ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Ji-Chun Yang,Yang Chen,Yu-Hao Li,Xue-Bo Yin
The combination of multidrug chemotherapy and photothermal therapy (PTT) enhances cancer therapeutic efficacy. Herein, we develop a simple and smart pH/NIR dual-stimulus-responsive degradable mesoporous CoFe2O4@PDA@ZIF-8 sandwich nanocomposite. The mesoporous CoFe2O4 core acts as T2-weighted magnetic resonance (MR) imaging probe, PTT agent, and loading platform of hydrophilic doxorubicin (DOX). A polydopamine (PDA) layer is used to avoid the premature leakage of DOX before arriving at tumor site, enhance PTT efficiency, and facilitate the integration of ZIF-8 (a kind of metal–organic framework). The ZIF-8 shell serves to encapsulate hydrophobic camptothecin (CPT) and as the switch for the pH and NIR stimulation-responsive release of the two drugs. Therefore, T2-weighted MR imaging-guided multidrug chemotherapy and PTT synergistic treatment is achieved. Two kinds of anticancer drugs, hydrophilic DOX and hydrophobic CPT, are successfully loaded in CoFe2O4 and ZIF-8, respectively, so no mutual interference between the two drugs exists. A unique two-stage stepwise release process is exhibited for CPT and DOX with an interval of 12 h to improve the anticancer efficacy under the acidic microenvironment of tumor tissue. NIR irradiation achieves the burst drug-release and PTT after laser stimulation, simultaneously. With this smart design, high drug concentration is achieved at the tumor site by quick release, especially for the therapeutic drugs that show nonlinear pharmacokinetics, and PTT is integrated efficiently. Furthermore, negligible biotoxicity and a remarkable synergic antitumor effect of the hybrid nanocomposites are validated by HepG2 cells and tumor-bearing mice as models. Our multidrug delivery-releasing composite improves tumor therapeutic efficiency significantly compared with a single-drug chemotherapy system. The simple multifunctional composite system can be applied as an effective platform for personal nanomedicine with diagnosis, smart drug delivery, and cancer treatment through its remarkable photothermal property and controllable multidrug release.
研究领域:
生物医学工程
·
纳米技术
·
癌症研究
·
诊疗学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Xiang Li,Hua-Mo Yin,En Luo,Songsong Zhu,Peng Wang,Zhen Zhang,Gui-Qing Liao,Jia-Zhuang Xu,Zhong-Ming Li,Ji-Hua Li
Although artificial polymeric scaffolds act as vital characters in bone repair, their application is limited due to their inferior bioactivity. Herein, osteoinductive poly(ε-caprolactone) (PCL) composite scaffolds were prepared by synchronously enlisting bioactive nanohydroxyapatite (nHA), bioglass (BG), and bone morphogenetic protein-2 (BMP-2), which was bound up with polydopamine (pDA). It was found that pDA deposition not only significantly enhanced hydrophilicity and cell affinity of composite scaffolds but also endowed steady immobilization of BMP-2 with long-term yet sustained release. Compared to pure PCL and PCL/nHA/BG (PHB) scaffolds, the designed PHB-pDA-BMP-2 scaffolds significantly induced the differentiation of bone marrow stromal cells toward an osteogenic lineage. Meanwhile, in vivo examinations revealed the prominent osteogenic capability of PHB-pDA-BMP-2 scaffolds, which enabled complete bone healing of calvarial bone defects in rabbits by 12 weeks. This finding indicates that the developed porous composite scaffolds hold great potential for bone regeneration.
研究领域:
组织工程
·
生物材料
·
再生医学
·
骨科
✓ 已验证
DOI
PubMed
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jingxuan Zhao,Ying Xue,Yue Wu,Xiaonan Hao,Shulin Sun,Huiliang Zhang
This study presents an innovative approach to membrane fabrication by integrating electrospinning with surface modification techniques to develop a novel dual-layer protective membrane system. The key innovation lies in the incorporation of photothermally responsive nanocomposites, enabling multifunctional membrane performance. The primary layer is a PVDF-PNIPAAm thermoresponsive matrix synthesized by radical polymerization, integrated with BN@PDA-Ag nanosheets. This design combines Ag nanoparticles’ photothermal conversion and BN’s thermal conductivity to regulate pore size via PNIPAAm chain conformational changes induced by temperature. The secondary layer, comprising CS@CNT and PVDF, significantly enhances membrane hydrophilicity and antifouling properties through chitosan’s hydrophilic groups and chelating capabilities. The membrane demonstrates self-cleaning, adaptive filtration, antifouling and high flux, representing a significant advancement in smart membrane technology for water treatment applications.
研究领域:
材料科学
·
环境工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Huiting Shan,Jun Liu,Xipeng Li,Yi Li,F. Handan Tezel,Baoan Li,Shichang Wang
Membrane distillation, which can utilize low grade energy, has attracted significant attention recently. However, membrane fouling is a big issue impeding its development and industrialization. Hence, it is essential to prepare amphiphobic membrane for comprehensive anti-fouling performance. Herein, a facile and biomimetic method is explored to design amphiphobic surface with special structure and controllable wettability . Commercial polyvinylidene fluoride (PVDF) was primarily functionalized with polydopamine (PDA) coatings and then nanoscale roughness was introduced on the membrane surface, followed by the fluorination of 1H,1H,2H,2H-perfluorodecanethiol. It is revealed that the amphiphobic property can be accurately controlled by controlling the dosage of Ag + . When the concentration of Ag + is 300 mM, the water and oil contact angle of the optimal membrane can achieve 167.6 ± 0.27° and 136.9 ± 0.4°, respectively, while the water sliding angle is only 3 ± 0.1°, which demonstrates prominent superhydrophobicity and oleophobicity. Furthermore, the amphiphobic membrane exhibits excellent chemical and thermal stability under harsh conditions as well as outstanding comprehensive anti-fouling capacity with higher flux and excellent salt rejection in the long-term direct contact membrane distillation (DCMD) experiments, which shows promising potentials for application in the field of membrane distillation.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
DOI
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Chunxia Liu,Mengjing Lin,Jing Dai,Binglin Chen,Jiali Wang,Jingyi Li,Xiaoyun Li,Ziyun Jiang,Miao Xiao,Mingliang Tang
Vascular calcification (VC) is a critical pathological hallmark of cardiovascular diseases but current therapeutic options remain inadequate. Nitric oxide (NO) homeostasis plays a vital role in endothelial function and phenotypic transformation of vascular smooth muscle cells (VSMCs), two key pathological processes in VC. In this study, Fe₃O₄@PDA@BNN6 (FPB) nanoparticles were prepared for directional and controllable NO therapy. Magnetic field enriched the nanoparticles to the site of VC and ultrasound triggered the controllable release of NO to regulate the homeostasis of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS), further activated sGC-cGMP-PKG signaling pathway. Both in the rat and in vitro VC models, the innovative therapy inhibited osteogenic like transformation of VSMCs, alleviated endothelial inflammatory response, regulated eNOS/iNOS homeostasis, and effectively improved VC. By ensuring optimal NO bioavailability for vascular homeostasis, this magneto-ultrasonically controlled strategy overcomes limitations of conventional NO-based therapies and paves the way for precision NO-mediated interventions in cardiovascular diseases. Statement of Significance Engineering innovation: Dual-modality nanoparticle system for precision NO delivery: Magnetic guidance directs the FPB to calcified lesions, reducing systemic off-target effects. Ultrasound-triggered release of NO to ensure on-demand delivery at VC sites. Mechanistic innovation: Restoring eNOS/iNOS homeostasis as a therapeutic axis: Directional and controllable NO therapy uniquely modulates eNOS/iNOS homeostasis, further activating the sGC-cGMP-PKG signaling pathway.
研究领域:
心血管医学
·
纳米医学
·
分子治疗
·
生物医学工程
·
氧化还原生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Nan Yao,Shifeng Ji,Yunqing Xing,Jinchao Chen,Yanrui Cheng,Xiaonan Ruan,Jiaxin Chen,Zhuo Li,Yingjie Zhang,Chunmei Gao,Changbing Ye
This study reports the development and performance of a chlorine-resistant, negatively charged loose nanofiltration (LNF) membrane designed for efficient dye/salt separation from textile wastewater. The membrane was constructed by incorporating a synergistic composite of zeolitic imidazolate framework-L (ZIF-L) and polydopamine (PDA) into a polyamide layer on a polyethersulfone (PES) support via interfacial polymerization. In this design, ZIF-L nanosheets create a highly permeable, loose network, while PDA acts as a crucial molecular linker to ensure homogeneous dispersion and structural integration. Characterization using SEM, XRD, FTIR, XPS, and AFM confirmed successful synthesis. The optimal membrane, loaded with 2 wt% ZIF-L/PDA, exhibited superior performance: a pure water flux of 31.56 L·m −2 ·h −1 ·bar −1 , which is 3.19 times greater than the pristine Thin-Film Composite (TFC) membrane. This membrane achieved high dye rejection rates: Eriochrome Black T (99.25 %), Acid Chrome Blue K (97.87 %), Direct Blue 71 (97.56 %), Congo Red (94.09 %), and Direct Red 23 (93.92 %). Simultaneously, it showed low rejection for salts, indicating high permeability: NaCl (7.80 %), MgCl 2 (9.89 %), MgSO 4 (15.39 %), and Na 2 SO 4 (23.97 %). Crucially, the membrane demonstrated robust stability under diverse and harsh conditions, including exposure to strong acid, strong alkali, high pressure, and during long-term continuous operation, along with markedly enhanced chlorine resistance. Therefore, the ZIF-L/PDA loose NF membrane presents significant potential for dye wastewater treatment applications.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jinqi Wang,Xiaolong Su,Qianqin Zhu,Yaling Zhai,Xin Dai,Ning Tang,Wangxiang Pan,Hengxue Xiang,Meifang Zhu
An increasing number of hospital-acquired infections (HNIs) confirms the urgency of medical protective fiber material (MDPF), which possesses high strength, low toxicity and excellent hydrophobicity and is considered as an effective method to deal with HNIs. However, the current performance of MDPF mainly relies on a single physical barrier mechanism, and pathogenic and contagious bacteria or virus attached on the surface barrier layer are one of the important paths for secondary infection. Therefore, research on the fabrication of highly effective antibacterial MDPF is of great significance for preventing contagious infections. Herein, high-strength, environment-friendly and antibacterial PE@PDA@ZnO-Ag (PE@PDAZA) nonwoven fabric was successfully prepared through a simple one-pot coating method. The functional fabric exhibits antibacterial rate up to 99.9 % against Escherichia coli ( E. coli ) and Bacillus subtilis ( B. subtilis ) with low amount of antibacterial agent additions. Moreover, the fabric exhibits tested tensile strength of 35.4 ± 2.9 MPa. This work provides a new strategy for preparing high-strength and automatically-protective MDPF, which can reduce hospital-acquired contagious infections through a simple post-treatment process and has great potential for large-scale production.
研究领域:
材料科学
·
生物医学工程
·
纺织工程
·
高分子科学
✓ 已验证
DOI
高影响因子
ENERGY CONVERSION AND MANAGEMENT
·
2022
·
IF 11.533
Zechang Wei,Chenyang Cai,Yu Fu
To reach global carbon neutralization, the use of clean energy and biomaterials has become a trend to reduce CO 2 emission. With the increasing concerns about freshwater shortage and crude oil pollution, water purification and sewage treatment have become particularly urgent. Solar energy is an environment-friendly energy to mitigate freshwater shortage stress and reduce crude oil pollution. However, how to make solar energy applied to effectively drive freshwater generation and crude oil pollution remedy is crucial. Herein, the electrospun membrane was explored as sustainable matrix with desirable solar-to-thermal performance. The strategy of spectrum-tailoring was proposed to tailor bandgap energy of vanadium disulfide (VS 2 ) for photothermal conversion promotion and interfacial evaporation efficiency. Inspired by mussel, dopamine was polymerized on surface of VS 2 (VS 2 @PDA) for spectrum tailoring (Solar absorptance, α, is 89.34 %). Bandgap energy of the complex favorably decreased from 2.06 to 1.41 eV. Combining the dual H-bonding networks, water evaporation enthalpy of the membranes dramatically decreased from 2370 to 1990.2 J/g and the resulted evaporators showed excellent salt resistance, with evaporation rate of 1.40 kg m -2 h −1 (enhancement factor is 2.032) and extraordinary cyclic evaporation performance. Additionally, sunflower-inspired tilting model was architectured to eliminate disturbance of sun irradiation incident angles for effective solar-driven interfacial generation. The resulted membrane effectively treated the seawater and decreased high viscosity of the super-viscous crude oil under the sun irradiation, thus showing great potential in seawater treatment and crude oil pollution remedy. The designs maximized utilization of solar energy and evaporation rates by treating seawater and reducing crude oil pollution without consuming additional energy, thus contributing to carbon neutralization. Therefore, the integration of dual H-bonding networks and spectrum-tailoring strategies would facilitate the structure-functional unification and desirable photothermal capabilities, and bring about an application potential in the development of composite evaporators for carbon neutralization.
研究领域:
材料科学
·
环境科学
·
能源科学
·
化学工程
·
可持续技术
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2021
·Vol. 13
·期 25
·2804-2811
·
IF 2.896
Feng Qin,Shujuan Wang,Mingxia Gao,Xiangmin Zhang
The highly effective detection of pathogens in complex biological samples is an attractive and critical topic of study. Bacitracin is a novel broad-spectrum antimicrobial peptide to enrich bacteria via interactions with the membrane surface of the different bacterial cells. In this study, for the first time, bacitracin was immobilized on the surface of Fe3O4@PDA magnetic nanoparticles for the enrichment of Staphylococcus aureus (G+) and Klebsiella pneumoniae (G−). Combined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a rapid and sensitive detection method for these two bacteria was developed. In this method, the detectable concentration of bacteria was decreased by 2–3 orders of magnitude in unenriched samples. The enrichment and identification can be completed in one hour. All these results demonstrated that the bacitracin-functionalized magnetic composite has potential for use in the large-scale enrichment and isolation of target pathogens from complex biological samples, opening a new avenue for the rapid and sensitive detection of pathogens.
研究领域:
微生物学
·
分析化学
·
医学检测
✓ 已验证
DOI
PubMed
高影响因子
Food Analytical Methods
·
2026
·Vol. 19
·期 10
·295
·
IF 3
Su Kaiyue,Peng Xinli,Zheng Yuze,Qiao Xuguang,Waterhouse Geoffrey I.N.,Xu Zhixiang
In this paper, a molecularly imprinted polymer with good benzopyrene adsorption performance and a PDA@Mn-ZIF-8 nanozyme with high catalytic activity were synthesized. The molecularly imprinted polymer was used as the biomimetic antibody, while the PDA@Mn-ZIF-8 was used as the marker. A novel direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method was established for the sensitive detection of benzopyrene. Under the optimal conditions, the detection limit (LOD and IC 15 ) and sensitivity (IC 50 ) of the BELISA method for benzopyrene were 0.52 µg L −1 and 65.64 µg L −1 , respectively. This method was successfully used to detect benzopyrene in chicken and pork samples, with recovery rates ranging from 89.12 to 105.26% for chicken and 92.83 to 112.31% for pork. The contents of benzopyrene in sausages and grilled lamb samples were determined by BELISA and HPLC, and no significant differences found between the results of the two methods. This work offers a new, rapid, and accurate method for the detection of benzopyrene in foods.
✓ 已验证
产品关联
DOI
高影响因子
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
·
2022
·
IF 3.369
Shuai Li,Yuanshu Xiao,Guohua Shan,Xinlei Fan,Mengru Wang,Rui Liu,Lixia Jia
Biomimetic structural colors have demonstrated significant practical promise in eco-friendly coloring. However, the development of novel, simple, and effective methods for the fabrication of photonic crystal structural colors remains an enormous challenge, particularly for flexible substrates . In this work, we prepared structural color coatings with bright, full-color, and low angle dependence on flexible textile substrates via simple vacuum-assisted filtration self-assembly (VAFS). The resultant photonic crystals were polycrystalline structures containing both face-centered cubic (FCC), simple cubic (SC), and amorphous structures (APS), resulting in structural color coatings with bright and low angle dependence. The precise regulation of different hues of structural colors can be achieved by changing the size of microspheres or mixing of microspheres with different sizes. Furthermore, various microspheres (e. g., SiO 2 , SiO 2 @PDA or P (St-MMA-AA)) and fabrics (cotton, linen, silk or wool fabric) can be utilized as self-assembly materials to create structural color coatings, demonstrating the simplicity, low-cost, and great compatibility. Meanwhile, this method may also be applied to the preparation of structural color coatings on substrates with pores, expanding the application of structural colors in various fields.
研究领域:
材料科学
·
纺织工程
·
光学
·
纳米技术
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2020
·
IF 10.317
Yaojie Wei,Zhongqun Liu,Xu Zhu,Le Jiang,Weidong Shi,Yingjin Wang,Nan Xu,Fangli Gang,Xiumei Wang,Lingyun Zhao,Jun Lin,Xiaodan Sun
Peri-implant aseptic inflammation and osteolysis can cause aseptic loosening, leading to the failure of implants. Therefore, aseptic loosening of orthopedic implants remains an imminent problem for the development of durable and effective implants. In this work, a common anti-inflammatory drug (aspirin, ASA) was loaded in poly(lactic-co-glycolic acid) (PLGA) to construct nanofiber coatings on titanium (Ti) via electrospinning. The adhesion of the nanofiber coatings to Ti was ensured by polydopamine (PDA) modification. A stable and sustainable release of aspirin from the nanofiber coatings could last up to 60 days. Such electrospun PLGA@ASA nanofiber coatings could promote proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) as well as inhibit M1 polarization and RANKL-induced osteoclast differentiation of macrophages in vitro . These results indicated that this facile formulation of the PLGA@ASA nanofiber coatings for long-term drug release could be expected to address the problem of aseptic loosening effectively in dual directions of both anti-inflammation and improving osseointegration simultaneously. Notably, the in vivo experiments demonstrated that PLGA@ASA nanofiber coatings did promote osseointegration ability of Ti implants significantly, even in challenging condition with wear particles, and also effectively inhibited Ti particle induced osteolysis around the implants. This work indicates a promising way for the development of durable and effective implants by using PLGA@ASA-PDA-Ti to address the problem of aseptic loosening in dual directions.
研究领域:
生物材料
·
骨科
·
组织工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）