ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2021
·Vol. 28
·期 28
·37781-37792
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IF 4.223
Wang Dan,Lou Jiangfei,Xu Jin,Yuan Jiugang,Wang Qiang,Wang Ping,Fan Xuerong
Alkylphenol polyethoxylates (APEO n ) are the second-largest category of commercial nonionic surfactants, which are difficult to degrade naturally in the environment. This study examined the degradation of octylphenol polyethoxylate (OPEO n ) by laccase and its laccase-mediated systems. The results showed that OPEO n was poorly degraded by laccase alone. 2, 2′-azino-bis [3-ethylbenzothiazoline-6-sulphonic acid] (ABTS), 1-hydroxybenzotriazole (HBT), and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) were selected as the redox mediators. Experimental results also indicated that 52.4% of the initial OPEO n amount was degraded by laccase in the presence of TEMPO. The degradation efficiency was analyzed using high-performance liquid chromatography. Furthermore, the structural characteristics of the degradation products were measured using matrix-assisted laser desorption/ionization-time of flight mass spectrometry and nuclear magnetic resonance spectroscopy, and it could be found that the laccase-TEMPO system could gradually shorten the ethoxylate chain by oxidizing the primary hydroxyl group of OPEO n , thereby degrading the OPEO n of the macromolecule into small molecules. The maximum of the ion peak distributions of OPEO n decreased from n = 8 finally down to 3. The novel enzymatic system introduced by this study will become a promising alternative method for high-efficiency APEO n conversion and had great potential value in wastewater treatment. Graphical abstract
研究领域:
环境科学
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生物化学
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PubMed
高影响因子
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2022
·Vol. 36
·期 4
·e22994
·
IF 3.568
Mingxin Liu,Guizhou Tao,Yiming Cao,Yu Hu,Zhe Zhang
Atherosclerosis (AS) is a chronic inflammatory disease with the formation and accumulation of macrophage-derived foam cells in the subendothelial space of blood vessels as one major characteristic. Insulin-like growth factor 2 messenger RNA (mRNA) binding protein 1 (IGF2BP1) is an RNA-binding factor and its elevation has been reported to be associated with macrophage infiltration into the atherosclerotic vascular wall. This study aims to investigate the roles of IGF2BP1 in AS-associated foam cell formation. Herein, ApoE−/− mice fed with high-fat diet developed atherosclerotic lesions in the aorta, where IGF2BP1 expression was upregulated and autophagy was impaired. IGF2BP1 expressed in F4/80+ macrophages and coexisted with p62. In vitro, IGF2BP1 expression was upregulated in RAW264.7 macrophages exposed to oxidized low-density lipoprotein (ox-LDL) (100 μg/ml). Interestingly, silencing of IGF2BP1 ameliorated ox-LDL-induced lipid accumulation and inflammation, and enhanced autophagic flux in macrophages. Furthermore, the expression of RUNX family transcription factor 1 (RUNX1), a gene that is able to inhibit autophagy in multiple cell types, was elevated in atherosclerotic aortas and in ox-LDL-treated macrophages. In addition, RNA immunoprecipitation results revealed that IGF2BP1 is bound to RUNX1 mRNA. Alterations induced by IGF2BP1 knockdown in ox-LDL-treated macrophages were abolished by RUNX1 overexpression. Furthermore, after autophagy inhibitor 3-methyladenine administration, silencing of IGF2BP1-reduced lipid accumulation and inflammation were recovered in RAW264.7 cells. In summary, our study demonstrated that silencing of IGF2BP1 restrained ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and facilitating autophagy in macrophages. IGF2BP1/RUNX1 axis may be considered as a potential therapeutic target in AS.
研究领域:
心血管疾病
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分子生物学
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免疫学
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细胞生物学
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PubMed
高影响因子
Journal of Functional Foods
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2026
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IF 3.9
Qiaolin Cai,Yutao Wu,Qing Gong,Binyong Guo,Yin-Yi Ding,Xiaofang Li,Haolei Wang,Zhenyu Gu,Tianyuan Song
Five novel anti-atherosclerotic peptides were identified from cowhide using peptidomics and virtual screening. • Peptides featuring the Xaa-Gly-Pro-Yaa motif exhibited robust antioxidant capacity and gastrointestinal digestive stability. • LGPRW significantly attenuated ox-LDL-induced macrophage inflammation by restoring NO and suppressing pro-inflammatory cytokines. Chronic inflammatory vascular diseases, driven by oxidative stress and lipid dysregulation, are increasingly recognized as the early initiating phenomena of various cardiovascular pathologies. Recent insights highlight animal-derived collagen peptides as beneficial agents for improving vascular function, attributable to their excellent biocompatibility and superior anti-inflammatory and antioxidant effects. This study employed cowhide Alcalase hydrolysate as raw material, utilizing chromatographic purification, peptidomics, molecular simulation, and in vitro assays to screen five bioactive peptides (GPAWR, GPWR, KGPWR, KWCAGPR, LGPRW). CA exhibited complete amino acid profiles and characteristic triple-helix structures, with purified fractions enriched in hydrophobic short peptides. In ox-LDL-induced RAW264.7 cells, these peptides significantly restored nitric oxide levels and suppressed pro-inflammatory cytokines, with LGPRW demonstrating superior efficacy. Under in vitro conditions, these novel bovine dermal collagen peptides effectively ameliorated ox-LDL-induced macrophage dysfunction through NO modulation and inflammation inhibition. These findings provided sequence-level evidence for exploring novel collagen fragments as potential natural anti-inflammatory agents. Download: Download high-res image (104KB) Download: Download full-size image
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高影响因子
RARE METALS
·
2021
·Vol. 41
·期 1
·166-178
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IF 4.003
Zhang Bo-Lin,Deng Li-Feng,Liu Bo,Luo Chun-Yun,Liebau Michael,Zhang Shen-Gen,Gläser Roger
Abstract Combining the redox properties of Co and the acid properties of Nb in a Co 3 -Nb-O x catalyst is shown to provide superior performance in the selective catalytic reduction of NO with NH 3 (NH 3 -SCR). Co 3 O 4 shows average activity, however, it exhibits a poor N 2 selectivity. Nb 2 O 5 is not active for NH 3 -SCR. However, the mixed Co 3 -Nb-O x catalyst shows higher NO conversion and N 2 selectivity than the single Co 3 O 4 and Nb 2 O 5 catalysts at 100–300 °C. The results of temperature programmed reduction by H 2 and X-ray photoelectron (XP) spectra indicate that the addition of Nb changes the chemical states of Co and decreases the concentration of Co 3+ and O α , adjusting the activity for catalytic oxidation to a moderate level. This suppresses the formation of undesired N 2 O from the over-oxidation of NH 3 . Incorporation of Co and Nb into one solid synergistically couples their redox behavior and surface acidity, ensuring the high catalytic activity and N 2 selectivity in NH 3 -SCR. Graphical Abstract
研究领域:
环境科学
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催化化学
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DOI
高影响因子
POLYMER
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2015
·
IF 3.562
Chun-Yu Zhang,Jing-Hui He,Cai-Jian Lu,Qian-Feng Gu,Lin-Xin Wu,Quan Liu,Hua Li,Qing-Feng Xu,Jian-Mei Lu
Two polymer-Hemin composites, AB type block copolymer (PStCH- b -P4VP): Hemin and homopolymer of poly(4-vinylpyridine) (P4VP): Hemin, can be fabricated into sandwich memory devices. The memory device characteristics of the PStCH- b -P4VP: Hemin blends can show Flash memory behavior, while the P4VP polymer with Hemin only shows write-once-read-many-times (WORM) performance. Charge transfer and nanocomposite redox are probably responsible for the conductance-switching behavior. The results of cyclic voltammogram (CV) measurement indicate that the reversible Fe III /Fe II redox reaction is preserved well in the composite PStCH- b -P4VP: Hemin, while only polymer oxidation is observed in the P4VP: Hemin system. Due to the hindrance of StCH moiety, the coordination of pyridine and Fe II can keep the Fe II active. The P4VP has a more flexible chain that saturates the Fe II center and results in stable coordination; Fe III /Fe II redox reaction is therefore an obstacle. By tuning the coordination surroundings of the metal ion , different memory types can be obtained.
研究领域:
材料科学
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化学
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Liu Tao,Wang Yunpeng,Wu Yifan,Jiang Wenchuan,Deng Yuchao,Li Qing,Lan Cheng,Zhao Zhiyu,Zhu Liangyu,Yang Dongsheng,Noël Timothy,Xie Heping
Electrochemical CO 2 capture driven by renewable electricity holds significant potential for efficient decarbonization. However, the widespread adoption of this approach is currently limited by issues such as instability, discontinuity, high energy demand, and challenges in scaling up. In this study, we propose a scalable strategy that addresses these limitations by transforming the conventional single-step electrochemical redox reaction into a stepwise electrochemical-chemical redox process. Specifically, the hydrogen evolution reaction (HER) at the cathode and the oxidation of a redox carrier at the anode are employed to modulate the pH of the electrolyte, thereby facilitating effective CO 2 capture. By decoupling the electrochemical swing for CO 2 capture from redox carrier regeneration in both temporal and spatial domains, this approach mitigates unwanted side reactions and enhances system stability. Our results demonstrate a stable CO 2 capture process sustained for over 200 h, with a electrical work of 49.16 kJ e mol -1 CO 2 at a current density of 10 mA cm -2 . Furthermore, a scaled-up system capable of producing approximately 0.4 kg of pure CO 2 per day maintained stable operation for 72 h, highlighting the potential feasibility of this method for large-scale decarbonization applications.
研究领域:
环境科学
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电化学工程
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PubMed
高影响因子
ACS Applied Materials & Interfaces
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2024
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IF 8.3
Shiyan Li,Xuwei Shang,Haiya Lou,Zixu Wang,Yihe Qiu,Shanshan Xiang,Fangying Yu,Hong Yuan
The immunosuppressive tumor environment, characterized by elevated redox levels, significantly impairs the effectiveness of oxidation and the immune response. Here, an electron-accepting-inspired glycopolymer-based nanoreactor (chitosan-grafted nitrobenzene nanoparticles) CNP employing hypoxia-activated group nitrobenzene was constructed to realize cascade bilateral regulation of ferroptosis and immune activation by intervening antioxidant systems. The as-prepared CNP could consume nicotinamide adenine dinucleotide phosphate (NADPH) in the hypoxia-response process, allowing it to be involved in the recycling of glutathione (GSH) and thioredoxin (Trx). This ultimately affects redox homeostasis, leading to reduced GSH levels, increased reactive oxygen species (ROS), and inhibition of (glutathione peroxidase 4) Gpx4. By taking advantage of the sensitivity difference between tumor cells and dendritic cells (DCs) to the ferroptosis inducer erastin (Er) based on varying xCT expression levels, we developed Er-loaded nanoparticles CNP/Er. These nanoparticles not only enhance ferroptosis in 4T1 cells through Gpx4 inhibition by CNP but also promote DC maturation by utilizing CNP’s hypoxia-responsive mechanism to increase ROS levels. The CNP/Er was believed to be an ideal candidate for bilateral regulation of ferroptosis and immune activation in one nanoreactor.
研究领域:
肿瘤学
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生物材料学
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免疫学
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Kaiyue Zhang,Bin Feng,Hong Wang,Lijie Liu,Liang Hu,Hui Zhao,Zeyu Xu,Xihao Zhang,Jianguo Liu
Vanadium flow batteries (VFBs) face critical challenges in power density due to sluggish redox kinetics and inefficient mass transport. Herein, we propose a dual-functional strategy that synergistically addresses both limitations through precursor morphology engineering. By precisely regulating hydrothermal crystallization kinetics, cobalt carbonate hydroxide (CCH) precursors evolve from 1D nanorods to 2D nanosheets, which transform into Co 3 O 4 nanoarrays after annealing while retaining structural features. The resulting 1D rod-like architectures create open mesoporous channels for rapid ion diffusion, while defective Co 3 O 4 surfaces enriched with oxygen vacancies enhance redox kinetics. DFT calculations reveal that oxygen vacancies upshift the Co d-band center in Co 3 O 4 , strengthening vanadium ion adsorption and accelerating redox reactions. Finite element analysis demonstrates that the rod-like microstructure enhances mass transport and reduces concentration polarization, while its uniform potential distribution suppresses parasitic side reactions. As a result, the VFB with Co 3 O 4 @CF-90 achieves a high energy efficiency of 74.4 % at 300 mA cm −2 , outperforming conventional carbon felt by 9.7 %, and maintains 80.2 % efficiency at 200 mA cm −2 over 400 cycles. This work establishes a scalable morphology-induced vacancy engineering paradigm for high-performance flow battery electrodes, decoupling catalytic and transport optimization through precursor design.
研究领域:
材料科学
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电化学
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Lifeng Hao,Junhuan Zhao,Kangyuan Li,Weiping Zheng,Yanfei Yang,Chenyang Qiu,Zewen Jiang,Wenjun Xia
We report a hydrothermal engineering strategy to synergistically regulate structural barriers, oxygen vacancy-driven redox cycling, and surface functionalization in Ce-NiCo-LDH coatings for ultralong corrosion protection. Vertically aligned LDH nanosheets constructed a tortuous labyrinth barrier to physically impede corrosive species penetration. Oxygen vacancies acted as electron reservoirs to drive Ce 3+ /Ce 4+ redox cycling, enabling dynamic passivation repair via preferential Ce 4+ → Ce 3+ reduction at vacancy sites. Surface functionalization further enhanced protection through two independent pathways: CTAB induced interlocked fibrous nanostructures for mechanical reinforcement, while PFDT grafting formed a fluorine-rich hydrophobic barrier through C-F dipole interactions. EIS characterization demonstrated a 3.6-fold enhancement in charge transfer resistance (Rct = 5.1 × 10 5 Ω·cm 2 ) for the sequentially hydrothermally processed Ce-NiCo-LDHs compared to their single-step counterparts (1.4 × 10 5 Ω·cm 2 ). The CTAB-modified coating achieved 99.0 % inhibition efficiency, while PFDT modification provided long-term hydrophobicity. This triple-scale synergy-structural obstruction, redox-mediated self-healing, and surface engineering-provides a universal framework for designing advanced protective coatings.
研究领域:
材料科学
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腐蚀工程
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表面工程
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DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
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2025
·
IF 7.9
Jiale Wang,Xinrui Qiang,Bingzhe Jia,Lei Wang,Jiarui Li,Haibo Che,Yichi Liu,Zhiqiang Li,Xinming Wu
MXene shows great potential in the field of flexible electrodes owing to its distinctive two-dimensional structure, high conductivity, and large specific surface area. Nonetheless, during repeated bending, the bonding between the electrode and the conductive substrate weakens, which leads to a decrease in conductivity and, ultimately, a decline in the cycling stability of flexible devices, limiting their practical applications. Based on this, this paper presents the preparation of a MXene-Ag composite with excellent flexibility and cycling stability through a simple redox reaction. Electrochemical performance tests reveal that the material achieves a high specific capacitance of 191 F g −1 at a current density of 1 A g −1 and demonstrates an impressive capacity retention of 95.8 % after 10000 cycles at 5 A g −1 . To further assess the electrochemical performance under bending conditions, MXene-Ag//AC flexible asymmetric solid-state supercapacitors are assembled. Surprisingly, after 1250 charge/discharge cycles at bending angles of 30°, 60°, and 90°, the device still maintains a capacitance retention of 97.2 % (5 A g −1 ), which is a 7 % increase compared to before Ag loading. This demonstrates that the addition of Ag contributes to the improved electrochemical cycling stability of the flexible device.
研究领域:
材料科学
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纳米技术
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电化学
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能源存储
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柔性电子器件
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DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2022
·
IF 10.753
Yifei Leng,Feiyu Liu,Huiping Cai,Fengyi Chang,Wen Xiong,Shushi Huang,Jun Wang
The catalysis of HRP coupling with redox mediator was a feasible technology for the transformation of antibiotics. This work screened three effective redox mediators syringaldehyde (SYR), acetosyringone (AS) and p -coumaric acid (PCA) for the norfloxacin (NOR) transformation in HRP/redox mediator system. Then, compared their transformation characteristics under varying conditions. The molecular docking results indicated HRP catalytic mediator was spontaneous, and the absolute value order of free energy between three redox mediators and HRP was consistent with the order of NOR removal in experiment. The presence of humic acid (HA) and polystyrene (PS) microplastics could block the removal of NOR, and the inhibition effect was proportional to the level of HA and PS particles. Seven and six possible intermediate products were identified by using SYR/AS and PCA as redox mediators, respectively, and potential NOR transformation pathways were proposed. SYR and AS treatment had the same transformation products and pathways due to their similar structure, including defluorination , oxidation, cross-coupled with mediator, demethylation and dehydrogenation . While for the PCA group, NOR not only performed the above action (except defluorination), but also underwent decarbonylation. These findings may expand our knowledge of the conversion and fate of fluoroquinolones through HRP coupled with redox mediator in the environment.
研究领域:
环境科学
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生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Diabetes and Metabolic Disorders
·
2026
·Vol. 25
·期 1
·142
·
IF 2.1
Zhang Li,Zhang Chuanqi,Liu Yueyan,Zhang Chenchen
Background Atherosclerosis (AS) remains a major cause of cardiovascular morbidity and mortality worldwide. and Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic phenotype is a critical event in atherosclerotic lesion development. Although miR-148b has been implicated in the regulation of VSMC phenotypic switching, its functional role and underlying mechanism in AS-associated VSMC phenotypic switching remain incompletely understood. Methods An in vitro AS-related VSMC model was established by treating T/G HA-VSMCs with oxidized low-density lipoprotein (ox-LDL). Cell proliferation and migration were assessed using CCK-8, EdU incorporation, and Transwell assays. RNA and protein expression levels were determined by qRT-PCR and western blotting, respectively. The targeted relationship between miR-148b and KLF4 was examined using dual-luciferase reporter and RNA immunoprecipitation assays. KLF4 protein stability and ubiquitination were assessed using cycloheximide chase, MG132 treatment, and immunoprecipitation followed by western blotting. Results miR-148b expression was significantly reduced in ox-LDL-treated VSMCs. Overexpression of miR-148b suppressed ox-LDL-induced VSMC proliferation and migration, and restored the expression of contractile phenotype markers, including SM22α and α-SMA. Mechanistically, KLF4 was identified as a downstream target of miR-148b. miR-148b reduced KLF4 expression through 3′-UTR-mediated repression and was associated with enhanced ubiquitination-dependent KLF4 protein degradation. Rescue experiments showed that KLF4 overexpression partially reversed the inhibitory effects of miR-148b on VSMC proliferation, migration, and phenotypic switching. Conclusion miR-148b attenuates ox-LDL-induced VSMC phenotypic switching, at least in part, by downregulating KLF4. These findings suggest that the miR-148b/KLF4 axis may represent a potential regulatory mechanism in AS-associated vascular remodeling .
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高影响因子
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