quaternized chitosan (QCS) with a high degree of substitution (107.84 %) was successfully prepared and characterized using ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and proton nuclear magnetic resonance ( 1 H NMR). A series of QCS/F127 thermosensitive hydrogels were prepared by physical cross-linking and used as potential wound dressings. Then the temperature sensitivity, hemostatic ability, antibacterial activity, and sustained drug release effect of the hydrogels were investigated to evaluate their multifunctionality as wound dressings. Finally, the effect of QCS concentration on hydrogel properties was explored. The results show that the composite hydrogels have significant hemostatic, antibacterial, and sustained drug release abilities, and they can be rapidly transformed into a gel state and adhere to skin upon reaching body temperature. In addition, the properties of the hydrogels can be adjusted by varying the concentration of QCS, which allows for the preparation of wound dressings that are responsive to needs. Therefore, multifunctional QCS/F127 hydrogels with temperature-response characteristics are of great clinical research value as wound dressings.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Jun Yin,Hui-fang Zhang
The block copolymer , Pluronic F127- block -poly(acrylic acid) (PAA-b-F127-b-PAA) was firstly synthesized via RAFT polymerization . Then, the copolymer was utilized as the blending modifier for fabricate polyethersulfone (PES)/PAA-b-F127-b-PAA composite membrane by nonsolvent induced phase separation technique. The hydrophilic PAA segments were concentrated onto the membrane surface due to the surface segregation phenomenon in the membrane formation process, which improved the hydrophilicity of the membrane surface and provided active sites for further surface grafting modification. Subsequently, the amine-terminated poly(sulfobetaine methacrylate) (NH 2 -PSBMA) was prepared through ARGET ATRP and used as surface modifier to fabricate PES/PAA-b-F127-b-PAA/PSBMA composite membrane by amination reaction. The composite membrane exhibited the highest pure water flux and oil flux around 358.25 and 217.53 L m −2 h −1 , which equal to 5.6 times and 19.6 times of unmodified PES membrane respectively. The flux recovery rate increased from 45.74% to 94.64%, suggesting the fouling-resistance of the composite membranes was greatly improved. The hydrophobic PPO segments of PAA-b-F127-b-PAA used as anchor segments and amalgamated with PES molecular by hydrophobic interaction and physical intertwisting, resulting in the PAA-b-F127-b-PAA was firmly embedded in the membrane. Moreover, the PSBMA segments were grafted onto the membrane surface by forming strong chemical bonds, exhibiting excellent stability. It shows that this membrane material prepared by physical blending and surface grafting has a good application prospect in oil/water separation.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
AAPS PHARMSCITECH
·
2016
·Vol. 18
·期 1
·147-155
·
IF 1.954
Fang Xiaobin,Xu Yingqi,Wang Shengpeng,Wan Jianbo,He Chengwei,Chen Meiwan
Gambogic acid (GA), a natural compound from gamboge resin, has been introduced as a promising antitumor drug contributing to its broad spectrum of antitumor activity. However, the poor aqueous solubility and short half-life hinder its clinical application. Pluronic F68 (F68) is a well-known amphiphilic block copolymer consisting of hydrophobic propylene oxide units and hydrophilic ethylene oxide. Although F68 has an amphiphilic structure, its short propylene oxide segment limits its dilution stability and drug-loading capacity. To overcome this limitation, we modified F68 by conjugating linoleic acid, a hydrophobic fatty acid, to increase the hydrophilic-hydrophobic interaction and thus improve the stability of F68 nano-spheres. This F68-linoleic acid (F68-LA) conjugate was synthesized and was used to load GA to improve its anticancer effects. GA-loaded F68-LA nano-spheres were stable for 6 days, with a mean diameter of 159.3 nm and zeta potential of −23.2 mV. The entrapment efficiency of GA in F68-LA nano-spheres was as high as 92.0%. Furthermore, F68-LA/GA nano-spheres exhibited an enhanced cytotoxic activity and proapoptotic effect against human ovarian cancer A2780 cells, compared with free GA. Our results showed that the F68-LA/GA nano-spheres might be a promising cancer-targeted drug delivery system in ovarian cancer therapy.
研究领域:
药学
·
纳米技术
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Yunran Zhang,Haiping Zhou,Zhe Zhang,Yijun Zhu,Tao Wang,Liguo Yu,Hongrui Song
Betulinic acid (BA) is a new class of anticancer drug , but its relatively short half-life and poor water solubility limit its therapeutic effect and clinical application. Herein, to tackle the dilemma, BA prodrugs were prepared by conjugating BA onto the polyethylene glycol (PEG) polymer via cleavable disulfide bonds. The prodrugs exhibited high water solubility (270-fold of free BA) and a relatively high drug-loading efficiency of 14.2 %. To further endow the BA prodrugs with a photothermal therapeutic effect, the near-infrared (NIR) agent Cypate was grafted on the Pluronic triblock copolymer . The different PEG polymers and different Pluronic polymers were chosen to obtain the optimal drug loading efficiency and the photothermal generation effect. The P-SS-BA/F68-Cy prodrug micelles integrate the redox-responsive BA prodrugs and the NIR-responsive amphiphilic triblock polymer into one single nanocomposite . The release of BA was less than 20 % in pH 7.4 PBS in the absence of glutathione (GSH), whereas the release of BA was obviously accelerated in pH 5.0 PBS with 10 mM GSH. In addition, the release of BA was further accelerated under the NIR irradiation. The P-SS-BA/F68-Cy micelles showed an excellent photothermal heating effect under NIR irradiation. The prepared P-SS-BA/F68-Cy micelles showed the synergistic thermochemotherapeutic effect on tumors both in vitro and in vivo . Therefore, the present study shows the great potential of dual-triggered drug delivery and thermochemotherapy for combination therapy.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）