CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yong Sun,Muhammad Danish,Meesam Ali,Ali Shan,Ming Li,Yanchen Lyu,Zhaofu Qiu,Qian Sui,Xueke Zang,Shuguang Lyu
The performance of trichloroethene (TCE) degradation was significantly improved with the addition of FeS in nanoscale calcium peroxide (nCP) environment and the enhancement of HO generation in nCP/Fe(II)/FeS system was confirmed by comparison with nCP/Fe(II) and nCP/FeS systems. The role of FeS in nCP/Fe(II)/FeS system demonstrated that the majority of reactive oxygen radicals (ROSs) was generated on the catalyst surface due to the heterogeneous reaction through FeS activated nCP in one hand, and the reductive FeS could promote TCE degradation by regenerating Fe(II) from Fe(III) in the other hand. The probe as well as scavenger test results suggested that the major ROSs was HO rather than O 2 − . Over 91.5% TCE could be degraded at the molar ratio of 2/2/4/1 of nCP/Fe(II)/FeS/TCE, in which more than 95.5% TCE was dechlorinated. The effect of surfactants on TCE degradation was evaluated. In contrast, further investigation found that BTEX removal was inhibited with the addition of FeS. In conclusion, this study revealed the well function and fundamental synergistic mechanism of FeS. Moreover, the degradation of TCE in actual groundwater confirmed that nCP/Fe(II)/FeS technique has a great advantage and potential in TCE contaminated groundwater remediation in ISCO practice.
研究领域:
环境科学
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化学工程
·
水处理
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产品关联
DOI
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Xiuwen Gao,Woding Deng,Jinhui Tan,Xiong Shuai,Jun Zan,Tailai Ye,Kaiwu Luo,Fangwei Qi,Yujun Wei,Cijun Shuai
Thermoelectric material could realize the thermal-electricity-reactive oxygen species (ROS) conversion under temperature gradient, being considered a promising candidate for tumor therapy. Nevertheless, it required exogenous excitation such as light irradiation, causing difficultity in achieving on-demand therapy. Herein, a tumor microenvironment responsive Bi 2 Te 3 –CaO 2 nanohybrid was synthetized by in situ growing calcium peroxide (CaO 2 ) nanoparticles on thermoelectric bismuth telluride (Bi 2 Te 3 ) nanosheets, and then blended with poly- l -lactic acid (PLLA) to fabricate a PLLA/Bi 2 Te 3 –CaO 2 scaffold. Once the acidic microenvironment of the tumor was sensed, the CaO 2 would serve as an intelligent switch, releasing heat through rapid hydrolysis and triggering the thermoelectrocatalysis of Bi 2 Te 3 to generate ROS, thereby achieving on-demand therapy. Results demonstrated that the scaffold exhibited rapid temperature rise and significant ROS catalytic formation ability in an acidic solution (pH 5.5), while no significant changes occurred in a neutral environment (pH 7.4). Annexin V-FITC/PI staining and JC-1 assay demonstrated that the generated ROS could induce tumor apoptosis by reducing mitochondrial membrane potential. Besides, the fluorescent probe test revealed that CaO 2 could also produce hydrogen peroxide (H 2 O 2 ) and calcium ions (Ca 2+ ) to interfere with intracellular Ca 2+ , thereby further enhancing the antitumor effect. Overall, this work proposed a novel perspective for on-demand antitumor therapy.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Pengfei Yang,Yi Chang,Jie Zhang,Fangli Gao,Xinhe Liu,Qingcong Wei,Xiaoming Ma,Yuming Guo
Photodynamic therapy (PDT) is proved to be a promising modality for clinical cancer treatment. However, it also suffers from a key obstacle in association with its oxygen-dependent nature which greatly limits its effective application against hypoxic tumors. Herein, on the basis of the unique property of calcium peroxide (CaO 2 ), we propose an O 2 -self-supply strategy for the promotion of PDT by combining the in situ O 2 -generation characteristic of calcium peroxide with the photosensitive nature of porphyrin . A shell of ZIF-8 was synthesized surround the CaO 2 core to prevent the CaO 2 from premature decomposition and increased the loading of THPP efficiently. Depending on the in situ self-supply of O 2 , the photosensitizer was able to exhibit an enhanced PDT effect that significantly inhibit the growth of tumor. Moreover, the enrichment of free calcium ions derived from the decomposition of CaO 2 under acidic tumor microenvironment also shows the unique ion-interference effect and contributes to the obvious inhibition against tumor growth. This work presents a synergistic strategy for the construction of a photodynamic promotion/ion-interference combined nano-platform which can also serve as an inspiration for the future design of effective nanocomposites in tumor treatment.
研究领域:
癌症治疗
·
纳米医学
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生物医学工程
·
化疗
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 50
·2106106
·
IF 18.808
Jie Shen,Huizhu Yu,Yimeng Shu,Ming Ma,Hangrong Chen
The efficacy of cancer therapy with reactive oxygen species (ROS) as the main therapeutic medium suffers from a deficiency of oxy-substrates, for example, insufficient endogenous hydrogen peroxide (H 2 O 2 ) in chemodynamic therapy (CDT) and inherent hypoxia in photodynamic therapy (PDT). Herein, a smart polyethylene glycol (PEG)-ylated nanosystem CaO 2 @ZIF-Fe/Ce6@PEG (abbreviation as CaZFCP) is constructed to achieve H 2 O 2 /O 2 self-supply and Ca 2+ overloading in tumor cells simultaneously for enhanced CDT/PDT. Under the weakly acidic tumor microenvironment, the activity components inside CaZFCP, that is, CaO 2 nanoparticles, Fe 2+ , and photosensitizer Chlorin e6 (Ce6) are released by the degradation of zeolitic imidazole framework-90 (ZIF-90). Thereinto, CaO 2 nanoparticles are further decomposed to generate H 2 O 2 and O 2 , which alleviates both the insufficient endogenous H 2 O 2 and hypoxia in tumor area, thus enhancing the efficiency of CDT and PDT by producing more hydroxyl radicals and singlet oxygen. Furthermore, Ca 2+ overloading induced by the decomposition of CaO 2 is available for amplifying intracellular oxidative stress, resulting in mitochondrial dysfunction, which further improves the efficacy of combined CDT/PDT. In vitro and in vivo experimental results confirm excellent tumor inhibition effect, which also provides a facile paradigm in ROS-involved cancer therapies.
研究领域:
癌症治疗
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纳米技术
·
生物医学工程
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药学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 10.6
Zhao Pan,Gong Liyang,Chang Le,Du Huiping,Geng Meijuan,Meng Siyu,Dai Liangliang
Chemodynamic therapy (CDT) is seriously limited by the inadequacy of exogenous catalytic ions and endogenous H 2 O 2 in tumors. Herein, a multifunction nano-bomb integrated with calcium peroxide (CaO 2 ) and β-lapachone as donors of H 2 O 2 and GSH-sensitive Fe-based coordination polymer as provider of catalytic ions was constructed for dual cascade-amplified tumor CDT. This hyaluronic acid (HA)-modified nano-bomb could be specially endocytosed by breast cancer cells through a targeting pathway, degraded and released cargoes in response to the GSH-rich cytoplasm. Furthermore, the released CaO 2 and β-lapachone could significantly self-generated sufficient H 2 O 2 , which could dual-cascade amplify CDT and induce severe oxidative to tumors via cooperating with the delivered iron ions from nano-bombs. Moreover, the unloaded iron and calcium ions could further accelerate tumor damage by overloading Ca 2+ and ferroptosis, as accompanied by good magnetic resonance imaging (MRI). In vitro and in vivo studies collectively reveal that this nano-bomb not only self-initiates double cascade-amplified CDT via self-generation of H 2 O 2 , but also efficiently activates ferroptosis and initiates Ca 2+ overloading, consequently significantly tumor growth suppression. This study offers a novel tumor-initiated nano-bomb for dual cascade-amplified CDT and bioimaging with activated ferroptosis and self-supplying H 2 O 2 .
研究领域:
纳米技术
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癌症治疗
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2022
·
IF 13.4
Feng Wang,Wenyi Dong,Zilong Zhao,Hongjie Wang,Wenting Li,Liang Zhang,Heng Ouyang,Xiao Huang,Ji Li
Polycyclic aromatic hydrocarbons (PAHs) are found ubiquitously in contaminated aquatic sediments. They are difficult to degrade, particularly the high-molecular-weight PAHs (e.g., benzo[a]pyrene, BaP). In this study, CaO 2 assisted with ferrous ion (Fe(II)) - citric acid (CA) was applied for the first time in BaP degradation in aquatic sediment. Among the treatment processes we studied, CaO 2 /Fe(Ⅱ)/CA could effectively degrade BaP at circumneutral pH (7.0 ± 0.3), reaching a maximum of nearly 80% under optimal conditions (0.84 mM CaO 2 , 0.21 mM Fe(Ⅱ), and 0.35 mM CA in per gram of dry sediment). Contrary to some external environmental factors such as temperature, common metal ions, and natural organic matters, a certain amount of moisture content and inorganic anions (Cl − , SO 4 2− ) exhibited a positive effect on BaP degradation, which can probably be contributed to the improved mass transfer rate in the non-homogeneous sediment-water mixture and a higher level of free radicals. The degradation kinetic dominated by hydroxyl radicals included three main stages contribution ∼29.4%, ∼43.1%, and ∼2.4% to BaP degradation, respectively. Based on the theoretical calculations of density functional theory, a pathway for BaP degradation was proposed. For the treatment of actual contaminated sediment, the CaO 2 /Fe(II)/CA process could realize the elimination of black-odor and effective removal of PAHs from the sediment, as well as negligible ecotoxicity on benthic organisms. This study provides a reference and guidance for the use of CaO 2 based Fenton-like systems in treating PAH-contaminated black-odor river sediments.
研究领域:
环境科学
·
污染治理
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Shuo Yang,Nan Wang,Xiao–kun Ouyang,Yiwei Wu,Junhua Hu
Infection and inflammation are key factors affecting wound healing. Hydrogels are excellent wound dressings that provide a moist healing environment and serve as carriers for drugs or functional components. This work proposes a composite hydrogel, APLCE, composed of methyl methacrylate L-arginine (M-L-Arg) as an NO donor, synthesized through free radical polymerization with acrylamide (AM) and polyethylene glycol (PEG). The hydrogel matrix exhibits good water retention and mechanical properties. CaO 2 and ε-poly-L-arginine (EPL) are embedded in the hydrogel to form APLCE, where the hydrolysis of CaO 2 releases H 2 O 2 , triggering the release of arginine to release NO, inhibiting wound inflammation and bacterial growth. EPL added to the hydrogel synergistically with NO exhibits an antibacterial effect, with a bacterial inhibition rate exceeding 99 %. Animal experiments show that APLCE can completely eradicate bacteria in infected wounds, promote new skin formation, and achieve a wound closure rate of 94 % within 14 days. These findings emphasize the potential clinical application of APLCE as an innovative wound dressing material.
研究领域:
材料科学
·
生物医学工程
·
药学
·
伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Tianqi Liu,Yanfang Sun,Guohua Jiang,Wenjing Zhang,Rui Wang,Lei Nie,Amin Shavandi,Khaydar E. Yunusov,Uladzislau E. Aharodnikau,Sergey O. Solomevich
Diabetes chronic wound is a severe and frequently occurring medical issue in patients with diabetes that often leads to more serious complications. Microneedles (MNs) can be used for wound healing as they can effectively pierce the epidermis and inject drugs into the wound tissue. However, common MN patches cannot provide sufficient skin adhesion to prevent detachment from the wound area. Inspired by the barb hangnail microstructure of porcupine quills, a porcupine quill-like multilayer MN patch with an adhesive back patching for tissue adhesion and diabetic wound healing was designed. Sodium hyaluronate-modified CaO 2 nanoparticles and metformin (hypoglycemic agent) were loaded into the polycaprolactone tips of MNs, endowing them with exceptional antibacterial ability and hypoglycemic effect. A flexible and adhesive back patching was formed by polyacrylamide-polydopamine/Cu 2+ composite hydrogel, which ensures that the MN patches do not peel off from the application sites and reduce bacterial infection. The bioinspired multilayer structure of MN patches exhibits satisfactory mechanical and antibacterial properties , which is a potential multifunctional dressing platform for promoting wound healing. Statement of significance The porcupine quill-like microneedles (MNs) with PAM-PDA/Cu 2+ (PPC) composite hydrogel back patching have been fabricated, which can enhance the adhesion property of MNs to the skin through a physical interlock of multilayer MNs and chemical bonding of hydrogel patching. CaO 2 -HA NPs and metformin were loaded into the polycaprolactone tips of MNs, endowing them with the exceptional antibacterial ability and hypoglycemic effect, which could accelerate diabetic wound healing. As a safe and effective strategy in transdermal delivery of drugs, the as-fabricated flexible multilayer MN patch with good antibacterial, hypoglycemic, and biocompatibility has been used to promote the healing of diabetic wound by releasing oxygen and inhibiting inflammation at the wound site.
研究领域:
生物医学工程
·
材料科学
·
药剂学
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 8
·3005-3018
·
IF 6.843
Chengqiang Wang,Haixia Xu,Chun Liu,Ziyue Peng,Ruoxing Min,Zhiming Zhang,Jianjun Li,Yanglei Jin,Yihan Wang,Zhihao Li,Jiasong Guo,Lixin Zhu
The osteonecrosis of femoral head (ONFH), a common refractory disease, is still not fully understood today. Hypoxia caused by ischemia is not only an important pathogenic factor but also a critical challenge for the survival of seed cells in the tissue engineering therapy of ONFH. To explore an efficient strategy to treat ONFH by targeting hypoxia, newly designed CaO2/gelatin microspheres were composited with 3D printed polycaprolactone/nano-hydroxyapatite (PCL/nHA) porous scaffold, sodium alginate/gelatin hydrogel, and bone marrow mesenchymal stem cells (BMSCs) to develop a novel tissue engineering scaffold and then transplanted into the core depression area of the ONFH rabbit model. The current data demonstrated that CaO2/gelatin microspheres can constantly release oxygen for 19 days. In vitro assays with BMSCs illustrated that scaffolds have high biocompatibility and are favorable for cell proliferation in extreme hypoxia (1% O2). The in vivo study demonstrated that the transplanted scaffold with oxygen-generating microspheres significantly enhanced the osteogenic and angiogenic effects compared to the scaffold without microspheres. Further assessments revealed that microspheres in the scaffold can reduce the local cell apoptosis and enhance the survival of grafted cells in the host. Collectively, the present study developed a novel oxygen slow-releasing composite scaffold, which can facilitate tissue engineering efficiency for treating the osteonecrosis of the femoral head by enhancing the angiogenesis and survival of grafted stem cells.
研究领域:
组织工程
·
骨科
·
干细胞生物学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Junjie Liu,Yajie Jin,Zan Song,Lihua Xu,Yue Yang,Xiu Zhao,Binghua Wang,Wei Liu,Kaixiang Zhang,Zhenzhong Zhang,Jinjin Shi
Although chemodynamic therapy (CDT) holds the advantage of tumor treatment by generating hydroxyl radicals (·OH) without the participation of O 2 , insufficient H 2 O 2 and the hindered Fe ion circulation remain major hurdles for its clinical application. Herein, we developed a hybrid nanoparticle with H 2 O 2 self-supply and iron ion self-circulation properties for enhanced CDT. Through encapsulation of CaO 2 with ZIF-8 and in situ assembled Fe 3+ /TA (tannic acid) on the surface, the hybrid nanoparticles (CaO 2 @ [email protected] ) were prepared. The Fe 3+ /TA coating could dissociate in response to lysosomal acidity, and release Fe 3+ and TA subsequently. Significantly, the unprotected CaO 2 can be degraded to H 2 O 2 and Ca 2+ , providing sufficient materials for CDT and resulting in a Ca 2+ “storm” for ion therapy. Meanwhile, TA could convert Fe 3+ to Fe 2+ , realizing a self-circulation for promoting the sustained generation of ·OH. Interestingly, Fe 3+ /TA coating endows the nanoparticles with photothermal property, which accelerated the degradation and further improved the efficiency of Fenton reaction, obtaining 77.7% of tumor growth inhibited rate without obvious adverse effect in tumor-bearing mice. Our findings showed CaO 2 @ [email protected] had potential to be applied for enhanced CDT synergistic antitumor ion therapy.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Yilu Zheng,Gareth R Williams,Ran Hu,Sen Tong,Jianxiang Xu,Tong Wang,Yanyan Zhang,Junzi Wu,Fan Li,Yingyu Cai,Li-Min Zhu
Background: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. It can selectively release Ca2+ and generate H2O2 in the tumor microenvironment (TME) by acid-triggered degradation of the two-layer protective shell (ie, unlocking the “double-lock”). This material, termed CaO2@ZIF8:CUR@PAA, comprises a CaO2 core coated with the ZIF-8 framework, which was then loaded with curcumin (CUR) and coated again with polyacrylic acid (PAA).Results: Under the slightly acidic conditions of the TME, the PAA shell (first lock) breaks down first exposing CaO2@ZIF8 and CUR inside the cell. Then, ZIF8 (second lock) is degraded in response to acid to deposit Ca2+, and H2O2. CUR can promote the release of Ca2+ from the endoplasmic reticulum to the cytoplasm, inhibit the outflow of Ca2+, and accumulates a large amount of Ca2+ intracellularly together with exogenous Ca2+ (calcium storms). The powerful calcium storm that causes mitochondrial dysfunction. The presence of a large amount of exogenous H2O2 causes further oxidative damage to tumor cell membranes and mitochondria where intracellular ROS production far exceeds clearance. CaO2@ZIF8:CUR@PAA NPs can induce cell S cycle arrest and apoptosis to inhibit tumor multiplication and growth. Oxidative damage-triggered immunogenic cell death (ICD) in turn leads to the polarization of macrophages to the M1 phenotype, inducing immunogenic cell death and inhibiting tumor cell proliferation and metastasis.Discussion: The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. The mode triggers apoptosis leading to ICD of tumor cells. The material induces cycle blockade during treatment to inhibit cell proliferation. Robust in vitro and in vivo data demonstrate the efficacy of this approach and CaO2@ZIF8:CUR@PAA as an anticancer platform, paving the way for nanomaterials in immune-triggered cancer therapy.Highlights: - A new calcium accumulation nanoplatform plays a role in activate antitumor immunity.- Double-locked structure slows down the premature decomposition of CaO2.- The platform allows Ca2+ and H2O2 to accumulate in tumor cells.- This leads to mitochondrial dysfunction, apoptosis, and M1 macrophage polarization.- Potent anti-tumor effects are seen both in vitro and in vivo.
研究领域:
癌症治疗
·
纳米技术
·
免疫学
·
细胞生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Yuejun Jiang,Cong Xu,Yunshi Li,Hong Wang,Lu Liu,Yicheng Ye,Junbin Gao,Hao Tian,Fei Peng,Yingfeng Tu,Yingjia Li
Developing multifunctional, stimuli-responsive nanomedicine is intriguing because it has the potential to effectively treat cancer. Yet, poor tumor penetration of nanodrugs results in limited antitumor efficacy. Herein, an oxygen-driven silicon-based nanomotor (Si-motor) loaded with MnO and CaO 2 nanoparticles is developed, which can move in tumor microenvironment (TME) by the cascade reaction of CaO 2 and MnO. Under acidic TME, CaO 2 reacts with acid to release Ca 2+ to induce mitochondrial damage and simultaneously produces O 2 and H 2 O 2 , when the loaded MnO exerts Fenton-like activity to produce ·OH and O 2 based on the produced H 2 O 2 . The generated O 2 drives Si-motor forward, thus endowing active delivery capability of the formed motors in TME. Meanwhile, MnO with glutathione (GSH) depletion ability further prevents reactive oxygen species (ROS) from being destroyed. Such TME actuated Si-motor with enhanced cellular uptake and deep penetration provides amplification of synergistic oxidative stresscaused by intracellular Ca 2 + overloading, GSH depletion induced by Mn 2+ , and Mn 2+ mediated chemodynamic treatment (CDT), leading to excellent tumor cell death. The created nanomotor may offer an effective platform for active synergistic cancer treatment.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）