Journal of Materials Chemistry B
·
2026
·
IF 6.2
Jiaxing Li,Chenyang Chu,Lijun Zhu,Zhong Du,Yaqi Cui,Jiabao Xiong,Chi Zhang,Yuxiang Gao,Biao Dong,Nuernisha Alifu
The clinical translation of photodynamic therapy (PDT) for cervical cancer is constrained by limited visible-light penetration and tumor hypoxia. These limitations are further aggravated by the oxygen-consuming nature of PDT itself. Although near-infrared (700–1700 nm, NIR) light activation can alleviate the penetration issue, overcoming hypoxia remains a paramount challenge. Herein, an oxygen self-sufficient theranostic nanoplatform, designated IFHFC nanoparticles (IFHFC NPs), is developed to synergistically enhance NIR-PDT by implementing a novel dual oxygen-supply strategy that integrates catalytic oxygen generation with physical oxygen delivery. The NPs deliver oxygen through two complementary routes. They catalyze the decomposition of endogenous hydrogen peroxide into oxygen and, under NIR irradiation, release stored oxygen to sustain local oxygen availability. This coordinated oxygenation alleviates hypoxia and increases cytotoxic reactive oxygen species generation. Both in vitro and in vivo studies confirm improved inhibition of cervical tumor growth. Overall, combining deep-tissue-penetrating NIR activation with dual-mode oxygenation offers a promising strategy for overcoming key barriers of PDT in solid tumor treatment.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Hanjing Lu,Min Li,Wenxuan Fan,Zhao Li,Ji Cheng,Rui Liu,Pan Xu,Ding Luo,Jinghua Li,Xiaoran Liu
Sepsis-associated acute lung injury (ALI) is a critical clinical problem owing to the complex interactions between inflammation and oxidative stress. It is often associated with high mortality rates and a lack of therapeutic options. To simultaneously combat the interconnected inflammatory and oxidative stress pathways in sepsis-associated ALI, we designed near-infrared (NIR)-responsive nanomedicine by co-loading ferroptosis inhibitor Ferrostatin-1 (Fer-1) with Prussian blue nanozymes (denoted as Fer-1@PB) to achieve synergistic therapy and enhanced efficacy. Fer-1@PB combines the multi-enzyme mimetic properties of PB nanoparticle-based nanozyme (PBzyme) for reactive oxygen species (ROS) scavenging and the ferroptosis-inhibitory function of Fer-1 with spatiotemporally controlled burst release under NIR irradiation. The 0.05), and the conclusion of colloidal stability remains completely unchanged. All the above revisions are limited to typographical adjustments, wording accuracy, and minor typo corrections. No experimental data, results, figures, or cistance. Sincerely, Xiaoran Liu (on behalf of all authors) Corresponding author"?> Fer-1@PB nanozymes exhibited strong therapeutic efficacy in cellular and animal sepsis-related ALI models, with an increased survival rate, reduced pulmonary edema and histopathological damage, and recovery of lung function. Mechanistic investigations using transcriptomic analysis (RNA-seq) and experimental validation revealed that the therapeutic effects were mediated by the modulation of the CXCL2/ARF6/NCF1 signaling axis. This study introduces Fer-1@PB as a highly efficient and biosafe nanotherapeutic approach for ALI via synergistic anti-oxidative and anti-inflammatory effects. It also outlines a new molecular mechanism of action, yielding new insights into the precise nanomedicine for inflammatory lung disease.
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MATERIALS RESEARCH BULLETIN
·
2026
·
IF 5.8
Zhiqi Yao,Kejie Li,Jiaqi Zhao,Haicheng Xia,Zuoling Fu,Sung Heum Park
A RE-doped Bi 4 Ti 3 O 12 perovskite-based luminescence material is developed. • Dual NIR-II emissions of Ho 3+ /Er 3+ are achieved under 980 nm excitation. • High performance (Sr=1.3% K-1) phonon-assisted ratiometric thermometer is constructed. High-performance optical thermometers operating in the second near-infrared (NIR-II) window hold great promise for biomedical applications due to their tissue penetration depth and minimal autofluorescence. However, developing reliable NIR-II thermometers with high sensitivity and robust performance across a wide temperature range remains a challenge. Herein, the luminescence properties and NIR-II ratiometric thermometric performance of Er 3+ , Ho 3+ , Yb 3+ co-doped Bi 4 Ti 3 O 12 (BTO) perovskite oxide were investigated. Upon 980 nm excitation, NIR-II emission from Er 3+ at 1560 nm ( 4 I 13/2 → 4 I 15/2 ) and Ho 3+ at 1200 nm ( 5 I 6 → 5 I 8 ) was achieved. A ratiometric thermometer was constructed using the temperature-dependent intensity ratio, I Er /I Ho . Relying on the thermal dependence of this ratio, the BTO system exhibits a relative sensitivity (S r ) of 1.3% at 333 K. Furthermore, the results suggest that phonon characteristics of the BTO host influence energy-transfer processes and NIR-II thermometric performance, highlighting importance of host properties in designing rare-earth-doped NIR-II thermometric materials. Download: Download high-res image (154KB) Download: Download full-size image A high-sensitivity NIR-II ratiometric thermometer is achieved in Bi 4 Ti 3 O 12 : Yb 3+ , Ho 3+ , Er 3+ Perovskites via a unique phonon-assisted energy transfer pathway.
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ACS Applied Nano Materials
·
2026
·Vol. 9
·期 31
·14854-14871
·
IF 5.8
Zhu Lijun,Xiong Jiabao,Du Zhong,Ma Kaikai,Chu Chenyang,Zhang Chi,Huang Siyu,Gao Yuxiang,Zhang Linxue,Wu Qinfen,Dong Biao,Alifu Nuernisha
Hollow manganese-dioxide-based nanoplatforms, which combine
hollow
structures with the intrinsic theranostic properties of Mn 2+ , have shown great potential for precise tumor diagnosis and treatment.
However, single imaging or therapeutic modalities are still insufficient
for high requirements of precise cancer theranostics. Herein, a hollow
manganese-based theranostic nanoplatform, MnO 2 –IR-820-Q/DOX@TMTP1
nanocomposite (Mn-NCs), was designed and synthesized. With the assistance
of the Mn-NCs, near-infrared-II (NIR-II, 900–1700 nm) fluorescence
imaging with high spatial resolution and low autofluorescence was
combined with magnetic resonance imaging (MRI) for highly efficient
and precise multimodal imaging of cervical tumors. The organic cyanine
dye IR-820 and PbS@CdS quantum dots (QDs) were integrated to form
a hybrid nanocomposite (IR-820-Q) with strong NIR-II fluorescence
emission, which was subsequently assembled onto a MnO 2 nanocarrier
to enable MRI and protect IR-820-Q from degradation. The hollow MnO 2 nanoshells served as a nanoscale structural framework for
IR-820-Q/DOX loading, tumor microenvironment-responsive degradation,
and Mn 2+ -mediated imaging/therapeutic functions. The cervical
tumor-targeting peptide TMTP1 was introduced to improve the tumor-targeting
potential of the nanocomposite, enabling NIR-II fluorescence visualization
of primary tumors and lymph node metastatic lesions. Therefore, Mn-NCs
are well suited for tumor-targeted imaging-guided intervention of
cervical cancer and lymphatic metastasis. By constructing the theranostic
nanoplatform, the photothermal therapy (PTT) as well as photodynamic
therapy (PDT) effect from the IR-820 was enhanced, and with the hydroxyl
radicals (via Fenton-like reaction) of Mn 2+ in the tumor
microenvironment, effective chemodynamic therapy (CDT) was also achieved.
The loading of doxorubicin (DOX) further endowed the nanoplatform
with a chemotherapeutic capability. Thus, the developed theranostic
nanoplatform showed strong NIR-II fluorescence/MRI-guided synergistic
PTT/PDT/CDT and chemotherapy, which significantly improved the therapeutic
outcomes. This study demonstrates a promising strategy for precise
cervical cancer diagnosis and treatment, highlighting the potential
of organic–inorganic hybrid nanomaterials for clinical translation.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Dayu Huang,Yuhang Zhang,Xingru Chen,Ziyong Cheng,Hongzhou Lian
The development of efficient and stable near—infrared (NIR) emitters using solution—processable materials remains a key challenge for flexible optoelectronics. This study addresses this need by constructing a novel ternary heterostructure through a room—temperature, sulfur—anion mediated transformation of CsPbCl 3 : Mn 2+ nanocrystals. Unlike conventional binary systems, this architecture enables a unidirectional energy cascade: from the CsPbCl 3 host to Mn 2+ emitters, and subsequently to the in—situ formed PbS domain, resulting in enhanced NIR emission. Systematic investigation reveals that optimal incorporation of C 6 H 18 SSi 2 is critical for modulating the heterointerface, which in turn opens a highly efficient energy transfer pathway. The resulting nanocomposite exhibits exceptional stability, retaining 95 % of its photoluminescence after six months under ambient conditions. Furthermore, the successful fabrication of flexible films with uniform electroluminescence underscores the practical potential of this heterostructure for next—generation optoelectronic devices.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
钙钛矿纳米晶
·
能量转移
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Advanced Therapeutics
·
2025
·
IF 2.6
Zhouyu Yu,Lijia Zou,Ruiqi Liu,Xiaoyan Zhang,Zhen Cheng,Si Chen,Baisong Chang
Liver fibrosis presents a significant global health challenge due to its potential progression to cirrhosis, liver failure, or hepatocellular carcinoma, highlighting the necessity for precise imaging of fibrosis progression. Here, a straightforward synthesis method is proposed to design bioresponsive nanoprobes capable of achieving high-resolution bioimaging of liver fibrosis. Janus MnO 2 -coated Ag/Ag 2 S nanoparticles modified by polyethylene glycol (denoted as jMAP) can inherit both the activatable properties from Ag/Ag 2 S and MnO 2 components in the pathological microenvironment. Multiple lines of evidence supported that overexpressed levels of reactive oxygen species (ROS) in liver fibrosis efficiently transformed jMAP nanoprobes to Ag 2 S products, activating bright fluorescence in the second near-infrared window (NIR-II, 1000–1700 nm). In addition, the catalase-like and superoxide dismutase-like activities of jMAP probes reduce hypoxia and oxidative stress with a clearance rate of about 73.3% toward ROS, thereby downregulating hypoxia-inducible factor (HIF-1 α ) and NADPH oxidase-4 (NOX-4) by 49.5% and 47.9%, respectively. Overall, the developed jMAP probes demonstrate impressive diagnostic accuracy, offering transformative prospects for liver fibrosis diagnosis.
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Small
·
2025
·
IF 12.1
Junyi Zeng,Hui Li,Deren Lan,Yuanchao Shi,Jiaxin Wang,Ying Li,Hui Shan,Ning Hu,Jibin Song,Jing Mu
Radiation-induced enteritis (RIE) remains a critical clinical challenge, demanding advanced strategies for diagnostic and therapeutic monitoring. Conventional assessment methods are often time-consuming and primarily detect anatomic changes at moderate or late stages, limiting timely intervention. Here, DSNP@786s@EM, an innovative biomimetic nanoprobe based on NaYbF 4 :2%Er,2%Ce@NaYF 4 :30%Nd downshifting nanoparticles (DSNP) is presented for real-time, in situ monitoring of RIE via ratiometric near-infrared II (NIR-II) fluorescence imaging. This system integrates downshifting core-shell nanoparticles with strong NIR-II emission under dual-wavelength excitation (808 and 980 nm), and a reactive oxygen species (ROS)-responsive IR786s dye, enabling absorption competition-induced emission (ACIE)-based dynamic ratiometric sensing. Additionally, the probiotic Escherichia coli Nissle 1917 (EcN) membrane (EM) camouflage of the nanoprobe enhances its intestinal retention and colon-specific targeting, leading to superior diagnostic performance. Comprehensive in vitro and in vivo studies validate DSNP@786s@EM as a highly sensitive and reliable tool for real-time, quantitative ROS monitoring in an RIE mouse model. Furthermore, ratiometric NIR-II fluorescence imaging effectively tracks therapeutic responses to dexamethasone, demonstrating its potential for monitoring treatment efficacy. These findings highlight the translational value of DSNP@786s@EM in advancing RIE diagnosis and management, with broader applicability to oxidative stress-related disorders and precision medicine.
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International Journal of Nanomedicine
·
2025
·
IF 6.5
Ling-zhijie Kong,Dong Zhou,Guoyan Mo,Mingyue Shu,Wenyan Yu,Hao Cheng,Kaichun Li
Introduction: The therapeutic efficacy of nanomedicine in oncology is predicated on its capacity to enhance drug uptake by cells and control drug release. While targeted nanomedicines are highly regarded for their potential, they are not spared from issues of colloidal instability and uncontrolled drug release.Methods: The hybrid system (Au@SiO2-HA-DOX) was designed to enhance colloidal stability and facilitate controlled drug delivery by coating gold nanorods with silica shells and hyaluronic acid (HA) for tumor targeting. The nanoparticles were characterized for morphology, size, zeta potential, and photothermal properties. The loading efficiency of doxorubicin (DOX) and its release behavior in response to pH, reactive oxygen species (ROS), and NIR stimulation were evaluated.Results: Under NIR irradiation, the nanoparticles exhibited excellent photothermal stability and sustained temperature elevation. In vitro studies demonstrated that the nanoparticles possessed good biocompatibility (cell viability exceeding 90%) and colloidal stability (7 days). The loading efficiency of DOX was enhanced to 65.9%, with sustained release characteristics. Furthermore, Au@SiO2-HA-DOX exhibited selective targeting and stronger cytotoxicity towards cancer cells. The cellular uptake efficiency was 1.7 times higher than that of the Free DOX at 24 h, with an IC50 value of 1.36 μM, compared to 2.01 μM for Free DOX. In vivo experiments in a mouse breast cancer model revealed significant tumor growth inhibited with NIR-assisted therapy, while maintaining stable body weight and preserving good biocompatibility.Conclusion: This nanohybrid system represents a promising strategy for improving the efficacy of chemotherapy and reducing toxicity in cancer treatment. It enhances drug enrichment and release in tumor tissues while minimizing the impact on normal tissues.
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DALTON TRANSACTIONS
·
2026
·
IF 3.3
Xiaofeng Jia,Yijia Guan,Weijie Cao,Xiaoshuo Zhang,Huazhen Duan,Hui Guo,Huichang Chen,Binbin Wang,Tao Li,Jianguo Liao
Alzheimer’s disease (AD), marked by the misfolding/aggregation of β-amyloid (Aβ), is a major global health challenge. Polyoxometalates (POMs), as anionic therapeutic agents, exhibit potential in depolymerizing Aβ fibrils, inhibiting Aβ fibrillation, and photocatalyst. To achieve targeted reactive oxygen species (ROS) amplification, we developed a chitosan-modified near-infrared (NIR)-responsive upconversion nanoplatform, UCNPs(Tm/Er)@SiO2@GPS@CH, as a targeted carrier for POMs. The nanoplatform was constructed by sequentially modifying upconversion nanoparticles (UCNPs) with a silica layer, 3-glycidoxypropyltrimethoxysilane (GPS, as a linker), and chitosan (CH, a cationic biomacromolecule). The cationic CH layer enabled efficient loading of anionic POMs through electrostatic interactions with an optimal POMs loading capacity of 415.41 μg/mg that positively correlated with CH modification levels. Under NIR irradiation, the nanoplatform triggered a photodynamic effect with abundant ROS. Notably, compared with the control group and Aβ monomer group, the ROS generation in the Aβ fibril group was approximately doubled, which further enhanced the targeted therapeutic efficacy of system. By integrating NIR responsiveness, cationic chitosan, targeted ROS generation, and low systemic toxicity, the nanoplatform provides a novel strategy for the photooxidative treatment of AD and offers insights into the design of chitosan-modified upconversion nanoparticles-based drug carrier systems.
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CERAMICS INTERNATIONAL
·
2026
·
IF 5.6
Runrun Li,Mingdong Deng,Fusheng Song,Runhua Liao
In this study, a series of BaAl 12- x Ni x O 19-δ ( x =0, 0.2, 0.4, 0.6, 0.8, 1.0) blue pigments were successfully synthesized via a solid-state reaction method. The results confirmed that Ni 2+ ions successfully substituted Al 3+ within the host lattice without altering the crystal structure. The synthesized pigments exhibited a distinct blue hue, attributed to the characteristic d-d transition in Ni 2+ ions. Additionally, the pigments demonstrated high NIR solar reflectance (ranging from 68.08% to 98.82%) within the wavelength range of 700-2500 nm, which is markedly superior to traditional cobalt blue (39%). In a practical thermal insulation test, a ceramic body coated with the BaAl 11.6 Ni 0.4 O 19-δ glaze showed a remarkable surface temperature reduction of 21.66% compared to an uncoated substrate. The combination of excellent color stability in glaze and superior NIR reflectance makes this BaAl 12- x Ni x O 19-δ system a highly promising candidate for use as a cool pigment in energy-efficient building materials, such as reflective coatings for roofs and walls.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 8
·1-9
·
IF 2.8
Peng Yanyan,Jiang Dayong,Zhao Man
The recent trend of combining perovskite with other materials to enhance optoelectronic performance has garnered significant interest. In this paper, MAPb 0.9 Sn 0.1 I 3 and ZnO–MAPb 0.9 Sn 0.1 I 3 photodetector were prepared by frequency magnetron sputtering and sol–gel spin-coating method. Hybrid heterojunction photodetectors have more beneficial optoelectronic performance compared to MAPb 0.9 Sn 0.1 I 3 photodetector, due to the presence of built-in electric fields, which can suppress the recombination of electrons and holes. At 7 V bias conditions, the responsivities of MAPb 0.9 Sn 0.1 I 3 photodetector were 0.022 and 0.015 A/W, and the responsivities of ZnO–MAPb 0.9 Sn 0.1 I 3 photodetector were 0.39 and 0.99 A/W obtained under 350 and 850 nm illumination, respectively. The maximum external quantum efficiency reaches 144.47%, the detection rate was 5.53 × 10 11 Jones and the light to dark ratio was 2.95 × 10 3 of ZnO–MAPb 0.9 Sn 0.1 I 3 photodetector. This study provides a basis for the preparation of perovskite heterojunction photodetectors with high optoelectronic performance. High performance UV–vis–NIR photodetectors based on ZnO/organic–inorganic hybrid Sn–Pb hybrid perovskite heterojunction.
研究领域:
材料科学
·
光电子学
·
半导体物理
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Theranostics
·
2026
·Vol. 16
·期 13
·7571
·
IF 14.9
Linlin Song,Meixu Chen,Huiling Wang,Xin Wang,Tianyue Xu,Heqing Zhang,Shuwen Ran,Liwen Huang,Yingying Ma,Zhihui Liu,Zihan Xu,Yujie Zhao,Zichang Liu,Yong Luo,Xiujun Yu,Yulan Peng,Hubing Shi,Jing Jing,Xiujing He
Rationale Triple-negative breast cancer (TNBC) remains one of the most aggressive subtypes due to its poor immunogenicity and resistance to systemic therapies. Methods Here, we report a multifunctional NIR-II light-triggered theranostic nanoplatform, termed LQPO, that integrates liposome, Ti 3 C 2 quantum dots (QDs), perfluorohexane (PFH), and ozone to enable multimodal imaging-guided photo-gas synergistic therapy. The QDs, embedded within the liposomal bilayer, act as highly efficient NIR-II photothermal transducers, while the PFH core serves as a liquid-gas phase-change medium capable of dissolving and releasing ozone under localized heating. Results Upon NIR-II irradiation, LQPO produced strong photothermal and photoacoustic signals for real-time photoacoustic (PA) and contrast-enhanced ultrasound (CEUS) imaging, accompanied by vaporization of the PFH core and burst release of ozone. This spatiotemporally coordinated cascade induced potent oxidative stress and hyperthermia, synergistically driving GSDME-dependent pyroptosis and immunogenic cell death (ICD). The resulting “in situ vaccination” effect remodeled the tumor immune microenvironment and primed tumors for PD-1 blockade therapy. In vivo , NIR-II-activated LQPO achieved efficient tumor accumulation, strong PA/CEUS imaging contrast, and pronounced inhibition of both primary and abscopal tumors when combined with αPD-1 therapy. No significant systemic toxicity was observed, confirming its favorable biosafety. Conclusions Overall, this study establishes a single-laser-activated nanoplatform that unifies real-time multimodal imaging and photo-gas synergistic therapy, and converts localized treatment into a systemic antitumor immune response upon integration with checkpoint inhibition.
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