Journal of Materials Chemistry B
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2015
·Vol. 3
·期 41
·8170-8179
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IF 4.726
Mo Sun,Heng-Yi Zhang,Qian Zhao,Xin-Yue Hu,Li-Hua Wang,Bo-Wen Liu,Yu Liu
Accurate imaging of soft tissues is one of the ultimate goals in biomedical imaging. Different imaging modalities can improve their disadvantages, and promote the imaging ability. However, once an imaging agent has been prepared, it is usually hard to adjust it according to the actual needs. Herein, we developed a supramolecular brush polymer (SBP) as a versatile imaging agent platform. The SBP platform (SBPP) is constructed by the intermolecular inclusion complexation of bridged tris(β-cyclodextrin) (1) with Mn(III)-porphyrin-bearing poly(ethylene glycol) (PEG) side chains (Mn(III)-TPP), and can further bind other functional groups by host–guest interactions of cyclodextrin and adamantine. The SBPP is characterized by UV/vis absorption spectroscopy, NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM). We demonstrated that this SBPP not only has no cellular toxicity against NIH 3T3 cells in in vitro cell experiments, but it also shows an efficient enhanced T1 relaxivity in in vitro MR imaging experiments. When used as multifunctional imaging agents, different imaging probes and/or targeting agents can be introduced to this SBPP as needed through simple host–guest interactions. In in vitro imaging experiments, it shows accurate imaging of different kinds of cancer cells by choosing on-demand targeting agents. These results suggest a promising strategy for engineering multifunctional imaging agents with SBPs.
研究领域:
生物医学工程
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材料科学
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医学影像学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xueliang Zhang,Changliang Zhang,Luyao Xiao,Xiaogan Zhao,Kai Ma,Feng Ji,Elham Azarpazhooh,Marjan Ajami,Xin Rui,Wei Li
This study assessed the potential prebiotic characteristics of the previously reported Lactiplantibacillus plantarum extracellular polysaccharide (EPS-T1) with immunological activity. EPS-T1 was a novel heteropolysaccharide composed of glucose and galactose (1.00:1.21), with a molecular weight of 1.41 × 10 6 Da. The monosaccharide composition, molecular weight, fourier transform infrared, and 1 H NMR analysis showed that EPS-T1 was well tolerated in the simulated oral cavity, gastric fluid, and small intestinal fluid environments, and was not easily degraded. Meanwhile, EPS-T1 could effectively be used as a carbon source to promote the growth of beneficial Lactobacillus species ( Lactobacillus delbrueckii ssp. Bulgaricus , Streptococcus thermophilus , Lacticaseibacillus rhamnose GG, Lactiplantibacillus plantarum , Lacticaseibacillus paracasei and Lactobacillus reuteri ). After 24 h of fecal fermentation, EPS-T1(5 mg/mL) effectively reduced the relative abundance of harmful bacteria such as the Escherichia-Shigella , Citrobacter , Fusobacterium , Parasutterella , and Lachnoclostridium . While, the level content of beneficial flora ( Bacteroides , Blautia , Phascolarctobacterium , Bifidobacterium , Parabacteroides , and Subdoligranulum ) were significantly increased. In addition, EPS-T1 was able to significantly promote the enrichment of short-chain fatty acids such as acetic acid, propionic acid and butyric acid . These results provide some basis for the functional application of EPS-T1 as a potential prebiotic.
研究领域:
微生物学
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营养学
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食品科学
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胃肠病学
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 14
·2200841
·
IF 11.092
Gexuan Jiang,Di Fan,Jiesheng Tian,Zhichu Xiang,Qiaojun Fang
Nanomaterials as T 1 / T 2 dual-mode magnetic resonance imaging (MRI) contrast agents have great potential in improving the accuracy of tumor diagnosis. Applications of such materials, however, are limited by the complicated chemical synthesis process and potential biosafety issues. In this study, the biosynthesis of manganese (Mn)-doped magnetosomes (MagMn) that not only can be used in T 1 / T 2 dual-mode MR imaging with self-confirmation for tumor detection, but also improve the photothermal conversion efficiency for MRI-guided photothermal therapy (PTT) is reported. The MagMn nanoparticles (NPs) are naturally produced through the biomineralization of magnetotactic bacteria by doping Mn into the ferromagnetic iron oxide crystals. In vitro and in vivo studies demonstrated that targeting peptides functionalized MagMn enhanced both T 1 and T 2 MRI signals in tumor tissue and significantly inhibited tumor growth by the further MRI-guided PTT. It is envisioned that the biosynthesized multifunctional MagMn nanoplatform may serve as a potential theranostic agent for cancer diagnosis and treatment.
研究领域:
生物医学工程
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纳米技术
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癌症研究
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分子影像
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诊疗一体化
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DOI
PubMed
高影响因子
Materials Today Bio
·
2026
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IF 11
Yuxing He,Nengyi Ni,Mengmeng Zhang,Yingqi Wang,Haohan Yang,Ke Ren,Yiyao Wang,Qianqian Gao,Mingda Du,Xiao Sun,Hongzan Sun
When traditional T 1 and T 2 contrast agents coexist, the magnetic coupling effect leads to signal interference, which severely limits the synergistic enhancement potential of dual-mode magnetic resonance imaging (MRI). In this study, we introduced an innovative “dispersion-reaggregation” dynamic regulation nano-platform (SPMN) activated by hypoxia and acidity, which achieved T 1 -T 2 dual-signal synergistic enhancement through a two-step distance coordination mechanism. Upon hypoxia-induced dissociation of the nanocarriers, Mn 2+ (the T 1 contrast agent) and SPIO (the T 2 contrast agent) were released. This initial separation prevented signal cancelation due to the magnetic coupling effect. Through dynamic regulation of spatial distance, interference between T 1 and T 2 signals was mitigated, thereby accomplishing the first step of distance coordination. Thereafter, the acidic microenvironment facilitated the aggregation of SPIO via molybdenum (VI)-based polyoxometalate (POM)-mediated protonation and hydrogen bonding, which further increased the distance from Mn 2+ . Notably, the saturation magnetization of SPIO aggregates significantly exceeded that of individual SPIO particles. Consequently, the aggregation of dispersed SPIO enhanced the inhomogeneity of the magnetic field, thereby improving the T 2 signal and achieving the second step of distance coordination, termed “regathering”. In conclusion, SPMN demonstrated substantial dual-modality MRI enhancement and held considerable promise for MRI-guided tumor diagnosis.
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2025
·
IF 9.6
Huanhuan Wu,Haoyu Wang,Jinwen Wei,Gang Shu,Shao-kai Sun,Cai Zhang,Dong Li
Acquiring multidimensional tumor and tumor-associated vascular information is essential for accurate diagnosis and treatment planning of glioma, yet effective imaging methods are still lacking. Here, ultrasmall manganese ferrite nanoparticles (UMFNs) are developed as a dual contrast-enhanced T 1 -weighted imaging (T1WI) and susceptibility-weighted imaging (SWI) probe for multidimensional diagnosis of glioma. The UMFNs are synthesized through thermal decomposition and functionalized with polyethylene glycol, ensuring excellent water dispersibility and biocompatibility. Characterization studies confirm the nanoparticles’ uniform size (3.8 nm) and high stability in various media. High r 1 (6.8 m m −1 s −1 ) and r 2 * (95.1 m m −1 s −1 ) values demonstrate the superior T 1 and T 2 * enhancement capabilities of UMFNs. In vivo imaging on a 3.0 T magnetic resonance imaging (MRI) scanner demonstrates that UMFN-enhanced SWI clearly delineates tumor margins and provides sustained tumor enhancement in ultrasmall orthotopic glioma (<2 mm). Besides, UMFN-enhanced SWI reveals distinct vascular structures associated with the glioma, including tortuous, thickened vessels indicative of tumor-induced angiogenesis. Whole-brain histological analysis corroborates these findings, demonstrating dense tumor proliferation and vascular remodeling. These results highlight the potential of UMFNs as a dual-enhanced agent for the early detection and high-resolution vascular mapping of glioma, providing an advanced multidimensional method for precise diagnosis of brain tumors.
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产品关联
DOI
PubMed
高影响因子
SOFT MATERIALS
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2021
·
IF 2.429
Wen Li,Danxiu Dong,Jinxuan Zou,Huiqiang Zhao,Weilu Zhang
To broaden the applications of alkyl gadolinium (Gd) compounds, a new enhanced hydrophilic soft congeries were fabricated with nonionic surfactant alcohol ethoxylate (AEO) when the micelles constructed in aqueous media. Polyamidoamine (PAMAM) dendrimer was also added to the micellar solution to improve their stability. It was found that the aggregates showed high nuclear magnetic resonance (NMR) contrast effect and hydrophilicity. Meanwhile, the release of gadolinium ions from the aggregates can be controlled by adjusting the solution pH, the temperature or the concentration PAMAM, respectively, suggested the great potential of the congeries as magnetic resonance imaging (MRI) contrast agent.
研究领域:
医学影像学
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材料科学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 41
·6716-6725
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IF 4.872
Yi Cao,Min Liu,Kunchi Zhang,Jingjin Dong,Guangyue Zu,Yang Chen,Tingting Zhang,Dangsheng Xiong,Renjun Pei
Macromolecular contrast agents (CAs) labeled with targeting molecules are gaining remarkable interest as promising materials overcoming the defects of small-molecule CAs. Designed on the basis of biocompatible poly(glycerol) (PG), a linear macromolecular contrast agent (CA) was synthesized with a composition of PG as a backbone and partial hydroxyl connected with gadolinium labeled poly(L-lysine) dendrons, where folic acid was also conjugated. This linear CA exhibited higher relaxivity (7.04 mM−1 S−1) relative to Magnevist® (3.98 mM−1 S−1), and showed negligible toxicity determined by WST assay and histological analysis. In vitro and in vivo magnetic resonance imaging (MRI) measurements presented obvious target specificity to KB cells and tumor. Moreover, high signal enhancement was observed in the tumor region at various time points after intravenous injection to ensure the long time window for imaging. All the findings make it an attractive candidate for tumor-targeted MRI CAs.
研究领域:
生物医学工程
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医学影像学
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 31
·
IF 1.768
Haitao Huang,Tao Yue,Yanyun Xu,Ke Xu,Haibo Xu,Shiyuan Liu,Jiahui Yu,Jin Huang
To enhance biocompatibility and physiological stability of hydrophobic MnO nanoparticles as contrast agent of T 1 -weighted magnetic resonance imaging (MRI), dopamine-functionalized poly(ethylene glycol) (PEG) was used to coat the surface of about 5 nm MnO nanoparticles. Although hydrophilic coating might decrease longitudinal relaxivity due to inhibiting the intimate contact between manganese of nanoparticle surface and proton in water molecules, higher longitudinal relaxivity was still maintained by manipulating the PEGylation degree of MnO nanoparticles. Moreover, in vivo MRI demonstrated considerable signal enhancement in liver and kidney using PEGylated MnO nanoparticles. Interestedly, the PEGylation induced the formation of about 120 nm clusters with high stability in storing and physiological conditions, indicating passive targeting potential to tumor and prolonged circulation in blood. In addition, the cytotoxicity of PEGylated MnO nanoparticles also proved negligible. Consequently, the convenient PEGylation strategy toward MnO nanoparticles could not only realize a good “trade-off” between hydrophilic modification and high longitudinal relaxivity but also contribute additional advantages, such as passive targeting to tumor and long blood circulation, to MRI diagnosis of tumor. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42360.
研究领域:
材料科学
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医学影像学
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生物医学工程
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产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Zhongtao Li,Jing Guo,Mengmeng Zhang,Guohua Li,Liguo Hao
Magnetic resonance molecular imaging can provide anatomic, functional and molecular information. However, because of the intrinsically low sensitivity of magnetic resonance imaging (MRI), high-performance MRI contrast agents are required to generate powerful image information for image diagnosis. Herein, we describe a novel T 1 contrast agent with magnetic-imaging properties facilitated by the gadolinium oxide (Gd 2 O 3 ) doping of mesoporous silica nanoparticles (MSN). The size, morphology, composition, MRI relaxivity ( r 1 ), surface area and pore size of these nanoparticles were evaluated following their conjugation with Gd 2 O 3 to produce Gd 2 O 3 @MSN. This unique structure led to a significant enhancement in T 1 contrast with longitudinal relaxivity ( r 1 ) as high as 51.85 ± 1.38 mM −1 s −1 . Gd 2 O 3 @MSN has a larger T 1 relaxivity than commercial gadolinium diethylene triamine pentaacetate (Gd-DTPA), likely due to the geometrical confinement effect of silica nanoparticles. These results suggest that we could successfully prepare a novel high-performance T 1 contrast agent, which may be a potential candidate for in-vivo MRI.
研究领域:
材料科学
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纳米技术
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医学影像
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产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2021
·
IF 4.641
Asim Mushtaq,Yike Hou,Cong Tian,Tianhao Deng,Changliang Xu,Zhichao Sun,Xiangdong Kong,M. Zubair Iqbal
Multifunctional magnetic photosynthesizer nanocomposites are highly desired to improve the efficacy of the early cancer diagnosis and therapy. However, design a highly biocompatible theranostic system with controlled size and shape at the nanoscale without altering the original properties of the primary materials is a challenging task. Herein, rhombic shaped manganese (Mn) doped titanium dioxide (TiO 2 ) nanocomposites are designed to enhance the generation of reactive oxygen species (ROS) by photocatalytic property and spin relaxation for MRI. Transmission electron microscopy (TEM) results revealed the average size of the synthesized Mn-TiO 2 rhombic nanocomposites (RNCs) was about 20–30 nm with homogeneous shape and dispersion. EDS and XPS analyses proved the incorporation of Mn ions into the anatase TiO 2 lattice. After Pluronic® F-68 surface modification, Mn-TiO 2 -PF-68 RNCs demonstrated negligible toxicity and physiological stability. Prepared fluorescein isothiocyanate (FITC) labeled RNCs are encapsulated by the plasma membrane and surrounded the nucleus of 4T1 mice breast cancer cells which improve the efficiency of prepared RNCs. In addition, the Mn 3+ ions remarkably enhanced the positive contrast (T 1 ) for magnetic resonance imaging (MRI) and presented significant r 1 relaxivity and low r 2 /r 1 relaxivity ratio. Finally, Mn 3+ doped with photosensitizers (TiO 2 ) also exhibited a great synergistic effect of photo-killing in vitro by developing hydroxyl radicals. Therefore, the as-prepared Mn–TiO 2 RNCs are promising candidate as a new kind of multifunctional agent for both MRI and PDT applications.
研究领域:
生物医学工程
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材料科学
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影像医学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2024
·
IF 18.5
Qianyu Yang,Gang Wu,Yefeng Yang,Yang Zhou,Jiali Song,Huile Gao,Weiyuan Huang
Based on the properties of photodynamic therapy (PDT) and magnetic resonance imaging (MRI), combining them to construct multifunctional nanotheranostics can leverage strengths and avoid weaknesses for tumor diagnosis and treatment. However, certain problems remain unsolved, notably the short observation window caused by insufficient retention time. In this study, a GSH-responsive shape-transformable nanotheranostics Gd-Ce6-FFVLGGGC-SS-PEG are designed (abbreviated as GdCFS) by combining a single metal Gd with Ce6, and peptide (Phe-Phe-Val-Leu-Gly-Gly-Gly-Cys) disulfide-conjugated with polyethylene glycol (PEG) to perform dual-modal T 1 /T 2 MRI specifically at the tumor site. Due to its amphiphilic features, GdCFS can self-assemble to spherical nanoparticles, while transforming to nanofibers (NFs) in the presence of intracellular overexpressed GSH stimuli. After NFs formation, the hydrophobic core of GdCFS is exposed, resulting in T 1 positive contrast enhancement, whereas NFs can simultaneously achieve T 2 negative contrast enhancement. Furthermore, GSH depletion can cause imbalance in intracellular redox state, ultimately improving PDT efficacy. GdCFS benefits from the shape-transformation in terms of sufficient retention time, thus positively minimizing the toxicity risk. On the tumor model of nasopharyngeal carcinoma, in vivo and in vitro outcomes confirm that GdCFS can be a promising candidate for early diagnosis, real-time monitoring, and precise treatment of tumors with great biocompatibility.
研究领域:
医学
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纳米医学
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肿瘤学
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影像学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Lile Dong,Peng Zhang,Pengpeng Lei,Shuyan Song,Xia Xu,Kaimin Du,Jing Feng,Hongjie Zhang
Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T1/T2-weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF3:Fe nanoparticles (PEG-GdF3:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T1/T2-weighted MRI and X-ray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T1 contrast, evident T2 contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF3:Fe NPs. Therefore, PEG-GdF3:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.
研究领域:
生物医学成像
·
纳米医学
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癌症诊断
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分子成像
·
放射学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）