INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
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IF 5.3
Yiwen Liu,Ruirui Liu,Qingliang Yang,Gensheng Yang
As a natural small molecule drug derived from turmeric, curcumin is known for its good biosafety and a range of beneficial effects, including anti-inflammatory, anti-spasmodic, antioxidant, antibacterial, anti-tumor, and neuroprotective effects. Even though, its insolubility in water and instability severely limit its bioavailability and clinical applications. The present study developed a deep eutectic solvent (DES) in oil microemulsion (DES/O-ME) system loaded with Cur for intranasal administration, aiming to enhance both the solubility and permeability of Cur to significantly increase its bioavailability. The project first constructed and screened the optimal choline chloride-based DES. Subsequently, the DES/O-ME system was prepared and optimized to achieve uniform particle size and stability using a pseudo-ternary phase diagram and electrical conductivity measurements. The resulting DES/O-ME system was thoroughly evaluated for its solubilization efficacy, permeability, mucosal cytotoxicity, and stability. Additionally, the therapeutic efficacy of the Cur-DES/O-ME was assessed in vivo using a murine model of allergic asthma. This comprehensive evaluation highlights the potential of the DES/O-ME system as a promising intranasal drug delivery platform to overcome the limitations of curcumin’s bioavailability and clinical application.
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JOURNAL OF POWER SOURCES
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2025
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IF 7.9
Zhongtao Shang,Tao Zhang,Qiao Yang,Dingke Wang,Yuyi Liao,Dongjia Xie,Yiyang Dai,Yuan Wang,Shaojun Yuan
Nanocomposites consisting of metal oxide and carbon materials are usually preferred as electrode for electrochemical energy storage. Nonetheless, their unsatisfied capacitance hinders the reached energy density of aqueous supercapacitors (SCs). Herein, Fe 2 O 3 /carbon heterointerface was constructed on porous carbon fiber (PCF), which could serve as an efficient active site for stabilizing K + and Na + storage. The theoretical calculations revealed the enhanced accumulation and transfer of charges around the Fe 2 O 3 /carbon interface, thus favoring the electron transfer and boosting the faradaic reaction. The interactions of Fe 2 O 3 and PCF was found to simultaneously cause faster ion transfer and more surface charge storage, which made the as-prepared Fe 2 O 3 @PCF electrode deliver a superior SCs performance in 2 M KCl or 1 M Na 2 SO 4 electrolyte. The asymmetric aqueous supercapacitor devices consisted of Fe 2 O 3 @PCF and MnO 2 /CC electrodes with maximum operating potential of 2.0 V achieved a high areal energy density of 0.126 mWh cm −2 at a power density of 1.2 mW cm −2 along with good stability.
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JOURNAL OF SOLID STATE CHEMISTRY
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2017
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IF 2.299
Zhen Ge,Xin Li,Wenguo Zhang,Qili Sun,Chunpeng Chai,Yunjun Luo
In this paper, the ultrafine Fe-O compound/ammonium perchlorate (AP) nanocomposites were prepared via in-suit growth method. The structure and morphology of the nanocomposites were characterized by infrared spectra, X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersion X-ray spectrometer (EDS) and transmission electron microscopy (TEM) test. The results showed that the prepared Fe-O compound nanoparticles were amorphous state and deduced as 2L-ferrihydrite. The size of Fe-O compound/AP nanocomposites could be effectively controlled by changing the recrystallization condition. 2L-ferrihydrite nanoparticles was evenly dispersed in the nanocomposites proved by EDS and TEM analysis. Furthermore, the thermal decomposition of Fe-O compound/AP nanocomposites was analysized by TG-DSC method. The prepared 2L-ferrihydrite nanoparticles of the nanocomposites showed good catalytic effect on AP because of their decreasing the decomposition temperature and increasing the total heat release of AP.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Wenxuan Li,Peifeng Li,Feiqiang He,Xiaoping Zhang,Yuling Zhu,Jianhua Ding
In this study, a foam fractionation technique was developed for the separation and enrichment of the trace m-phenylenediamine (MPD) and o-phenylenediamine (OPD) in solution. Firstly, a self-designed foam fractionation device was assembled and built, followed by a comprehensive characterization on gas types, foam fractionation column parameters, and porous sieve plate material used in the apparatus. Subsequently, the most crucial parameters for the separation and enrichment, such as surfactant species, solution pH, electrolyte categories, and gas flow rate, were identified and optimized. The mechanisms of key processes during foam fractionation under the influence of these parameters were thoroughly discussed. Other influencing factors, such as surfactant concentration, foam collection time, and solution volume in the fractionation column, were optimized using response surface methodology (RSM). Under these optimal conditions, maximal enrichment ratios of 138.2 and 85.5 were achieved for MPD and OPD, respectively. Finally, foam fractionation coupled with high-performance liquid chromatography (HPLC) was employed to detect MPD and OPD in the solution. The results demonstrated limits of detection (LOD) of 1.5 × 10 −2 μg/L and 1.5 μg/L for MPD and OPD, with relative standard deviation (RSD) values of 4.1 % and 3.9 %. When testing various actual samples, the recoveries were in the range from 92.0 % or greater in all cases. The method exhibited advantages of high sensitivity, precision, and accuracy, attributed to the high enrichment efficiency of foam fractionation. In conclusion, the foam fractionation method established in this study offers simplicity in apparatus, operational convenience, environmental friendliness (minimized use of organic solvents), and high enrichment efficiency. It proves valuable for the quantitative analysis of trace amounts of MPD and OPD in solution, presenting a novel approach for the detection of trace organic compounds in solutions.
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MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Zhenhe Wang,Shujin Ge,Shihao Chen,Xia Sun,Wei Chen,Qiuhong Li
Gaseous amines such as trimethylamine and ammonia are characteristic compounds for monitoring the quality of animal foodstuff like salmon meat. However, there is no existing colorimetric film with both hydrophobicity and UV-proof properties for salmon freshness monitoring in humid and light conditions. Addressing this challenge, a new colorimetric film was developed for monitoring salmon freshness by coating W/O Pickering emulsion containing microencapsulated red cabbage anthocyanin solution onto polyvinylidenefluoride film. The W/O Pickering emulsion was obtained using 3-(Trimethoxysilyl)propyl methacrylate modified TiO 2 @SiO 2 as the emulsifier. The ability of UV resistance and preventing anthocyanin from dissolving out of the film were verified by testing the light and water stability of film. The response of the colorimetric film to gaseous amines was investigated, and the performances including selectivity and linear range were evaluated. Based on this, the colorimetric film was successfully employed to monitor the freshness of salmon within 7 days at 4 ℃.
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Science Bulletin
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2024
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IF 18.8
Wei Lv,Zilei Shen,Junlin Liu,Xudong Li,Fang Ding,Dongyue Zhang,Licheng Miao,Xuefeng Lyu,Ruijie Li,Miaomiao Wang,Yiming Li,Jingwen Meng,Chao Xu
In this study, we successfully synthesized a δ-MnO 2 cathode with O vacancies, encapsulated by C derived from pyromellitic acid, using a facile hydrothermal method followed by annealing in an Ar atmosphere. The cathode’s structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product Zn 4 SO 4 (OH) 6 ·4H 2 O, regulating the Mn valence state, and suppressing the Jahn–Teller effect through the synergy of C encapsulation and O vacancies. This results in remarkable electrochemical performance, including a large capacity of 421.2 mAh g −1 at 0.1 A g −1 , a high specific energy density of 595.53 Wh kg −1 , and exceptional long-cycle life stability with 90.88% over 4000 cycles at 10 A g −1 , together with superior coulombic efficiency (∼100%) in pure ZnSO 4 electrolyte. Moreover, the cathode materials demonstrate specific antitumor efficacy. In brief, this work introduces an in situ synthetic C encapsulated δ-MnO 2 with O vacancies expected to be applied in both large-scale energy storage and biomedicine.
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Acta Pharmaceutica Sinica B
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2024
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IF 14.7
Jinhu Liu,Han Yang,Xiao Sang,Tong Gao,Zipeng Zhang,Shunli Fu,Huizhen Yang,Lili Chang,Xiaoqing Liu,Shuang Liang,Shijun Yuan,Suyun Wei,Yuxin Yang,Xiaoxin Yan,Xinke Zhang,Weiwei Mu,Yongjun Liu,Na Zhang
Cytopharmaceutical based on macrophages is a breakthrough in the field of targeted drug delivery. However, it remains a challenge to localize and control drug release while retaining macrophage activity and exerting its immunotherapeutic effect. Herein, a localized light-triggered release macrophage cytopharmaceutical (USIP@M) was proposed, which could utilize the tumor targeting and immunotherapy effects of macrophages to reverse the immune suppression of tumor microenvironment (TME). Amphiphilic block copolymers with ultraviolet (UV)-responsive o -nitrobenzyl groups were synthesized and co-loaded with sorafenib (SF), IMD-0354 (IMD), and upconverting nanoparticles (UCNPs), which were then taken up by macrophages, and the targeted delivery of drugs was realized by using the tumor tropism of macrophages. UCNPs converted near-infrared light with strong penetrability and high safety into UV light, which promoted the photoresponsive depolymerization of block copolymers and production of exosomes from USIP@M, accelerated drug efflux and maintained the activity of macrophages. IMD simultaneously polarized carrier macrophages and tumor-associated macrophages to exert the antitumor effect of macrophages, enhance T cell immunity, and alleviate the immunosuppressive state of TME. Synergistically with the chemotherapeutic effect of SF, it could effectively kill tumors. In conclusion, based on the localized light-triggered release strategy, this study constructed a novel macrophage cytopharmaceutical that could localize and control drug release while retaining the activity of macrophages and exerting its immunotherapeutic effect, which could effectively treat solid tumors.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Wenqian Cao,Yumeng Qi,Ying Zhang,Ruixue Guo,Ruijuan Qu,Zunyao Wang
Photolysis is the main pathway for the degradation of persistent organic pollutants (POPs). Most investigations, however, have been limited to the ultraviolet or visible region, and the reaction mechanism of infrared (IR) light is still unclear. In this study, the photodegradation of o,p' -dichlorodiphenyltrichloroethanes ( o,p' -DDT) on the silica (SiO 2 )/air interface under different irradiation light sources was systematically investigated. Interestingly, for the first time, effective degradation of o,p' -DDT under IR light irradiation was observed, which was ascribed to the anti-Stokes Raman scattering process of SiO 2 . Moreover, desert sands could also serve as a vector for the photodegradation of o,p' -DDT. The lower removal efficiency of desert sands compared to pure SiO 2 was a combined effect of differences in Fe 3+ component and SiO 2 content. It is worth noting that direct photodegradation plays a dominant role in the photodegradation of o,p' -DDT on SiO 2 . Besides, indirect photodegradation resulted mainly from •OH (25.0%), O 2 • − (6.9%), and 1 O 2 (5.6%) generated in the reaction system. In addition to hydroxylation and dechlorination products, the formation of four novel silicon-based products was observed, which resulted from the direct reaction of silyl radicals with o,p' -DDT. This study revealed that the specific Raman scattering effect of SiO 2 played a vital role in the self-purification process of POPs upon SiO 2 -based environmental matrices. The light-mediated decontamination system upon SiO 2 constructed in this study could provide critical information for addressing POPs contamination on sands.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
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IF 20.2
Hailong Tang,Yongqing Ma,Ganhong Zheng,Chuhong Zhu,Meiling Wang,Yilin Lu,Xiao Sun
Photocatalytic CH 4 conversion to CH 3 OH under mild conditions is undoubtedly an efficient strategy to realize CH 4 upgrading. In this work, in-situ formed highly reactive Fe IV =O complex with a bound Cl axial ligand was detected at ambient temperature and its contribution to CH 4 photoxidation to CH 3 OH was deeply investigated. Under optimized experimental condition, a high CH 3 OH yield of 3026.1 mmol mol Fe −1 (6.76 mmol g cat −1 h −1 ) with selectivity of 73.6 % was obtained during 8 h. Isotope labeling mass spectroscopy experiments manifested that O 2 was the only source of oxygen in products. The formation of Cl-(H 2 O) 4 Fe IV O complex was confirmed using low-temperature electron spin resonance spectroscopy and cryogenic Raman spectroscopy (ν(Fe O) = 828 cm −1 ). Through density functional theory (DFT) calculation, we showed that the Cl axial ligand acts as an “electron reservoir” during CH 4 conversion, i.e., electron acceptor during the process of CH 4 oxidation to CH 3 OH, while electron donor in CH 3 OH desorption. This not only lowered C-H cleavage energy, but also facilitated CH 3 OH desoption and inhibited overoxidation. As far as we know, Cl-(H 2 O) 4 Fe IV O is the first detected Fe IV O complex generated directly from O 2 and Fe 3+ at ambient temperature.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Riguang Cheng,Zhaoyu Liu,Pantrangi Manasa,Zhongxian Zhao,Hongge Pan,Fen Xu,Lixian Sun,Federico Rosei
The inherent thermodynamic stability and slow kinetics of LiAlH₄ pose significant challenges for its practical application in hydrogen storage. This study addresses these limitations by introducing nanoflower-structured layered double oxides (Co₃O₄@CoNi-LDO) as a performance-enhancing catalyst. The Co₃O₄@CoNi-LDO was synthesized through a hydrothermal process followed by calcination and subsequently incorporated into LiAlH₄ via mechanical ball milling. Experimental results demonstrate that the addition of 7 wt% Co₃O₄@CoNi-LDO substantially improves the hydrogen desorption properties of LiAlH₄. The hydrogen release temperatures for the two-step desorption process are reduced to 85.1 °C and 177.0 °C, respectively, with a total hydrogen release of approximately 6.87 wt% below 300 °C. Moreover, the activation energy of the two desorption steps is lowered by 20.0% and 46.3% compared to pristine LiAlH₄. The modified material also exhibits superior rehydrogenation performance, absorbing approximately 0.64 wt% hydrogen within 5 h-markedly better than pristine LiAlH₄. Mechanistic studies reveal that the in-situ formation of catalytically active species, such as Al₁₃Co₄ and Al₀.₉Ni₄.₂₂, anchored on the LiAlH₄ matrix, plays a pivotal role in facilitating hydrogen transfer. These catalytic sites effectively reduce the energy barriers for hydrogen desorption, enhancing the kinetics of the process. This work highlights the potential of Co₃O₄@CoNi-LDO nanoflowers as a highly effective catalyst for improving the hydrogen storage capabilities of LiAlH₄, paving the way for its application in advanced energy storage systems.
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ACS Central Science
·
2024
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IF 12.7
Xiangfeng Meng,Yue Zhou,Lei Xu,Limu Hu,Changjiang Wang,Xiao Tian,Xiang Zhang,Yi Hao,Bo Cheng,Jing Ma,Lei Wang,Jialin Liu,Ran Xie
Glycosylation plays a pivotal role in the intricate landscape of human cholangiocarcinoma (CCA), actively participating in key pathophysiological processes driving tumor progression. Among the various glycosylation modifications, O-linked β-N-acetyl-glucosamine modification (O-GlcNAcylation) emerges as a dynamic regulator influencing diverse tumor-associated biological activities. In this study, we employed a state-of-the-art chemical proteomic approach to analyze intact glycopeptides, unveiling the critical role of O-GlcNAcylation in orchestrating Keratin 18 (K18) and its interplay with tricarboxylic acid (TCA) cycle enzymes, specifically isocitrate dehydrogenases (IDHs), to propel CCA progression. Our findings shed light on the mechanistic intricacies of O-GlcNAcylation, revealing that site-specific modification of K18 on Ser 30 serves as a stabilizing factor, amplifying the expression of cell cycle checkpoints. This molecular event intricately fosters cell cycle progression and augments cellular growth in CCA. Notably, the interaction between O-GlcNAcylated K18 and IDHs orchestrates metabolic reprogramming by down-regulating citrate and isocitrate levels while elevating α-ketoglutarate (α-KG). These metabolic shifts further contribute to the overall tumorigenic potential of CCA. Our study thus expands the current understanding of protein O-GlcNAcylation and introduces a new layer of complexity to post-translational control over metabolism and tumorigenesis.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2018
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IF 11.698
Ruyi Zhong,Zisheng Zhang,Huqiang Yi,Lei Zeng,Chao Tang,Limin Huang,Meng Gu
Visible-light photocatalytic hydrogen evolution is a key step towards utilizing solar energy. Here we constructed covalently bonded oxidized graphitic C 3 N 4 /TiO 2 (O-g-C 3 N 4 /TiO 2 ) heterostructure with high surface area via an in-situ solvothermal synthetic strategy. The edge-anchoring of two-dimensional (2D) TiO 2 on 2D O-g-C 3 N 4 was evidenced by the HAADF-STEM EDS mapping, EELS and XPS analysis. Density functional theory computations suggest strong affinity between TiO 2 and O-g-C 3 N 4 2D structures through N O Ti covalent bonding, which drastically enhances the synergetic effect of the light absorption of O-g-C 3 N 4 and high surface area of TiO 2 . The as-formed heterojunction can remarkably boost the visible-light photocatalytic activity for H 2 evolution by 6.1 times compared to physical mixture of TiO 2 nanosheets (NS) and O-g-C 3 N 4 .
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