Advanced Therapeutics
·
2025
·
IF 2.6
Zhouyu Yu,Lijia Zou,Ruiqi Liu,Xiaoyan Zhang,Zhen Cheng,Si Chen,Baisong Chang
Liver fibrosis presents a significant global health challenge due to its potential progression to cirrhosis, liver failure, or hepatocellular carcinoma, highlighting the necessity for precise imaging of fibrosis progression. Here, a straightforward synthesis method is proposed to design bioresponsive nanoprobes capable of achieving high-resolution bioimaging of liver fibrosis. Janus MnO 2 -coated Ag/Ag 2 S nanoparticles modified by polyethylene glycol (denoted as jMAP) can inherit both the activatable properties from Ag/Ag 2 S and MnO 2 components in the pathological microenvironment. Multiple lines of evidence supported that overexpressed levels of reactive oxygen species (ROS) in liver fibrosis efficiently transformed jMAP nanoprobes to Ag 2 S products, activating bright fluorescence in the second near-infrared window (NIR-II, 1000–1700 nm). In addition, the catalase-like and superoxide dismutase-like activities of jMAP probes reduce hypoxia and oxidative stress with a clearance rate of about 73.3% toward ROS, thereby downregulating hypoxia-inducible factor (HIF-1 α ) and NADPH oxidase-4 (NOX-4) by 49.5% and 47.9%, respectively. Overall, the developed jMAP probes demonstrate impressive diagnostic accuracy, offering transformative prospects for liver fibrosis diagnosis.
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高影响因子
Small
·
2025
·
IF 12.1
Junyi Zeng,Hui Li,Deren Lan,Yuanchao Shi,Jiaxin Wang,Ying Li,Hui Shan,Ning Hu,Jibin Song,Jing Mu
Radiation-induced enteritis (RIE) remains a critical clinical challenge, demanding advanced strategies for diagnostic and therapeutic monitoring. Conventional assessment methods are often time-consuming and primarily detect anatomic changes at moderate or late stages, limiting timely intervention. Here, DSNP@786s@EM, an innovative biomimetic nanoprobe based on NaYbF 4 :2%Er,2%Ce@NaYF 4 :30%Nd downshifting nanoparticles (DSNP) is presented for real-time, in situ monitoring of RIE via ratiometric near-infrared II (NIR-II) fluorescence imaging. This system integrates downshifting core-shell nanoparticles with strong NIR-II emission under dual-wavelength excitation (808 and 980 nm), and a reactive oxygen species (ROS)-responsive IR786s dye, enabling absorption competition-induced emission (ACIE)-based dynamic ratiometric sensing. Additionally, the probiotic Escherichia coli Nissle 1917 (EcN) membrane (EM) camouflage of the nanoprobe enhances its intestinal retention and colon-specific targeting, leading to superior diagnostic performance. Comprehensive in vitro and in vivo studies validate DSNP@786s@EM as a highly sensitive and reliable tool for real-time, quantitative ROS monitoring in an RIE mouse model. Furthermore, ratiometric NIR-II fluorescence imaging effectively tracks therapeutic responses to dexamethasone, demonstrating its potential for monitoring treatment efficacy. These findings highlight the translational value of DSNP@786s@EM in advancing RIE diagnosis and management, with broader applicability to oxidative stress-related disorders and precision medicine.
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PubMed
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Ling-zhijie Kong,Dong Zhou,Guoyan Mo,Mingyue Shu,Wenyan Yu,Hao Cheng,Kaichun Li
Introduction: The therapeutic efficacy of nanomedicine in oncology is predicated on its capacity to enhance drug uptake by cells and control drug release. While targeted nanomedicines are highly regarded for their potential, they are not spared from issues of colloidal instability and uncontrolled drug release.Methods: The hybrid system (Au@SiO2-HA-DOX) was designed to enhance colloidal stability and facilitate controlled drug delivery by coating gold nanorods with silica shells and hyaluronic acid (HA) for tumor targeting. The nanoparticles were characterized for morphology, size, zeta potential, and photothermal properties. The loading efficiency of doxorubicin (DOX) and its release behavior in response to pH, reactive oxygen species (ROS), and NIR stimulation were evaluated.Results: Under NIR irradiation, the nanoparticles exhibited excellent photothermal stability and sustained temperature elevation. In vitro studies demonstrated that the nanoparticles possessed good biocompatibility (cell viability exceeding 90%) and colloidal stability (7 days). The loading efficiency of DOX was enhanced to 65.9%, with sustained release characteristics. Furthermore, Au@SiO2-HA-DOX exhibited selective targeting and stronger cytotoxicity towards cancer cells. The cellular uptake efficiency was 1.7 times higher than that of the Free DOX at 24 h, with an IC50 value of 1.36 μM, compared to 2.01 μM for Free DOX. In vivo experiments in a mouse breast cancer model revealed significant tumor growth inhibited with NIR-assisted therapy, while maintaining stable body weight and preserving good biocompatibility.Conclusion: This nanohybrid system represents a promising strategy for improving the efficacy of chemotherapy and reducing toxicity in cancer treatment. It enhances drug enrichment and release in tumor tissues while minimizing the impact on normal tissues.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaoyue Hao,Yong Liu,Gaorong Han,Gaoling Zhao,Dongxue Liu,Huitao Dai,Sainan Ma,Likun Wang
Over half of the solar energy comes from the infrared region, which makes electrochromic materials that modulate infrared transmittance essential for the thermal management of smart windows. However, existing electrochromic materials do not perform well in the near-infrared region, which exhibits slow response time, weak adhesion to conductive substrates, and poor long-term cycling stability. In the present work, we successfully synthesized WO 3 @ITO nanorod samples with hierarchical core–shell structure by hydrothermal and in-situ solvothermal methods. ITO-coated WO 3 nanorods and some ITO nanocrystals were firmly integrated with WO 3 nanorods, resulting in a corn-like hybrid heterogeneous structure. The unique WO 3 @ITO hierarchical core–shell structure improves the electronic properties and the adhesion to substrates, reducing the energy barrier of ion diffusion and increasing the ion flux. Enhanced electrochromic performance in NIR range with a high optical modulation of 53.3 % in 1600 nm and long-term reversibility (maintaining 91.5 % of its original contrast after 1000 cycles) was achieved. In addition, response time (t c = 3.5 s, t b = 4.6 s) and coloration efficiency (112.5 cm 2 ‧C -1 ) have been significantly improved, which is almost twice that of unmodified WO 3 nanorods (t b = 8.6 s and CE = 56.4 cm 2 ‧C -1 ), showing a good application prospect in smart windows.
研究领域:
材料科学
·
能源技术
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Yingcui Bu,Yingyu Zhu,Yuxin Yang,Ting Wang,Xiaojiao Zhu,Xingxing Chen,Qiong Zhang,Mingdi Yang,Hongping Zhou
At present, some progress has been made in developing NIR light-responsive free radical generators. However, the efficacy of theranostics continues to be hindered by tumor-associated inflammatory reactions. Hence, fulfilling the in situ release of free radicals upon NIR light excitation specifically activated by the inflammation microenvironment would be an ideal strategy for efficient inflammation eradication and tumor suppression but remains a challenge. Herein, a SO2 (overexpressed reactive sulfur species in inflamed site)-stimulated phototheranostic agent (CVS) is successfully developed. Through a specific response to both endogenous and exogenous SO2 with a low LOD (31.7 nM), CVS demonstrates the “switch on” two-photon activity as well as efficient OH· generation. Remarkably, in CVS-treated H22-tumor-bearing mice, the NIR light-activated accurate inflammation eradication and tumor suppression are accomplished. This reactive phototheranostic platform not only facilitates the quantification of SO2 during inflammation but also renders it a potent NIR antihypoxic tumor agent.
研究领域:
生物医学工程
·
药理学
·
肿瘤学
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PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Da Feng,Li Guo,Yihan Zhao,Fang Yuan,Lulu Ning,Yuan Guo,Jianjian Zhang
Real-time monitoring of the lysosomal microenvironment using small-molecule probes is critical for understanding the complex interactions between organelles and diseases associated with lysosomal dysfunction. Most traditional fluorescent-dye-based lysosome probes rely on the protonation of the nitrogen atom in the morpholine unit to visualize the lysosomal microenvironment by inhibiting the photoinduced electron transfer (PET) effect. However, these probes often face selectivity issues within the complex cellular microenvironment. For instance, classic hemicyanine dyes (HD) show nonspecific fluorescence responses in the liver due to inappropriate pKa value, leading to low imaging contrast and the risk of false positives. Herein, a series of novel pH/viscosity-activatable, lysosomal-targeted near-infrared (NIR) fluorescent probes were developed by incorporating naphthalimide dye with hemicyanine dyes. These probes exhibit no fluorescence at physiological pH and weak fluorescence under acidic conditions (key 1), with substantial fluorescence activation triggered by abnormal viscosity in pathological tissues (key 2). Notably, NpCy-4 demonstrated a superior signal-to-background ratio (SBR) for cellular imaging and proved effective for real-time in situ diagnosis of acute gastritis.
研究领域:
生物化学
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医学影像学
·
分子生物学
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PubMed
高影响因子
DALTON TRANSACTIONS
·
2026
·
IF 3.3
Xiaofeng Jia,Yijia Guan,Weijie Cao,Xiaoshuo Zhang,Huazhen Duan,Hui Guo,Huichang Chen,Binbin Wang,Tao Li,Jianguo Liao
Alzheimer’s disease (AD), marked by the misfolding/aggregation of β-amyloid (Aβ), is a major global health challenge. Polyoxometalates (POMs), as anionic therapeutic agents, exhibit potential in depolymerizing Aβ fibrils, inhibiting Aβ fibrillation, and photocatalyst. To achieve targeted reactive oxygen species (ROS) amplification, we developed a chitosan-modified near-infrared (NIR)-responsive upconversion nanoplatform, UCNPs(Tm/Er)@SiO2@GPS@CH, as a targeted carrier for POMs. The nanoplatform was constructed by sequentially modifying upconversion nanoparticles (UCNPs) with a silica layer, 3-glycidoxypropyltrimethoxysilane (GPS, as a linker), and chitosan (CH, a cationic biomacromolecule). The cationic CH layer enabled efficient loading of anionic POMs through electrostatic interactions with an optimal POMs loading capacity of 415.41 μg/mg that positively correlated with CH modification levels. Under NIR irradiation, the nanoplatform triggered a photodynamic effect with abundant ROS. Notably, compared with the control group and Aβ monomer group, the ROS generation in the Aβ fibril group was approximately doubled, which further enhanced the targeted therapeutic efficacy of system. By integrating NIR responsiveness, cationic chitosan, targeted ROS generation, and low systemic toxicity, the nanoplatform provides a novel strategy for the photooxidative treatment of AD and offers insights into the design of chitosan-modified upconversion nanoparticles-based drug carrier systems.
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高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 5.6
Runrun Li,Mingdong Deng,Fusheng Song,Runhua Liao
In this study, a series of BaAl 12- x Ni x O 19-δ ( x =0, 0.2, 0.4, 0.6, 0.8, 1.0) blue pigments were successfully synthesized via a solid-state reaction method. The results confirmed that Ni 2+ ions successfully substituted Al 3+ within the host lattice without altering the crystal structure. The synthesized pigments exhibited a distinct blue hue, attributed to the characteristic d-d transition in Ni 2+ ions. Additionally, the pigments demonstrated high NIR solar reflectance (ranging from 68.08% to 98.82%) within the wavelength range of 700-2500 nm, which is markedly superior to traditional cobalt blue (39%). In a practical thermal insulation test, a ceramic body coated with the BaAl 11.6 Ni 0.4 O 19-δ glaze showed a remarkable surface temperature reduction of 21.66% compared to an uncoated substrate. The combination of excellent color stability in glaze and superior NIR reflectance makes this BaAl 12- x Ni x O 19-δ system a highly promising candidate for use as a cool pigment in energy-efficient building materials, such as reflective coatings for roofs and walls.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 8
·1-9
·
IF 2.8
Peng Yanyan,Jiang Dayong,Zhao Man
The recent trend of combining perovskite with other materials to enhance optoelectronic performance has garnered significant interest. In this paper, MAPb 0.9 Sn 0.1 I 3 and ZnO–MAPb 0.9 Sn 0.1 I 3 photodetector were prepared by frequency magnetron sputtering and sol–gel spin-coating method. Hybrid heterojunction photodetectors have more beneficial optoelectronic performance compared to MAPb 0.9 Sn 0.1 I 3 photodetector, due to the presence of built-in electric fields, which can suppress the recombination of electrons and holes. At 7 V bias conditions, the responsivities of MAPb 0.9 Sn 0.1 I 3 photodetector were 0.022 and 0.015 A/W, and the responsivities of ZnO–MAPb 0.9 Sn 0.1 I 3 photodetector were 0.39 and 0.99 A/W obtained under 350 and 850 nm illumination, respectively. The maximum external quantum efficiency reaches 144.47%, the detection rate was 5.53 × 10 11 Jones and the light to dark ratio was 2.95 × 10 3 of ZnO–MAPb 0.9 Sn 0.1 I 3 photodetector. This study provides a basis for the preparation of perovskite heterojunction photodetectors with high optoelectronic performance. High performance UV–vis–NIR photodetectors based on ZnO/organic–inorganic hybrid Sn–Pb hybrid perovskite heterojunction.
研究领域:
材料科学
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光电子学
·
半导体物理
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高影响因子
Theranostics
·
2026
·Vol. 16
·期 13
·7571
·
IF 14.9
Linlin Song,Meixu Chen,Huiling Wang,Xin Wang,Tianyue Xu,Heqing Zhang,Shuwen Ran,Liwen Huang,Yingying Ma,Zhihui Liu,Zihan Xu,Yujie Zhao,Zichang Liu,Yong Luo,Xiujun Yu,Yulan Peng,Hubing Shi,Jing Jing,Xiujing He
Rationale Triple-negative breast cancer (TNBC) remains one of the most aggressive subtypes due to its poor immunogenicity and resistance to systemic therapies. Methods Here, we report a multifunctional NIR-II light-triggered theranostic nanoplatform, termed LQPO, that integrates liposome, Ti 3 C 2 quantum dots (QDs), perfluorohexane (PFH), and ozone to enable multimodal imaging-guided photo-gas synergistic therapy. The QDs, embedded within the liposomal bilayer, act as highly efficient NIR-II photothermal transducers, while the PFH core serves as a liquid-gas phase-change medium capable of dissolving and releasing ozone under localized heating. Results Upon NIR-II irradiation, LQPO produced strong photothermal and photoacoustic signals for real-time photoacoustic (PA) and contrast-enhanced ultrasound (CEUS) imaging, accompanied by vaporization of the PFH core and burst release of ozone. This spatiotemporally coordinated cascade induced potent oxidative stress and hyperthermia, synergistically driving GSDME-dependent pyroptosis and immunogenic cell death (ICD). The resulting “in situ vaccination” effect remodeled the tumor immune microenvironment and primed tumors for PD-1 blockade therapy. In vivo , NIR-II-activated LQPO achieved efficient tumor accumulation, strong PA/CEUS imaging contrast, and pronounced inhibition of both primary and abscopal tumors when combined with αPD-1 therapy. No significant systemic toxicity was observed, confirming its favorable biosafety. Conclusions Overall, this study establishes a single-laser-activated nanoplatform that unifies real-time multimodal imaging and photo-gas synergistic therapy, and converts localized treatment into a systemic antitumor immune response upon integration with checkpoint inhibition.
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高影响因子
Small
·
2023
·Vol. 19
·期 19
·2207520
·
IF 13.3
Jianan Chen,Zhaobing Tang,Yangzhou Zhou,Shuo Ding,Liang Li,Lei Qian,Chaoyu Xiang
Formamidine lead iodide (FAPbI 3 ) is an important material for realizing high-performance near-infrared light-emitting diodes (NIR-LEDs). However, due to the uncontrollable growth of solution-processed films which usually causes low coverage, and poor surface morphology, the development of FAPbI 3 -based NIR-LEDs is hindered, restraining its potential industrial applications. In this work, by employing glutamine (Gln) in perovskite precursor, the quality of FAPbI 3 film is improved significantly. Due to the ameliorated solution process by the organic additive, the film coverage over the substrate is substantially enhanced. Meanwhile, the trap state of grain is largely reduced. Consequently, NIR perovskite LEDs are demonstrated with a maximum external quantum efficiency (EQE) of 15% with the emission peak at 795 nm, which is four times higher than the device with pristine perovskite film.
研究领域:
材料科学
·
光电学
·
化学
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 31
·10694-10702
·
IF 6.4
Yiwen Zhu,Yifan Yang,Yongqi Zhu,Yifan Chen,Zhenyu Liu,Fengmeng Lei,Hua Yu,Qinan Mao,Jiasong Zhong,Jing Wang
Near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs) have been attracting considerable attention as a new solid-state light source for night vision technology and biological imaging applications. Nevertheless, the requirement for toxic and concentrated HF in the previous synthesis of fluoride phosphors may cause environmental pollution and safety problems. Here, we report a feasible HF-free green synthesis method using a two-step process to prepare the Cr3+ source and a series of Cr3+, Li+ doped NIR phosphors using aqueous solution and methanol solution. X-ray diffraction analysis indicates that the pure target material was successfully synthesized. The luminescence intensity of K2ZnF4:Cr3+,Li+ is 2.58 times improved compared with K2ZnF4:Cr3+. Furthermore, the prepared phosphors show broadband emission in the range of 650 to 1000 nm, with a full width at half-maximum (FWHM) of 139 nm peaking at 783 nm. The NIR output power of the pc-LED fabricated with the K2ZnF4:Cr3+,Li+ phosphor and a 450 nm blue chip reaches 1007 mW at 320 mA. This work provides a promising phosphor for application as a NIR light emitting diode and has important implications for the green synthesis of HF-free Cr3+-doped fluorides in the future.
研究领域:
材料科学
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光电
·
化学
·
环境科学
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高影响因子
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