FOOD CHEMISTRY
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2026
·
IF 10.4
Guocong Ma,Mingwu Qiao,Dan Hai,Yan Ma,Ge Bai,Peijun Zhao,Xianqing Huang,Xinyu Sun,Lianjun Song
FA-SA conjugate with excellent antioxidant activity was prepared. • FA-SA-PP NPs exhibited good antioxidant and DPP-IV inhibit activity. • SA-based HBs achieved the intestinal-targeted release of FA-SA-PP NPs. • NPs provide I-level defense system and HBs provide II-level defense system for PP. Pea peptides (PP) with hypoglycemic activity were prone to decrease activity due to their sensitivities to pH, temperature and enzymes. Herein, ferulic acid modified sodium alginate conjugate was prepared and employed as the carrier for fabricating FA-SA-PP NPs with the PP encapsulation efficiency (EE) of 99.69%, which formed the I-level fence for protecting PP. Further, SA-based hydrogel beads loaded with FA-SA-PP NPs (EE: 99.87%) were prepared for forming the II-level fence to protect PP. Results showed that FA-SA-PP NPs@SA HBs had good stability in SGF, and gradually swelled and released FA-SA-PP NPs in SIF. Besides, the digested products of FA-SA-PP NPs@SA HBs still showed good antioxidant and DPP-IV inhibitory activities. Overall, the “double fence” effect protection mechanism can achieve the combination of antioxidant and hypoglycemic functions, and realize the intestinal-targeted release of PP, which shows great application potential in reducing oxidative stress damage and nutrition intervention to diabetes. Download: Download high-res image (162KB) Download: Download full-size image
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高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Lingli Long,Minghua Lai,Xuhong Mao,Jiahao Luo,Xin Yuan,Li-Ming Zhang,Zunfu Ke,Liqun Yang,David YB Deng
Purpose Peptide drugs have been used in therapy various diseases. However, the poor bioavailability of peptide drugs for oral administration has limited their clinical applications, on account of the acidic environment and digestive enzymes inside the human gastrointestinal tract. To enhance stability in the human gastrointestinal tract, bioavailability, and targeted drug delivery of peptide drugs through oral administration, a vitamin B12-modified amphiphilic sodium alginate derivative (CSAD-VB12) was synthesized.Materials and methods A vitamin B12-modified amphiphilic sodium alginate derivative (CSAD-VB12) was synthesized via the N,N’-dicyclohexylcarbodiimide active method at room temperature, and then characterized using FTIR and 1H NMR spectroscopy. Insulin was used as a model peptide drug and the insulin-loaded CSAD-VB12 (CSAD-VB12/insulin) nanoparticles with negative zeta potentials were prepared in PBS (pH=7.4). Scanning electron microscopy was used to observe CSAD-VB12/insulin as spherical nanoparticles. The CSAD-VB12 derivatives and CSAD-VB12/insulin nanoparticles displayed nontoxicity towards the human colon adenocarcinoma (Caco-2) cells by CCK-8 test. Caco-2 cell model was used to measure the apparent permeability (Papp) of insulin, CSAD/insulin and CSAD-VB12/insulin. Furthermore, confocal was used to confirm the endocytosis of intestinal enterocytes. Type 1 diabetes mice were used to evaluate the intestinal absorption and retention effect of test nanoparticles.Results They were observed as spherical nanoparticles in the size of 30–50 nm. The CSAD-VB12 derivatives and CSAD-VB12/insulin nanoparticles displayed nontoxicity towards the human colon adenocarcinoma (Caco-2) cells. Comparing with insulin and the CSAD/insulin nanoparticles, the CSAD-VB12/insulin nanoparticles exhibited higher permeation ability through intestinal enterocytes in the Caco-2 cell model. Oral administration of the CSAD-VB12/insulin nanoparticles to Type 1 diabetic mice yields higher intestinal retention effect, targeted absorption, and outstanding efficacy.Conclusion CSAD-VB12 derivatives enhance the small intestinal absorption efficacy and retention of peptide by oral administration, which indicated that it could be a promising candidate for oral peptide delivery in the prospective clinical application.
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DYES AND PIGMENTS
·
2022
·
IF 5.122
Xiangyong Wu,Xian Deng,Ying Song,Zhenxiao Zhang,Hao Su,Ying Han,Yihui Shen,Sitong Liu,Keying Sun,Hongyan Yao,Shaowei Guan
Photochromic hydrogels have broad prospects in wearable optoelectronic technology, rewritable information storage technology, biological imaging agents and chemical sensors, etc. However, it is still a challenge to develop photochromic hydrogels with high transparency, mechanical properties, fast response, stability and color reversibility. In this study, a novel photochromic hydrogel (PAAm/SA-Mo7) was prepared by loading ammonium molybdate (Mo7) into a double-network hydrogel of polyacrylamide (PAAm) and sodium alginate (SA) through a facile one-step method. The introduction of SA and Mo7 significantly improved the mechanical properties of hydrogels, and the maximum elongation and breaking energy are 27.5 and 86 times higher than those of pure PAAm . Furthermore, the photochromic hydrogels have fast response and stable reversible color change. The coloring process of hydrogels can be precisely controlled by the time and intensity of UV irradiation, and the fading process can also be controlled by temperature. The photochromic hydrogel can be applied to self-erasing rewritable media and information storage. This work provides a new approach for the development of flexible wearable optoelectronic materials.
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POLYMER BULLETIN
·
2022
·Vol. 80
·期 11
·11899-11917
·
IF 2.843
Li Dongze,Liao Yuqing,Chen Xiuqiong,Wang Hongcai,Wen Yanshi,Cheng Kaiyue,Chen Weiwei,Yan Huiqiong,Lin Qiang
To address the functional defect of alginate hydrogel in tissue engineering applications, we adopted the interpenetrating polymer network technology as well as the incorporation of SiO 2 nanoparticles and the surface coverage of gelatin to fabricate homogeneous oxidized sodium alginate/silica/polyacrylamide–gelatin (OSA/SiO 2 /PAM-GT) composite hydrogels, using hydroxyapatite/D-glucono-δ-lactone (HAP/GDL) complex as the gelling system. Specially, the effect of SiO 2 nanoparticles on the microstructure, mechanical properties, in vitro swelling, biodegradability, biomineralization and biocompatibility of the composite hydrogels was investigated. The resultant OSA/SiO 2 /PAM-GT composite hydrogels exhibited relatively regular 3D morphology with well-developed pore structure with HAP/GDL as the cross-linking agents. The incorporation of SiO 2 nanoparticles could effectively regulate the pore structure, mechanical properties, swelling ratio, in vitro biodegradability and biomineralization of OSA/SiO 2 /PAM-GT composite hydrogels. Meanwhile, the OSA/SiO 2 /PAM-GT composite hydrogels could also support the adhesion, proliferation and differentiation of MG-63 cells, which could be applied to the tissue engineering field.
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POLYMER INTERNATIONAL
·
2022
·Vol. 72
·期 5
·471-481
·
IF 3.213
Hongcai Wang,Xiuying Sun,Ting Shang,Dongze Li,Shanshan Cao,Xiuqiong Chen,Huiqiong Yan,Qiang Lin
To improve the bio-applicability of alginate hydrogels, a combination of interpenetrating network technology, oxidation of alginate, surface coverage of gelatin and endogenous crosslinking of hydroxyapatite/ d -glucono- δ -lactone complex was designed to construct homogeneous oxidized sodium alginate/polyacrylamide–gelatin (OSA/PAM-GT) composite hydrogels. The effects of mass ratio of PAM chemical crosslinked networks and OSA ionic crosslinked networks on the microscopic morphology, mechanical properties, swellability, biodegradability and biocompatibility of the composite hydrogels were comparatively studied. Experimental results showed that porous OSA/PAM-GT composite hydrogels with regular morphology can be prepared through the interpenetration of OSA ionic crosslinked network and PAM chemical crosslinked network via hydrogen bonds and Schiff bases, which not only enhanced the mechanical properties and thermal stability of the composite hydrogels, but also regulated their swelling and in vitro biodegradability. When the mass ratio of OSA to PAM was 1:2, the cell proliferation activity on OSA/PAM-GT composite hydrogels was the best, but excessive PAM reduced the living space of cells and hindered their growth due to the reduction of porosity. Considering the results obtained, interpenetrating network technology in combination with surface coverage of GT would be a useful method for alginate hydrogels to broaden their applications in the field of biomedicine. © 2022 Society of Industrial Chemistry.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Wei Wang,MingYue Liu,Muhammad Shafiq,HaiYan Li,Rashida Hashim,Mohamed EL-Newehy,Hany EL-Hamshary,Yosry Morsi,Xiumei Mo
Electrospun fibers provide a promising platform for wound healing; however, they lack requisite characteristics for wound repair, including antibacterial and anti-inflammatory properties and angiogenic ability. Sodium alginate (SA) is being used for different types of applications. However, the poor spinnability of SA restricts its applications. The objectives of this study were three-fold: a) to synthesize oxidized sodium alginate (OSA) to improve its spinnability, b) to fabricate composite fibrous membranes by blending OSA along with zinc oxide nanoparticles (ZnO-NPs), and c) to decipher antibacterial and anti-inflammatory properties as well as biocompatibility of membranes in vitro and in vivo . OSA displaying different oxidation degrees ( D ox (%)) was synthesized by varying the molar ratio of sodium periodate to SA. OSA ( D ox, ∼48 %) afforded smooth and uniform fibers; 0.5 wt% of adipic dihydrazide (ADH) evolved into structurally stable and water-insoluble membranes. Composite fibrous membranes containing 2 wt% of ZnO-NPs displayed good biocompatibility and bactericidal effect against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) in vitro . In addition, composite membranes showed remarkable epithelialization, neovascularization, and anti-inflammatory response than that of the membranes devoid of ZnO-NPs. Conclusively, these composite fibrous membranes may have broad implications for wound healing applications.
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Polymers
·
2022
·Vol. 14
·期 9
·1679
·
IF 4.967
Hongcai Wang,Xiuqiong Chen,Yanshi Wen,Dongze Li,Xiuying Sun,Zhaowen Liu,Huiqiong Yan,Qiang Lin
Oxidized sodium alginate (OSA) is selected as an appropriate material to be extensively applied in regenerative medicine, 3D-printed/composite scaffolds, and tissue engineering for its excellent physicochemical properties and biodegradability. However, few literatures have systematically investigated the structure and properties of the resultant OSA and the effect of the oxidation degree (OD) of alginate on its biodegradability and gelation ability. Herein, we used NaIO4as the oxidant to oxidize adjacent hydroxyl groups at the C-2 and C-3 positions on alginate uronic acid monomer to obtain OSA with various ODs. The structure and physicochemical properties of OSA were evaluated by Fourier transform infrared spectroscopy (FT-IR),1H nuclear magnetic resonance (1H NMR), X-ray Photoelectron Spectroscopy (XPS), X-ray Diffraction (XRD), and thermogravimetric analysis (TGA). At the same time, gel permeation chromatography (GPC) and a rheometer were used to determine the hydrogel-forming ability and biodegradation performance of OSA. The results showed that the two adjacent hydroxyl groups of alginate uronic acid units were successfully oxidized to form the aldehyde groups; as the amount of NaIO4increased, the OD of OSA gradually increased, the molecular weight decreased, the gelation ability continued to weaken, and degradation performance obviously rose. It is shown that OSA with various ODs could be prepared by regulating the molar ratio of NaIO4and sodium alginate (SA), which could greatly broaden the application of OSA-based hydrogel in tissue engineering, controlled drug release, 3D printing, and the biomedical field.Keywords:oxidized sodium alginate;oxidation degree;biodegradation gelation ability;rheological properties
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CELLULOSE
·
2022
·Vol. 29
·期 9
·5339-5358
·
IF 6.123
Liu Yansong,Zhao Wenjing,Zhang Jiayue,Ren Yuanlin,Liu Xiaohui,Qu Hongqiang
Inspired by the intrinsically flame-retardant alginate fiber, a novel eco-friendly, biomass-based flame retardant was developed to endow lyocell fabrics with excellent flame-retardant properties by using bio-material glycine, aspartic acid as raw materials. Furthermore, glycine and aspartic acid were converted into sodium carboxylate (glycine-Na and aspartate-Na), respectively. Then, lyocell fabric was respectively modified by glycine-Na and aspartic acid-Na to prepare flame retardant lyocell fabric (G-lyocell-Na and A-lyocell-Na). The combustion test result showed that the modified fabrics exhibited self-extinguishing characteristics and high char-forming ability. In addition, compared to the control sample, the peak of heat release rate (PHRR) of G-lyocell-Na and A-lyocell-Na reduced by 36.5% and 49.9%. TG-IR and Raman spectra results indicated that both the condensed and gas phase played the flame retardant role. The electron withdrawing effect of the Na + reduced the activation energy, promoted the pyran ring-opening reaction and reduced the decomposition temperature. Therefore, the flame retardant lyocell fabric decomposed and formed more char residue containing Na 2 CO 3 . The expanded char layer formed during combustion could effectively block the release of heat and the overflow of combustible gases, so that the modified lyocell fabric showed highly flame-retardant efficiency. In this work, a novel preparation strategy that can endow lyocell fabric with good flame retardant properties without traditional flame retardant elements such as P, Cl and Br was proposed, which was green, environment-friendly and in line with sustainable development. Graphic abstract
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Polymers
·
2022
·Vol. 14
·期 4
·731
·
IF 4.967
Hao Cheng,Jie Cao,Wenru Liu,Jun Mei,Jing Xie
In this study, we characterized an active film made of sodium alginate (SA)—locust bean gum (LBG) containing daphnetin-based film. Physicochemical characteristics, as well as antioxidant and antibacterial properties, were investigated. The results showed that the addition of a low concentration of daphnetin increased the flexibility of SA–LBG cling film, leading to an improvement in elongation at break and tensile strength. As the daphnetin content increased, solubility, brightness and transparency of the cling film decreased, and the moisture permeability increased. The antioxidant capacity and antibacterial activity of films with daphnetin were improved compared to those of the basal film. In addition, the cling film formed by adsorption had higher bacterial (Shewanella putrefaciensandPseudomonas fluorescens) inhibition and antioxidant activity rates than direct film formation. The results indicate that the combination of daphnetin in SA–LBG film provides an active film with antioxidant and antibacterial properties, with potential for the development of food-grade packaging material.Keywords:active film;physicochemical characteristics;daphnetin;scanning electron microscopy;antimicrobial activity
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NANOTECHNOLOGY
·
2022
·Vol. 33
·期 24
·245701
·
IF 3.953
Ziyan Kong,Huiying Wang,Kun Hou,Lunhui Guan
The research on low-cost, high-performance non platinum group metal (PGM) oxygen reduction reaction (ORR) catalysts is of great significance for the rapid promotion of fuel cells' practical applications. In this work, Mn–N–C catalyst with outstanding activity was prepared through using hydrogel formed by coordination of sodium alginate (SA) and Mn2+ as the precursor. During the preparation process, g-C3N4 was added to improve the surface area enrich the pore structure of catalysts, as well as to function as the nitrogen source. Compare with commercial Pt/C catalyst, the optimum Mn–N–C catalyst possesses extraordinary ORR activity in alkaline electrolytes, with a half-wave potential (E1/2) of 0.90 V. In addition, the Mn–N–C catalyst also displays exceptional stability in alkaline and acidic electrolytes, much superior to Pt/C catalyst.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xiaoya Tao,Hang Shi,Ailing Cao,Luyun Cai
In this research, ovalbumin (OVA) and sodium alginate (SA) were used as the materials to prepare OVA-SA composite carriers, which protected and encapsulated the hydrophobic kaempferol (KAE) and the hydrophilic tannic acid (TA). To achieve the purpose of targeted delivery, the TA-Fe 3+ coating film was prepared. Results showed that the observation of small diffraction peaks in carriers proved the formation of TA/Fe 3+ coating film on the surface of four composite nanoparticles (pOVA, pOVA-SA, pOVA-KAE-SA, and pOVA-KAE-TA-SA). The protein structure of the composite nanoparticles coated with TA/Fe 3+ changed, and the order of the changes was pOVA-KAE > pOVA > pOVA-KAE-SA > pOVA-KAE-TA-SA > pOVA-SA. This phenomenon is due to the fact that the chromophore –C=O and the auxo-chromophore –OH are in the opposite position in the benzene ring of TA, and the two substituents have opposite effects and synergize, resulting in the different degrees of redshift of the composite nanoparticle λ max . Additionally, pOVA-SA had the highest α-helix content and the lowest random coils, conferring the protein structure the strongest stability. The coating of TA/Fe 3+ increased the system stability and the thermal stability of the composite nanoparticles. Additionally, the carriers were endowed with antioxidant activity, and their antibacterial ability against Staphylococcus aureus and Escherichia coli was pOVA-KAE-TA-SA > pOVA-KAE-SA > pOVA-KAE > pOVA-SA > pOVA based on the difference in antibacterial diameter (D, mm) and square (S, mm 2 ). pOVA-KAE-TA-SA had the strongest antioxidant activity and antibacterial ability, which improved the bioavailability of TA/KAE. These results provide a theoretical basis for the application of OVA-SA composite nanoparticles in the delivery of bioactive compounds.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jundong Zhu,Xue Li,Dongxiao Li,Chongwen Jiang
As advanced thermal management materials, aerogels have great research value in the fields of engineering insulation, pipeline transportation, and packaging insulation. The composite interaction of the two-phase interface and the construction of a porous structure have an important impact on the thermal properties. Herein, a novel HANRs/SAB composite aerogel was prepared using sodium alginate (SA) with hydroxyapatite nanorods (HANRs), combined with boric acid crosslinking and freeze drying. In the prepared sample, the calcium ions in HANRs and SA formed the first layer of binding force and the chemical crosslinking of sodium alginate with boric acid formed the second layer of strong binding force, which effectively supported the skeleton of the aerogel and enhanced the overall mechanical properties. The modulus and maximum compressive strength of the obtained HANRs/SAB aerogel were 2.39 and 0.75 MPa, respectively, while the bulk density was 0.038–0.068 g·cm–3. Based on the prominent physical structure, the as-prepared HANRs/SAB aerogel exhibited good thermal insulation (∼35.15 mW·m–1·K–1) and outstanding flame retardant performance. Flame-retardant boric acid and high-thermal stability HANRs could effectively prevent heat transfer and organic combustion, thus resulting in an extremely low smoke gas release (11.3 m2 m–2). Therefore, the low-cost biopolymer composite aerogel based on a crosslinking strategy has broad application prospects in the field of thermal insulation and flame retardancy.
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