Journal of Materials Chemistry B
·
2016
·Vol. 5
·期 4
·849-857
·
IF 4.872
Lingjie Wu,Ming Wu,Xinyi Lin,Xiaolong Zhang,Xiaolong Liu,Jingfeng Liu
Highly efficient accumulation of nanoscaled theranostic agents in a tumor site is crucial for cancer diagnosis and therapy. In this study, we designed a drug-loaded charge-switchable nanohybrid system (HNPs–DA) triggered by the low pH value of tumor microenvironment (pH 6.5) to enhance the uptake efficiency of NPs in cancer cells; the nanohybrid could exhibit T2-MR imaging enhancement and chemotherapy ability, ascribed to the loaded magnetite nanocluster (MNC) and paclitaxel (PTX), respectively. The HNPs–DA comprises two distinct functional components: (1) a biocompatible amphiphilic polymer (Pluronic F127) to act as a nanovehicle for MNC and PTX after self-assembly in an aqueous solution; and (2) a hydrophilic polymeric shell derived from stearoyl-polyethylenimine-2,3-dimethylmalefic anhydride (SC-g-PEI-DMMA). SC-g-PEI-DMMA switches the surface charge of the HNPs–DA from negative to positive by diminishing the anionic part of DMMA and sequentially recovering the cationic instinct of the PEI part at pH 6.5, which could facilitate the cellular uptake and therefore enhance the theranostic effects. In vitro studies demonstrated a darker T2-MRI image in the HNPs–DA-treated HepG2 cells at pH 6.5 as compared to that at pH 7.4. Moreover, CCK8 assay indicated that HNPs–DA exhibited a much higher cytotoxicity against HepG2 cells at pH 6.5, and flow cytometric analysis suggested that the cell death induced by HNPs–DA occurred via apoptosis, which was detected by Annexin V antibody and propidium iodide staining.
研究领域:
生物医学工程
·
癌症治疗
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2015
·
IF 4.762
Cheng-Feng Du,Jian-Rong Li,Bo Zhang,Nan-Nan Shen,Xiao-Ying Huang
Presented here are the syntheses, structures, and properties of an In-Sn-Se compound based on a ternary super-supertetrahedral T2,2 cluster nested by Bmmim cations and two of its alkali-doped quaternary analogues. By means of a one-pot ionothermal method, an alkali metal ion (Cs+ or Rb+) could be precisely doped into the central cavity of the cluster, forming an alkali@T2,2@Bmmim quaternary cluster. Remarkably, the undoped compound exhibited excellent stability and visible light photodegradation ability over a wide range of pH, especially in acidic conditions.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2023
·
IF 6.6
Na Tang,Yi Zhu,Ziwei Lu,Jiali Deng,Jiajing Guo,Xinyi Ding,Jingyi Wang,Rong Cao,An Chen,Zhongyi Huang,Hongwei Lu,Zhongling Wang
MR-guided focused ultrasound surgery (MRgFUS) is driving a new direction in non-invasive thermal ablation therapy with spatial specificity and real-time temperature monitoring. Although widely used in clinical practice, it remains challenging to completely ablate the tumor margin due to fear of damaging the surrounding tissues, thus leading to low efficacy and a series of complications. Herein, we have developed novel pH-responsive drug-loading magnetosomes (STPSD nanoplatform) for increasing the T2-contrast and improved the ablation efficiency with a clinical MRgFUS system. Specifically, this STPSD nanoplatform is functionalized by pH-responsive peptides (STP-TPE), encapsulating superparamagnetic iron oxide (SPIO) and doxorubicin (DOX), which can cause drug release and SPIO deposition at the tumor site triggered by acidity and MRgFUS. Under MRgFUS treatment, the increased vascular permeability caused by hyperthermia can improve the uptake of SPIO and DOX by tumor cells, so as to enhance ultrasound energy absorption and further enhance the efficacy of chemotherapy to completely ablate tumor margins. Moreover, we demonstrated that a series of MR sequences including T2-weighted imaging (T2WI), contrast-enhanced T1WI imaging (T1WI C+), maximum intensity projection (MIP), volume rendering (VR) and ADC mapping can be further utilized to monitor the MRgFUS ablation effect in rat models. Overall, this smart nanoplatform has the capacity to be a powerful tool to promote the therapeutic MRgFUS effect and minimize the side effects to surrounding tissues.
研究领域:
肿瘤学
·
生物医学工程
·
纳米技术
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Jianmin Xiao,Guilong Zhang,Junchao Qian,Xiao Sun,Jie Tian,Kai Zhong,Dongqing Cai,Zhengyan Wu
Magnetic relaxation switch demonstrated that the aggregated nanomagnetic iron oxide (NMIO) nanocrystal possessed a lower T2 value and better relaxivity compared with monodispersed NMIO nanocrystal. However, we found that NMIO nanoclusters (NMIONCs) showed a different magnetic resonance (MR) imaging property in comparison with NMIO nanocrystals. Herein, three types of NMIONCs were used to explore the effects of size and compositions on the variations of magnetism and MR contrast ability. It was found that the transverse relaxation rate (r2) of NMIONCs depended on the contact area between particles and water molecules. The smaller size and higher solubility could carry out higher contact area between NMIONCs and water molecules. Therefore, the monodispersed NMIONC showed a better T2 contrast ability in comparison with the aggregated NMIONC. In addition, for NMIONCs with the same composition, the magnetism and contrast ability gradually increased with the particle size decreasing. In vivo, NMIONCs that possessed the best solubility and the smallest size showed the most effective MR contrast effect for the liver region of mice. As a result, the size and composition of NMIONCs played important roles for enhancing contrast behavior. This study provides a new idea to develop high-performance T2 contrast agents by modulating the size and composition of particles.
研究领域:
材料科学
·
生物医学工程
·
医学影像
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Bio
·
2026
·
IF 11
Yuxing He,Nengyi Ni,Mengmeng Zhang,Yingqi Wang,Haohan Yang,Ke Ren,Yiyao Wang,Qianqian Gao,Mingda Du,Xiao Sun,Hongzan Sun
When traditional T 1 and T 2 contrast agents coexist, the magnetic coupling effect leads to signal interference, which severely limits the synergistic enhancement potential of dual-mode magnetic resonance imaging (MRI). In this study, we introduced an innovative “dispersion-reaggregation” dynamic regulation nano-platform (SPMN) activated by hypoxia and acidity, which achieved T 1 -T 2 dual-signal synergistic enhancement through a two-step distance coordination mechanism. Upon hypoxia-induced dissociation of the nanocarriers, Mn 2+ (the T 1 contrast agent) and SPIO (the T 2 contrast agent) were released. This initial separation prevented signal cancelation due to the magnetic coupling effect. Through dynamic regulation of spatial distance, interference between T 1 and T 2 signals was mitigated, thereby accomplishing the first step of distance coordination. Thereafter, the acidic microenvironment facilitated the aggregation of SPIO via molybdenum (VI)-based polyoxometalate (POM)-mediated protonation and hydrogen bonding, which further increased the distance from Mn 2+ . Notably, the saturation magnetization of SPIO aggregates significantly exceeded that of individual SPIO particles. Consequently, the aggregation of dispersed SPIO enhanced the inhomogeneity of the magnetic field, thereby improving the T 2 signal and achieving the second step of distance coordination, termed “regathering”. In conclusion, SPMN demonstrated substantial dual-modality MRI enhancement and held considerable promise for MRI-guided tumor diagnosis.
✓ 已验证
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 14
·2200841
·
IF 11.092
Gexuan Jiang,Di Fan,Jiesheng Tian,Zhichu Xiang,Qiaojun Fang
Nanomaterials as T 1 / T 2 dual-mode magnetic resonance imaging (MRI) contrast agents have great potential in improving the accuracy of tumor diagnosis. Applications of such materials, however, are limited by the complicated chemical synthesis process and potential biosafety issues. In this study, the biosynthesis of manganese (Mn)-doped magnetosomes (MagMn) that not only can be used in T 1 / T 2 dual-mode MR imaging with self-confirmation for tumor detection, but also improve the photothermal conversion efficiency for MRI-guided photothermal therapy (PTT) is reported. The MagMn nanoparticles (NPs) are naturally produced through the biomineralization of magnetotactic bacteria by doping Mn into the ferromagnetic iron oxide crystals. In vitro and in vivo studies demonstrated that targeting peptides functionalized MagMn enhanced both T 1 and T 2 MRI signals in tumor tissue and significantly inhibited tumor growth by the further MRI-guided PTT. It is envisioned that the biosynthesized multifunctional MagMn nanoplatform may serve as a potential theranostic agent for cancer diagnosis and treatment.
研究领域:
生物医学工程
·
纳米技术
·
癌症研究
·
分子影像
·
诊疗一体化
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yang Zhang,Sijie Cheng,Yu He,Chaojie Tang,Feng Liu,Yun Sun,Shuo Zhao,Greta S. P. Mok,Hong Yang,Zhiguo Zhou,Wu Wang
Thrombosis is closely related to the instability of intracranial aneurysm (IA), whose rupture is associated with high morbidity and mortality. It is difficult to detect an IA-related thrombus because traditional magnetic resonance imaging (MRI) and even contrast-enhanced MRI cannot clearly distinguish a thrombus from the surrounding tissues. Herein, a nanoplatform [(MFe2O4–ZnDPA nanoparticles (NPs)], consisting of Zn0.4Co0.6Fe2O4@Zn0.4Mn0.6Fe2O4 NPs for imaging and Zn(II)-bis(dipicolylamine) (ZnDPA) for thrombus targeting, is constructed to target an experimental aneurysm-related thrombus in rabbits via MRI. In vitro experiments including platelet safety evaluation primarily prove that MFe2O4–ZnDPA NPs with a high MRI transverse relaxation time (T2) have good biocompatibility. MFe2O4–ZnDPA NPs could target a thrombus via the special interaction between ZnDPA and phosphatidylserine of activated platelets in the thrombus through MRI and Fe quantification assays. Moreover, after MFe2O4–ZnDPA NPs are injected into the ear vein of common carotid artery aneurysm model rabbits, MRI shows that MFe2O4–ZnDPA NPs could accumulate in the aneurysm-related thrombus from 0 to 15 min after injection and decrease in the next 45 min. Meanwhile, MFe2O4–ZnDPA NPs could decrease the MRI T2 signal of the aneurysm-related thrombus to enhance the outline of the aneurysm. This study demonstrates that a nanoplatform can enhance the detection of an aneurysm-related thrombus as well as aneurysm itself to assist further treatment of IA.
研究领域:
医学成像
·
纳米技术
·
神经病学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Lile Dong,Peng Zhang,Pengpeng Lei,Shuyan Song,Xia Xu,Kaimin Du,Jing Feng,Hongjie Zhang
Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T1/T2-weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF3:Fe nanoparticles (PEG-GdF3:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T1/T2-weighted MRI and X-ray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T1 contrast, evident T2 contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF3:Fe NPs. Therefore, PEG-GdF3:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.
研究领域:
生物医学成像
·
纳米医学
·
癌症诊断
·
分子成像
·
放射学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Songhan Hu,Mingyuan Ma,Wei Sun,Guowei Pan,Kai Wang,Qiang Wang
The impacts of nanoplastics on the environment and organisms are gradually increasing, using MRI to detect the metabolic pathways of nanoplastics has low sensitivity and requires magnetic particles for enhanced visualization. In this study, we used Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles as magnetic particles and coated them with polystyrene to afford polystyrene composite microspheres (ZMF@PS) with enhanced contrast performance. The effects of the polymerization parameters on the morphology and loading rate of the magnetic ZMF@PS composite microspheres were investigated. In addition, the effect of the magnetic contrast agent (ZMF particles) on the magnetic properties of the ZMF@PS composite microspheres was examined. The results show that when MAA and KPS quantities are 1 mL and 0.02 g, respectively, ZMF was uniformly distributed in the ZMF@PS composite microspheres exhibiting a good coating effect, with an average microsphere size of only 151.09 nm. Regarding the contrast performance, an increase in the ZMF content increased the loading rate, saturation magnetization intensity, and relaxation rate of the ZMF@PS composite microspheres.
研究领域:
材料科学
·
医学影像
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Qianyu Yang,Gang Wu,Yefeng Yang,Yang Zhou,Jiali Song,Huile Gao,Weiyuan Huang
Based on the properties of photodynamic therapy (PDT) and magnetic resonance imaging (MRI), combining them to construct multifunctional nanotheranostics can leverage strengths and avoid weaknesses for tumor diagnosis and treatment. However, certain problems remain unsolved, notably the short observation window caused by insufficient retention time. In this study, a GSH-responsive shape-transformable nanotheranostics Gd-Ce6-FFVLGGGC-SS-PEG are designed (abbreviated as GdCFS) by combining a single metal Gd with Ce6, and peptide (Phe-Phe-Val-Leu-Gly-Gly-Gly-Cys) disulfide-conjugated with polyethylene glycol (PEG) to perform dual-modal T 1 /T 2 MRI specifically at the tumor site. Due to its amphiphilic features, GdCFS can self-assemble to spherical nanoparticles, while transforming to nanofibers (NFs) in the presence of intracellular overexpressed GSH stimuli. After NFs formation, the hydrophobic core of GdCFS is exposed, resulting in T 1 positive contrast enhancement, whereas NFs can simultaneously achieve T 2 negative contrast enhancement. Furthermore, GSH depletion can cause imbalance in intracellular redox state, ultimately improving PDT efficacy. GdCFS benefits from the shape-transformation in terms of sufficient retention time, thus positively minimizing the toxicity risk. On the tumor model of nasopharyngeal carcinoma, in vivo and in vitro outcomes confirm that GdCFS can be a promising candidate for early diagnosis, real-time monitoring, and precise treatment of tumors with great biocompatibility.
研究领域:
医学
·
纳米医学
·
肿瘤学
·
影像学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 21
·3099-3104
·
IF 1.9
Dong Li,Minghui Hua,Kun Fang,Rong Liang
High-performance magnetic resonance (MR) imaging contrast agents are the key to reliable and accurate diagnosis of diseases using the MR imaging technique. In particular, dual-modal MR imaging nanoprobes that integrated the advantages of a high contrast effect and impressive sensitivity of T1- and T2-weighted MR imaging, respectively, have attracted increasing attention in recent years. However, the current methods for the fabrication of the dual-modal MR imaging nanoprobes suffer from a tedious synthesis procedure, harsh synthesis condition and ambiguous toxicity, strongly hindering their clinic transformation. Herein, we proposed a biomineralization approach for the fabrication of bovine serum albumin (BSA)–Fe3O4 nanoparticles with undoubted biosafety and robust T1 and T2 MR imaging ability in a facile way under mild conditions. BSA not only served as a template to control the growth of nanocrystal, but also enabled the favorable water solubility of the nanoprobe. The outstanding biocompatibility of BSA–Fe3O4 nanoparticles was proven by systematic in vitro and in vivo toxicity assessments, and dual-modal T1 and T2 MR imaging in vivo was achieved successfully. In addition, the nanoprobe was successfully applied for in vivo MR imaging of liver with a broad time window, and the metabolic investigation of BSA–Fe3O4 nanoparticles revealed that they could be eliminated from the body, ensuring a negligible adverse effect. The proposed biomineralization approach opens a new way for the fabrication of dual-modal MR contrast imaging nanoprobe with undoubted biosafety, and other functional proteins also exhibit great potential for the fabrication of dual-modal MR contrast imaging nanoprobe with specific functions with respect to biomineralization.
研究领域:
医学影像学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Zhongzhong Lu,Jincong Yan,Mingsheng Xu,Lina Sun,Jihuan Liu,Ye Zhang,Lei Shi,Xifeng Fei,Yi Cao,Renjun Pei
Magnetic resonance imaging (MRI), one of the most general imaging techniques in the clinic, is widely employed for tumor diagnosis with the assistance of contrast agents (CAs). However, currently available CAs in the clinic suffer from shortcomings of a short blood circulation time, lack of specificity to pathological location, insufficient imaging window, and potential biotoxicity of the gadolinium ion. To overcome these problems, on the basis of extremely small iron oxide nanoparticles (ESIONPs), a hypoxia-responsive T1-to-T2 switchable MRI contrast agent was designed and constructed. In detail, polyacrylic acid-modified ESIONPs (ESIONPs-PAA) were first synthesized, and then, nitroimidazole derivatives and cysteine molecules were sequentially coupled on the surface of ESIONPs-PAA to obtain a hypoxia-responsive MRI contrast agent (HR-ESIONPs). Since 2-nitroimidazole and cysteine molecules on the surface of HR-ESIONPs can form an irreversible bond induced by the nitroreductase in the hypoxic tumor microenvironment, monodispersed HR-ESIONPs could transform into the nanocluster form, which can specially provide T2 contrast enhancement. In vitro experiments show that monodispersed HR-ESIONPs could effectively aggregate in the mimical hypoxic environment of tumors and switch from a T1 to T2 contrast agent. Moreover, in vivo experiments further confirm that HR-ESIONPs could effectively accumulate and realize the MRI signal switch from T1 to T2 contrast enhancement in tumors originating from the aggregation of HR-ESIONPs induced by the hypoxic environment, which promotes the diagnostic precision of tumors. Additionally, with the confirmation of favorable biosafety on cells and mice, hypoxia-responsive HR-ESIONPs are potential platforms to improve the diagnostic accuracy and sensitivity of MRI for tumors.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）