Nature Communications
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2026
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IF 18.1
Tang Jiawen,Zhang Junyu,Liu Jiacheng,Li Yunsong,Shao Ahu,Wang Zhiqiao,Wang Xin,Jia Qiurong,Liu Ting,Liu Zhe,Wang Jian-Gan,Wang Zhaohui,Xu Fei,Ma Yue
Practical implementation of solid polymer electrolytes is constrained by interfacial instability and manufacturing scalability. Here, we report a roll-to-roll compatible, 9.6-μm-thick solid polymer electrolyte membrane synthesized via in situ 1,3-dioxolane polymerization catalyzed by Lewis-acidic Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 on a polyethylene matrix, achieving a 99.1% conversion rate. The resulting membrane demonstrates 191.7 MPa mechanical strength and 418.7 mS ionic conductance at 25 °C. To resolve multiscale interfacial incompatibilities, a dual-additive strategy is employed: tris(4-fluorophenyl) phosphine constructs a fluorine-rich interphase extending positive electrode tolerance to 4.8 V, while Mg(TFSI) 2 forms a Li–Mg alloy lowering the negative electrode Li⁺ diffusion barrier to 0.127 eV. Validated in 1.2 Ah pouch cells, this system attains specific energy and energy density of 456.7 Wh kg⁻ 1 and 911.1 Wh L⁻ 1 (based on the total mass and volume of the pouch cell, respectively), stable wide-temperature cycling (−20 to 55 °C), and prevents thermal propagation under abuse conditions.
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高影响因子
Nature Communications
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2026
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IF 18.1
Chen Yunyi,Qian Xitang,Lyu Yuxiang,Qiu Yican,Zhou Siyu,Lan Xinyi,Lu Siqi,Shao Minhua
Initial-anode-free lithium metal batteries offer the potential for high energy density and simplified manufacturing, positioning as a transformative platform for sustainable energy storage. However, their implementation is hindered by the low reversibility of lithium plating/stripping. Herein, we propose a dynamic integrated interface engineering strategy that incorporates an Ag-based multifunctional initiator into the electrolyte. This additive consists of Ag + paired with anions capable of generating Lewis acids, enabling electrode-electrolyte interfacial coupling through in situ polymerization, while simultaneously enhancing the lithiophilicity of current collectors via Ag + -driven in situ deposition. The controlled release of the additive regulates the solvation structure, leading to the solid electrolyte interphase with an inverted organic-rich inner/inorganic-rich outer architecture, which represents a deliberate departure from conventional models. The anion anchoring effect reinforces the self-healing capability of the interphase, ensuring the construction of fast Li-ion transport pathways and a durable protective barrier, realizing highly stable operation of initially anode-free quasi-solid-state batteries. Specifically, the Cu | |LiFePO 4 cell exhibits 90% capacity retention after 200 cycles at 0.1 C, and a 2 Ah-level pouch cell delivers a specific energy of 467 Wh kg −1 based on total cell weight. This work provides an effective unified approach to address multiple interfacial challenges in initially anode-free lithium batteries.
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Nature Communications
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2026
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IF 18.1
Xinyao Ji,He Shan,Jiazuo Zhou,Chengyu Wang,Yifan Liu,Fangmiao Wang,Lei Qiao,Zimeng Liu,Meichen Li,Kai Zhang,Yudong Li,Wenbo Zhang,Haiyue Yang,Ruzhu Wang
Sorption-based atmospheric water harvesting (AWH) is a promising approach to relieve water scarcity in off-grid arid regions. Practical deployment remains limited by slow sorption kinetics caused by diffusion resistance and by intermittent desorption under diurnal and weather-dependent solar input. Here we report a hybrid solar and phase-change-material (PCM) hygroscopic wood composite (PHW) that integrates a water-sorption zone and an energy-management zone. The sorption zone uses a LiCl-embedded wood sponge with vertically aligned, multilayer channels to accelerate mass transport and shorten the time to equilibrium. The energy-management zone employs a PCM-based photothermal hydrogel to enhance solar-to-thermal conversion and store heat for sustained desorption. The PHW achieves a water uptake capacity of 0.59–3.03 g g -1 at 15-90% RH and reaches equilibrium within 360 min. The PCM hydrogel provides a heat-storage enthalpy of 155.51 J g -1 and an energy-conversion efficiency of 90.80%, enabling continuous water release under weak light and in darkness. In outdoor tests across cool winter and hot summer conditions and in different climate regions, a large-scale PHW array delivers a daily water yield of 0.96–1.72 L water kg sorbent -1 day -1 via continuous multi-cycle sorption–desorption. This hybrid sorption and thermal-management strategy advances all-weather AWH and improves real-world applicability. Most atmospheric water harvesters suffer from slow sorption and intermittent solar-driven desorption. Here, the authors develop a hybrid wood composite with a phase change material that stores solar heat. It rapidly captures water across a wide humidity range and releases it continuously, even in darkness, achieving a daily yield of 0.96–1.72 L kg⁻¹.
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PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Yang Shuang,Wan Wei,Qu Ziyu,Yi Keke,Zhang Di,Jiang You,Ye Zihong,Fang Xiang,Xie Jie,Dai Xinhua
Steroid hormones play crucial regulatory roles in human growth, development, reproduction, and the maintenance of internal environmental homeostasis. Because the concentrations of most hormones in the body are extremely low and their chemical properties vary widely, developing an accurate and sensitive quantitative method has become a primary objective in clinical diagnostics. In this study, an isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) method was developed and validated for the simultaneous quantification of 22 steroid hormones in human serum. To enhance extraction and purification efficiency, a protein precipitation–solid-phase extraction (PP-SPE) approach was employed, forming a “dual purification” strategy. The limits of quantification for progesterone, cortisol, dihydrotestosterone, and dehydroepiandrosterone sulfate were 0.05, 0.50, 0.05, and 1.00 ng/mL, respectively, representing an improvement over previously reported values obtained using similar sample pretreatment methods. Method validation results demonstrated strong linearity for all 22 steroid hormones ( R 2 > 0.98). Accuracy ranged from 86.9% to 119.5%, intra-day precision was below 9.7%, inter-day precision was below 12.0%, and the matrix effect was controlled within 80.3%–118.1%. These findings indicate that the method is accurate, reliable, and suitable for analyzing multiple components in complex serum matrices. Twenty real serum samples were analyzed to evaluate the clinical applicability of the method. The results demonstrated that this method can be used clinically to monitor steroid hormone levels, assist in diagnosing and treating endocrine disorders, and provide a diagnostic basis for adrenal diseases. It holds significant reference value for clinical laboratory testing. Graphical
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Qi Xuedi,Xu Zenghui,Ji Zhongyin,Kong Xiaojian,Sun Zhiwei
Consumption of food containing residues of nitrofuran metabolites may pose potential risks to human health. Although many countries have prohibited the use of nitrofurans as veterinary drugs, their illegal application persists. The detection of nitrofuran (NF) metabolites is essential for ensuring food safety. In this study, we designed and synthesized a pair of novel isotope-coded derivatization (ICD) reagents, 2-(4-formylphenyl)-1-phenyl-1H-naphtho[1,2-d]imidazole (d 0 -PPIB) and 2-(4-formylphenyl)-1-(pentadeuteriophenyl)-1H-naphtho[1,2-d]imidazole (d 5 -PPIB), using phenyl as the isotope-coded group. With the aid of the ICD reagents, a sensitive and accurate method for determination of NFs using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was established. The instrumental analysis time is remarkably short, with the four target analytes separated within just 4 min. The derivatization process was efficiently completed in only 15 min using microwave-assisted techniques, substantially reducing the overall experimental duration. The method achieved excellent sensitivity, with detection limits ranging from 0.011 to 0.019 μg/L, and the measurement error ranged from −2.2 to 3.5%. The intra- and inter-day precision was consistently high, with relative standard deviations (RSDs) below 5%. This ICD-based strategy effectively mitigates matrix effects while reducing costs and improving accuracy. Using one pair of ICD reagents (d 0 /d 5 -PPIB), multiple analytes are concurrently derivatized to generate their isotope-labeled internal standards, markedly decreasing commercial stable isotope-labeled (SIL) internal standard consumption. The method was successfully applied to quantify NF metabolites in three food samples. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
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2026
·Vol. 61
·期 35
·26088-26113
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IF 4.4
Li Jingmei,Pang Zibo,Qi Junxiao,Lu Jiamin
In this study, CuTCPP was loaded onto the surface of g-C 3 N 4 through a simple organic reaction to prepare a series of g-C 3 N 4 -CuTCPP (CNTP) photocatalytic composite materials. The material was characterized using XRD, SEM, EDS, and other methods to analyze its physicochemical properties. The biological safety of materials was evaluated through in vitro cytotoxicity experiments. Using E. coli , S. aureus , P. aeruginosa , B. subtilis , and C. albicans as model microorganisms, the broad-spectrum antibacterial performance of composite materials was tested under visible light to investigate the effects of concentration gradient and light exposure time on sterilization efficiency. The antibacterial mechanism was further revealed through reactive oxygen species fluorescence detection, free radical scavenging experiments, and evaluation of cell membrane damage. In addition, livestock and poultry wastewater was used as actual water samples to verify the practical application potential of the materials. Graphical abstract
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Nature Communications
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2026
·Vol. 17
·期 1
·1806
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IF 18.1
Zhong Wei,Liu Nana,Chen Binbin,Sun Huiqi,Fei Xiao,Lian Jiazhang,Guo Junling,Wang Bo,Wang Yajie
Methanol is a promising one-carbon (C1) feedstock for microbial bioconversion; however, engineered Saccharomyces cerevisiae often faces energetic constrains during its assimilation. Here, we develop SC-AOX 25 , an energy-efficient methylotrophic S. cerevisiae , through engineering of heterologous methanol-formaldehyde-formate (MFF) oxidation pathways coupled with adaptive laboratory evolution. SC-AOX 25 efficiently generates adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH) during methanol metabolism while co-assimilating methanol-derived intermediates (formaldehyde, formate, and CO₂) via native glyoxylate-serine cycle, pentose phosphate pathway, and reductive glycine pathway. Key energy modules - Fdh1 sc , Adh2 m , Aox m , and Rgi2 m - are characterized for their roles in ATP/NADH synthesis and methylotrophic growth. Formaldehyde-induced DNA-protein crosslinks (DPCs) and large repeated DNA fragments suggest strategies for methanol detoxification and phenotype enhancement. Utilizing SC-AOX 25 , we enable CO₂ assimilation through non-native Calvin cycle during methanol fermentation, establishing the engineered strain as a robust and energy-efficient methylotrophic platform for further C1 engineering.
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Science China-Chemistry
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2026
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IF 9.8
Sun Xiaoning,Shu Zixin,Li Hongxiang,Ding Chunmei,Qin Meng,Li Jianshu
The rapid and precise identification of antimicrobial resistance (AMR) at the point of care is critical for mitigating the global AMR crisis. However, conventional diagnostic methods are often constrained by prolonged turnaround times, operational complexity, and the need for sophisticated instrumentation. Herein, via engineering the crosslinkers, a β -lactamase ( β L) responsive photonic crystal hydrogel (PCH) was developed for the visual detection and rapid susceptibility assessment of drug-resistant bacteria. A disulfide bond-containing crosslinker was first introduced into the PCH, followed by a reduction reaction to leave reactive sites for introducing a β L-cleavable crosslinker via thiol-maleimide click chemistry. Upon β L exposure, the hydrogel undergoes enzymatic cleavage, leading to a decrease in crosslinking density, lattice expansion, and a measurable colorimetric shift. The sensor demonstrated high sensitivity, with a detection limit of 0.012 U/mL for β L and 47.2 CFU/mL for drug-resistant Pseudomonas aeruginosa , with visually detectable color changes in 10 min. The platform’s applicability was further validated in complex biofluids containing multiple microorganisms, achieving a detection limit of 60.1 CFU/mL for drug-resistant bacteria in artificial urine, far below the clinical threshold for urinary tract infections (⩾ 10 3 CFU/mL). Additionally, the PCH was applied for rapid phenotypic antibiotic susceptibility testing, reducing the assay time from 24 h to 2 h by categorizing antibiotics based on their efficacy. This work presents a sensitive, rapid, and cost-effective strategy that shows potential for guiding antimicrobial therapy and advancing point-of-care diagnostics.
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Nature Communications
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2026
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IF 18.1
Luo Kai,Qian Xiong,Meng Jiashen,Wang Xuanpeng,Qin Yukun,Wang Jinshuo,Zhang Meng,Yan Xiaoxue,Liu Fang,Wang Minghao,Hu Chuanlin,Hu Shuguang,Poon Chi Sun,Wang Fazhou
Molten-salt aluminum batteries are promising for grid-scale energy storage, leveraging the abundance and recyclability of aluminum along with the intrinsic safety, non-flammability, and high ionic conductivity of chloroaluminate electrolytes. However, conventional polymeric binders lack stability in high-temperature, corrosive molten-salt environments, leading to electrode structural degradation and premature battery failure. Here we propose thick cement-graphite electrodes for molten salt aluminum batteries that feature a self-supporting structure, high mechanical strength, high thermal tolerance, and resistance to chemical corrosion. In this design, graphite provides continuous electron-conducting pathways, while hydrated cement phases encapsulate and interconnect graphite, forming an inorganic skeleton with measurable mechanical properties, chemically inert, and hierarchically porous. Operating at 150 °C, the Al| |cement-graphite cells achieve a long cycle life of over 11,000 cycles at 16 mg cm –2 and 10 A g –1 , rate capability (retaining nearly 80 mAh g –1 at 15 A g –1 ) and stable cycling performance under high mass loadings up to 100 mg cm –2 . After extended cycling, the cement-graphite electrode retains its structural integrity. Multi-cell assemblies demonstrate scalability, while cost analysis shows cost savings associated with cement binders for molten-salt batteries.
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Probiotics and Antimicrobial Proteins
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2026
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IF 5.3
Zhao Mengyao,Wu Feifan,Xu Zenghao,Han Xing,Mao Sai,Zhang Hongying,Zhang Yina,Yang Mingfan
Pseudorabies virus (PRV) infection poses a significant health challenge to swine production, inducing oxidative stress, inflammatory responses, and reduced growth performance. Probiotic fermentation of medicinal plants is a promising strategy for generating novel probiotic-derived products for improving animal health. In this study, Phellodendron amurense (PA), a plant with both medicinal and dietary applications, was fermented with Lactobacillus plantarum R (LpR). We investigated the potential of fermented extract (FPAE) as a probiotic-derived feed additive for swine and its underlying mechanisms. Nontargeted UPLC‒MS/MS metabolomics revealed that fermentation significantly reshaped the metabolic profile of PAs, with marked enrichment of phenolic acids, flavonoids, and alkaloids. Specifically, the berberine content increased 2.5-fold, and the levels of antioxidant components such as ferulic acid and kaempferol were significantly increased. In vitro, FPAE inhibited PRV replication in PK-15 cells in a concentration-dependent manner (84.15% inhibition at 5 mg/mL). It also alleviated virus-induced oxidative stress, as evidenced by restored glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities and reduced malondialdehyde (MDA) levels. The supernatant of LpR showed no antiviral activity, confirming that the enhanced efficacy resulted from biotransformation of the plant matrix. In vivo, daily oral administration of FPAE (crude drug concentration of 125 mg/mL, 200 µL/mouse, equivalent to 892 mg/kg) significantly improved the survival rate (80% vs. 53.33% in the model group, and higher than the 73.33% in the unfermented PAE group); increased the average daily weight gain and feed conversion ratio; reduced the viral loads in the brain, lung, spleen and kidney; and, compared with PAE, more effectively reduced viral loads in the brain and alleviated pathological damage; and alleviated clinical symptoms and pathological damage to the brain. Furthermore, FPAE suppressed systemic inflammatory responses (decreased serum IL-6, P < 0.05) and enhanced antioxidant defense (increased GSH-Px activity, P < 0.05, P = 0.004). Through a multi-dimensional “constituent–cell–animal” approach, this study demonstrated that probiotic fermentation restructures the chemical composition of Phellodendron amurense and synergistically regulates host oxidative stress and inflammatory responses to confer protection against viral infection. These findings provide a theoretical basis for developing LpR-fermented Phellodendron amurense as a functional feed additive to control PRV infection in swine.
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Nature Communications
·
2026
·Vol. 17
·期 1
·7928
·
IF 18.1
Zhao Jing,Ma Qun,Luo Xueqin,Liu Hong,Xu Shijun,Lian Gangping,Liu Yang,Liang Huageng,Zhou Lei,Lin Meihua,Guo Wei,Xia Fan
Artificial chemical synapses, which specifically identify, transmit, and process molecular information, find promising applications in precision medical diagnosis, neural-electronic interface, and in-memory computing. However, to implement biomarker-triggered neuronal excitability modulation with artificial iontronic devices remains a significant challenge. Herein, we demonstrate a capture DNA integrated angstrom-fluidic chemical synapse in which the intramembrane ionic conductance can be switched between excitatory and inhibitory states by specific DNA-target interactions on the outer membrane surface. Experimental results and theoretical calculations unveil that capture of specific biomarker results in a bidirectional space charge polarization, and establishes opposite local concentration gradient at the membrane surface. Driven by this reversible concentration gradient, cation influx or efflux modulate the number density of ionic charge carriers inside the membrane, analogy to the hyperpolarization and depolarization modes of biological chemical synapses. Using a convolutional neural network algorithm to process the ionic conductance enhancement and depletion signals, we develop a diagnostic approach for early prostate cancer with 100% accuracy for both retrospective analysis of 105 clinical specimens, and prospective double-blind trials ( n = 10). This work sheds light on artificial chemical synapses based medical diagnosis, and provides a blueprint for neural-like iontronic network for chemical information processing.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Li Qing,Wang Ke,Chen Xiaoling,Hu Jinmei,He Xin,Zhou Lin
Given the global rise in obesity and metabolic syndrome, plant-based functional beverages that regulate glycemia and lipidemia have attracted increasing interest. This study focused on Millettia speciosa Champ. leaf Golden-flower fungus fermented tea (MLGFT), a novel fermented tea developed from underutilized leaf biomass. The brewing process was optimized via single-factor and response surface methodology, yielding optimal parameters of 85 °C, 7.3 min, and 146 mL of water, which maximized total phenolic content (124 µg/mL). The optimized tea infusion (OTI) exhibited potent in vitro enzyme inhibition: (93.45 ± 0.98) % against α-glucosidase, (45.52 ± 1.11) % against α-amylase, and (81.47 ± 0.90) % against pancreatic lipase. In cellular models, the freeze-dried extract (ME) dose-dependently enhanced glucose consumption in insulin-resistant HepG2 cells, with effects comparable to metformin at 100 mg/L. In a model of lipid accumulation, ME at 100 mg/L significantly improved the lipid profile, reducing TC, TG, and LDL-C by 63.02%, 43.50%, and 71.79%, respectively, while increasing HDL-C by 46.15%. UPLC-HRMS analysis revealed that the extract is rich in phenolics, particularly epicatechin gallate. These findings demonstrate that MLGFT exhibits notable dual hypoglycemic and hypolipidemic effects, supporting its use as a promising functional beverage for metabolic health management.
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