JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Hoan Duong Quoc,Cuong Ngo Tuan,Vy Nguyen Thi Ha,Chi Mai Phuong,Thinh Nguyen Huu,Hieu Nguyen Trung,Thao Le Phuong,Vinh Nguyen Thi Ngoc,Hai Le Thi Hong
A novel benzo[ d ]thiazole derivative (B31) was synthesized via a green method. Aggregation–induced emission (AIE) behavior was investigated in a dimethyl sulfoxide (DMSO)/water mixture. The solution of B31 exhibited fluorescence emission at approximately 500 nm with maximum intensity observed at 40% water content. B31 functioned as a selective fluorescence chemosensor for Al 3+ ion with detection limit of 24 nM. In addition, a new complex [Al( B31 –2H)(NO 3 )] (AlB31) was prepared and characterized by electrospray ionization mass spectrometry (ESI–MS), infrared spectroscopy (IR), and proton nuclear magnetic resonance spectroscopy ( 1 H NMR) spectra. Notably, the quantum yields of AlB31 complex in DMSO was approximately 60-foldhigher than that of the free B31 ligand, accompanied a significant Stokes shift. Density functional theory (DFT) calculations were performed to rationalize the optical properties of the studied compounds. The weak fluorescence of B31 is likely caused by the rotation of the naphthalene ring around the –CH = N– bond in the S 1 excited state. A plausible photoemission mechanism for the AlB31 c omplex has also been proposed.
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ACS Synthetic Biology
·
2024
·
IF 3.7
Tianfu Wu,Yihan Chen,Wanqing Wei,Wei Song,Jing Wu,Jian Wen,Guipeng Hu,Xiaomin Li,Cong Gao,Xiulai Chen,Liming Liu
Aromatic d-amino acids (d-AAs) play a pivotal role as important chiral building blocks and key intermediates in fine chemical and drug synthesis. Meso-diaminopimelate dehydrogenase (DAPDH) serves as an excellent biocatalyst in the synthesis of d-AAs and their derivatives. However, its strict substrate specificity and the lack of efficient engineering methods have hindered its widespread application. Therefore, this study aims to elucidate the catalytic mechanism underlying DAPDH from Proteus vulgaris (PvDAPDH) through the examination of its crystallographic structure, computational simulations of potential energies and molecular dynamics simulations, and site-directed mutagenesis. Mechanism-guided computational design showed that the optimal mutant PvDAPDH-M3 increased specific activity and catalytic efficiency (kcat/Km) for aromatic keto acids up to 124-fold and 92.4-fold, respectively, compared to that of the wild type. Additionally, it expanded the substrate scope to 10 aromatic keto acid substrates. Finally, six high-value-added aromatic d-AAs and their derivatives were synthesized using a one-pot three-enzyme cascade reaction, exhibiting a good conversion rate ranging from 32 to 84% and excellent stereoselectivity (enantiomeric excess >99%). These findings provide a potential synthetic pathway for the green industrial production of aromatic d-AAs.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Derui Zheng,Yu Wang,Jianhua Zu,Siyu Liu
This study developed a novel defective composite material (UiO-66/D-AMP) based on defect engineering and in situ synthesis of ammonium phosphomolybdate (AMP) for the highly selective capture of Cs + and Sr 2+ . The changes in adsorption capacity and surface functional groups of the composite before and after defect engineering were analyzed by adsorption experiment and FT-IR characterization. It was found that the defect-engineered composite had obvious carboxyl groups, and the adsorption efficiency of Sr 2+ was effectively improved. Several analytical methods were employed to verify the effective incorporation of AMP onto the UiO-66 framework. SEM-EDS was utilized to examine surface morphology and elemental composition. FTIR confirmed the presence of functional groups, while XRD analysis validated the crystalline structure. Additionally, TG assessed thermal stability, and BET measurements determined the material's surface area and porosity, collectively confirming AMP loading. The UiO-66/D-AMP composite exhibited significant adsorption affinity for both Cs + and Sr 2+ ions, demonstrating its potential for radioactive wastewater treatment. Under alkaline conditions (pH 10), the composite demonstrated exceptional removal efficiencies of 98.43% for Cs + and 99.54% for Sr 2+ . The maximum adsorption capacities were determined to be 104.3 mg/g for Cs + and 20.18 mg/g for Sr 2+ . Notably, the adsorption kinetics revealed rapid equilibration times of 5 min for Cs + and 60 min for Sr 2+ . The adsorption kinetics of Cs + and Sr 2+ followed the pseudo-second-order model, while the adsorption isotherms fitted well with the Langmuir model. In mixed solutions containing Cs + , Sr 2+ , and four competing ions, UiO-66/D-AMP exhibited excellent selectivity for both Cs + and Sr 2+ . Remarkably, the adsorption capacities for Cs + and Sr 2+ remained stable following exposure to various adsorbed doses. XPS provided direct evidence for the ion exchange mechanism between Cs + and NH 4 + during adsorption. Sr 2+ first exchanged with H + on UiO-66/D-AMP, then coordinated with the oxygen atom in the carboxyl group to be adsorbed.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 4
·1-9
·
IF 5.705
Song Jinyi,Yang Chengcheng,Ma Jiao,Han Qian,Ran Peiyao,Fu Yingzi
An electrochemical chiral multilayer nanocomposite was prepared by modifying a glassy carbon electrode (GCE) via opposite-charge adsorption of amino-modified β-cyclodextrin (NH 2 -β-CD), gold-platinum core-shell microspheres (Au@Pts), polyethyleneimine (PEI), and multi-walled carbon nanotubes (MWCNTs). The modified GCE was applied to the enantioselective voltammetric determination of tryprophan (Trp). The Au@Pts enable an effective immobilization of the chiral selector (NH 2 -β-CD) and enhance the electrochemical performance. Scanning electron microscopy, transmission electron microscopy, UV-vis spectroscopy, FTIR and electrochemical methods were used to characterize the nanocomposite. Trp enantiomers were then determined by differential pulse voltammetry (DPV) (with a peak potential of +0.7 V vs. Ag/AgCl). The recognition efficiency was expressed by an increase in peak height by about 32% for DPV determinations of L-Trp compared to D-Trp in case of a 5 mM Trp solution of pH 7.0. Response was linear in the 10 μM to 5.0 mM concentration range, and the limits of detection were 4.3 μM and 5.6 μM with electrochemical sensitivity of 43.5 μA·μM −1 ·cm −2 and 34.6 μA·μM −1 ·cm −2 for L-Trp and D-Trp, respectively (at S/ N = 3).
Schematic of an electrochemical chiral multilayer nanocomposite composed of multi-walled carbon nanotubes (MWCNTs), polyethyleneimine (PEI), gold-platinum core-shell microspheres (Au@Pt) and amino-modified β-cyclodextrin (NH 2 -β-CD). It was prepared by modifying a glassy carbon electrode (GCE) for enantioselective voltammetric determination of tryptophan (Trp) enantiomers.
研究领域:
分析化学
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生物化学
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2017
·
IF 1.174
Lei Guo,Yangdong Hu,Lianying Wu,Chen Liang,Weitao Zhang
To achieve green hydrolysis technology of hemicellulose through repeated using hydrolysate, the hydrolysis of hemicellulose in corncob was studied. The influence of repeated use of corncob hydrolysate on concentrations of d -xylose and l -arabinose was investigated. The loss rates of d -xylose in the prepared d -xylose solutions both with and without corncob, and repeated using corncob hydrolysate under identical acidity condition were discussed. The result shows that d -xylose concentration and l -arabinose concentration are all gradually increasing with the growing time of repeated use of corncob hydrolysate. After the fifth repetition, the concentrations of d -xylose and l -arabinose are 196.7 g·L − 1 and 22.0 g·L − 1 , respectively. Substance inhibiting the degradation of d -xylose is generated during repeated use of corncob hydrolysate, and the production is further proved by the change of d -xylose concentration and the loss rate of d -xylose over heating time.
研究领域:
生物技术
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化学工程
·
可持续化学
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Tao Wen,Qiyi Nie,Longbo Han,Zhongliang Gong,Dapeng Li,Qiang Ma,Zhiyu Wang,Weitao He,Liang Wen,Hailong Peng
D- limonene is the main volatile gas in citrus, and its content changes significantly after the citrus becomes infected, thus making it possible to use gas-derived information to identify pest-infested citrus. In this study, a quartz crystal microbalance (QCM) sensor based on a molecularly imprinted polymers (MIPs) coating was used to identify the citrus infested with Bactrocera dorsalis . The experimental results show that within the concentration range of 300–2100 mg m −3 , the sensor’s response to the concentration follows a linear trend, and its sensitivity was 0.078 Hz (mg m −3 ) −1 ; the detection limit was 41.40 mg m −3 . The sensor’s reproducibility and repeatability were both higher than 95%, and the one-month frequency drop deviation was less than 5%. The results confirmed that the MIPs-QCM sensor can rapid detection and nondestructive of infested citrus.
研究领域:
分析化学
·
植物保护
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Journal of Water Process Engineering
·
2021
·
IF 5.485
Zhe Wang,Kaiyuan Ma,Yufeng Zhang,Xinbo Zhang,Huu Hao Ngo,Jianqiang Meng,Lingzhong Du
Removing micro-pollutants is an important global challenge for the development of good adsorbents and environmental engineering issues. In this work, the structure of hierarchically and interconnected porous polymer has been fabricated by a high internal phase emulsion (HIPE) with water-in-oil and used for removing boron from water. This porous polymer was synthesized via monomer radical polymerization and utilized the active sites of monomer –Cl. In this way the vicinal hydroxyl group of N-Methyl- d -glucamine (NMG) was successfully introduced and grafted into HIPE by nucleophilic substitution reaction under the catalysis of triethylamine. The maximum boron uptake capacity was 2.54 mmol/g at a boron concentration of 100 mg/L, and reached adsorption equilibrium after about 2 h. Compared to traditional adsorption membrane materials, the HIPE porous polymer had better mechanical strength and able to resist acid and alkaline in the long-term. Meanwhile the regeneration efficiency of the HIPE30 %-g-PNMG porous polymer remained at 100 % after being used for 10 cycles.
研究领域:
环境工程
·
材料科学
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 30
·1-13
·
IF 2.8
Huang Yi-Rui,Li Wei,Wang Ze-Hong,Jian Xiao-Jian,Zhou Zi-Zhe,Jia Xiang-Xiang,Liu Hong-Yu,Lu Yi-Fan,Wang Jun-Chuan,Wu Xiang-Feng,Wang Hui,Zhou Er-Peng
Chiral optoelectronic sensors detect chirality by selectively binding with chiral substrates, causing changes in electrical signals, which have attracted wide attention for their chiral recognition ability. In this study, the Ti 3 C 2 /ZIF-67/D-His electrochemical sensors were successfully synthesized. Firstly, ZIF-67/D-His was obtained using hexahydrated cobalt nitrate, dimethylimidazole, and D-histidine (D-His). Then, the ZIF-67/D-His film was grown on the surface of the Ti 3 C 2 film using a spin-coating method. By changing the spin-coating cycles, the influence of the ZIF-67/D-His film thickness on the detection performance was studied. The results showed that when the spin-coating cycle was three, the electrochemical sensor (Ti 3 C 2 /ZIF-67/D-His-3) exhibited good detection performance for D-Ala with a detection limit of 1.1 μM, and additionally demonstrated an excellent selective detection ability for D-Ala, with a significant difference in the differential pulse voltammetry (DPV) current intensity between D-Ala and L-Ala solutions. Besides, the detection curve for D-Ala showed a linear relationship with the concentration of the D-Ala solution. Furthermore, the Ti 3 C 2 /ZIF-67/D-His-3 electrochemical sensor demonstrated good stability and could be reused multiple times after simple cleaning. The Ti 3 C 2 /ZIF-67/D-His prepared in this work shows promising application potential in the area of electrochemical sensors.
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Journal of Ovarian Research
·
2025
·Vol. 19
·期 1
·8
·
IF 4.2
Ling Xiaomei,Xie Cong,Li Ming,Li Jie,Liu Shun,Sun Liyue,Zeng Xinxin,Zhang Zhen,Zhang Xuhui,Liang Lei
Background Ovarian dysfunction caused by aging restricts female reproductive capacity and causes age-related health problems. Ferroptosis is an important mode of cell death during accelerated aging. Oviductus Ranae (OR), a traditional Chinese medicine, has been used to treat ovarian age-related diseases in women. However, the mechanisms through which OR mitigates ovarian aging, especially ferroptosis regulation, remain unclear. This study investigated the pharmacological effects and mechanisms of OR for ovarian aging in rats. Methods Sprague–Dawley female rats were divided into six groups: aging group induced with D-galactose; experiment groups treated with OR at low, middle, and high concentrations; positive control treated with estradiol valerate; and control group with no treatment. After 42 d, ovarian tissue and serum were collected for biochemical determination, hematoxylin and eosin staining, immunohistochemistry, enzyme-linked immunosorbent assay, reverse transcription-quantitative polymerase chain reaction, western blotting, and RNA sequencing analysis. To elucidate the mechanism underlying the effects of OR on ferroptosis in ovarian granulosa cells (OGCs), in vitro experiments were conducted. Results Treatment with OR improved ovarian follicular development and serum hormone levels, reduced iron deposition, enhanced cell proliferation, and inhibited apoptosis in D-galactose-induced ovarian aging rats. Ferroptosis was alleviated in the ovaries and serum by elevated glutathione and decreased lipid peroxidation production. RNA-seq showed that OR induced changes in 2,768 genes that were involved in ovarian steroidogenesis, glutathione metabolism, lipid metabolism, and ferroptosis pathways. Notably, OR downregulated ACSL4, LPCAT3, and ALOX12 mRNA and protein expressions, while upregulating FTH1, FTL, SLC7A11, GSS, and GPX4, which serve as critical regulators in ferroptosis. OGCs pretreated with OR-containing serum before erastin exposure exhibited enhanced viability, reduced ferrous iron, total iron, and lipid peroxidation levels, improved antioxidant activity, and stabilized mitochondrial function, indicating effective ferroptosis inhibition. Furthermore, OR-containing serum pretreatment inhibited ferroptosis in OGCs by regulating the GPX4/ACSL4 axis. Conclusions OR resists ovarian damage and prevents aging through antiferroptosis mechanisms by regulating the GPX4/ACSL4 axis in OGCs and aging rats. These results highlight the potential of OR as a therapeutic agent for the prevention and treatment of ovarian aging.
研究领域:
药理学
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生殖医学
·
细胞生物学
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中医药学
·
衰老研究
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JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Xinlin Zhu,Yi Dong,Ya Zhang,Chenghai Gao,Lijian Ding,Yonghong Liu,Zhiran Ju
Gouty arthritis, driven by monosodium urate (MSU) crystal deposition and dysregulated inflammation, remains a therapeutic challenge due to the limitations of current treatments. Here, we investigate Herdmanine D (HDD), a marine-derived alkaloid from the ascidian Herdmania momus. It was optimized via structure–activity relationship (SAR) studies and computational modeling to enhance its binding to peroxisome proliferator-activated receptor γ (PPAR-γ), which regulates the PPAR-γ/NF-κB signaling pathway in gout pathogenesis. The optimized HDD derivative 9a demonstrated potent PPAR-γ binding affinity and pharmacokinetic properties, effectively suppressing NF-κB-driven pro-inflammatory cytokines in vitro. In murine MSU-induced gouty arthritis models, 9a alleviated synovial inflammation and tissue damage. Mechanistically, 9a activated PPAR-γ to inhibit NF-κB and attenuate NLRP3 inflammasome assembly. This work highlights HDD as a unique marine scaffold for next-generation antigout therapeutics, merging marine natural product safety with rational design to address unmet clinical needs.
研究领域:
药理学
·
海洋天然产物
·
炎症性疾病
·
药物设计与开发
·
风湿病学
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JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Tian Yi Wu,Wen Jie Cao,Zi Ling Li,Yan Chun Gong,Xiang Yuan Xiong
Drugs with different solubility can be selectively embedded into polymersomes with the hydrophilic core and hydrophobic bilayer. Novel folate-targeted Pluronic/poly (D,L-lactide-b-glycolide) polymersomes were constructed and used for the co-delivery of paclitaxel (PTX) and doxorubicin (DOX) to improve their inhibitory effect over cancer cells. The particle size of blank polymersomes was mainly distributed below 125 nm. The release of PTX and DOX from polymersomes showed an initial burst release followed by a sustained and slow release. The in vitro cytotoxicity data showed that the targeted co-loaded polymersomes (PTX&DOX FA-Ps) exhibited better inhibitory effect than single-loaded polymersomes and free drugs did. Furthermore, PTX&DOX FA-Ps showed the synergistic therapeutic effect over OVCAR-3 cancer cells. The cellular uptake results also showed that folate modified polymersomes had excellent targeting performance. Therefore, the folate-targeted Pluronic/poly (D,L-lactide-b-glycolide) polymersomes have potential application value as novel drug carriers to co-deliver PTX and DOX.
研究领域:
药学
·
纳米技术
·
癌症研究
·
药物递送系统
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 22
·14473
·
IF 6.208
Guojing Li,Mengqian Yang,Qilong Sha,Li Li,Xiaogang Luo,Fengshou Wu
Organic nanomaterials have attracted considerable attention in the area of photodynamic and photothermal therapy, owing to their outstanding biocompatibility, potential biodegradability, well-defined chemical structure, and easy functionalization. However, it is still a challenge to develop a single organic molecule that obtains both photothermal and photodynamic effects. In this contribution, we synthesized a new boron-dipyrromethene (BODIPY)-based derivative (DPBDP) with an acceptor–donor–acceptor (A-D-A) structure by coupling 3,6-di(2-thienyl)-2,5-dihydropyrrolo [3,4-c] pyrrole-1,4-dione (DPP) and BODIPY. To enhance the hydrophilicity of the BODIPY derivative, the polyethylene glycol (PEG) chains were introduced to themeso- position of BODIPY core. The amphiphilic DPBDP was then self-assembled into related nanoparticles (DPBDP NPs) with improved hydrophilicity and enhanced absorbance in the NIR region. DPBDP NPs could simultaneously generate the singlet oxygen (1O2) and heat under the irradiation of a single laser (690 nm). The1O2quantum yield and photothermal conversion efficiency (PCE) of DPBDP NPs were calculated to be 14.2% and 26.1%, respectively. The biocompatibility and phototherapeutic effect of DPBDP NPs were evaluated through cell counting kit-8 (CCK-8) assay. Under irradiation of 690 nm laser (1.0 W/cm2), the half maximal inhibitory concentration (IC50) of DPBDP NPs was calculated to be 16.47 µg/mL. Thus, the as-prepared DPBDP NPs could be acted as excellent candidates for synergistic photodynamic/photothermal therapy.Keywords:BODIPY;nanoparticles;self-assembly;photodynamic therapy;photothermal therapy
研究领域:
生物医学工程
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材料科学
·
肿瘤学
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