CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Chao Wang,Xu Wang,Binglei Wang,Guozheng Xiao,Ruiqing Qiao,Fan Zhang,Yu Bai,Yizhuo Li,Yusheng Wu,Zhanjie Wang,Hongjie Wang
A dense β-Si 3 N 4 coating toughened by β-Si 3 N 4 nanowires/nanobelts was prepared by a combined technique involving chemical vapor deposition and reactive melt infiltration to protect porous Si 3 N 4 ceramics in this work. A porous β-Si 3 N 4 nanowires/nanobelts layer was synthesized in situ on porous Si 3 N 4 ceramics by chemical vapor deposition, and then Y–Si–Al–O–N silicate liquid was infiltrated into the porous layer by reactive melt infiltration to form a dense composite coating . The coating consisted of well-dispersion β-Si 3 N 4 nanowires/nanobelts, fine β-Si 3 N 4 particles and small amount of silicate glass . The testing results revealed that as-prepared coating displayed a relatively high fracture toughness, which was up to 7.9 ± 0.05 MPa m 1/2 , and it is of great significance to improve thermal shock resistance of the coating. After thermal cycling for 15 times at ΔT = 1200 °C, the coated porous Si 3 N 4 ceramics still had a high residual strength ratio of 82.2%, and its water absorption increased only to 6.21% from 3.47%. The results will be a solid foundation for the application of the coating in long-period extreme high temperature environment.
研究领域:
材料科学
·
表面工程
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2012
·
IF 2.422
Tianfei Zhang,Hengde Li,Weigang Zhang,Kazuhiro Tamura
(Liquid + liquid) equilibrium (LLE) data for {water (1) + methanol (2) + β-citronellol (3)} and {water (1) + ethanol (2) + β-citronellol (3)} ternary systems at T = (283.15, 298.15, and 313.15) K are reported. The immiscible region of (water + methanol + β-citronellol) system was found to be larger than that for the ethanol system at the same temperature. The effect of the temperature on the ternary (liquid + liquid) equilibria was examined and discussed. The experimental (liquid + liquid) equilibrium data have been satisfactorily represented by using extended UNIQUAC and modified UNIQUAC models.
研究领域:
化学工程
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物理化学
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Zejun Xu,Yi Zhang,Qian Hu,Qiao Tang,Jiake Xu,Jianping Wu,Thomas Brett Kirk,Dong Ma,Wei Xue
The development of biocompatible vector for hydrophobic drug delivery remains a longstanding issue in cancer therapy. We design and synthesis a drug delivery system based on HPG modified β -CD ( β -CD-HPG) by conjugating HPG branches onto β -CD core and its structure was confirmed by NMR, FTIR, GPC and solubility. In vitro biocompatibility tests showed that HPG modification significantly improved red blood cells morphology alteration and hemolysis cause by β -CD and β -CD-HPG displayed cell safety apparently in a wide range of 0.01–1 mg/mL. An anti-cancer drug, docetaxel, was effectively encapsulated into β -CD-HPG which was confirmed by DSC analysis. This copolymer could form nanoparticles with small size (< 200 nm) and exhibited better DTX loading capacity and controlled release kinetics without initial burst release behavior compared with β -CD. Furthermore, antitumor assay in vitro show that β -CD-HPG/DTX effectively inhibited proliferation of human breast adenocarcinoma cells. Therefore, β -CD-HPG/DTX exhibit great potential for cancer chemotherapy.
研究领域:
药学
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生物材料
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
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2015
·Vol. 5
·期 63
·51364-51370
·
IF 3.84
Zongxue Yu,Yang Pan,Yi He,Guangyong Zeng,Heng Shi,Haihui Di
As part of this work, polyvinylidene fluoride (PVDF) membranes were prepared via a phase inversion method. A novel β-cyclodextrin (β-CD)–PVDF membrane was prepared via an interfacial reaction, using Trimesoyl Chloride (TMC) and β-CD as cross-linking and modification agents, respectively. The membranes were modified by a simple dip-coating method. The results of comparison between the modified and unmodified membranes by attenuated total reflectance Fourier transform infrared spectroscopy (FTIR-ATR) and X-ray photoelectron spectroscopy (XPS) methods confirmed successful grafting of β-CD on the membrane surfaces. The morphology of the membrane was investigated by scanning electron microscopy (SEM) and atomic-force microscopy (AFM). The roughness of PVDF membranes increased after their surfaces were grafted with β-CD. It was also found that β-CD–PVDF membranes had higher permeate flux and hydrophilicity than those of the pristine PVDF membranes. Furthermore, in protein fouling experiments, bovine serum albumin (BSA) was used as a protein model solution. Modified membranes exhibited a higher flux recovery ratio. The experiment showed that the anti-fouling performance of β-CD–PVDF membranes was more effective in reducing the irreversible membrane fouling. The results of this study hold promise for useful applications of β-CD–PVDF membranes in membrane separation areas.
研究领域:
材料科学
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环境工程
✓ 已验证
产品关联
DOI
高影响因子
Biochemistry and Biophysics Reports
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2021
·
IF 0
Xiaomin Zhang,Yidan Chen,Ju Yao,Yingxin Zhang,Mengying Li,Bo Yu,Kaifeng Wang
Temozolomide (TMZ) is a widely used chemotherapeutic agent for malignant glioma. β-Elemene has been reported to have the ability of passing through the blood-brain barrier and reverse multidrug resistance. In the present study, transport of drugs through the in vitro blood-brain barrier (BBB) model also suggested that β-elemene can assist in TMZ transport to the brain. Plasma and brain pharmacokinetics demonstrated that when β-elemene is used in combination with TMZ, the metabolic rate of TMZ in plasma is slowed, and mean residence time (MRT) in brain is prolonged. The brain tissue distribution at 1 h indicated that the combination of TMZ and β-elemene promotes the distribution of β-elemene in the brain but slightly reduces the distribution of TMZ in the brain. Furthermore the antitumor effect and toxicity in vivo were also investigated. The combination of β-elemene and TMZ was well tolerated and significantly inhibited tumor growth in glioma xenografts. In summary, the present study indicates a synergistic antitumor effect of β-elemene and TMZ in glioma.
研究领域:
肿瘤学
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药理学
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神经科学
✓ 已验证
产品关联
DOI
PubMed
BIOSCIENCE REPORTS
·
2019
·Vol. 39
·期 1
·
IF 2.535
Chen Gang,Chen Weicheng,Ye Ming,Tan Weiqiang,Jia Bing
Neuroblastoma is the most common tumor in children, with a very poor prognosis. It is urgent to identify novel biomarkers to treat neuroblastoma, together with surgery, chemotherapy, and radiation. Human tripartite motif 59 (TRIM59), a member of the TRIM family, has been reported to participate in several human tumors. However, the exact role of TRIM59 in neuroblastoma is unknown. In the present study, real-time PCR and Western blot were used to measure mRNA and protein levels of TRIM59 in four neuroblastoma cell lines and in neuroblastoma tissues. Lentiviruses targeting TRIM59 were used to up/down-regulate TRIM59 expression levels. Cell Counting Kit-8 and Annexin-V/PI were used to analyze cell proliferation and apoptosis in neuroblastoma cell lines. Our data showed that TRIM59 knockdown inhibits cell proliferation while inducing apoptosis in SH-SY5Y and SK-N-SH neuroblastoma cell lines. TRIM59 knockdown up-regulated expression of Bax and Bim and down-regulated levels of Survivin, β-catenin, and c-myc. Interestingly, the inhibition of cell proliferation caused by TRIM59 knockdown could be blocked by LiCl, which is an agonist of Wnt/β-catenin signaling pathway. In contrast, TRIM59 overexpression could increase cell proliferation, up-regulate Survivin, β-catenin and c-myc, down-regulate Bax and Bim, and these effects could be blocked by XAV939, which is an inhibitor of Wnt/β-catenin signaling pathway. In addition, TRIM59 was up-regulated and positively related with β-catenin in neuroblastoma tissues. In conclusion, TRIM59 was up-regulated in neuroblastoma, and TRIM59 knockdown inhibited cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma.
研究领域:
肿瘤学
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细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2022
·
IF 13.4
Lin Sun,Guizhou Xu,Yizhou Tu,Wenrui Zhang,Xuejiao Hu,Pingping Yang,Daishe Wu,Ying Liang,Dongyang Wei,Aimin Li,Xianchuan Xie
Keeping water clean is of vital significance for human health and environmental protection. In order to remove organic micro-pollutants and natural organic substances in water bodies and kill pathogenic microorganisms simultaneously, this study synthesized a multifunctional porous β-cyclodextrin polymer with a high specific surface area by introducing quaternary ammonium groups and rigid benzene rings, respectively, which was then polymerized with crosslinking agent-4,4′-bis (chloromethyl)-1,1′-biphenyl (BCMBP) in an ionic liquid system. The grafting of quaternary ammonium groups was beneficial for the removal of negative-charged humic acid (HA) and sterilization. The introduction of numerous rigid structures during benzylation and Friedel-Crafts alkylation reaction could significantly improve the porosity and specific surface area of the polymer, conducive to the exposure of cyclodextrin binding sites and contaminant adsorption. By changing the proportions of quaternization and benzylation, the structure and surface properties of the polymer could be adjusted, thus further regulating the adsorption performance. Compared with activated carbon, the polymer named BQCD-BP with a huge surface area of 1133 m 2 g −1 prepared under optimized conditions showed outstanding adsorption performance and sterilization ability. The pseudo-second-order kinetic constant of BQCD-BP reached 1.2058 g·mg −1 ·min −1 , which was approximately 50 times greater than that of activated carbon (0.0256 g·mg −1 ·min −1 ) under the same experimental condition. The adsorption capacity of BQCD-BP to HA was twice as high as that to AC, and the antibacterial ability of BQCD-BP was significant, achieving 90% at the dosage of 1g L −1 . Moreover, the adsorption process was hardly affected by the hydrochemical conditions, and the polymer was easy to regenerate. In addition, the excellent adsorption and antibacterial performance of the polymer were also identified by natural water treatment. COD was almost completely removed, and the removal efficiency of TP reached 92% after contact with BQCD-BP. The sterilization rate of BQCD-BP to viable bacteria in complex water bodies reached 82%. Undoubtedly, BQCD-BP is a potential multifunctional water treatment material with reasonable design in the actual water purification.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
POLYMER INTERNATIONAL
·
2011
·Vol. 60
·期 10
·1455-1460
·
IF 2.056
Xiuling Ma,Zhen Chen,Riyao Chen,Xi Zheng,Xiao Chen,Ruifang Lan
The objective of this study was to identify a kind of molecular imprinting polymer (MIP) which was suitable for recognizing naringin (NG) in aqueous medium. Based on two crosslinkers (hexamethylene diisocyanate and epichlorohydrin) and two polymerization methods (solution polymerization and emulsion polymerization), four non-covalent naringin-β-cyclodextrine (NG-β-CD) imprinted polymers were prepared by using β-CD as a functional monomer and NG as a template molecule. The binding property and selectivity were evaluated by equilibrium binding experiments. These demonstrated that all the sites in the MIPs show good selective binding ability for NG from naringin dihydrochalcone, a structurally similar molecule. Of the four MIPs, rod-like 3# MIP which was prepared by emulsion polymerization using hexamethylene diisocyanate as crosslinker exhibited the highest selectivity, its imprinting factor α being 1.53. Scatchard analysis of 3# MIP suggests that there are two classes of binding sites during the MIP's recognition of NG. Additionally, the 3# MIP could be used at least five times without any loss in sorption capacity. Copyright © 2011 Society of Chemical Industry
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SN Applied Sciences
·
2019
·Vol. 1
·期 3
·1-10
·
IF 0
He Shiwei,Xu Ruidong,Guo Yuqing,Zhao Zhuo,Yu Bohao,Xiao Saijun,Lv Huihong
In this study, β-PbO 2 –Co 3 O 4 composite coatings were synthesized on a substrate using the electrodeposition method in an electrolyte containing Pb 2+ and Co 3 O 4 particles. The preparation process study shows that the β-PbO 2 bath containing Co 3 O 4 particles becomes more stable for an ultrasonic dispersion time within 30 min, with the stability beginning to decrease after the ultrasonic time exceeds 30 min. Co 3 O 4 particles in the β-PbO 2 bath are positively charged, with anions being adsorbed onto the particles. The nucleation behavior study shows that the electric field force plays a dominant role in the adsorption process for the Co 3 O 4 particles. The nucleation and growth of β-PbO 2 on the Co 3 O 4 particles started for the particles closer to the substrate. In addition, the thickness of the β-PbO 2 layer on the Co 3 O 4 particles was inversely proportional to the distance between the Co 3 O 4 particles and the substrate. Compared to the pure PbO 2 electrode, the oxygen evolution overpotentials for the β-PbO 2 –Co 3 O 4 electrode are decreased significantly, which demonstrates an energy-saving effect.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
Biochemistry and Cell Biology
·
2025
·
IF 2.1
Hongyu Wang,Liyang Liang,Yanfei Wang,Xuan Zhong,Chao Zhang,Zhipeng Liu,Jinzhong Liu,Wanning Hu
WD repeat domain 4 (WDR4) has been reported to promote tumor metastasis in various cancers. However, its precise function in colorectal cancer (CRC) has not been reported yet. Herein, the expression pattern of WDR4 in CRC was determined by analyzing Gene Expression Omnibus datasets (GSE110225, GSE127069, GSE156355, and GSE184093) and GEPIA online dataset. In vitro and in vivo experiments, including CCK-8, colony formation, flow cytometry, wound healing, transwell assays, and xenograft mouse models, were used to investigate the role of WDR4 in CRC. Firstly, data from Kaplan–Meier database showed that high expression of WDR4 was associated with the poor prognosis of CRC patients. Then, upregulation of WDR4 was confirmed in clinical CRC tissues. In vitro functional experiments suggested that overexpression of WDR4 promoted cell proliferation, migration, and invasion, while knockdown of WDR4 has the opposite effects. Also, the oncogenic role of WDR4 was also verified in in vivo experiments. CO-IP-LC/MS analysis uncovered that glycogen synthase kinase 3β (GSK3β) is the central protein that binds to WDR4. Mechanistically, WDR4 activated the β-catenin pathway by promoting GSK3β phosphorylation. This study demonstrates that WDR4 promotes CRC progression through activating GSK3β/β-catenin pathway, indicating that WDR4 might be a potential therapeutic target for CRC treatment.
研究领域:
肿瘤学
·
分子生物学
·
医学遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2024
·
IF 2.6
yufei Song,Xiaojie Guo,Wenxiang Mu,Xutang Tao,Zeliang Gao
β-Ga2O3 is an ultra-wide bandgap semiconductor with immense potential applications in high voltage, electronic devices, and deep-ultraviolet optoelectronic devices, etc. However, to date, the growth of bulk β-Ga2O3 crystals has predominantly utilized melt methods, which are heavily dependent on specific growth vessels. In this work, bulk crystal β-Ga2O3 with a size of 7 × 13 × 4 mm3 is grown using TeO2-Li2CO3 as flux by a top-seeded solution growth (TSSG) method for the first time. It is noteworthy that the saturation point of β-Ga2O3 in the flux has been reduced to 1023 K, significantly lower than its melting point of 2073 K. The resulting β-Ga2O3 crystal exhibits well-formed faces, predominantly the (010), (100), (01(-)1), and (11(-)1(-)) forms, which closely align with the ideal morphological predictions made by the Bravais-Friedel and Donnay-Harker methods.The full-width at half maximum (FWHM) of the rocking curves for the (010) oriented plane is determined to be 140.4″. This work provides a potential β-Ga2O3 crystal growth method with a little platinum loss at a low temperature.
研究领域:
材料科学
·
半导体物理
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2024
·Vol. 35
·期 16
·165502
·
IF 2.9
Yongfeng Zhang,Shuainan Liu,Ruiliang Xu,Shengping Ruan,Caixia Liu,Yan Ma,Xin Li,Yu Chen,Jingran Zhou
β-Ga2O3 has been widely investigated for its stability and thermochemical properties. However, the preparation of β-Ga2O3 thin films requires complex growth techniques and high growth temperatures, and this has hindered the application of β-Ga2O3 thin films. In this study, β-Ga2O3 thin films with good crystalline quality were prepared using a green method, and an ultraviolet (UV) detector based on β-Ga2O3 with a photocurrent of 2.54 × 10–6 A and a dark current of 1.19 × 10–8 A has been developed. Two-dimensional materials have become premium materials for applications in optoelectronic devices due to their high conductivity. Here, we use the suitable energy band structure between Nb2C and Ga2O3 to create a high carrier migration barrier, which reduces the dark current of the device by an order of magnitude. In addition, the device exhibits solar-blind detection, high responsiveness (28 A W−1) and good stability. Thus, the Nb2C/β-Ga2O3 heterojunction is expected to be one of the promising devices in the field of UV photoelectric detection.
研究领域:
材料科学
·
光电子学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）